News from LabRulezGCMS Library - Week 41, 2026

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 5th October 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by Metrohm and posters by Shimadzu / ASMS, Thermo Fisher Scientific / Metabolomics and Waters Corporation / ASMS!<h3>1. Metrohm: Carbonate in lithium carbonate by potentiometric titration</h3>Determination of carbonate in lithium carbonate by potentiometric titration according to draft standard ISO 10662<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_t_251_download_c1c530d784.pdf">Full PDF for download</a></li></ul>Lithium carbonate is one of the main lithium salts in cathode materials used for lithium-ion batteries. Accurate carbonate and overall purity determination in this raw material are essential because even trace impurities can affect key physicochemical properties, ultimately influencing electrochemical behavior in downstream applications. This is especially significant in battery-grade materials, where strict compositional tolerances are required to ensure consistent manufacturing performance, long-term cell stability, and overall safety. This Application Note describes carbonate content determination in lithium carbonate on an automated OMNIS system with Dis-Cover lids. The ISO 10662 draft method quantifies the main content of lithium carbonate to enable a precise assessment of material purity.<h4>EXPERIMENTAL</h4>The analysis is carried out on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=220&amp;search=OMNIS+Titrator">OMNIS Advanced Titrator </a>with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=220&amp;search=OMNIS+Sample+Robot">OMNIS Sample Robot</a> equipped with a dUnitrode and Dis-Cover lids (Figure 1). A blank analysis is performed with a start volume of hydrochloric acid and titrated until after the equivalence point. Samples are titrated with hydrochloric acid until after the second equivalence point.<h4>CONCLUSION</h4>The OMNIS Titrator and OMNIS Sample Robot with Dis-Cover lids provide a fast and reliable determination of carbonate in lithium carbonate according to draft standard ISO 10662. The OMNIS system can be expanded to other titration applications as required.<h3>2. Shimadzu / ASMS: Comprehensive Untargeted Metabolomic Analysis from Five Stages of Blueberry Development by High Resolution Accurate Mass Spectrometry</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/MP_459_Comprehensive_Untargeted_Metabolomic_Analysis_from_Five_Stages_of_Blueberry_Development_by_High_Resolution_Accurate_Mass_Spectrometry_bc0aadf181.pdf">Full PDF for download</a></li></ul>Metabolomic studies of blueberry cultivars and growth stages have been conducted to identify optimal cultivation conditions maximizing antioxidant production. Many of these studies utilize reversed phase (RP) chromatography and target fragmentation data collection at the most abundant chemical species as observed by electrospray ionization mass spectrometry (ESI MS). However, this strategy may miss important metabolites suppressed by matrix effects or unfavorable ionization. A comprehensive untargeted metabolomic study was performed to determine how diverse chromatographic separation and multiple fragmentation strategies could impact the identification of additional metabolites. The expanded metabolomics data was used to assess differences across fruit developmental stages and determine if unique metabolomic populations could be identified between stages.<h4>Methods</h4>All samples were analyzed in triplicate and in a randomized order using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=nexera+hplc">Nexera HPLC</a> and a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=9050">Shimadzu LCMS-9050 Q-TOF</a>. To maximize feature identification across the blueberry developmental stages, both RP and hydrophilic interaction liquid chromatography (HILIC) were used. Mass spectrometry data was collected with ESI in positive and negative mode using data-independent analysis (DIA) and data-dependent analysis (DDA), generating 8 different analytical methods in total.<h4>Conclusions</h4>The Shimadzu LCMS-9050 provided a comprehensive analysis of plant extracts when complementary chromatographic and MS analysis modes were utilized. All five growth stages showed distinct metabolimic populations. Overall differentiation of groups is captured by any of the analytical methods employed, but the same approach can be used to get a more holistic approach to metabolome coverage. If reduced analysis time is preferred, a combination of HILIC DDA and RP DDA methods characterize most metabolites.<h3>3. Thermo Fisher Scientific / Metabolomics: Pushing the limits of structural lipidomics: enhanced sensitivity and MS³-driven annotation on Orbitrap Tribrid Apex Small Molecule MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004763_ccs_surepac_protein_reverse_phase_mabs_separation_po004763_na_en_56199ec50d.pdf">Full PDF for download</a></li></ul>Advances in lipidomic analysis require mass spectrometry deliver high sensitivity, rapid acquisition, and efficient parallel use of multiple mass analyzers. Orbitrap Tribrid Apex Small Molecule MS was evaluated to meet these demands through improved sensitivity, faster polarity switching, and enhanced parallelization between the Orbitrap analyzer and linear ion trap analyzer. High-resolution MS enables effective resolution of isobaric lipid species, while alternative fragmentation strategies with rapid MSⁿ, supports confident lipid identification and structural annotation of lipid classes. The parallel operation of the Orbitrap analyzer and linear ion trap analyzer minimizes duty-cycle limitations while maximizing data density and throughput. Leveraging these instrument enhancements, robust lipidomics workflows were demonstrated through method evaluation with lipid reference materials and application to complex biological samples from plants.<h4>Materials and methods</h4>Instrumentation and methods: A <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1988">Thermo Scientific Accucore C30 HPLC Column</a> (150 mm x 2.1 mm, 2.6 µm particle size) connected to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744">Thermo Scientific Vanquish Horizon UHPLC System</a> and a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=3&amp;search=Orbitrap+Tribrid+Apex">Orbitrap Tribrid Apex Small Molecule MS</a> were used to acquire the data.<h4>Conclusions&nbsp;</h4>We have successfully demonstrated the utility of the Orbitrap Tribrid Apex Small Molecule MS for structural lipidomics, using various fragmentation strategies on an LC timescale. We applied this to study lipid extracts from a plant and annotated around 1700 high grade lipids.<h3>4. Waters Corporation / ASMS: Tandem Quadrupole DESI Imaging To Visualize Spatial Distribution of Gefitinib and Related Metabolites in Rat Liver</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009433_4e913e0193.pdf">Full PDF for download</a></li></ul><div><div><section><div><div><div><div><div><div>This poster presents a targeted DESI-MS/MS imaging workflow for visualizing the spatial distribution of gefitinib and its metabolites in rat liver after a single therapeutic subcutaneous dose. The study addresses a common limitation in drug-distribution studies: spatial localization is often assessed using radiolabeled compounds, which may not be available during early drug discovery. DESI offers a label-free ambient ionization approach with minimal sample preparation, enabling direct mapping of drugs and metabolites in tissue.Male Wistar rats received gefitinib at 10 mg/kg, while plasma, urine, and liver samples were collected over a 24-hour period. Plasma and urine were analyzed by LC-MS/MS for pharmacokinetics and metabolite identification, whereas fresh-frozen liver sections were analyzed by targeted DESI MRM imaging on a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2100">Xevo TQ-Absolute XR tandem quadrupole mass spectrometer</a>. Liver sections were cryosectioned to 10 µm thickness and analyzed using DESI with a methanol/water solvent containing formic acid.&nbsp;The targeted DESI imaging experiment detected gefitinib together with six metabolites in liver tissue. Signal intensities were generally highest at approximately 1 hour after dosing, but the compounds remained detectable at 24 hours. Importantly, this was achieved at a therapeutically relevant dose rather than the much higher doses often required for imaging studies. The spatial imaging data also showed good agreement with LC-MS/MS pharmacokinetic profiles, particularly for gefitinib and the M11 metabolite.&nbsp;Overall, the poster demonstrates that tandem quadrupole DESI MRM imaging can complement conventional LC-MS/MS by adding spatial information to quantitative pharmacokinetic and metabolite data. The approach enables label-free mapping of drug distribution directly in tissue and may therefore provide a useful tool for drug metabolism and disposition studies during discovery and development.</div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 41, 2026

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 5th October 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you technical note by Agilent Technologies, application notes by LECO and Thermo Fisher Scientific and poster by Shimadzu / AOAC!<h3>1. Agilent Technologies: ATR Sampling Accessories for the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?instrumentationItems=89&amp;mainauthorItems=10&amp;search=635">Agilent Cary 635 FTIR</a> Spectrometer</h3>An easy and versatile way to perform FTIR measurements<ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/5991_6858_EN_bcf9447b77.pdf">Full PDF for download</a>&nbsp;</li></ul>Attenuated total reflectance (ATR) is the most widely used sampling methodology for Fourier transform infrared (FTIR) spectroscopy. This popularity is due to its ability to quickly and easily measure a broad range of sample types, including liquids, solids, powders, semisolids, and pastes. The Agilent Cary 635 FTIR spectrometer uses a versatile modular concept, where precisely optimized sampling modules are attached to the front of the Cary 635 FTIR engine. Depending on the specific application or sample, different ATR sensors are used. Permanently aligned optics allow a wide range of modules to be swapped in seconds, with no user alignment. The Cary 635 FTIR accommodates a wide selection of ATR sensors, and features the ability to switch from one ATR sensor to another instantaneously.&nbsp;For most applications, single reflection zinc selenide (ZnSe), diamond, and germanium (Ge) ATR sampling modules are available for the Cary 635 FTIR. These modules are used with a sampling press, and are excellent for analyzing solid materials, as well as liquids, pastes, and gels. The diamond sensor is highly durable, and the best choice for harder materials. The ZnSe sensor is a good choice for softer solids. The Ge sensor, with a shorter pathlength, is the best choice for highly absorbing samples. In addition, the multireflection ZnSe ATR sampling module is a great option for the analysis of liquids, pastes, and gels, where extra sensitivity is&nbsp;needed.&nbsp;Because these sampling technologies are custom engineered for the Cary 635 FTIR, the analyst can have confidence in the results, whichever ATR sensor is chosen for their application. This custom engineering translates into the highest performance, sensitivity, and ease-of-use of any spectrometer in its class.<h4>ATR sensors for the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?instrumentationItems=89&amp;mainauthorItems=10&amp;search=635">Cary 635 FTIR&nbsp;</a></h4>Whether your applications require the single reflection ZnSe, diamond or Ge, or the multireflection ZnSe, the Cary 635 FTIR delivers class-leading performance. Unlike other FTIR spectrometers that use third-party accessories, sampling technology for the Cary 635 FTIR is custom designed by Agilent engineers, and perfectly matched to the optical characteristics of the spectrometer. The rugged, no‑alignment design permits instantaneous exchange of these ATR sampling technologies, so that any sample type you might face will readily be accommodated.&nbsp;<h5>Zinc selenide (ZnSe) ATR modules&nbsp;</h5>ZnSe is a semiconductor-type material that has been used for many years as an ATR sensing element. It is relatively hard, has a broad wavelength range, and is insoluble in water. For this reason, it is an excellent choice for pliable solids, pastes, gels, and liquids. It can be used to analyze aqueous solutions in the pH 5 to 9 range. The Cary 635 FTIR has two variations of ZnSe sampling technology available: multireflection and single reflection sensors.&nbsp;<h5>Single reflection ZnSe ATR module&nbsp;</h5>Because of the relatively short pathlength of infrared light into the sample, this sensor is ideal for neat samples; that is, samples that are relatively concentrated or pure. The single reflection ZnSe module is a good choice for identification of softer materials, as well as viscous liquids. When measuring solids, such as polymer films, it can be used with the Cary 635 FTIR.&nbsp;<h5>Multireflection ZnSe ATR module&nbsp;</h5>The exceptional performance of the Cary 635 FTIR, combined with the increased pathlength of the multireflection ATR sensor, demonstrates a spectrometer system of unsurpassed sensitivity. Lower concentration components in pastes, gels and liquids can be measured. Solutes in diluted or concentrated aqueous solutions in the pH range of 5 to 9 can also be analyzed. Since the multireflection sensor is recessed slightly in its stainless steel holder, it is ideal for analyzing nonviscous liquid samples. This sensor is a superior choice when qualitative or quantitative measurements are required. It is not recommended for use with solid materials, since it is not used with the pressure clamp.&nbsp;<h3>2. LECO: Temperature-Dependent Determination of Total Organic Carbon (TOC) in Geological Materials</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/RC_612_TOC_GEOLOGICAL_MATERIALS_203_821_543_d525d35b59.pdf">Full PDF for download</a></li></ul>Total Organic Carbon (TOC) determination in geological materials—such as metal-bearing ores, oil shales, minerals, and aggregates—is routinely performed to assess organic matter content. This is an essential quality control procedure used to identify locations of natural hydrocarbon fuel deposits and to ensure the quality and compositional integrity of raw materials used in construction.&nbsp;The organic Carbon content of rock and shale samples is one of the most important parameters used in the evaluation of sediments as a potential source for petroleum or natural gas. TOC content controls the hydrocarbon generation potential of the rock and the content of adsorbed natural gas within the rock, as it is the source material responsible for the formation of natural hydrocarbon fossil fuel deposits.&nbsp;The determination of TOC is also an important quality control procedure used during the manufacturing of cement, from the raw material to the final product. TOC content is used to monitor the quality of raw materials such as limestone and shale and manage the kiln operation. This allows manufacturers to ensure that the final product meets the requirements necessary for optimal performance and compliance with environmental regulations.<h4>Instrument Model and Configuration&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1845">LECO RC612</a> is a multiphase Carbon and moisture determinator with a variable ramp furnace and a wide Carbon detection range that is specifically designed to differentiate various forms of Carbon by the temperature at which they combust or decompose. This capability facilitates the temperature differentiation determination of the different species of Carbon in geological materials. The following application note outlines the instrument parameters and procedure for temperature-dependent Carbon determination using the RC612.<h4>Typical Results</h4>The low Carbon calibration was performed utilizing a single standard, linear, force through origin calibration, using LECO 502-029 Synthetic Carbon (1.00 % C). The high Carbon calibration was performed utilizing a linear, full regression calibration, using LECO 502-030 Synthetic Carbon (4.99 % C) and LECO 501-034 Calcium Carbonate (12.01 % C). The results are reported on a dry basis.<h3>3. Shimadzu / AOAC: Rapid analysis of harmful heavy metals in pet food using EDXRF</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/aoac_2026_24_4b781e06d8.pdf">Full PDF for download</a></li></ul>On June 1, 2009, the Act on Ensuring the Safety of Pet Food was enacted in Japan, and compositional standards for dog and cat food were established. The ordinance specifies maximum levels for toxic heavy metals in pet food: cadmium (Cd) ≤ 1 μg/g, lead (Pb) ≤ 3 μg/g, and inorganic arsenic (As) ≤ 2 μg/g.&nbsp;Although atomic absorption spectrophotometry (AA) and inductively coupled plasma mass spectrometry (ICP-MS) are commonly used for heavy metal analysis, they require complicated pretreatment such as acid digestion and skilled operators.&nbsp;In this study, we focused on X-ray fluorescence analysis, which enables simple and rapid pretreatment, and analyzed five elements: Cd, Pb, As, mercury (Hg), and selenium (Se). This poster presents the usefulness of X-ray fluorescence analysis for toxic heavy metals in pet food and discusses prospects.<h4>Methods</h4>An energy-dispersive X-ray fluorescence spectrometer, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=altrace">ALTRACE</a> (EDXRF; Shimadzu Corporation), was used for the analysis (Fig. 1). Table 1 summarizes the analytical conditions.&nbsp;The main features of EDXRF are as follows:&nbsp;<ul><li>Samples can be analyzed directly or with only simple pretreatment, such as grinding.&nbsp;</li><li>Elements from sodium (11Na) to uranium (92U) can be analyzed.&nbsp;</li><li>Various sample types, including solids, powders, and liquids, can be analyzed.&nbsp;</li><li>Typical measurement times range from a few minutes to several tens of minutes.</li><li>Quantification limit is well below 1 ppm.</li></ul><h4>Conclusion&nbsp;</h4>X-ray fluorescence analysis enables the determination of harmful heavy metals with simple sample pretreatment. ALTRACE, characterized by its high sensitivity, demonstrated a lower limit of quantification sufficient for analysis at the level of a few ppm, as well as good reproducibility.Since XRF is an elemental analysis technique, separate analysis is required to distinguish between the chemical forms of inorganic and organic arsenic; however, it is considered useful for the screening of hazardous heavy metals.<h3>4. Thermo Fisher Scientific: Characterizing carbon materials with Raman spectroscopy</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/D19504_cc33b312f3.pdf">Full PDF for download</a></li></ul>Carbon nanomaterials have revolutionized the field of material science in recent years. Individual carbon nanomaterials offer a wide range of useful properties pertaining to electrical conductance, thermal resistance, and exceptional strength, making them very interesting materials to a broad range of industries. The high-level of interest in the processing, modification, and customization of these materials has created a strong demand for techniques that can be used to characterize carbon nanomaterials. Raman spectroscopy is one technique that has proven to be very well suited to many of the characterization needs with these materials.&nbsp;Raman spectroscopy is most sensitive to highly symmetric covalent bonds with little or no natural dipole moment. The carbon-carbon bonds that make up these materials fit this criterion perfectly and as a result Raman spectroscopy is highly sensitive to these materials and able to provide a wealth of information about their structure. As we shall see, Raman spectroscopy is capable of discerning even slight changes in structure making it a very valuable tool in the characterization of carbon nanomaterials.<h4>Raman highly sensitive to morphology&nbsp;</h4>Raman spectroscopy is particularly well suited to molecular morphology characterization of carbon materials. Every band in the Raman spectrum corresponds directly to a specific vibrational frequency of a bond within the molecule. The vibrational frequency and hence the position of the Raman band is very sensitive to the orientation of the bands and weight of the atoms at either end of the bond. Figure 2 shows an example in which the Raman spectrum of diamond is compared to the Raman spectra of crystalline silicon and germanium. These spectra show us several things. First, note that in the case of diamond, where the material consists of highly uniform C-C bonds in a tetrahedral crystal structure, the Raman spectrum is very simple. It consists of only a single band because all of the bonds in the crystal are of the same orientation and strength resulting in a single vibrational frequency. We also see that the spectrum of diamond is easily distinguished from the spectra of silicon and germanium by the frequency (cm-1 position) of the band even though they share the same tetrahedral crystal configuration. The heavier atoms of silicon and germanium slow the vibrational frequency and shift the corresponding Raman band to lower frequency as well.&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2239">Thermo Scientific DXR3 Raman Microscope</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2235">Thermo Scientific DXR3 SmartRaman Spectrometer</a></li></ul><h4>Conclusions&nbsp;</h4>Raman is a very powerful and valuable technique that can be of great benefit to characterization of carbon nanomaterials. Raman is particularly well suited to detect small changes in structural morphology of carbon nanomaterials making it an indispensable tool for many material scientists working with carbon nanostructures. Raman instruments are very fast and provide a great deal of flexibility in samples that can be accommodated. Every lab that is characterizing carbon nanomaterials will benefit from having access to Raman instrumentation.

News from LabRulezICPMS Library - Week 41, 2026

Article

Application

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Agilent Technologies

Technology Networks

GERSTEL

Phenomenex

Restek Corporation

Waters Corporation

SCION Instruments

Charge variant analysis is a demanding application for applied liquid LCMS instruments offer great specificity, selectivity, and sensitivity. Therefore, this technique is widely used in clinical research labs that are regularly tasked with developing fast and reliable methods to analyze a wide range of analytes. Often in these laboratories space is at a premium so a smaller LCMS instrument is an advantage.
We will review several common applications for clinical research labs, for example: 25-hydroxyvitanmin D, testosterone and the measurement of other analytes in biological matrices using the Agilent Ultivo TQ LCMS system. Recommendations and experience gained from developing these methods will also be presented.
<blockquote>
Presenter: Andre Szczesniewski (Applications Chemist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Andre graduated from University of Illinois in Urbana-Champaign with a master’s degree in Food Science. Working for over 30 years in the instrumentation industry as an applications chemist, Andre has specialized in the development and implementation of LC-MS applications for various industries including clinical research. He has expert knowledge of chromatography (from nano- to preparative-scale) and mass spectrometry with extensive practical knowledge in areas of small and large molecules, quantitation, proteomics, metabolites identification, forensics, clinical, toxicology, food and environmental analysis.
</blockquote>
<blockquote>
Presenter: Jennifer Hitchcock (LCMS Applications Scientist, Agilent Technologies Inc.)
</blockquote>
<blockquote>
Jennifer is an Application Scientist with Agilent Technologies, developing methods utilizing LC and RapidFire front ends with mass spec detection for clinical and cannabis labs. Prior to joining Agilent in 2015, Jennifer worked as an R&amp;D scientist in a clinical testing lab in North Carolina. In her spare time, Jennifer enjoys spending time with her family in Richmond, Virginia.
</blockquote>

Agilent Technologies: LCMS Applications for Clinical Research using the Agilent Ultivo TQ

LCMS Applications for Clinical Research using the Agilent Ultivo TQ

Bulk gas supply in the form of liquid nitrogen dewars and cylinders present laboratories with safety risks stemming from the frequent need to handle and manage gas supplies. Laboratory staff are at risk of injury every time they need to move a gas cylinder and a leak from bulk storage can result in the development of a potentially deadly atmosphere.
Flammable gases such as hydrogen present additional risks of fire or explosion, which need to be addressed through safe gas handling, storage and detection in the laboratory, increasing the cost of their use.
<h3>Attend this webinar to learn about:</h3>
<ul>
<li>General gas cylinder safety tips</li>
<li>Risks associated with bulk gas supply</li>
<li>The risks of using nitrogen and hydrogen in the laboratory</li>
<li>Benefits of using a gas generator to supply nitrogen and/or hydrogen</li>
</ul>
<blockquote>
Presenter: Dr. Ed Connor (Product Manager, PEAK Scientific)
</blockquote>

Unsplash/Julia Lobkova: Gas Safety in Your Laboratory

Gas Safety in Your Laboratory

Using technical controls in laboratory informatics solutions is the best way to achieve both data integrity and regulatory compliance.
Whilst designing electronic workflows, three principles of laboratory automation must be followed:
<h5>1. Data acquisition at the point of origin:</h5>
Always interface instruments to acquire analytical data
<h5>2. Never transcribe data:</h5>
All data must be transferred electronically between systems using validated processes to avoid making transcription errors
<h5>3. Know where data is stored:</h5>
This may involve location and file naming conventions so that data can be retrieved easily for audit or inspection quickly and easily
Data process mapping should be used to identify vulnerabilities in the process and well as process inefficiencies and by using the three automation principles above, the vulnerabilities can be eliminated as well as ensuing data integrity and regulatory compliance is achieved. This results in a more efficient and effective process.
Further examples upon the approaches involving sample preparation and chromatographic analysis will also be discussed.
<h3>Watch this webinar, to learn:</h3>
<ul>
<li>How to ensure the integrity and compliance of reported data, from sampling to reporting.</li>
<li>How to utilise technical controls in laboratory informatics to ensure integrity and compliance.</li>
<li>The three principles of laboratory automation for designing effective workflows.</li>
</ul>
Presenter: Bob McDowall (Director, R D McDowall Limited)

Technology Networks: Data Reporting, Integrity and Compliance

Data Reporting, Integrity and Compliance

She will also provide an introduction to SCION GC and HPLC Instruments for complete Cannabis Analysis including:
<ul>
<li>Introduction to Cannabis Analysis using both GC and HPLC instruments</li>
<li>Demonstrated applications highlighting key features of Cannabis Analysis</li>
</ul>
<blockquote>
Presenter: Ashleigh Mellor (LC Product Manager at SCION Instruments)
</blockquote>

HPLC Applications

Concerned about your validated LC method working on the new HPLC instrument? Excited about getting even more out of your method?
<blockquote>
Presenter: Douglas J. Turk, Ph.D. (Business Unit Manager, Eurofins BioPharma Product Testing)
</blockquote>
<blockquote>
Douglas J. Turk is Business Unit Manager of Eurofins BioPharma Product Testing in Toronto, Canada. Doug is responsible for the scientific operations, management, technical and administrative functions of the BPT Laboratory. He directs the research, development, chemical release testing, microbial testing and regulatory affairs for our GMP accredited laboratory. Doug has over 30 years of experience in pharmaceutical R&amp;D and analytical testing in both large pharma and contract research organizations. Doug received a Doctor of Philosophy degree in analytical neurochemistry from the University of Oklahoma in Norman as well as a Bachelor of Science degree (honors) in Chemistry and a Master of Science degree in Analytical Chemistry both from McGill University in Montreal. He was a founding member of the annual Land O’Lakes Bioanalytical conference and has a continuing interest in a number of scientific organizations including the American Association of Pharmaceutical Scientists, American Chemical Society, American Society for Mass Spectrometry, Chemical Institute of Canada, Canadian Society for Pharmaceutical Scientists, the Global CRO Council and Sigma Xi – the Scientific Research Society.
</blockquote>
<blockquote>
Presenter: Pauline McGregor, Ph.D. (CChem MRSC, PMcG Consulting)
</blockquote>
<blockquote>
Pauline McGregor Ph.D. CChem MRSC founded PMcG Consulting in September 2006. She has over thirty years’ experience in the Pharmaceutical industry and holds a PhD in organic, analytical chemistry . She originally came to Canada from Edinburgh, Scotland in 1995 to carry out her postdoctoral studies at the University of Western Ontario.
</blockquote>
<blockquote>
Pauline brings a technical expertise to laboratories which enable her to assist them to develop, transfer, verify and validate analytical procedures, and also optimize efficiency with regards to laboratory operations and troubleshooting in an analytical development and QC environment. She been involved in the development and evolution of lifecycle management for analytical procedures and AQbD since 2010. Pauline was a member of the USP expert panel for Validation, Verification and Transfer of Analytical Procedures and a member of a USP Chemical Medicines expert review committee. She continues to be a USP volunteer Expert Advisor and is a Member of the Royal Society of Chemistry , UK.
</blockquote>
<blockquote>
Presenter: Amanda Dlugasch (Application Chemist, Waters Corporation)
</blockquote>
<blockquote>
Amanda Dlugasch is an Applications Chemist II in the Systems Development Laboratory at Waters Corporation in Milford, MA. She received her B.A. in Chemistry from Manhattanville College and her M.S. in Chemistry from Sacred Heart University. She started at Waters Corporation in the Instrument Evaluation group developing qualification protocols for newly released products. Upon transferring to the Systems Development Laboratory, her initial focus was to evaluate and provide application and training material for the release of ACQUITY Arc UHPLC System. Currently, she is studying how LC instrument design and LC system characteristics influence chromatography when transferring, scaling and modernizing methods.
</blockquote>
<blockquote>
Moderated by: Isabelle Vu Trieu (Pharmaceutical Market Development Manager, Americas, Waters Corporation)
</blockquote>
<blockquote>
Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With 17 years of experience in chromatography and mass spectrometry, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France.
</blockquote>

Waters Corporation: LC Method Migration: Moving methods to newer LC assets within or across labs

Save Time and Money with Waters Session 8: LC Method Migration: Moving methods to newer LC assets within or across labs

The importance of the LC column regarding the successful outcome of analyses is often being underestimated. It is regarded as a consumable but is in fact a high-tech product whose performance depends on the applicability for a specific method and a specific instrument but also crucially on its proper treatment.
Very often the column does not get the appropriate attention although it is mostly small details which need to be considered. As a consequence, unnecessary and easily avoidable errors are caused which compromise the whole system. Frequently their origin can´t be found immediately.

Restek: The LC column - an unknown creature?

The LC column - an unknown creature?

Basics on LC columns, their production, stability, aging and tips for handling and care, prevention of typical errors.

<blockquote>
Darshan Engineer (Senior Business Development Manager, Phenomenex India)
</blockquote>
<blockquote>
Darshan Engineer has 15 years of chromatographic experience and is an expert in practical HPLC/UHPLC/LC-MS/Sample Prep method development and troubleshooting. In his current role as a Sr. Market Development Manager at Phenomenex India, Darshan provides technical assistance to customers across India, including on-site method development assistance, application support, and troubleshooting. Darshan also delivers chromatography and product trainings and seminars at customer sites.
</blockquote>
<blockquote>
Prior to joining Phenomenex, Darshan worked with Lambda Therapeutics and Accutest Laboratories Ltd, where he was involved with HPLC, LC-MS method development. Darshan holds a master’s degree in Organic Chemistry from Gujarat University and also holds a Diploma in Business Management from ICFAI University. 
</blockquote>

Phenomenex: Separation Science – Columns, A Wonderful Tool

Separation Science – Columns, A Wonderful Tool

<blockquote>
Presenter: Jack Stuff, Ph.D. (GERSTEL’s Analytical Services Manager)
</blockquote>

Gerstel: Advances in Analytical Pyrolysis: Focus on Microplastics and Forensics Analysis

Advances in Analytical Pyrolysis: Focus on Microplastics and Forensics Analysis

As part of the close collaboration between Phenomenex and chromatographers in the Food and Environmental Field, you are invited to our online seminar.
<h3>Agenda:</h3>
<ul>
<li>10:00 Introduction (Kate Parkinson)
</li>
<li>10:05 Sample Preparation and Chromatography Considerations in PFAS LC-MS-MS workflows for Complex Matrices (Jörg Baute)
</li>
</ul>
(20 minutes presentation + 5 minutes questions)
<ul>
<li>10:30 Confident quantification of per-/polyfluoroalkyl substances (Jianru Stahl-Zeng)</li>
</ul>
(25 minutes Presentation + 5 Minutes Questions)
<ul>
<li>11:00 GC-MS: Improving Speed and Resolution of Dioxin and PCB Analysis of Environmental and Food Samples (Patrick Borkulo-Sankofa)</li>
</ul>
(25 minutes Presentation + 5 Minutes Questions)
<ul>
<li>11:30 PPCP in water intended for human consumption (Jianru Stahl-Zeng)</li>
</ul>
(25 minutes Presentation + 5 Minutes Questions)
<ul>
<li>12:00 End</li>
</ul>
<blockquote>
Presenter: Patrick Borkulo-Sankofa (Senior Technical Consultant, Food and Environmental Accounts in Benelux, Phenomenex)
</blockquote>
<blockquote>
Presenter: Jörg Baute (European Business Development Manager/Bioseparation Specialist, Phenomenex)
</blockquote>
<blockquote>
Presenter: Jianru Stahl-Zeng (Senior Technical Marketing Manager , Environmental Applications, SCIEX)
</blockquote>

Advancements in Food and Environmental Applications - analysis of Dioxins and PCBs, PFAS, and PPCPs

Some of the most frequently asked questions we see are about HPLC capillaries and fittings.
Problems with LC connections are often mistaken for column issues and can be a source of frustration and downtime. 
<h3>In this webinar we will take look at your instrument’s flow path and discuss</h3>
<ul>
<li>Standard LC system capillaries</li>
<li>Fitting types and valve connections</li>
<li>System volume and dispersion</li>
<li>Application specific capillaries, including Bio-Inert and PFAS</li>
<li>Troubleshooting clogs</li>
</ul>
<blockquote>
Presenter: Mark Powell (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark Powell is an Applications Engineer located at Agilent’s Little Falls site in Wilmington, DE. Before joining Agilent in 2011, Mark worked in the pharmaceutical industry synthesizing, purifying and analyzing drug candidates. He provides applications assistance and technical support for Agilent’s HPLC columns and consumables.
</blockquote>