NIST26 includes integrated processing tools for LC-MS/MS data, but there are situations where working directly from instrument vendor software can be faster and more practical. When only a few peaks need to be evaluated, when mzML conversion is inconvenient, or when nominal-mass data are involved, spectra can be transferred directly into NIST Library Search for identification. This workflow can streamline spectral searching while still providing access to NIST high-resolution and low-resolution libraries, public MS/MS resources, and flexible search settings.<h4>When does direct transfer from vendor software make sense?</h4>NIST26 provides integrated data processing in the Chromatogram tab, including workflows for deconvolution and library searching. In many cases, this is the most comprehensive way to process LC-MS/MS datasets.However, chromatogram-based processing generally requires conversion of the original vendor data into mzML, for example using ProteoWizard/MSConvert. If a chromatogram is relatively simple, deconvolution is unnecessary, and only a small number of peaks need to be investigated, converting and processing the entire file may add unnecessary steps.In these situations, it can be more efficient to select an MS/MS spectrum directly in the original vendor software and send it to NIST Library Search.There are also other cases where direct transfer becomes particularly useful. Some proprietary data formats may not convert cleanly into mzML, while nominal-mass MS/MS data are not supported for MS/MS searching in the NIST26 Chromatogram tab. For this type of data, transferring or importing spectra into Library Search becomes the practical alternative.<h4>Which vendor software can send spectra directly to NIST?</h4>Several major instrument platforms provide direct integration with NIST Library Search.The workflow is available with software from:<ul><li>Agilent, including MassHunter and OpenLab,</li><li>Waters,</li><li>Thermo Fisher Scientific.</li></ul>Wiley KnowItAll can also import spectra into NIST Search and supports numerous vendor data formats through its own software environment.For some other platforms, direct NIST integration may not be available. In those situations, spectra can potentially be exported in text-based formats such as TXT or MSP ASCII and then imported into the Spectrum List in NIST Library Search.Direct transfer is generally more convenient because it avoids intermediate export and import steps.<h4>A practical Agilent example</h4>The workflow can be demonstrated using Agilent software.An analyst first selects the desired MS/MS region, averages the spectrum if necessary, and transfers it into the spectrum display. From there, the spectrum can be sent to NIST using the Search Using NIST MS Program command.Once properly configured, NIST automatically receives the spectrum and initiates the specified search. Before relying on this workflow, however, the import and library search parameters should be checked carefully.<h4>Setting up accurate-mass spectrum import</h4>For high-resolution MS/MS data, the first important step is found under Spectrum Import Options.Accurate-mass spectra should be imported with the appropriate number of decimal places for precursor and product ions, and the Accurate m/z spectrum type must be selected.Preserving mass accuracy is essential because one of the main advantages of HRMS library searching is the ability to distinguish candidates using precise precursor and fragment masses.Once the import settings are correct, the next step is configuring the library-search parameters.<h4>Searching without a precursor ion</h4>Depending on how the spectrum is selected or averaged in the vendor software, precursor information may not always be transferred automatically.NIST26 can still search such a spectrum using HiRes NoPrecursor mode.Alternatively, if the precursor m/z is known, it can be entered manually and the search can then include precursor information.The no-precursor approach can be convenient when quickly screening manually selected MS/MS spectra, particularly when the fragment pattern itself contains enough information to generate useful candidate matches.<h4>Setting mass tolerances</h4>For accurate-mass MS/MS searching, suitable precursor and product-ion tolerances are essential.An example configuration uses:<ul><li>20 ppm for the precursor ion</li><li>40 ppm for product ions</li></ul>These settings can be kept consistent with those used in the NIST26 Chromatogram workflow.Proper tolerance settings help balance search sensitivity with selectivity. If tolerances are too wide, more irrelevant candidates may be returned; if they are too narrow, valid matches can be missed because of normal measurement variation.<h4>Combining multiple spectral libraries</h4>One of the strengths of NIST Search is the ability to search multiple libraries simultaneously.A typical configuration can include the NIST high-resolution MS/MS library together with the NIST low-resolution tandem library.The NIST low-resolution library can participate in accurate-mass workflows because it contains the required indexing information. This is important because not every custom or older low-resolution library will necessarily be compatible with the same type of high-resolution search.Additional public resources can also be included, such as:<ul><li>MS-DIAL positive-mode libraries</li><li>MS-DIAL negative-mode libraries</li><li>MoNA LC-MS/MS</li></ul>Combining commercial and public libraries can substantially broaden spectral coverage. In the demonstrated workflow, several million spectra could be searched in a single configuration.For laboratories dealing with unusual metabolites, impurities, environmental contaminants, or compounds outside mainstream commercial libraries, this expanded search space can be particularly valuable.<h4>Structure searches require separate library selection</h4>MS/MS searching and structure searching do not necessarily use the same library selections.If structural searching is required, the appropriate structure-containing libraries must also be loaded in the corresponding Library Search settings.This distinction is easy to overlook when first configuring NIST26. A library may contain useful spectra but no associated structures, or the structure database may need to be explicitly selected before substructure or related structural searches can be performed.<h4>Automating the search</h4>Once the library and tolerance settings have been defined, Automatic Search can be enabled.This allows the spectrum transferred from vendor software to trigger a search immediately rather than requiring the user to launch it manually each time.For repeated workflows involving many manually selected peaks, this small automation can save considerable time.After the configuration has been optimized, it is useful to save it as a dedicated setup—for example, a configuration specifically designed for vendor-imported spectra.<h4>Understanding the result table</h4>NIST search results are typically ranked by score, but additional parameters can also help interpret the matches.Fields can include:<ul><li>score,</li><li>reverse score,</li><li>partial spectrum search score,</li><li>dot product,</li><li>molecular weight,</li><li>other user-selected parameters.</li></ul>The search result display can be customized by right-clicking the column headers and adding or removing fields.Although the standard score will usually remain the primary ranking criterion, alternative metrics can be useful when evaluating spectra with missing fragments, additional peaks, partial spectral overlap, or related structures.<h4>Why it can be useful to keep duplicate matches visible</h4>NIST includes a Best Matching Only option that reduces duplicate or repeated entries in the displayed results.When enabled, the software may reduce a list containing several library records of the same compound to the best representative match.This makes the result list easier to review, but it can also hide useful information.For initial evaluation, it is often preferable to leave this option disabled so that all matching spectra remain visible. Multiple spectra of the same compound may come from different collision energies, instruments, ion forms, or libraries, and reviewing these variations can provide useful confirmation.Filters can always be applied later once the analyst understands the full result set.<h4>Visual comparison of unknown and library spectra</h4>NIST Library Search provides several complementary views of each candidate.The experimentally acquired unknown spectrum is displayed together with the selected library spectrum, while a head-to-head spectral comparison provides an immediate visual representation of matching and non-matching ions.This is important because library-search scores should not be treated as a fully automated identification decision.A strong match should still be examined visually, especially when dealing with complex spectra, low-abundance fragments, co-isolated ions, or compounds with closely related structural analogues.The combination of numerical scoring and visual inspection provides a stronger basis for interpretation.<h4>An important issue with the Intensity Threshold setting</h4>One practical software issue deserves particular attention when importing high-resolution spectra.The Spectrum Import Options window includes an Intensity Threshold function that can remove low-intensity signals and reduce spectral noise.In principle, this would be useful. However, when an intensity threshold is applied, imported high-resolution spectra may lose their decimal mass information and be transferred as nominal-mass spectra instead.An accurate-mass peak such as 176.0815 could therefore appear simply as m/z 176.For HRMS users, this effectively removes one of the most important dimensions of the data and can compromise accurate-mass searching.Until this behavior is corrected, the safer approach is to avoid using the Intensity Threshold option during high-resolution spectrum import and perform any necessary filtering elsewhere.<h4>A related display issue in the Chromatogram window</h4>A second software behavior concerns how Spectrum Import Options are reflected in the Chromatogram tab.If the decimal precision is set to zero for importing low-resolution spectra, the head-to-head spectral display may subsequently show masses truncated according to those settings.Importantly, this is a display issue only.It does not change the accurate-mass deconvolution results or the library-search table. The underlying processed data remain unaffected; only the visual comparison at the top of the Chromatogram window reflects the altered import settings.Understanding this distinction can prevent users from mistakenly assuming that accurate-mass data have been lost from the processed results.<h4>When direct vendor-to-NIST searching is most useful</h4>Direct transfer from vendor software is not intended to replace the complete NIST26 Chromatogram workflow.Instead, it provides a complementary route for situations where full chromatographic processing is unnecessary or unavailable.It can be particularly effective when:<ul><li>only a few peaks need identification,</li><li>deconvolution is not required,</li><li>mzML conversion adds unnecessary processing,</li><li>vendor files cannot be converted reliably,</li><li>nominal-mass MS/MS spectra need to be searched,</li><li>spectra have already been reviewed and selected in the vendor environment.</li></ul>For these cases, direct spectrum transfer offers a fast route from the original MS/MS data to spectral library identification.<h4>Connecting vendor software with broader NIST26 capabilities</h4>The workflow also illustrates a broader advantage of NIST26: analysts do not have to choose between the instrument vendor's software and an independent spectral-search environment.Vendor software can remain the primary platform for inspecting chromatograms and selecting spectra, while NIST provides access to large commercial libraries, public MS/MS databases, flexible scoring, spectral comparison, and additional interpretation tools.Used together, these environments can provide a practical workflow for both rapid routine searching and more detailed unknown identification.The key is careful configuration. Accurate-mass import settings, mass tolerances, library selection, search mode, and result-display options all influence how effectively the workflow performs.Once these parameters are properly established and saved, sending a spectrum from the vendor software to NIST26 can become a rapid and repeatable part of everyday LC-MS/MS data interpretation.

Sending MS/MS (Tandem) Spectra to NIST26 Search

UCTP-REFINE Lab is a research group at the University of Chemistry and Technology Prague focused on sustainable waste valorization, chemical recycling, and the production of alternative feedstocks for chemicals and fuels. The team combines chemical engineering, catalysis, and advanced analytical chemistry to study the thermal and catalytic conversion of complex waste streams, particularly plastics, tires, and biomass, including pyrolysis and upgrading of resulting oils. A strong emphasis is placed on comprehensive characterization of feedstocks, intermediates, and products to link composition and process conditions with product quality and support the development of circular, resource-efficient technologies.<h3>PhD position Chemometric processing of GC×GC data from alternative fuels and oils produced via thermochemical conversion of biomass and plastics</h3><h4>Expected experience:</h4><ul><li>Master's degree in chemistry or chemical engineering</li><li>Strong background in analytical chemistry and chemistry in general; a background in chemical engineering is beneficial</li><li>Experience with chromatography is mandatory.</li><li>Experience with chemometric data processing (e.g. in Python) and GC×GC is not required but is beneficial.</li><li>Top-level English, both spoken and written, ideally proven by a certificate.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/refine_lab_equipment_33ff27095e.jpg" alt="UCTP-REFINE-lab: Process Gas Chromatograph with Electrolyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_refine_lab_equipment_33ff27095e.jpg 208w," sizes="100vw" width="500" height="375"><h4>Expected work:</h4><ul><li>Close collaboration with all involved colleagues and relevant partners from the project consortium.</li><li>GC×GC analysis of complex samples utilizing FID, MS and NCD detectors.</li><li>The focus will be on alternative fuels and oils from thermochemical depolymerisation of biomass and plastics, as well as the samples after hydrotreating.</li><li>Advanced GC×GC data processing using chemometrics for prediction model development.</li><li>Participation also in sample production.</li><li>Contribution to project reports, publications, and conference presentations.</li></ul><h4>What we offer:</h4><ul><li>A young but fast-growing Team with strong international collaborations with academia and industry.</li><li>Top-level facilities and expertise in hydrotreating and liquid product analysis.</li><li>Work on a prospective topic in close collaboration with top EU companies as part of a demonstration EU project.</li><li>Competitive income, which level depends entirely on your activity and productivity.</li></ul>Questions? Feel free to contact our students Adham (yaghia@vscht.cz) or Vít (vyskocit@vscht.cz).<ul><li>Preferred start: early 2027</li><li>Application deadline: 30th October 2026</li><li>Funding: Fully funded PhD position as part of an upcoming HE project.</li></ul>If you are interested and meet the criteria, apply through the application form below.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://www.uctp-refine-lab.com/joining-our-team-form-gcxgc">Apply through this form</a></blockquote>

PhD position Chemometric processing of GC×GC data from alternative fuels and oils

The integrity of sport depends on the ability to detect prohibited substances accurately, reliably and with confidence. However, as doping strategies become increasingly sophisticated, the analytical demands placed on anti-doping laboratories continue to evolve.Today’s laboratories must do more than test for a static list of known compounds. They need broad analytical strategies capable of addressing hundreds of substances across multiple chemical classes, identifying emerging threats and supporting defensible confirmation and reporting of adverse analytical findings. For more than 25 years, Thermo Fisher Scientific has worked globally with World Anti-Doping Agency (WADA)-accredited laboratories to advance the analytical science supporting modern anti-doping programs.<h3>Anti-doping testing is a moving target</h3>The World Anti-Doping Agency publishes an annually updated Prohibited List that provides a global framework for testing programs. Yet the list is non-exhaustive, meaning laboratories may also need to detect structurally related compounds and substances across several categories, with similar chemical structure and biological activity. That creates a significant analytical challenge. Anti-doping laboratories must be prepared to monitor a broad range of compounds while maintaining the sensitivity, specificity, and confidence required for both initial testing and confirmation. At the same time, the landscape continues to change. Emerging substances, rapidly expanding doping strategies and new approaches to sample collection and analysis are creating multiple considerations for anti-doping laboratories to consider. Dried blood spots (DBS), for example, have gained attention as a complementary approach to traditional urine and venous blood collection supporting applications such as detecting steroid esters and monitoring peptides. High-resolution mass spectrometry is also enabling laboratories to consider both targeted analysis and retrospective interrogation of previously acquired data as scientific knowledge and regulations evolve.<h3>From screening to confident confirmation</h3>No single analytical technique can address every anti-doping challenge.With respect to chemical analysis of toxicologically relevant compounds, modern doping control laboratories employ complementary technologies—including liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) and isotope ratio mass spectrometry (IRMS)—depending on the compounds and analytical questions involved.For initial testing, laboratories may need to efficiently screen biological samples for numerous prohibited substances spanning categories such as steroids, stimulants, metabolic modulators, diuretics, narcotics, cannabinoids and peptides.When &nbsp;an initial Testing Procedure produces a result requiring confirmation, laboratories need analytical approaches capable of supporting confident confirmation.This combination of broad screening and targeted confirmation has made mass spectrometry central to modern anti-doping science.<h3>Expanding possibilities with LC-MS</h3>High-resolution accurate-mass mass spectrometry can provide precise mass measurements while supporting comprehensive screening of known and suspected substances, while preserving information-rich data that can support investigation of emerging or previously untargeted compounds.An important advantage of high-resolution mass spectrometry is the ability to revisit previously acquired data. As new substances, metabolites or other analytical targets are identified, laboratories can potentially re-process previously acquired full scan data (and any corresponding MSn experiment) without reanalyzing the original sample. This strategy is currently used by laboratories to support global re-testing programs.&nbsp; Triple quadrupole <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?category=20&amp;manufacturerItems=3">LC-MS</a> can complement these workflows by supporting sensitive, targeted quantitation and confirmation of prohibited substances.Together, these approaches provide laboratories the flexibility needed to address today’s testing requirements while giving laboratories greater flexibility to respond to emerging analytical challenges.<h3>The continuing role of GC-MS/MS</h3>Gas chromatography coupled with triple quadrupole mass spectrometry remains an important technology in anti-doing laboratories, particularly for urinary steroid profiling and the screening and confirmation of anabolic- &nbsp;androgenic steroids and other GC-amenable prohibited substances.GC-MS/MS can support both screening and confirmation while providing the sensitivity, selectivity and dymanic range required for screening and confirmatory analysis.The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/485">Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS</a> is designed to maximize sample throughput, helping laboratories address the demands of routine testing while maintaining analytical performance across a wide dynamic range. &nbsp;The TSQ 9610 incorporates NeverVent technology, designed to increase instrument uptime by reducing the disruption associated with routine source maintenance.As anti-doping workflows evolve, bridging screening and confirmation together within robust analytical strategies can help laboratories respond efficiently to increasingly complex testing requirements.<h3>When identifying a steroid isn’t enough</h3>In some anti-doping investigations, simply detecting a compound does not provide the complete answer.Testosterone, for example, can be produced naturally by the body or administered externally as an anabolic steroid. In cases where laboratories need to distinguish between endogenous and exogenous sources, isotope ratio mass spectrometry can provide another layer of information.GC-IRMS can help laboratories determine whether selected urinary steroids are consistent with an endogenous or exogenous origin by comparing carbon isotope ratios.The result is an analytical toolkit in which different technologies answer different questions—from broad screening and sensitive confirmation to determining the origin of a compound.<h3>Putting advanced workflows into practice</h3>Technology is only part of the equation. Real-world anti-doping laboratories also need to manage high sample volumes, turnaround expectations and continually changing analytical requirements.At Laboratoire Anti-Dopage Français (LADF), Director Dr. Magnus Ericsson and his team use advanced mass spectrometry workflows to support anti-doping testing.According to Ericsson, integration of <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=20&amp;manufacturerItems=3">Thermo Scientific TSQ</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=37&amp;manufacturerItems=3&amp;search=vanquish">Vanquish systems</a> has helped enhance efficiency and turnaround while supporting more than 40,000 sample analyses since 2023.Experiences like these demonstrate how integrated analytical workflows can help laboratories translate advances in mass spectrometry into routine anti-doping operations.<h3>Preparing for what comes next</h3>Anti-doping science has advanced dramatically—from early testing approaches to today’s sophisticated, — mass spectrometry technologies; including but not limited to <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/products?category=20&amp;manufacturerItems=3">GC-MS/MS</a>, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?category=20&amp;manufacturerItems=3">LC-MS/MS</a>, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=22&amp;manufacturerItems=3">high-resolution accurate-mass MS</a> and<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/products?category=351&amp;manufacturerItems=3"> isotope ratio MS</a> workflows.But the science cannot stand still.Emerging compounds, evolving regulations and increasingly sophisticated doping strategies mean laboratories must continually evaluate how they manage and process samples and then screen, identify, quantify and confirm prohibited substances. The goal remains constant: provide accurate, high-quality analytical results that help protect the integrity of competition.Explore the technologies, workflows and expert perspectives shaping the next generation of anti-doping testing in our comprehensive eBook, Upholding the Integrity of Sport.<blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://documents.thermofisher.com/TFS-Assets/CMD/brochures/eb-004467-cl-cmd-ms-antidoping-eb004467-na-en.pdf">Download the anti-doping eBook</a></h5></blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#AntiDoping #MassSpectrometry #SportsIntegrity #WADA

Advancing Anti-Doping Science: Analytical Strategies for the Evolving Fight Against Doping

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UCTP-REFINE Lab is a research group at the University of Chemistry and Technology Prague focused on sustainable waste valorization, chemical recycling, and the production of alternative feedstocks for chemicals and fuels. 

UCTP-REFINE Lab

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

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SCIEX

Waters Corporation

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Carbon in soils and solid wastes isn’t monolithic—it exists in a complex spectrum. From easily oxidized organic carbon to highly stable “black/pyrogenic” carbon and inorganic carbonates, each fraction carries entirely different environmental and agricultural implications. Traditional testing methods often require tedious, hazardous acid pretreatments to separate these fractions, slowing down your lab and risking sample integrity.Join us as we explore the ISO 17505 temperature-dependent differentiation approach. Discover how staged heating programs and time-resolved CO2 measurement can seamlessly separate and report TOC, ROC, and TIC—giving you actionable data for soil health, carbon sequestration studies, and waste characterization.<h4>What Attendees Will Learn</h4><ul><li>The Power of ISO 17505: How temperature-dependent differentiation provides a more accurate, multi-layered carbon profile than standard TOC analysis.</li><li>Fraction Specificity Demystified: A clear breakdown of how to isolate and interpret TOC400 (Total Organic Carbon at 400°C), ROC (Residual Organic Carbon), and TIC900 (Total Inorganic Carbon at 900°C).</li><li>Workflow Optimization: How to eliminate manual acid pretreatment entirely, drastically reducing lab prep time and chemical hazards.</li><li>Real-World Applications: Case studies demonstrating successful fraction analysis across diverse soil types, sediments, and solid wastes.</li></ul><blockquote>Presenter: Adam Darling (Lead Application Scientist, Inorganic Chemistry, LECO Corporation)</blockquote></div></div></div>

LECO: Unlocking the Complete Carbon Profile - Temperature-Dependent Differentiation Using ISO 17505

Unlocking the Complete Carbon Profile: Temperature-Dependent Differentiation Using ISO 17505

Explore ISO 17505 for advanced carbon profiling. Eliminate manual acid pretreatment and seamlessly separate TOC, ROC, and TIC via staged heating

Complete Carbon Profile: TOC, ROC & TIC via ISO 17505

The analysis of microplastics (MP) becomes more difficult for smaller sizes, especially in complex matrices such as sediment of natural waters. In this work, we analyzed MPs in sediment using laser direct infrared (LDIR) imaging, a relatively new technique in environmental MP studies.&nbsp;Sediment samples were spiked with analytical surrogates (polyethylene spheres), and subjected to density separation, wet peroxide oxidation, calcite removal, and filtration. The extracted particles were coated on to a low-emissivity glass slide which was first examined on a stereomicroscope. Six slides (two sediment samples and four different blanks) were further analyzed using an Agilent LDIR system. Approximately 520 and 430 MP/g were found in the two samples, with diameter ranging 20-3,384 mm and 84% being smaller than 100 mm. The increase in particle count with decreasing particle sizes followed a power law curve, suggesting that a large portion of the smaller MPs was generated by the breakdown of larger plastic pieces. Major polymers found in this work included polyamide, polyester, polytetrafluoroethylene, and polyacetal. Most MPs were fragments, while beads and fiber were also found. In the two sediment samples, 14% and 46% of the total particles, respectively, were composed of non-plastic micro-sized particles, including natural polyamide, cellulose, chitin, rubber, and "unknown". Challenges, potential biases, and uncertainties are discussed. This work is the first application of LDIR imaging on MPs in natural sediment.<blockquote>Presenter: An Li (Professor Emerita, Environmental and Occupational Health Sciences, University of Illinois Chicago)Dr. An Li is a Professor Emeritus in School of Public Health, University of Illinois Chicago. She is an environmental chemist, with her research focus on how human activities influence the natural environment and how the changes in turn affect human health. Her research particularly focuses on persistent and bioaccumulative organic chemicals which are potentially toxic. She has led a number of federally funded projects and programs, including the Great Lakes Sediment Surveillance Program (GLSSP) funded by the US EPA. Dr. Li has published two books Physical and Chemical Processes in the Aquatic Environment (2014) and Persistent Organic Pollutants in Asia (2007), &gt;100 journal articles, as well as numerous other publications.</blockquote>

Agilent Technologies: Characterization of Microplastics in Sediment Using LDIR Microscopy

Characterization of Microplastics in Sediment Using LDIR Microscopy

Explore microplastics analysis in sediment using Agilent LDIR microscopy. Learn sample prep and polymer identification

LDIR Microscopy: Microplastics Characterization in Sediment

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Join our live webinar where industry leaders share cutting-edge solutions, real-world insights, and practical troubleshooting strategies for PFAS analysis.Whether you're facing challenges in sample prep, background signal, or reporting, our experts have guided hundreds of professionals to success—and now it’s your turn.With policies shifting and compliance requirements tightening, staying ahead is essential. Explore the ever-evolving landscape of PFAS regulations around the world as our experts break down the latest global regulatory trends and provide proven lab techniques to help you tackle challenges and adhere to stringent standards.<h5>In this webinar, you’ll gain:</h5><ul><li>A deep dive into PFAS regulations across key regions</li><li>Practical strategies to ensure compliance in your testing workflows</li><li>Lab-proven techniques for detecting and analyzing PFAS effectively</li><li>Insights from industry leaders on navigating future changes</li></ul>Enhance your PFAS knowledge and refine your approach to regulatory adherence today!<h5>Who should attend:</h5><ul><li>Lab technicians, scientists, analytical chemists &nbsp;and lab managers working in environmental and food labs</li></ul><blockquote>Presenter: Dr. Jianru Stahl-Zeng Jianru (Senior Market Development Manager, SCIEX)Dr. Jianru Stahl-Zeng Jianru is Senior Market Development Manager. She has been part of SCIEX since 2001. She initially was part of the application support team and covered not only proteomics, but also small molecules applications. Jianru moved to technical marketing and focused on food and environmental applications. Since 2018 she has been managing the EMEA technical marketing team and projects. Jianru is also the Global Technical Leader for food and environmental applications. On January 2026, she took the role of Senior Market Development Manager, FEF, EMEAI.</blockquote></div></div></div>

SCIEX: PFAS regulations in food and food packaging implemented – proven lab strategies for your PFAS success

PFAS regulations in food and food packaging implemented – proven lab strategies for your PFAS success

Learn proven lab strategies for PFAS testing in food and food packaging. Master global regulations, sample prep, and background noise control.

PFAS Regulations in Food and Food Packaging

<h3>Advancing HPLC Performance with Inert Column Technology</h3>Interactions between analytes and metal surfaces can have an even greater impact on large molecule applications, where sample recovery, peak shape, and quantitative accuracy are critical. Join us to learn how inert column technologies are helping scientists overcome these challenges in the analysis of peptides, proteins, oligonucleotides, and other advanced therapeutics.<h4>Why you should attend</h4>Explore recent innovations in inert column technology and learn how they can address analytical challenges in biopharmaceutical workflows.<h5>Learn more about:</h5><ul><li>The causes and effects of analyte interactions with metal surfaces in HPLC columns and systems</li><li>The analyte types that are susceptible to these interactions, including proteins, peptides, oligonucleotides, and other emerging modalities</li><li>The separation conditions that influence the severity of these interactions</li><li>The benefits of inert HPLC columns and systems for biopharmaceutical characterization and quality control</li></ul><h5>Who should attend</h5>This webinar is designed for scientists and managers involved with HPLC analyses of biopharmaceuticals.Don't miss it!<blockquote>Speaker: Szabolcs Fekete PhD (Consulting Scientist, Genetic Medicine, Waters Corporation)Szabolcs Fekete received his PhD in Analytical Chemistry from the Technical University of Budapest. He worked in analytical R&amp;D in the pharmaceutical industry for 10 years, then joined the University of Geneva in Switzerland as a research associate.He joined Waters Corporation in 2021 and is now a consulting scientist. His current interests include separations of new chemical modalities, fundamentals of chromatography, column technology, and new method development approaches. He has co-authored ~230 publications (including peer reviewed journal articles, book chapters, handbooks, and application notes).</blockquote>

Waters Corporation: The Future of Inert LC Separations

Breaking Barriers: The Rise of Inert Column Technologies for HPLC Biomolecule Separations

Explore inert HPLC column technologies for proteins, peptides, and oligonucleotides, improving recovery, peak shape, accuracy, and method performance.

Advancing HPLC Performance with Inert Column Technology

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Glycoproteomics asks mass spectrometry to solve a difficult problem: capture the heterogeneity that makes glycosylation biologically important without losing the structural information needed to understand it. For O-linked glycopeptides in particular, researchers need to determine where glycans are located, how they are structured, and which glycoforms are present.Join Dr. Nicholas Riley of the University of Washington for a closer look at how new fragmentation capabilities on the Thermo Scientific™ Orbitrap™ Tribrid™ Apex MultiOmics Mass Spectrometer are opening additional ways to investigate this complexity. Drawing on his lab’s work with O-glycopeptides, Riley will explore infrared photoactivation during electron transfer dissociation (IR-ETD) and how it can be combined with collisional activation to generate complementary, information-rich spectra.You’ll see how adjusting IR laser power and collision energy changes the fragmentation information available from the same complex biomolecule. Riley will also discuss the data-analysis challenges created by richer spectra. Attendees will have the opportunity to participate in the live Q&amp;A following the presentation.&nbsp;<h5>Who should attend?</h5>Researchers in glycoproteomics, proteomics, glycobiology, mass spectrometry, PTM analysis, advanced fragmentation methods, and glycopeptide/glycoproteoform characterization.<h5>What you can expect to learn</h5><ul><li>Why O-glycopeptide heterogeneity and site localization remain challenging</li><li>How IR-assisted ETD can provide complementary structural information</li><li>How tuning laser power and collision energy can favor different fragment-ion populations</li><li>Opportunities for glycoproteomics data analysis and informatics</li><li>How complementary ion-ion approaches including PTCR may connect glycopeptide heterogeneity with intact glycoproteoform characterization</li></ul><blockquote>Presenter: Brett Larsen (Sr. Marketing Specialist Proteomics, Thermo Fisher Scientific)Brett Larsen is a leader in chemoproteomics and post-translational modification analysis at Thermo Fisher Scientific. With over 25 years of mass spectrometry experience, he has led proteomics at LTRI Toronto and advanced applications at MDS Proteomics. Brett brings practical expertise in translating complex workflows into real-world discovery.Presenter: Nicholas M. Riley, PhD (Assistant Professor of Chemistry, University of Washington)Dr. Riley earned his PhD in mass spectrometry instrumentation and proteomics at the University of Wisconsin–Madison and completed postdoctoral research with Carolyn Bertozzi at Stanford. He launched the Riley Research Group at the University of Washington in 2023 to study glycosylation using MS-based multi-omics, chemical biology, and bioinformatics.Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)</blockquote></div></div></div>

Thermo Fisher Scientific: The Groundbreakers Series: Pushing Boundaries 

Enhancing access to the glycoproteome through advances to the Thermo Scientific™ Orbitrap™ Tribrid™ mass spectrometer platform

Learn how IR-ETD and collisional activation on the Orbitrap Tribrid Apex improve O-glycopeptide characterization, site localization, and structural analysis.

Thermo Scientific Orbitrap Tribrid Apex multiomics MS

<h4>Combining Reflectometry and Ellipsometry for High-Accuracy Optical Metrology</h4>This webinar will introduce the principles behind Bruker’s Filmtek spectroscopic reflectometer/ellipsometers and explore how modern optical metrology approaches can overcome many of the limitations associated with conventional single-technique measurements.<h5>Attendees will discover:</h5><ul><li>How Filmtek systems independently determine thickness, refractive index (n), and extinction coefficient (k) across a wide range of materials and structures</li><li>How patented DPSD and MADP technologies and complementary optical data help overcome the limits of conventional single-technique measurements</li><li>Why independent determination of thickness and refractive index is essential for complex multilayer stacks and other challenging applications</li></ul><h4>Webinar Summary</h4>Accurate characterization of thin films and complex multilayer stacks is increasingly critical in semiconductor manufacturing, specifically: photonics, MEMS, advanced packaging, optical coatings, and emerging materials research. This webinar provides an introduction to the unique principles of the Bruker Filmtek spectroscopic reflectometer/ellipsometers, while exploring how modern optical metrology approaches can overcome many of the limitations associated with conventional single-technique measurements.Attendees will learn how the Filmtek systems combine multi-angle reflectometry and spectroscopic ellipsometry to independently determine film thickness, refractive index (n), and extinction coefficient (k) across a wide range of materials and structures. The presentation will cover the underlying measurement physics, patented Multi-Angle Differential Power Spectral Density (DPSD) and Multi-Angle Differential Polarimetry (MADP) technologies, and the advantages of collecting complementary optical data from the same measurement location.Real-world application examples will illustrate measurement performance on semiconductor, dielectric, photonic, and multilayer structures ranging from ultra-thin films to complex stacks. Participants will gain practical insight into obtaining accurate thickness and optical constant measurements, improving process control, and addressing challenging applications where independent determination of thickness and refractive index is essential.&nbsp;<blockquote>Speaker: Lawrence Rooney (Senior Application Scientist, Bruker)</blockquote>

Bruker: Beyond Traditional Ellipsometry: High-Accuracy Thin Film and Multilayer Metrology

Beyond Traditional Ellipsometry: High-Accuracy Thin Film and Multilayer Metrology

Learn how Bruker Filmtek systems combine reflectometry and spectroscopic ellipsometry for high-accuracy thin film and multilayer stack metrology

Thin Film Metrology with Bruker Filmtek

This webinar provides a foundational overview of sample enrichment approaches and LC analysis workflows for oligonucleotides, DNA, and RNA-based therapeutic molecules.We will start by exploring the molecular structure and challenges associated with these molecules and learn about the various chromatographic techniques for their comprehensive characterization.The session will cover the practical approaches for sample preparation and selectivity optimization for gaining higher sensitivity and efficiency in LC-MS/MS methods. Attendees will gain insight into how the method development and optimization approaches can be applied across a variety of DNA and RNA-based molecules for solving the prevalent bioanalytical challenges.<h4>One webinar, two viewing options</h4><h5>Viewing Options</h5>Session 1<ul><li>Tuesday, October 27, 2026 Los Angeles: 10:00 AM PT | New York: 1:00 PM EST Mexico City: 12:00 PM CDT</li></ul>Session 2<ul><li>Wednesday, October 28, 2026 London: 9:00 AM GMT | Berlin: 10:00 AM CET&nbsp; Mumbai: 2:30 PM IST</li></ul><h4>Key Learning Points</h4><ul><li>Describe Nucleic Acids and Oligonucleotides, including their molecular structure, their production process, and how they are delivered as therapeutic medicines.&nbsp;</li><li>Define the ubiquitous challenges associated with these molecules and define the Critical Quality Attributes (CQAs) for mRNA and explain how they relate to product quality, safety, and performance.&nbsp;</li><li>Describe common sample enrichment approaches for these molecules.</li><li>Understand the typical workflow designs and their role in supporting downstream LC and LC-MS/MS analysis. &nbsp;</li></ul><h4>Who Should Attend</h4><ul><li>Any scientists and professionals working in biopharma, life sciences, CROs, CDMOs or analytical laboratories interested in learning about Oligonucleotides and Nucleic Acid based therapeutic analysis workflows as well as sample enrichment and sample preparation approaches. &nbsp;</li></ul><blockquote>Speaker: Namrata Saxena (Technical Manager, Phenomenex)&nbsp;Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains. Namrata is based in Sydney, Australia and can be reached through e-mail or phone.&nbsp;</blockquote>

Phenomenex: Fundamentals First Bio Series: Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

Learn LC-MS/MS workflows and sample enrichment strategies for oligonucleotides and nucleic acid therapeutics in this Phenomenex technical webinar

Oligonucleotide LC-MS/MS Bioanalysis

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is widely recognized for its high sensitivity, selectivity, and ability to analyze multiple targets simultaneously, making it an increasingly valuable tool for clinical laboratories. However, complex sample preparation and analytical workflows can present challenges for routine implementation and scalability.Join SelectScience® for an expert-led webinar exploring a fully automated LC-MS/MS solution that combines ready-to-use RECIPE reagent kits with the Shimadzu CLAM-2040 automated sample preparation module. Designed to automate the entire workflow from sample preparation through to analysis, this integrated approach has the potential to improve standardization, efficiency, and ease of operation within routine clinical testing environments.Using therapeutic drug monitoring (TDM) as an example, Akihiro Kunisawa, Shimadzu Europa GmbH, will demonstrate a workflow capable of delivering results in less than five minutes per sample. You will also hear from Amanda Bergamin from St. Vincent's Hospital, Australia, as she shares her experience implementing the CLAM-2040 for clozapine testing, meeting growing demand for mass spectrometry-based testing, and improving workflow efficiency through integration with hospital middleware systems.Whether you are looking to expand your laboratory's LC-MS/MS capabilities or explore opportunities for greater automation, this webinar will provide practical insights into the technologies and approaches helping to drive adoption in routine clinical practice.<h5>Certificate of attendance</h5>All attendees who join the live webinar will automatically receive a certificate of attendance, including a summary of key learning outcomes, to support their continuing professional development.If you watch the on-demand recording, you may request a certificate of attendance by emailing editor@selectscience.net.<h5>Webinar Details</h5>• Cost: Free to attend • Location: Online • Duration: 60 minutes • Format: Expert presentation followed by a live Q&amp;A session<h5>Can't attend live?</h5>Register to receive access to the recording after the event, allowing you to catch up on the discussion and revisit key insights at your convenience.<h5>About CLINICAL24</h5>CLINICAL24 is a global initiative dedicated to exploring the challenges facing modern clinical laboratories and highlighting the technologies, expertise, and collaborative approaches helping to improve patient care worldwide.<h4>Who should attend?</h4><ul><li>Clinical laboratory professionals involved in diagnostic testing, including lab managers, medical technologists, and clinical scientists seeking to streamline LC-MS/MS workflows and increase throughput.</li><li>Healthcare and clinical decision-makers including pathologists, clinical chemists, and laboratory directors interested in adopting automated, scalable mass spectrometry solutions.</li></ul><h4>What will this webinar cover?</h4><ul><li>How full automation can transform LC-MS/MS from a specialist technique into a routine testing solution for clinical laboratories.</li><li>How the combination of the Shimadzu CLAM-2040 and ready-to-use RECIPE reagent kits streamlines the entire workflow from sample preparation to result generation.</li><li>Real-world experiences from St. Vincent's Hospital on implementing automated LC-MS/MS workflows for clozapine testing and meeting growing testing demands.</li><li>How integration with laboratory middleware systems can improve workflow efficiency, reduce manual intervention, and support scalable routine operations.</li><li>Practical insights into how automation can accelerate the adoption of LC-MS/MS in routine clinical laboratories while enhancing productivity and standardization.</li></ul><blockquote>Presenter: Amanda Bergamin (Senior Scientist, The Chromatography Department at St. Vincent’s Pathology, Melbourne)Amanda Bergamin is the Senior Scientist in the Chromatography Department at St. Vincent’s Pathology Melbourne. She implemented the organization’s first LCMS diagnostic testing services and is rapidly expanding the range of services offered. With 15 years of experience across multiple industries, she has developed and implemented LCMS assays for high-throughput and routine applications. Her work has ranged from pesticide analysis for the grain export industry to high-throughput screening of hundreds of thousands of drug compounds at the Walter and Eliza Hall Institute of Medical Research (WEHI). She is passionate about delivering high-quality results at breakneck speed while making LCMS technology accessible to all scientists.</blockquote><blockquote>Presenter: &nbsp;Akihiro Kunisawa (Manager of the Clinical MS Solution Center, Clinical MS Solution Center at Shimadzu Europa GmbH)Akihiro Kunisawa is the Manager of the Clinical MS Solution Center at Shimadzu Europa GmbH and has been based in Europe since 2025. He joined Shimadzu Corporation in Japan in 2015 and has approximately 10 years of experience in LC-MS/MS. Throughout his career, he has developed analytical methods using liquid chromatography and mass spectrometry for pharmaceutical analysis, comprehensive metabolite profiling, and clinical applications, while also collaborating extensively with universities and hospitals. His main areas of expertise include metabolomics of small-molecule metabolites, therapeutic drug monitoring (TDM), and newborn screening (NBS). He has developed LC-MS/MS methods for a wide range of clinical applications, including vitamin D metabolites, disease-related biomarkers, and therapeutic drugs. A particular focus of his work is the automation of the entire analytical workflow, including sample preparation. He is currently working on fully automated LC-MS/MS solutions designed to make advanced clinical mass spectrometry simpler and more accessible for routine laboratories.</blockquote><blockquote>Moderator: Lucy Lawrence (Science Editor, SelectScience)Nazim Boutaghou received a Master’s degree in Chemistry and Biology from the University of Bordeaux. Nazim later joined Dr. Richard Coles’ group at Louisiana State University in New Orleans to advance his work in Mass Spectrometry. He is currently the product manager for the Life Sciences at Shimadzu Scientific Instruments.</blockquote></div></div></div>

SelectScience: Simplifying & automating clinical mass spec workflows with real-world case studies

Simplifying & automating clinical mass spec workflows with real-world case studies

Learn how the Shimadzu CLAM-2040 and RECIPE kits automate clinical LC-MS/MS workflows, delivering rapid TDM results in under five minutes per sample

Automated Clinical LC-MS/MS Workflows

Generating high-quality screening and ADME data quickly enough to guide early drug discovery decisions can place significant demands on analytical workflows. Acoustic ejection mass spectrometry (AEMS) offers an alternative approach by combining contactless sample introduction with rapid, label-free mass spectrometric analysis. In this webinar, explore its application to native mass spectrometry screening and microsomal intrinsic clearance assays through two early drug discovery case studies. By attending, you will discover how these workflows enable direct molecular measurements at high throughput and gain practical insight into their performance and analysis times compared with conventional liquid chromatography-mass spectrometry workflows.<h5>Attend this webinar to:</h5><ul><li>Understand how AEMS, using the Echo® MS+ system, supports high-throughput label-free screening</li><li>Hear how AEMS can be used for native mass spectrometry to directly direct non-covalent protein-ligand interactions at throughput suitable for high-throughput screening</li><li>Learn how AEMS has been used for a microsomal intrinsic clearance assay, where dramatically reduced analysis times allow&nbsp;</li><li>faster turnaround of ADME data&nbsp;</li></ul><blockquote>Presenter: Kerri Grove, PhD (Associate Director, Novartis)Kerri Grove earned B.S. degrees in Chemistry and Biochemistry from Bethel University and a Ph.D. in Chemistry from Vanderbilt University. She now works at Novartis in the Global Discovery Chemistry group where her work includes MALDI imaging mass spectrometry for tissue distribution studies, metabolite identification for structural elucidation of drug metabolites, and ADME screening assays.</blockquote>

Technology Networks: Supporting Drug Discovery With Acoustic Ejection Mass Spectrometry

Supporting Drug Discovery With Acoustic Ejection Mass Spectrometry

Learn how SCIEX acoustic ejection mass spectrometry (AEMS) on Echo MS+ speeds drug discovery with high-throughput native MS screening and ADME assays

SCIEX Echo MS+ Acoustic Ejection MS

<h4>Automate 12-Channel Workflows Without Redeveloping Your Methods</h4>Plate-based assays often rely on 12-channel, row-by-row pipetting, yet many automation platforms require laboratories to redesign established methods around column-based workflows.In this webinar, discover how the Andrew+ Robot’s new 12-channel pipetting capability automates familiar bench methods with minimal method adaptation.See how OneLab Software translates protocols without coding, preserves workflow order and timing, and supports GxP and 21 CFR Part 11 requirements.Learn how laboratories can reduce repetitive manual pipetting, improve consistency and traceability, and expand throughput across serial dilutions, ELISA, immunoassays, endotoxin testing, cell-based assays, genomics, and other plate-based workflows.<h5>Why you should attend</h5><ul><li>Understand how native 12-channel, row-by-row pipetting supports established plate-based workflows.</li><li>Learn how to transfer a bench protocol into OneLab Software without coding or unnecessary method redevelopment.</li><li>Explore opportunities to reduce hands-on time, repetitive pipetting, and transcription errors while improving consistency and traceability.</li><li>See how the Andrew+ Robot supports regulated laboratories with GxP-ready capabilities, 21 CFR Part 11 audit trails, and qualification documentation.</li><li>Identify relevant applications, including serial dilutions, ELISA, immunoassays, endotoxin testing, cell-based assays, genomics, and other plate-based workflows.</li></ul><h5>Who should attend</h5>This webinar is designed for Laboratory managers and directors, QC and QA managers, Analytical development and method-development scientists, Bioassay and assay-development scientists, Research scientists, Laboratory automation specialists, Operations leaders responsible for throughput, compliance, or method transfer.<blockquote>Speaker: Guillaume Mignard (Lab Automation Product Marketing Manager, Waters Corporation)Guillaume Mignard serves as the Lab Automation Product Manager at Waters Corporation, a position he has held since 2025. He previously occupied the roles of Product Manager and Product Designer of the OneLab™ Software.Since his start at Waters in 2017, he has led the strategic vision, design, and deployment of the OneLab™ Software, a cloud-based platform that democratizes laboratory automation for scientists worldwide.Guillaume initiated his professional journey as a UX/UI designer specializing in business software, where he pioneered user-centric design principles at a time when such approaches were still emerging beyond web marketing.</blockquote>

Automate More, Redevelop Less, With 12-Channel Pipetting

Andrew+ and OneLab Software automate 12-channel plate workflows, reduce manual pipetting, improve traceability, and support GxP and 21 CFR Part 11 requirements.

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