<p><strong>A team from CEITEC Masaryk University (MUNI) in collaboration with researchers from two research institutes in Norway has, for the first time, captured how echovirus 18, a member of the enterovirus genus, releases its genetic material into cells to initiate infection. The study provides a structural view of an early stage of viral infection under near-native conditions. Using cryo-electron microscopy, the researchers discovered that the virus does not release its RNA through a small pore in its capsid, as had long been assumed. Instead, its protein shell partially disassembles, creating a large opening through which the viral genetic material escapes into the host cell. A detailed understanding of this genome release mechanism could eventually help develop compounds preventing enteroviruses from infecting cells.</strong></p><p>Enteroviruses are common human pathogens causing diseases ranging from the common cold and gastrointestinal infections to severe neurological disorders. Echovirus 18, the virus investigated in this study, is known primarily as a cause of meningitis and encephalitis in children. It belongs to the picornaviruses, a family of small, non-enveloped viruses whose genetic material is protected by a protein shell, the capsid, organized with icosahedral symmetry.</p><p>To replicate within a cell, the enteroviruses must release their RNA – the molecule that carries viral genetic information – from the capsid, into the cell cytoplasm. Although this step is crucial for initiating infection, it has never been observed in infected cells.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_z_CEITEC_jako_prvni_zachytili_jak_enteroviry_spousteji_infekci_bunek_71d553bb0e.jpg" alt="CEITEC/Plevka Lab: CEITEC Scientists Are the First to Capture How Enteroviruses Initiate Infection: View into a cell infected by echovirus 18. Echovirus 18 is shown in green and yellow, ribosomes in violet, and actin filaments in cyan. Scale 50 nm. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_z_CEITEC_jako_prvni_zachytili_jak_enteroviry_spousteji_infekci_bunek_71d553bb0e.jpg 221w," sizes="100vw" width="1600" height="1128"></p><p><i>“For a long time, two main theories existed about how picornaviruses deliver their RNA genomes into cells. One proposed that the genome leaves the capsid through a small opening. The other, supported by earlier work from our laboratory, suggested that the genome escapes from partially disassembled capsids missing pentamers of capsid proteins. However, both models were based on experiments with virus particles outside cells. We wanted to go one step further and see what really happens during infection inside a cell,”</i> says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/liya-mukhamedova-ph-d/u89248?page=publication"><strong>Liya Mukhamedova</strong></a><strong>, the study’s first author from CEITEC MUNI</strong>.</p><p>Using cryo-electron microscopy, which allows scientists to visualize biological structures at exceptionally high resolution, the researchers observed individual echovirus 18 particles directly within infected cells. They discovered that empty virus particles in infected cells lack parts of their capsids. It is through these openings that the virus releases its RNA.</p><p>The study also revealed the role of the FcRn receptor, a cell-surface molecule that enteroviruses use to enter cells. The binding of the virus to the receptor triggers structural changes in the viral particle that prime it for subsequent genome release. The team showed that receptor binding causes the loss of the so-called pocket factor, a small molecule that normally helps stabilize the virus particle. The virus otherwise remains largely intact, suggesting that receptor binding is only the first step toward uncoating, while additional factors within the cell are required to complete the process and trigger genome release.</p><p><i>“Infection is a complex process, during which enterovirus particles sense various interactions with cell components. The binding of echovirus 18 to the FcRn host-cell receptor triggers conformational changes in the virus, priming it for genome release.”</i> – explains <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/pavel-plevka-ph-d/u26854"><strong>Pavel Plevka</strong></a><strong>, head of the Structural Virology Research Group</strong>.</p><p>The researchers did not observe the so-called activated particles that are key intermediates in the enterovirus uncoating process. This suggests that genome release in cells occurs much faster than previous experiments had suggested.</p><p>By combining structural data obtained from studies of virus particles outside living cells with observations of infected cells, the study offers a picture of how enterovirus infection begins. Moving beyond simplified experiments with isolated virus particles, it brings scientists closer to understanding the earliest stages of enterovirus infection as they occur in living cells. The study, was published in the <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1073/pnas.2601182123"><strong>PNAS journal</strong></a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_z_CEITEC_jako_prvni_zachytili_jak_enteroviry_spousteji_infekci_bunek_2_3601bf1df9.jpg" alt="CEITEC/Plevka Lab: CEITEC Scientists Are the First to Capture How Enteroviruses Initiate Infection: Reconstructions of E18 particles from infected cells. The particles are rainbow-colored based on the distance from the particle center. Scale 10 nm." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_z_CEITEC_jako_prvni_zachytili_jak_enteroviry_spousteji_infekci_bunek_2_3601bf1df9.jpg 245w," sizes="100vw" width="1600" height="906"></p><blockquote><h4><strong>Article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.pnas.org/doi/10.1073/pnas.2601182123"><strong>Particles of echovirus 18 open to release their genomes in vivo</strong></a></h4><p>Liya Mukhamedova, David Buchta, Zuzana Trebichalská, Yevgen Levdansky, Jana Moravcová, David Potěšil, Zbyněk Zdráhal, Dominik Hřebík, Lucie Nepovímová, Torleif Tollefsrud Gjølberg, Jan Terje Andersen, Jiří Nováček, Tibor Füzik, and Pavel Plevka</p><p><i><strong>Proc. Natl. Acad. Sci. U.S.A.</strong></i>, 2026, <strong>123</strong>, e2601182123</p><div>&nbsp;</div><div><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1073/pnas.2601182123">https://doi.org/10.1073/pnas.2601182123</a></div><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Enteroviruses cause a broad spectrum of human diseases, ranging from mild respiratory or gastrointestinal infections to severe neurological disorders such as aseptic meningitis and encephalitis. Enterovirus cell entry involves receptor-mediated endocytosis followed by destabilizing rearrangements of the virus capsid that enable genome release. However, the mechanism of enterovirus genome release has not been visualized in infected cells. Here, we used cryoelectron tomography and microscopy to image echovirus 18 (E18) entry into host cells and its interaction with the neonatal Fc receptor (FcRn). 30 min postinfection, endosomes and cytoplasm contained empty capsids missing one or several pentamers of capsid proteins, providing evidence that in vivo E18 releases its genome through capsid opening. In vitro, FcRn binding induced the expulsion of pocket factors from hydrophobic pockets in VP1, priming the virus for uncoating. The cryoelectron microscopy reconstruction of genome-containing particles of E18 inside infected cells did not reveal pocket factors, indicating that receptor binding triggers the same priming process during infection. We did not detect activated particles in infected cells, suggesting that these intermediates are short-lived and rapidly release their genomes in vivo. Our results identify capsid opening as the in vivo mechanism of echovirus 18 genome release, providing structural evidence for a process previously only inferred from in vitro experiments.</p>

CEITEC Scientists Are the First to Capture How Enteroviruses Initiate Infection 

<p><strong>ISC 2026 officially opened in Prague on Sunday, September 6, bringing the international separation science community together at the Prague Congress Centre. The first day began with six Short Courses covering topics from analytical procedure lifecycle and mass spectral interpretation to HILIC, oligonucleotides, LC/MS data analysis, and supercritical fluids. In the afternoon, conference chairs Michal Holčapek and Lucie Nováková welcomed participants during the Opening Ceremony, followed by the J.F.K. Huber Medal Award Ceremony. The scientific program then moved into its first plenary session, spanning spintronics, single-cell proteomics and robust LC-MS, and rapid evaporative ionisation mass spectrometry. The opening day concluded with the Welcome Reception, giving participants their first opportunity to meet colleagues from around the world and begin a week of scientific exchange, new ideas, and chromatography in the heart of Prague.</strong></p><h4><strong>Sunday, September 6th</strong></h4><h5><span><strong>8:30–15:45 Short Courses 3 - 8</strong></span></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Short_Courses_Koen_Sandra_176f1c6d52.jpg" alt="ISC: ISC 2026 - Day 1: Short Course SC 6 Oligonucleotides and Other Biopharmaceuticals (Koen Sandra)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Short_Courses_Koen_Sandra_176f1c6d52.jpg 235w," sizes="100vw" width="1600" height="1067"></p><h5><span><strong>16:00–16:30 Opening Ceremony</strong></span></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/articles?search=hol%C4%8Dapek"><span><strong>Michal Holčapek</strong></span></a><span>, Czech Republic</span></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/articles?search=Lucie+Nov%C3%A1kov%C3%A1"><span><strong>Lucie Nováková</strong></span></a><span>, Czech Republic</span></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Opening_Novakova_and_Holcapek_bbf9dd44e3.jpg" alt="ISC: ISC 2026 - Day 1: Michal Holčapek and Lucie Nováková opened ISC 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Opening_Novakova_and_Holcapek_bbf9dd44e3.jpg 235w," sizes="100vw" width="1600" height="1067"></p><h5><span><strong>16:30–17:00 Award Ceremony</strong></span></h5><ul><li>J.F.K. Huber Medal (awarded by the Austrian Society for Analytical Chemistry)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_JFK_Huber_Award_winner_Dave_846f6a5dff.jpg" alt="ISC: ISC 2026 - Day 1: Davy Guillarme as a 2026 recipient of the J.F.K. Lecture Award of the Austrian Society of Analytical Chemistry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_JFK_Huber_Award_winner_Dave_846f6a5dff.jpg 235w," sizes="100vw" width="1600" height="1066"></p><h4><strong>Plenary lectures</strong></h4><h5><strong>17:00 - 17:30 Spintronics: A new paradigm in digital bits</strong></h5><ul><li>Tomáš Jungwirth, Czech Republic&nbsp;&nbsp;&nbsp;&nbsp;</li></ul><p>Besides the rapid developments in the big world of cloud data centers and AI, a remarkable paradigm shift is occurring on the level of the smallest “elementary particle” of information technologies – the single physical bit. For the first time in the history of microprocessor chips, semiconductor bits are being replaced by a fundamentally distinct technology. The technology is based on magnets and is called spintronics. All major developers and manufacturers of the advanced chip technologies are now implementing these new spintronic bits. Not across the entire microprocessor chip, but in some of its vital memory parts. The transition to the spintronic bits is happening because further miniaturization of semiconductor bits has become prohibitively expensive or even reached fundamental physical limits. In the talk we will introduce the distinct physical principle behind the spintronic bits, and highlight some of the recent adbances in spintronics research and development.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Tomas_Jungwirth_dd6eeca2b5.jpg" alt="ISC: ISC 2026 - Day 1: Spintronics: A new paradigm in digital bits (Tomáš Jungwirth, Czech Republic)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Tomas_Jungwirth_dd6eeca2b5.jpg 245w," sizes="100vw" width="1595" height="1008"></p><h5><strong>17:30 - 18:00 Single cell proteomics requires robust LC-MS: Unexpected findings bring new biological understanding</strong></h5><ul><li>Jennifer Van Eyk, USA&nbsp;&nbsp;&nbsp;&nbsp;</li></ul><p>Underlying precision medicine is the concept that an individual’s Omic signature (including the proteome) will provide a physician with clinically actionable diagnosis and a subsequent mechanistic therapeutic route that is appropriate for a particular person. This concept is based on the idea of pathological heterogeneity and recognizes the impact of differences in the heath state of individuals. The deployment of single cell technologies has demonstrated heterogeneity within a single cell type which impacts the degree of cellular heterogeneity within an organ. Unlike bulk proteomic approaches, which average signals across heterogeneous populations, single-cell proteomics captures the molecular diversity of cell. Today single-cell proteomics can provide high-resolution characterization of protein quantities and variability within the structural composition and signaling dynamics within individual cells which requires robust, precise and sensitive liquid chromatography and mass spectrometry (LC-MS) workflows with sufficient throughput to quantitatively analyze 1000s of single cells.</p><p>We have developed stable and precise single cell LC-MS workflow based on high-flow, dual trap with a single analytical column system that can achieve 96 samples per day. Furthermore, we have coupled this with a novel parallel sample preparation method on demand within the autosampler reducing sample lose and matching throughput with the LC-MS. Here, we have investigated the proteomic heterogeneity of cardiac muscle cells, cardiomyocytes, the specialized cells that contain the contractile proteins and which are responsible for the heart contraction and relaxation. By applying single-cell proteomics to cardiomyocytes isolated from human and mouse hearts, as well as human iPSC-derived cardiomyocytes, we uncovered previously unrecognized cellular subpopulations distinguished by differences in contractile and metabolic protein expression. As well unexpectedly, we unambiguously identified proteins traditionally considered absent in adult cardiomyocyte, such as slow skeletal troponin T, previously thought to be restricted to fetal or skeletal muscle or those proposed to be limited to non-cardiac cell types (e.g., neuronal proteins) or species (e.g., myosin heavy chain 7b). This suggests an unexpected fluidity in cardiac protein expression. Furthermore, single cell proteomics has provided critical insight into protein-level remodeling in heart failure, where the same single amino acid mutation in a contractile protein can give rise to diverse clinical phenotypes. At the single cell level, the mutant protein dosage in each cell drives a continuum of subproteomic pathological alterations. Only with precise protein quantification at the single cell level, is this understanding possible – all of which hinges on the LC-MS performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Jennifer_Van_Eyk_f8641196ff.jpg" alt="ISC: ISC 2026 - Day 1: Single cell proteomics requires robust LC-MS: Unexpected findings bring new biological understanding (Jennifer Van Eyk, USA)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Jennifer_Van_Eyk_f8641196ff.jpg 235w," sizes="100vw" width="1600" height="1066"></p><h5><strong>18:00 - 18:30 Rapid evaporative ionisation mass spectrometry: From MSI to LC-MS</strong></h5><ul><li>Zoltan Takats, United Kingdom&nbsp;&nbsp;&nbsp;&nbsp;</li></ul><p>Rapid Evaporative Ionisation Mass Spectrometry (REIMS) was originally developed for mass spectrometry-guided surgery applications, enabling the direct, real-time analysis of surgical aerosols for in-situ histological identification of tissues in cancer surgery. Coupling the technique with various surgical and non-surgical lasers led to the recognition, that the technique has comparable sensitivity to other, widely used desorption ionisation methods including DESI and MALDI. Laser Ablation REIMS using 3 μm wavelength picosecond lasers was demonstrated to provide sub-cellular resolution metabolic and lipidomic images at 2-5 μm spatial resolution, with clear visualisation of cellular nuclei. The method was subsequently used for regenerative neuroscience and cancer biology applications. The unexpectedly high sensitivity of the method (fg amounts of lipids and metabolites / pixel) encouraged us to attempt using REIMS as an LC-MS ion source. The current commercially available REIMS instrumentation utilises the so-called matrix-assited REIMS technology, involving the co-introduction of a polar solvent (water, acetonitrile or aliphatic alcohols) together with the sample aerosol. The fused droplets containing solvent and soluble components of the aerosol are introduced into the vacuum where they impact a heated (≈900 ºC) surface resulting in their 'rapid evaporation' yielding the detected ion population. In this context, the ionisation matrix was replaced by LC effluent, leading to a fundamentally new way of ionisation. The new technique termed LC-REIMS was characterised using reversed phase LC applications including lipid and metabolite profiling. The new ionisation method was found to exhibit high similarity to sonic spray and related techniques, in spite of the high temperature involved. Analytical sensitivity for complex lipids and amino acids were found to be comparable to those in ESI or APCI, albeit the relative response factors followed markedly different trends. As the technology represents an LC-MS coupling without any requirement for pressurised gas or high voltage, it has significant application potential for field instrumentation including industrial process control or security screening.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Zoltan_Takats_3e0c11a22e.jpg" alt="ISC: ISC 2026 - Day 1: Rapid evaporative ionisation mass spectrometry: From MSI to LC-MS (Zoltan Takats, United Kingdom)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Zoltan_Takats_3e0c11a22e.jpg 129w," sizes="100vw" width="1600" height="1933"></p><h5><span><strong>18:30–19:30 Welcome Reception</strong></span></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Welcome_reception_36bfcb7276.jpg" alt="ISC: ISC 2026 - Day 1: Welcome reception" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Welcome_reception_36bfcb7276.jpg 235w," sizes="100vw" width="1600" height="1067"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_ISC_2026_Day_1_Welcome_reception_2_4ae69091a6.jpg" alt="ISC: ISC 2026 - Day 1: Welcome reception" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_ISC_2026_Day_1_Welcome_reception_2_4ae69091a6.jpg 235w," sizes="100vw" width="1600" height="1067"></p>

ISC 2026 - Day 1

ISC 2026 - Day 2

Article

Events

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Waters Empower Chromatography Data System (CDS)

Empower Chromatography Data System (CDS) has been intentionally designed to help you address your most rigorous chromatographic, regulatory, and networking challenges.

<div><div id="title-230ef9ecce" data-locator="title-with-text"><h3><strong>Elevate your chromatography with the universal language of the lab</strong></h3></div></div><div><div id="text-3b75bcd8fb" data-locator="text"><p><strong>Simplifying the way you collect, manage, and report chromatography test results is critical to your lab efficiency. With a suite of flexible functionalities that grows to meet your changing quality, business, and laboratory needs, Empower Chromatography Data System (CDS) has been intentionally designed to help you address your most rigorous chromatographic, regulatory, and networking challenges.</strong></p><p>Empower CDS<strong> </strong>helps your entire laboratory operate more efficiently and securely with the industry's most advanced data acquisition, management, processing, analytics, and reporting capabilities. Easily scalable from a single workstation to an enterprise-wide network, where you can work at the bench, across sites, and even remotely with on-premises or cloud options, Empower CDS provides an environment where your records are traceable, so you always have full control of your most critical asset - your data.</p><div><div id="text-8f4122209c" data-locator="text"><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-07744ba23e" data-locator="text"><ul><li><strong>Store and retrieve chromatography data using an embedded, relational database</strong>; simplifying data retrieval by searching with criteria that is meaningful to you</li><li><strong>Save time, reduce manual integration, and calculate more precise peak integrations</strong> with the ApexTrack algorithm in Empower CDS</li><li><strong>Easily control</strong> Waters high-performance liquid chromatography (HPLC), UHPLC, and UPLC systems, as well as non-Waters HPLC, gas chromatography (GC), photodiode array detector (PDA), and mass spectrometry (MS) systems</li><li><strong>Achieve more enhanced detection capabilities</strong> when using Waters mass detectors or the Waters ACQUITY UPLC PDA Detector</li><li><strong>Grow seamlessly from a single workstation to an enterprise-wide system</strong> with the scalable, modular architecture in Empower CDS, which fits into the most modern and secure high-availability corporate architecture</li><li><strong>Deploy applications</strong> such as dissolution, method validation, integrated chemical structures, and polymer or size exclusion analysis</li></ul></div></div><div><div id="text-a7790dd22b" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>For advanced data acquisition, management, processing, reporting, and distribution of chromatography analysis data.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Empower_Chromatography_Data_System_CDS_Operate_more_efficiently_and_securely_with_the_flexible_capabilities_of_Empower_Chromatography_Data_System_CDS_9625ca12d5.jpg" alt="Waters Empower Chromatography Data System (CDS): Operate more efficiently and securely with the flexible capabilities of Empower Chromatography Data System (CDS)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Empower_Chromatography_Data_System_CDS_Operate_more_efficiently_and_securely_with_the_flexible_capabilities_of_Empower_Chromatography_Data_System_CDS_9625ca12d5.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div id="text-f39d8a00c0" data-locator="text"><h3 data-locator="modal-title"><strong>Interface options unique to your users</strong></h3><p>Empower Software represents a fundamental shift in <strong>UPLC/UHPLC, HPLC, and LC-MS</strong> system usability. It is equipped with unique interface options designed for your lab, regardless of the task or user's skill level. When users log in, they are presented with the application that provides the appropriate workflow for them. If authorized, users can select another software interface that is suitable for their current task.</p><h5><strong>The three Empower Software applications are:</strong></h5><ul><li><strong>QuickStart</strong>&nbsp;- Collect, process, and report data from a single-window access. Use a wizard to set up methods and run assays. Navigate the entire Empower environment from one screen, including instrument control, view plotted data in real time, view raw data, and access tools to customize and print reports.</li><li><strong>Pro</strong>&nbsp;- Access to all software functions for advanced users, system administrators, or anyone who needs total control.</li><li><strong>Open Access</strong>&nbsp;- Select your method and the number of samples you need to run and get started with the click of a mouse. No chromatography experience is necessary.</li></ul><figure class="image"><img style="aspect-ratio:1024/594;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Empower_Chromatography_Data_System_CDS_The_Empower_Quick_Start_interface_uses_a_navigation_bar_to_guide_you_through_the_software_and_all_tasks_are_carried_out_in_one_window_dfe3ec8bb7.jpg" alt="Waters Empower Chromatography Data System (CDS): The Empower QuickStart interface uses a navigation bar to guide you through the software and all tasks are carried out in one window." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Empower_Chromatography_Data_System_CDS_The_Empower_Quick_Start_interface_uses_a_navigation_bar_to_guide_you_through_the_software_and_all_tasks_are_carried_out_in_one_window_dfe3ec8bb7.jpg 245w," sizes="100vw" width="1024" height="594"></figure><div><div id="text-b65d021cbc" data-locator="text"><h3 data-locator="modal-title"><strong>Ideal for data analysis</strong></h3><h5><strong>Improve data analysis workflows and information sharing across your lab with Empower Software, which helps you achieve:</strong></h5><ul><li><strong>Reliable shoulder peak detection</strong> - ApexTrack effectively detects and integrates shouldered peaks, providing more reliable detection of low-level peaks on noisy or sloping baselines for less manual manipulation and more accurate results.</li><li><strong>Automated custom calculations</strong> - Simply use a wizard to set up your parameters, like averages or % relative standard deviation (RSD). After configuring the calculation once, Empower Software automatically determines the answer when data is processed - no more data transfer, spreadsheet manipulation, or transfer errors.&nbsp;</li><li><strong>Better information sharing </strong>- Easily share information with colleagues worldwide with results and reports stored within the same database. Create combined summary reports across laboratories, instruments, and projects, regardless of where data was acquired or processed. Create PDFs or email reports, distribute methods and information electronically, access information between remote sites, and review and electronically sign off results.</li><li><strong>Fast access to information </strong>- Empower CDS has an embedded relational database, enabling you to store chromatographic results, automatically linking all metadata without manual information tracking or documentation, and better preparing you for review questions or audits. Find data fast and easily with relevant search terms and automatic time stamps of user activity - without a flat file environment, awkward naming conventions, or manual method and result versioning.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Empower_Chromatography_Data_System_CDS_9a791332d9.jpg" alt="Waters Empower Chromatography Data System (CDS): As an example of the breadth of technology that Empower offers, the software can control mass spectrometry (MS) instruments and acquire and process MS data. Spectral information from multiple detection modes can be viewed simultaneously. This enables scientists to easily perform complex analyses with minimal training, increasing lab productivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Empower_Chromatography_Data_System_CDS_9a791332d9.jpg 245w," sizes="100vw" width="1024" height="553"></p><div><div id="text-a10f03a0ca" data-locator="text"><h3 data-locator="modal-title"><strong>At-a-glance key chromatography data views to maximize lab resources</strong></h3><p>Empower Laboratory Analytics assembles and displays critical chromatography performance data in easy-to-view, graphical dashboards so you can focus on what’s most important―the interpretation of key information, not its collection.&nbsp;</p><p>Empower Laboratory Analytics offers a range of prebuilt dashboard types, including system summary, system usage, project usage analysis, and methods analysis. These at-a-glance dashboards let you quickly and accurately determine how laboratory resources are being used, without significant manual effort. With these dashboards, you can make evidence-based decisions on which improvements are needed to increase laboratory efficiency.&nbsp;</p><p>With Empower Laboratory Analytics, you can maximize system utilization and better manage resources. You can quickly identify training needs, error messages affecting workflows, and non-robust processing methods. With Empower Software, your lab can better plan for capital expenditures and identify opportunities to shorten run times with UPLC/UHPLC technology.</p></div></div><div><div id="text-497ef11ba3" data-locator="text"><h3 data-locator="modal-title"><strong>Monitor your chromatography system anytime, anywhere</strong></h3><h5><strong>Empower Mobile gives you wireless access to Empower Software from a tablet or smartphone, making it easier to know what’s happening in your laboratory no matter where you are to:</strong></h5><ul><li>Improve laboratory efficiency</li><li>Easily find and share results remotely</li><li>Expedite workflow for signoff on reports</li><li>Lower operating costs for system administration tasks</li><li>Reduce sample and mobile phase waste</li></ul><p>Whether you are an analyst, manager, or system administrator, this easy-to-use application, specially designed to run on mobile devices, gives you the flexibility to work on other priorities, knowing that you can use your mobile device at any time to monitor system status, perform routine system administration tasks, and review and sign off reports.</p><p>Empower Mobile is versatile and has been optimized to work with Apple iPad and iPhone and Android tablet and smartphone devices. Empower Mobile can be installed on your Empower Software network in either workgroup or enterprise configurations, all at no additional cost to you.&nbsp;</p><div><div id="text-8f9e5e7bd5" data-locator="text"><blockquote><h3><strong>Empower 3.9.0 is here</strong></h3><h5><strong>Keep your lab current with the latest Empower Software release built to enhance efficiency, productivity, and compliance readiness so you can drive better scientific and business outcomes across your organization.</strong></h5><h4><strong>With Empower 3.9.0 you can:</strong></h4><ul><li><strong>Reduce risk: </strong>Full Windows® 11 support to keep your data safe with the latest Microsoft® updates.</li><li><strong>Increase efficiency: </strong>Updates in the Review window simplify work for users when workflows require technical controls to reduce the potential for human bias.</li><li><strong>Reduce cost and effort: </strong>New Empower RapidDeploy Software option for LAC/E devices reduces the effort spent planning, preparing, and coordinating LAC/E device upgrades and significantly reduces resource constraints often encountered during upgrades — reducing upgrade costs and minimizing downtime during upgrades so you can&nbsp;keep your operations current.</li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/services/software-services/software-upgrades/empower-software-upgrade-request.html"><strong>Upgrade to the latest version!</strong></a></h4></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters MassLynx Mass Spectrometry Software

With development largely driven by input from our extensive user base, MassLynx provides the fundamental platform to acquire, analyze, manage, and share mass spectrometry information.

<h3><strong>Our well-established MassLynx software package delivers market-leading versatility and flexibility for all application areas.</strong>&nbsp;</h3><div><div id="text-f93532e53f" data-locator="text"><p><strong>MassLynx was first pioneered to simplify interaction with mass spectrometry (MS) and has continually improved to meet changing customer needs. The result: a market-leading software solution that allows users to best leverage their MS system and harness real-time intelligence, ensure MS system performance, and more quickly convert sample data into valuable knowledge. With development largely driven by input from our extensive user base, MassLynx provides the fundamental platform to acquire, analyze, manage, and share mass spectrometry information.</strong></p><p>MassLynx Software features a <strong>21 CFR Part 11-compatible security</strong> including <strong>file encryption, audit log</strong>, and <strong>secure archival/retrieval technology</strong> with flexible security policies to meet your lab requirements. Waters also offers excellent <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=1000349" data-di-id="di-id-5aca7e0f-b105e917"><strong>service and suppor</strong>t</a> to get the system up and running – for on-time results without the stress.</p><h2><strong>MassLynx Quantitation Applications</strong></h2><div><div id="title-eb2a5ffa29" data-locator="title-with-text"><h4><strong>Streamline quantitative data acquisition and processing</strong></h4></div></div><div><div id="text-baefaeaec6" data-locator="text"><p>The rate determining step in many analyses is not data acquisition, but the speed your data can be converted into useful information.</p><p>To assist you with both application-specific data acquisition and the transformation of data into usable results, MassLynx for quantitation offers a range of <strong>application managers</strong> with specialized data processing functionalities, which eliminates the need for complex time-consuming manual data review, increasing your productivity.</p><p>The functionality of <strong>MassLynx application managers</strong> has been guided by our customers and optimized for your data analysis and processing requirements.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Mass_Lynx_Quantitation_Applications_b5a284165b.jpg" alt="Waters: MassLynx Quantitation Applications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Mass_Lynx_Quantitation_Applications_b5a284165b.jpg 245w," sizes="100vw" width="1428" height="625"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-4b29255c4a" data-locator="text"><ul><li>A tried and well-established software package, MassLynx delivers the versatility and flexibility you require for all of your quantitation applications</li><li>MassLynx security system provides compliance ready tools to meet GxP and 21 CFR Part 11 regulations and TargetLynx XS delivers the information necessary for regulatory compliance</li><li>Inlet method editor and MS method editor allow the user to intuitively build LC-MS/MS methods for quantitative data acquisition</li><li>Auto-dwell for MRM dwell times makes it easy to optimize MRM methods to maximize points per peak and get the best quantitative performance</li><li>IntelliStart guarantees maximum system performance and usability for reproducible results</li></ul></div></div><div><div id="text-adc477d45b" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>MassLynx quantitation applications streamline quantitative data acquisition and processing.</p><div><div id="title-be02784995" data-locator="title-with-text"><h2><strong>MassLynx Mass Detection Applications</strong></h2></div></div><div><div id="title-d5b484d548" data-locator="title-with-text"><h4><strong>Intuitively interact with your mass detection system with MassLynx</strong></h4></div></div><div><div id="text-0fc50dc8ea" data-locator="text"><p>The challenges of mass spectrometry (MS) analyses are often compounded by the use of several types of analytical instruments and high personnel turnover. To maintain and even increase laboratory productivity and efficiency, MassLynx Software simplifies interaction with your mass detection system. MassLynx enables users with a wide range of expertise to easily acquire high-quality mass spectral data with minimal training.</p><p>MassLynx application managers enable you to focus the power of MS on your laboratory's tasks.</p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-fb3c291dd5" data-locator="text"><ul><li>MassLynx delivers the versatility and flexibility you require for all of your mass detection applications</li><li>Easy-to-use application managers enable you to simply transform mass spectral data into usable results</li><li>Intuitive setup and interaction with the mass detector guarantees optimal performance and reproducible results</li><li>Routinely using the same intuitive software provides familiarity and simplicity for more efficient workflows</li><li>Inlet method editor and MS method editor allow the user to intuitively build LC-MS methods for qualitative and quantitative data acquisition</li></ul></div></div><div><div id="text-4b89cfd965" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>Masslynx Application Managers enable laboratories to confidently produce high quality results without complexity.</p><p><img style="aspect-ratio:1086/319;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Mass_Lynx_Mass_Detection_Applications_f261c2afd6.jpg" alt="Waters: MassLynx Mass Detection Applications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Mass_Lynx_Mass_Detection_Applications_f261c2afd6.jpg 245w," sizes="100vw" width="1086" height="319"></p><div><div id="title-67851c4cd4" data-locator="title-with-text"><h2><strong>MassLynx High-Resolution Applications&nbsp;</strong></h2></div></div><div><div id="title-1688118c0d" data-locator="title-with-text"><h4><strong>Fully characterize your samples with Waters high-resolution mass spectrometry</strong></h4></div></div><div><div id="text-fc7cb897e2" data-locator="text"><p>As the power of high-resolution mass spectrometry (HRMS) allows today’s labs to obtain high quality data, the challenge is then to confidently identify and characterize components of interest.</p><p>Waters MassLynx Applications enable your lab to efficiently process and interpret HRMS data sets – whether your samples are biological, chemical, environmental, or pharmaceutical, we have a solution that meet your needs, whether it's based on gas chromatography (GC-MS) or liquid chromatography mass spectrometry (LC-MS).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Mass_Lynx_High_Resolution_Applications_9811f2e6b9.jpg" alt="Waters: MassLynx High-Resolution Applications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Mass_Lynx_High_Resolution_Applications_9811f2e6b9.jpg 245w," sizes="100vw" width="1422" height="594"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-b16ee61766" data-locator="text"><ul><li>Rapidly identify metabolites with MetaboLynx XS</li><li>Achieve confident structural elucidation with MassFragment</li><li>Automate the processing of LC-MS, GC-MS, LC-MS/MS, or GC-MS/MS data with ChromaLynx</li><li>Meet quantitative and qualitative proteomics research requirements with ProteinLynx Global Server (PLGS)</li></ul></div></div><div><div id="text-1dee9a4274" data-locator="text"><h3><strong>Recommended Use&nbsp;</strong></h3><p>For identifying and characterizing data acquired using high-resolution mass spectrometry.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Products from category Chromatography software from Waters - page 1

Related content

ISC 2026 - Day 2

CEITEC Scientists Are the First to Capture How Enteroviruses Initiate Infection

ISC 2026 - Day 1