Researchers from CATRIN at Palacký University have used gold nanostructures to develop new methods capable of detecting very low concentrations of substances important for the functioning of the human body, including dopamine and serotonin. The results, achieved by researchers from the Nanomaterials in Biomedicine group in collaboration with other colleagues, have significant potential for future rapid, sensitive and personalised diagnostics.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Vedci_ukazali_jak_pomoci_zlata_citliveji_sledovat_dopamin_a_serotonin_5d493a6dbb.jpg" alt="CATRIN: Scientists show how gold can improve detection of dopamine and serotonin" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Vedci_ukazali_jak_pomoci_zlata_citliveji_sledovat_dopamin_a_serotonin_5d493a6dbb.jpg 245w," sizes="100vw" width="453" height="177">In a study published in <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.sbsr.2026.101026">Sensing and Bio-Sensing Research</a>, the researchers developed a special “plasmonic paper” coated with gold nanostars. “It enables tears to be collected easily and subsequently analysed for dopamine levels. These levels may be associated with Sjögren’s syndrome, an autoimmune disease that is sometimes mistaken for dry eye syndrome,” explained first author Klára Dzurillová.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2214180426000760?via%3Dihub">Plasmonic paper for point-of-care SERS biosensing of dopamine from tears</a></h4>Klára Gajdošová, Zuzana Chaloupková, Jana Soukupová, Jiří Hošek, Kateřina Poláková, Václav Ranc&nbsp;Sens. BioSensing Res., 2026, 52, 101026<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.sbsr.2026.101026">https://doi.org/10.1016/j.sbsr.2026.101026</a>&nbsp;<h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>The second study, published in <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1007/s00604-026-08164-7">Microchimica Acta</a>, focused on the simultaneous detection of serotonin and sertraline, a commonly used antidepressant belonging to the SSRI group. The use of SERS technology (surface-enhanced Raman spectroscopy) made it possible to significantly amplify the signal from the molecules being monitored using a specially modified surface. In this case, the researchers used very small gold nanocones separated by gaps of less than 20 nanometres. These gaps create so-called hot spots, areas where the electromagnetic field is greatly enhanced, making it possible to detect even very small amounts of the target substance.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://link.springer.com/article/10.1007/s00604-026-08164-7">Precise and simultaneous SERS detection of sertraline and serotonin on large-scale sub-20 nm plasmonic gold nanocone arrays</a></h4>Klára Gajdošová, Thanh-Lam Bui, Zuzana Chaloupková, S. M. Hossein Hejazi, Radek Zbořil, Štěpán Kment, Václav Ranc &amp; Kateřina PolákováMicrochim. Acta, 2026, 193, 450<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1007/s00604-026-08164-7">https://doi.org/10.1007/s00604-026-08164-7</a>&nbsp;<h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>“Using the new approach, we were also able to detect serotonin and sertraline simultaneously. In the future, the method could therefore make it possible to monitor both the concentration of the antidepressant and serotonin, whose level is affected by the treatment. This could contribute to a more accurate assessment of treatment efficacy and its adjustment to the individual patient,” said corresponding author Kateřina Poláková, Leader of the Nanomaterials in Biomedicine research group.Both approaches use surface-enhanced Raman spectroscopy (SERS) and achieved very low detection limits even in the presence of other substances that can interfere with the measurements.

Scientists show how gold can improve detection of dopamine and serotonin

<div><div>Scientists have developed a new fluorine-based tracer that can be tracked using magnetic resonance imaging (MRI) to monitor how quickly food moves through the gastrointestinal tract. The new method has so far been successfully tested in rats in a preclinical study, but it could eventually help diagnose gastrointestinal motility disorders or monitor treatment response. The study was published in Advanced Healthcare Materials.</div></div><div>The rate at which food moves through the stomach and intestines (gastrointestinal transit) provides important information about the health of the digestive system. Gastrointestinal transit is commonly assessed using methods that involve ionizing radiation, such as contrast X-ray imaging or scintigraphy. However, the associated radiation exposure makes these methods less suitable for frequent monitoring and limits their use in certain groups of patients, including pregnant women and children.A team of researchers from IOCB Prague, the First Faculty of Medicine of Charles University, and Ghent University has developed a new way to monitor gastrointestinal transit using MRI, which does not involve any ionizing radiation. The method relies on water-soluble, fluorinated polymer tracers that remain in the gastrointestinal tract and can be detected using fluorine-19 magnetic resonance imaging (¹⁹F MRI).“The advantage of fluorine is that it is naturally present in the human body only in negligible amounts. This means that when we track the fluorine signal, there is virtually no background interference. We see only our tracer and can determine where it is in the gastrointestinal tract,” explains Ondřej Groborz of IOCB Prague, first author of the study.<h3>Less fluorine, more suitable properties</h3><div>The new method combines conventional MRI, which shows the anatomy of the gastrointestinal tract, with ¹⁹F MRI, which reveals the polymer tracer itself. Overlaying the two images enables the researchers to pinpoint the tracer’s location, while comparing images taken at different time points shows how food moves through the gastrointestinal tract over time.Fluorinated compounds have been investigated for gastrointestinal imaging before. However, many of them are extremely hydrophobic and do not mix well with chyme, the semi-fluid contents of the digestive tract. Instead, they can form separate layers, resulting in imaging artifacts.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Pruchod_potravy_travicim_traktem_lze_sledovat_bez_ionizujiciho_zareni_Pomuze_novy_polymer_d818d4b08f.webp" alt="IOCB Prague: A new polymer could enable gastrointestinal transit monitoring without ionizing radiation: The passage of a polymeric contrast agent through the digestive tract of a rat over time. Its signal, detected using ¹⁹F magnetic resonance imaging (¹⁹F MRI), is shown in red. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Pruchod_potravy_travicim_traktem_lze_sledovat_bez_ionizujiciho_zareni_Pomuze_novy_polymer_d818d4b08f.webp 245w," sizes="100vw" width="1620" height="872"><div>The newly developed polymers, by contrast, are hydrophilic and water-soluble, allowing them to remain evenly mixed with the chyme and enabling researchers to track its movement through the digestive system.Polymer chemist Kristýna Kolouchová of Ghent University in Belgium explains that developing such a tracer was not straightforward. “We needed to strike the right balance in the fluorine content of our tracer. For ¹⁹F MRI, we want the fluorine content to be as high as possible, but too much fluorine adversely affected the tracer’s properties. In the end, we found the right balance: the polymer remained highly soluble while providing a stable signal.”</div><h3>Next-generation polymer headed for patent protection</h3><div>The researchers tested the method in rats by administering the polymer tracer directly into their stomachs and using MRI to track its passage through the gastrointestinal tract until it was excreted. They found no evidence of systemic uptake or damage to the tissues examined.The research is still at the preclinical stage and represents an initial proof-of-concept in an animal model. Before the method can potentially be used in clinical practice, its safety and reliability will need to be demonstrated in humans, a process that could take several years. The researchers are already working on a next generation of the polymer, which they plan to patent and develop further for practical applications. Companies have also expressed interest in the technology.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.71667">Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine-19 Magnetic Resonance Imaging</a></h4>Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna KolouchováAdv. Healthcare Mater., 2026, e71667<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/adhm.71667">https://doi.org/10.1002/adhm.71667</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote></div></div>

A new polymer could enable gastrointestinal transit monitoring without ionizing radiation

How Chromatography Helps Build Better Catalysts

Article

Scientists

Interview

Science and research

Video

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Agilent Technologies

Quantum Analytics

SelectScience

Shimadzu Corporation

Waters Corporation

Automation series: The #ConnectedLaboratory is real!
Have you joined the &quot;Meet the #ConnectedLaboratory&quot; series last year? If not have a look <a href="https://lcms.labrulez.com/webinars?search=%23ConnectedLaboratory&amp;tags=5">@Meet the #ConnectedLaboratory</a> to learn how easy it can be to get back some of your valuable time or complement your existing automation solutions in a flexible way.
Ready to take the next step? Learn how OneLab can become your sample preparation partner, get access to liquid handling tips &amp; tricks, be the first to learn about the newest additions and learn from your peers, sharing their experience implementing the #ConnectedLaboratory.
<h3>Part 4: Meet your peers and see how they implemented the #ConnectedLaboratory</h3>
Hear how existing users have implemented the #ConnectedLaboratory.
<blockquote>
Presenter: Evelien Dejaegere (Marketing Manager Chemistry EMEA, Waters Corporation)
</blockquote>
<blockquote>
Evelien joined Waters in 2005 and is currently a Marketing Manager in the European Chemistry organization. She is passionate on leveraging products and solutions to solve analytical challenges &quot;from sample to result&quot; with the aim to help advancing science and basically make our world a better place.
</blockquote>
<blockquote>
Recently, Evelien has a focus on laboratory automation workflows, helping customers turn samples into results with robustness, reliability and reproducibility. Involved with product development and commercialization, Evelien is keenly interested in learning about the challenges faced in the analytical laboratory, in order to facilitate the development of enabling technologies.
</blockquote>

Waters Corporation: Automation series The #ConnectedLaboratory is real!

The #ConnectedLaboratory is real! - Part 4: Meet your peers and see how they implemented the #ConnectedLaborator

Hear how existing users have implemented the #ConnectedLaboratory.

Meet your peers. Implementation the #ConnectedLaboratory

Quality is imperative throughout the entire development, validation, and final release testing of any therapeutic product. Often involving many complex and multifaceted challenges, vendors have a responsibility to ensure that their products meet defined criteria to deliver reliability and peace of mind to the end user.
In this online seminar series, software specialists will discuss how a modern chromatography data system (CDS) can provide a secure software platform from its early design, offering all the tools you need to maintain the integrity of your data, while alleviating concerns associated with regulatory audits.
If you would like to attend a webinar but are unable to join live, please do still register as all registrants will receive an on-demand link which you can use to watch the webinar after the live date.
<h3>Webinar 3. Ensuring system quality to deliver easier audits</h3>
<ul>
<li>Find out how you can prepare for an inevitable audit</li>
<li>Learn about current regulatory requirements and what this means for your lab</li>
<li>Discover expert hints and tips for an effective system review</li>
</ul>
<blockquote>
Presenter: Patrick Kenny (Software Compliance Product Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Patrick Kenny holds BS and MS degrees in chemistry from the University of Massachusetts Dartmouth and University of Massachusetts Amherst. Kenny spent 13 years in management and director roles in pharmaceutical laboratories. In these roles, he represented the chemistry lab in FDA, EMA, ISO, QP and customer audits. Kenny’s extensive regulated-lab management experience gives him a unique insight into the challenges lab managers face on a daily basis. He uses this knowledge to help customers best utilize their software to achieve regulatory compliance while realizing high productivity.
</blockquote>

Ensuring system quality to deliver easier audits

Find out how you can prepare for an inevitable audit. Learn about current regulatory requirements and what this means for your lab.

This two-day event will be a unique opportunity to network with your peers and learn about their successes.
WEOF 2022 will take a hybrid format, with options to attend the event in person either in Wilmslow, UK or in Guyancourt (Paris area), France. Virtual attendees will have access to oral lecture content but will be unable to attend our hands on, interactive sessions or the conference dinner 
<h3>WEOF 2022 Agenda</h3>
Our agenda will be a mix of talks from the scientific community, Waters’ presentations to better address your analytical needs and live demos on LC/MS and software.
<h5>Topics will include:</h5>
<ul>
<li>Existing and new analytical methods for synthetic oligonucleotides</li>
<li>Existing and new analytical methods for gene therapy therapeutics</li>
<li>Charge detection Mass Spectrometry</li>
<li>Latest hardware and software developments for all nucleic acid based therapeutics</li>
</ul>
<h3>WEOF 2022 Agenda</h3>
<h5>9.30 - 10.30 Introduction and Agenda Paris</h5>
<h5>9.40 - 10.40 Waters Solutions for Gene Therapy Analytics</h5>
<ul>
<li>Evelien Dejaegere, Waters Corporation</li>
<li>Paris</li>
</ul>
<h5>10.35 - 11.35 Break*</h5>
<h5>10.55 - 11.55 LC Methods for AAV Analysis</h5>
<ul>
<li>Patrick Hoering, Pharmaron</li>
<li>Wilmslow</li>
</ul>
<h5>11.20 - 12.20 An Overview of Charge Detection Mass Spectometry [CDMS]</h5>
<ul>
<li>Steve Preece, Waters Corporation</li>
<li>Wilmslow</li>
</ul>
<h5>11.45 - 12.45 Lunch*</h5>
<h5>12.45 - 13.45 Developments in Analytics for mRNA</h5>
<ul>
<li>Nick Pittman, Waters Corporation</li>
<li>Wilmslow</li>
</ul>
<h5>13.05 - 14.05 Analysis of mRNA on the BioAccord System</h5>
<ul>
<li>Filip Bergqvist, Cytiva</li>
<li>Paris</li>
</ul>
<h5>13.30 - 14.30 Aggregation, Titre and Full/empty Analysis of AAVs by Liquid Chromatography</h5>
<ul>
<li>Waters Corporation*</li>
<li>Local Programme</li>
</ul>
<h5>14.10 - 15.10 Break*</h5>
<h5>14.30 - 15.30 Identity and Modification of AAV Capsid Proteins by LC-MS. Peptide Mapping</h5>
<ul>
<li>Waters Corporation*</li>
<li>Local Programme</li>
</ul>
<h5>15.10 - 16.10 mRNA and Lipid Nanoparticle Workshop</h5>
<ul>
<li>Waters Corporation*</li>
<li>Local Programme</li>
</ul>
<h5>15.50 - 16.50 Close</h5>

Waters Corporation: Waters European Oligonucleotide Forum

Waters European Oligonucleotide Forum 2 - Day 2

We are delighted to continue our annual series dedicated to the oligonucleotide analytical community in Europe.

GC-FID is a widely favored analytical tool for VOC analysis in environmental testing labs. Analysts often turn to methanizers to catalytically convert carbon monoxide and carbon dioxide to methane, which can then be detected at very low levels using an FID. But every technology has its limitations. Existing methanizers have numerous weldments that are potential points of failure and leaks. Unexpected failures and the difficult replacement process often result in downtime and reduced testing throughput. Plus, with catalyst poisoning and too many analytes with not enough time nor standards to sufficiently quantify, labs need innovative solutions to come to the rescue.
The focus of this webinar will be on improved techniques for GC-FID. We’ll highlight innovative techniques that expand the capabilities of FID with universal carbon response. We’ll be joined by Activated Research Company, a top partner of Quantum Analytics, who has been developing analytical tools to help scientists better understand the physical world around us.
<h3>Key webinar takeaways:</h3>
<ul>
<li>Look inside two 3D printed microreactors for GC-FID.</li>
<li>Learn about a simplified greenhouse gas analyzer that is gaining widespread popularity.</li>
<li>Build a better understanding of formaldehyde analysis with GC.</li>
<li>Walkthrough calibration-free analysis of complex VOC matrices.</li>
</ul>
<blockquote>
Presenter: Connor Beach (Sales Engineer, Activated Research Company (ARC))
</blockquote>
<blockquote>
Beach leads the company’s sales engineering efforts domestically, with responsibility for technical sales in North America. He works closely with the product team and the ongoing product innovation efforts at ARC in both gas chromatography and liquid chromatography. Beach worked with ARC in 2015 on the initial product development of the Polyarc system where he tested the new two stage reactor system for calibration free GC analysis as well as application testing. He has three publications related to his efforts with the Polyarc system. In his previous role with Honeywell Beach served as a Process Design Engineer. Before joining Honeywell in 2019, Beach served as a Lead R&amp;D Engineer at Sironix Renewables where he was responsible for the operation of a laboratory including initial setup, general maintenance, data collection/analysis, equipment procurement, and new experiment designs. At Sironix Renewables he utilized the Polyarc to streamline analysis of novel chemicals. Beach holds a Bachelors degree in Chemical Engineering from the University of Minnesota -Twin Cities.
</blockquote>

Pixabay/Darkmoon_Art: Simplified Environmental Testing with GC-FID

Simplified Environmental Testing with GC-FID

Explore innovative techniques for GC-FID designed to improve workflows and increase testing capabilities. 

As the world of therapeutics changes rapidly, so do the challenges we face in glycan analysis. Innovative modalities are bringing new obstacles for experts to navigate with never required before CQA’s to analyse. Join us as we bring together some of the most influential figures in the glycan world to discuss innovations, challenges and solutions around glycan analysis.
This one day meeting offers a mix of presentations from industry experts in the field of glycobiology, a live panel discussion and on-demand content in our virtual lab.
<h5>Use the opportunity to:</h5>
<ul>
<li>Learn about the latest developments in analytical technologies in the biopharmaceutical industry</li>
<li>Listen to experts discuss their challenges with new therapeutic modalities and how they are overcoming them</li>
<li>Participate in a discussion after each session and interact with peers to obtain new ideas</li>
<li>Network with experts and like-minded individuals in glycan analysis</li>
<li>Learn about Agilent’s solutions in the virtual demo lab and ask questions</li>
</ul>
This is a meeting for the glycan community, by the glycan community – feel free to get involved, ask questions, make suggestions!
We can’t wait to welcome you!
<h5>Confirmed speakers:</h5>
<ul>
<li>Michael Bulter (Principal Investigator, NIBRT)</li>
<li>Yongjing Xie (Post-doctoral researcher, NIBRT)</li>
<li>Ganesh Pravin Gharat MS.c (Manager Process Analytics-R&amp;D, Intas Pharmaceuticals Ltd)</li>
<li>Monique van Scherpenzeel (CEO &amp; Founder, GlycoMScan B.V)</li>
<li>Tea Petrović (Laboratory Analyst; Ph.D student, Genos Ltd, Croatia)</li>
<li>Gordan Lauc (Professor at the University of Zagreb and Founder of Genos Glycoscience Research Laboratory Genos Ltd, Croatia)</li>
</ul>

Agilent Technologies: Agilent Virtual  Glycan Day 2022

Agilent Virtual  Glycan Day 2022

Join us for a day of talks from Glycan Experts across the industry!

This webinar describes analytical methods used for screening of extractables and leachables (E&amp;L) in pharmaceutical packaging and product.
Extractables analysis was performed by Direct TD-GCMS, while leachables by liquid injection-GCMS. Identification was carried out using NIST 14 Library and Shimadzu Polymer Additives Library. Instead of time-consuming solvent extraction procedure, a simpler Direct Thermal Desorption technique is used to perform extraction of the extractable compounds from polymer packaging. The result of extractables is compared with leachables analysis result from the product contained in the packaging.
Learning Objectives:
<ul>
<li>To provide a general knowledge of Extractables and Leachables
</li>
<li>To provide a simpler solution to E&amp;L screening
</li>
</ul>
<blockquote>
Presenter: Cynthia Lahey (Assistant Manager, Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
Cynthia started working with GC and GCMS in Shimadzu (Asia Pacific) in 2003, including various techniques such as headspace, SPME, thermal desorption and pyrolyzer. She has delivered numerous GC &amp; GCMS training courses, participated in international seminars, workshops and conferences as well as developed application notes for Shimadzu (Asia Pacific).
</blockquote>

Shimadzu: E&L Screening in Pharma Packaging and Product by GCMS

E&L Screening in Pharma Packaging and Product by GCMS

Analytical methods used for screening of extractables and leachables (E&L) in pharmaceutical packaging and product.

This webinar discusses about total solution approach for USP Chapters &lt;232&gt;/ &lt;233&gt; and ICHQ3D.
We will clarify regulatory requirements and recommended analytical methods for elemental impurities analysis in Pharmaceuticals.
Join us to learn about total workflow of microwave digestion for sample preparation and instrumental analysis using ICPMS following total regulatory compliance for data management. Also learn about how to overcome the challenges posed by ICHQ3D guideline, by removing metals from APIs or intermediates using metal scavengers.
<h5>Learning Objectives:</h5>
<ul>
<li>Elemental Impurities Regulations: USP Chapters &lt;232&gt;/ &lt;233&gt;, ICH Q3D
</li>
<li>Elemental Analysis Workflow using ICPMS in compliance with USP &lt;232&gt; and &lt;233&gt;
</li>
<li>Implementing Microwave Digestion technology for Sample preparation 
</li>
<li>Mitigating the common Metal Impurities in Pharmaceutical Products using Metal Scavengers
</li>
</ul>
<blockquote>
Presenter: Dr. Pravin Konde (Product Specialist (Atomic Spectroscopy), Shimadzu Asia Pacific)
</blockquote>
<blockquote>
Dr. Pravin is a Product Specialist (Atomic Spectroscopy) at Shimadzu Asia Pacific and has been based at Singapore. He has more than 12 years of industry experience of which about 10 years in analytical instruments with expertise in trace element analysis applications using AAS, ICP-OES &amp; ICP-MS. He is engaged primarily in technical support to regional sales teams and customers. Prior to joining industry, he has done his PhD in Chemistry from Institute of Chemical Technology (formerly UDCT), Mumbai, India.
</blockquote>
<blockquote>
Presenter: Yogesh Baldua (Dy. General Manager (Elemental &amp; Spectroscopy), Toshvin Analytical Pvt. Ltd.)
</blockquote>
<blockquote>
Yogesh is Deputy General Manager at Toshvin Analytical, India. He has overall 20 years of working experience in analytical instruments industry and has worked with many leading Multinational and Indian organizations. In his current role at Toshvin, he provides product and technical support to the sales team on Shimadzu elemental analysis products like AAS, ICPE, ICPMS and PreeKem Scientific for wide range of microwave digestion systems.
</blockquote>
<blockquote>
Presenter: Sunil Rana (Global Business Manager for Biotage Scale-Up business, Biotage AB, Sweden)
</blockquote>
<blockquote>
Dr. Sunil gained his BSc. Double Honours degrees in Chemistry and Biochemistry from the University of Southampton, UK in 1997 and completed an organic polymer/peptide chemistry PhD. with Professor Mark Bradley. During an Industrial post-doc at Argonaut Technologies, USA, he developed novel supported reagents/scavengers, then headed the analytical and chemical production groups. In 2008, he moved from Senior Scientist/Project Manager to Global product management. Sunil has an MBA from the Open University (UK), is a member of the ACS (21+yrs) and been involved in numerous publications and patent applications. He is Global Business Manager for Biotage Scale-Up business.
</blockquote>

Shimadzu: USP <232>/ <233> and ICH Q3D | Prepare Your Lab to Measure and Mitigate Elemental Impurities in Drug Products

USP <232>/ <233> and ICH Q3D | Prepare Your Lab to Measure and Mitigate Elemental Impurities in Drug Products

Total solution approach for USP Chapters <232>/ <233> and ICHQ3D.

USP <232>/ <233> and ICH Q3D for Elemental Impurities

Shimadzu Total Lab for Biopharma provides innovative and versatile analytical solutions for the biopharmaceutical market with a comprehensive range of instruments including LC/MS and Spectroscopy.
In this seminar we would like to introduce analytical solutions developed at Shimadzu that can help in establishing workflow for mAb discovery, clinical evaluation, biosimilar characterization, process development and QA/QC for batch release testing.
<h5>Learning Objectives:</h5>
<ul>
<li>Structure and funciton of monoclonal antibody
</li>
<li>Shimadzu application for mAb characterization 
</li>
<li>The range of instruments Shimadzu can offer for these workflow
</li>
</ul>
<blockquote>
Presenter: Dr. Wang Tianhua (Product Specialist, Shimadzu Asia Pacific)
</blockquote>
<blockquote>
Tianhua did his PhD in University of Pennsylvania (Chemical and Biomolecular Engineering). He then spent 5 years in the analytics group at Bioprocessing Technology Institute. His research interest includes drug discovery for infectious disease (SARS-CoV and Ebola), biopharmaceutical production system optimization and mAb Characterization with particular focus in glycan profiling and glycomics study. Tianhua joined Shimadzu in 2017 as a product specialist for life science products.
</blockquote>
<blockquote>
Presenter: Nicole Zhang (Senior Product Specialist, Shimadzu Asia Pacific)
</blockquote>
<blockquote>
Nicole studies in UK in Microbiology and Immunology, prior joining Shimadzu, she worked in different companies in analytical instrument industry for more than 10 years, from Chemist to marketing and in charge of different technologies from LC, MS to Spectro products. She joined Shimadzu at the year of 2018 as spectroscopy product specialist and in charge of food quality and safety market.
</blockquote>

Shimadzu: Integrating powers of MS and Spectroscopy - Solutions for mAB characterization

Integrating powers of MS and Spectroscopy - Solutions for mAB characterization

Analytical solutions developed at Shimadzu that can help in establishing workflow for mAb discovery.

Integrating powers of MS and Spectroscopy

Presentation Topics
<ul>
<li>Origins of the Digital Ion Trap
</li>
<li>Ion Trap v. Digital Ion Trap
</li>
<li>Shimadzu&#39;s Journey to the MALDI Digital Ion Trap
</li>
<li>Basic Proteomics
</li>
<li>Glycomics
</li>
<li>Antibody Drug Conjugates
</li>
<li>Summary and Acknowledgements
</li>
</ul>

Shimadzu: Proteomic Analysis Using a Miniature MALDI Digital Ion Trap Mass Spectrometer

Proteomic Analysis Using a Miniature MALDI Digital Ion Trap Mass Spectrometer

Proteomic Analysis Using a Miniature MALDI Digital Ion Trap

The hunt for novel drug candidate is a tedious and time-consuming process. A good workflow efficiency, from start of chemistry to purification to structural elucidation should streamline the discovery process and increase the success rate of developing novel candidate compound.
In this Mass Discussion, Dr. Ramesh Appadurai from Syngene International and Pottayil G Sasikumar from Aurigene Discovery Technologies will share their experience in running successful R&amp;D pipeline with the latest technology advancement. Let us also take a brief glimpse of Shimadzu&#39;s innovative drug discovery solutions which are designed to provide comprehensive and holistic workflow solution, ensuring faster result generation and maximizing ROI
<h5>Learning Objectives:</h5>
<ul>
<li>Analytical approaches for successful and innovative drug discovery pipeline
</li>
<li>Shimadzu&#39;s unique Drug Discovery Workflow
</li>
<li>Peptide-based drug candidates for cancer immunotherapy
</li>
</ul>
<blockquote>
Presenter: Dr Ramesh Appadurai (Research Director – Discovery Analytical Chemistry, Syngene International)
</blockquote>
<blockquote>
Dr Ramesh Appadurai Research Director and Head of Discovery Analytical Chemistry’ for Syngene International, a Contract Research Organization [CRO] company. He has over 16 years plus experience in this field Discovery Analytical Chemistry. Being in Discovery Analytical Lab, his key expertise is in developing efficient purification workflows.
</blockquote>
<blockquote>
Presenter: Dr. Pottayil G Sasikumar (Independent consultant and Advisor - Peptide Chemistry, Aurigene Discovery Technologies Limited, Bangalore)
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Dr. Pottayil G Sasikumar has more than 15 years of experience in peptide therapeutics and peptide/amino acid inspired small molecule drug discovery. He joined Aurigene Discovery Technologies Limited in 2006, and established the peptide department. As Research Director, he headed various aspects of peptide therapeutics including the lead optimization and CMC activities. His research mainly focuses on innovative chemical biology research fundamentally linked to outstanding immunological questions, to create new solutions for immune-related diseases. He is the co-inventor of an anti-cancer drug CA-170 (First orally bioavailable checkpoint inhibitor- Immuno-oncology agent) currently in Phase 2b/3 clinical trials and several other drugs which are in various phases of clinical development. 
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<blockquote>
Presenter: David Chan (Assistant Product Manager, Shimadzu (Asia Pacific) Pte. Ltd)
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<blockquote>
As LC Product Manager, David Chan is based in Shimadzu Asia Pacific, managing and handling the LC product line in the region. Before joining Shimadzu Asia Pacific, David was a Drug Discovery Chemist with more than 10 years of experience in small molecule design and synthesis. He understands the day-to-day difficulties faced by the synthetic chemist well through his extensive working experience, and knows how to apply the correct technology advancement to overcome these issues, in order to streamline the tedious discovery process.
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Toolkit for Treasure Hunt - Drug Discovery Made Easy