<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 19th October 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and<strong> LECO </strong>and brochure by<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: Determination of 366 Pesticides in Cocoa Liquor</strong></h3><p><strong>Using Agilent Captiva EMR-GPD passthrough cleanup and GC/MS/MS and LC/MS/MS detection</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_pesticides_cocoa_ms_5994_9043en_agilent_508ce8da26.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>Cocoa liquor is a key and central intermediate used in the manufacture of a wide range of cocoa-derived products, including chocolate, cocoa butter, and cocoa powder. Its production begins with the processing of cocoa beans (as shown in Figure 1) and it contains both cocoa butter and cocoa solids, making it the most representative and analytically challenging matrix for studying cocoa flavor, quality, safety, and authenticity.<sup>1</sup>&nbsp;</p><p>As cocoa beans are vulnerable to fungal infections and insect infestation, pesticides are often applied during cultivation and post-harvest processing. Consequently, regulatory agencies worldwide, such as the EU and US FDA, require stringent monitoring of pesticide residues in cacao-derived products to ensure consumer safety and compliance with maximum residue limits (MRLs).<sup>2</sup>&nbsp;</p><p>However, pesticide analysis in cocoa liquor presents significant analytical challenges. The high lipid content, natural pigments, and abundant matrix coextractives can cause severe matrix effects, detector contamination, and reduced method robustness. These issues demand highly sensitive, selective, and rugged instrumentation capable of operating reliably even in the presence of complex sample backgrounds.&nbsp;</p><p>To meet these analytical needs, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890</strong></a>/<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7010D"><strong>7010D GC/MS/MS</strong></a> and the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=1290+infinity+III"><strong>Agilent 1290 Infinity III</strong></a>/<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=6475"><strong>6475 LC/MS/MS</strong></a> systems provide powerful complementary platforms for comprehensive pesticide monitoring. The 7010D GC/MS/MS, equipped with the high-efficiency electron ionization source and the industry-leading femtogram‑level sensitivity, enables confident quantification of pesticide residues with outstanding selectivity through dynamic multiple reaction monitoring (dMRM). For thermally labile or highly polar pesticides that are unsuitable for GC analysis, the 6475 LC/MS/MS system offers superior sensitivity, robust spray stability, and advanced dMRM acquisition tailored for trace-level quantification, even in challenging matrices.&nbsp;</p><p>This application note demonstrates a combined GC- and LC-based workflow that is optimized for cocoa liquor, including sample preparation, matrix cleanup strategies, and dMRM method development. As shown in Figure 2, 76&nbsp;analytes were analyzed by GC/MS/MS and 308 analytes were analyzed by LC/MS/MS. The GC/MS/MS analysis included 18 analytes that can also be determined using LC/MS/MS; thus, this workflow covers a total of 366&nbsp;unique pesticides. Together, the 7010D GC/MS/MS and 6475 LC/MS/MS deliver a comprehensive solution covering a broad range of pesticide chemistries while maintaining excellent accuracy, precision, and long‑term instrument&nbsp;robustness.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>This study successfully demonstrated a robust and sensitive method for the quantitative analysis of 366 pesticides in cocoa liquor using the Agilent 8890/7010D GC/MS/MS and the 1290 Infinity III/6475 LC/MS/MS system.&nbsp;</p><p>To achieve the most efficient use of instrument cycle time, both GC/MS/MS and LC/MS/MS data were acquired in dMRM mode. The dMRM methods were created and developed based on the Agilent MRM databases.&nbsp;</p><p>The optimized workflow included sample extraction with the Bond Elut QuEChERS AOAC extraction kit followed by cleanup with the Agilent Captiva EMR-GPD kit. This workflow provided excellent linearity, recovery, and reproducibility.</p><h3><strong>2. LECO: Modern-day Urinalysis; Combining Enhanced Chromatography with High Resolution Time-of-Flight Mass Spectrometry to Discover Potential Prostate Cancer Biomarkers in Human Urine</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/PEG_GC_HRT_4_D_PROSTATE_CANCER_BIOMARKERS_URINE_203_821_733_f14aae3a13.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Urinalysis is one of the oldest diagnostic practices in medicine, with origins tracing back to ancient civilizations that recognized urine as a reflection of internal health. Early physicians in Mesopotamia, Egypt, and Greece visually inspected urine for its color, clarity, sediment, and odor, laying the groundwork for uroscopy. By the Middle Ages, urine wheels were developed to standardize interpretations, although these assessments remained largely qualitative and speculative (Figure 1, left). A major shift occurred in the 17th and 18th centuries with advances in chemistry, enabling the identification of specific urinary components such as glucose in diabetic patients. The 19th and early 20th centuries introduced microscopy and standardized chemical assays, solidifying urinalysis as a core clinical tool for detecting infections, metabolic disorders, and renal dysfunction.&nbsp;</p><p>Today, urinalysis plays a crucial role in identifying disease-associated biomarkers, particularly for conditions where early detection is crucial. In oncology, urine-based assays are being developed for cancers such as bladder, prostate, kidney, and even systemic malignancies. These assays leverage signatures such as extracellular vesicles, circulating tumor DNA, metabolites, and protein fragments. Machine learning and high-throughput analytical platforms now integrate urinary biomarker profiles to enhance diagnostic accuracy, predict disease progression, and guide personalized therapies. This study describes the utilization of enhanced chromatography and high resolution time-of-flight mass spectrometry for the discovery of potential prostate cancer biomarkers in urine.</p><h4><strong>Experimental&nbsp;</strong></h4><p>Data were acquired on a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/39"><strong>LECO Pegasus HRT 4D system</strong></a> equipped with a Multi-Mode Source™ (MMS™), enabling Electron Ionization (EI), Positive Chemical Ionization (PCI), and Negative Chemical Ionization (NCI) to be performed with the same hardware. <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/82"><strong>Auto Sampler - LECO L-PAL 3</strong></a>, Gas Chromatograph - Agilent 8890 w/ <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/44"><strong>LECO QuadJet Thermal Modulator</strong></a>.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>From ancient visual inspection to modern molecular profiling, the evolution of urinalysis reflects continuous scientific progress—positioning urine as a powerful, noninvasive window into human health and a promising frontier for + next-generation disease detection. Today, LECO's Pegasus HRT 4D and ChromaTOF brand software provide robust analytical capabilities for complex biological samples and were used in the annotation of potential prostate cancer biomarkers in urine. The instrument generates comprehensive, untargeted datasets that can be interrogated through a variety of software tools, such as ChromaTOF Tile, which was demonstrated in this note. Automated Peak Find processing delivers extensive lists of annotated sample components through spectral-similarity searches and formula determinations based on high resolution, accurate-mass ions. Confident annotation of biomarkers associated with diseases such as prostate cancer can be accomplished with the workflows demonstrated in this application note.</p><h3><strong>3. Shimadzu: Run Smarter, Go Greener: Smart Energy Saving In </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=2060"><strong>Nexis GC-2060</strong></a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/s_gc_f34_b226302147.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>The New Industry Standard For Sustainable Laboratories&nbsp;</strong></h5><p>Rising power demand and higher electricity prices highlight the need for smart energy management in modern laboratories. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=2060"><strong>Nexis GC-2060 </strong></a>delivers the ideal solution, combining energy savings, rapid readiness, and operator convenience. This allows laboratories to reduce running costs, limit heat output, and keep productivity high.</p><h5><strong>ECO Idling: Smart Standby Without The Wait&nbsp;</strong></h5><p>ECO Idling is Shimadzu’s smart standby feature that balances productivity with energy and gas savings. The system tracks usage patterns and visualizes workloads to recommend an optimized eco-schedule, automatically switching the GC between active and low-consumption states. The system adapts to your workflow instantly: Start a run, and it automatically resumes analysis ready performance. When work stops, it slips into the ECO state to lower power and gas use. For Nexis GC-2060 systems with a built-in ECO button, operators can turn ECO Idling on or off with a single touch—making it incredibly simple to lower laboratory running costs.</p><h5><strong>Tech Tip: Why Does GC Require A Stabilization Period Before Analysis?&nbsp;</strong></h5><p>Moisture adsorbed on columns and detectors is a common cause of prolonged start-up and stabilization times. Maintaining the column at 50°C reduces the relative humidity to approximately 13% (assuming 23°C room temperature).&nbsp;</p><p>Use ECO Idling to schedule automated column cleaning followed by an oven warm-up before you start your day. This guarantees the system is fully stabilized and ready when you walk in, eliminating daily start-up delays and maximizing throughput.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 43, 2026

News from LabRulezLCMS Library - Week 43, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 19th October 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, LECO, Metrohm </strong>and <strong>Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: Nickel and Cobalt Separation using Methyl Fluoride for Ni-59 Determination by ICP-QQQ</strong></h3><p><strong>Evaluation of the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=8900"><strong>Agilent 8900 ICP-QQQ</strong></a><strong> for novel isobar separation affecting radionuclides</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/2026_10_15_Nickel_and_Cobalt_Separation_using_Methyl_Fluoride_for_Ni_59_Determination_by_ICP_QQQ_c37c0a26b0.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Decommissioning of nuclear sites represents a significant global challenge given the range of sample types and radionuclides that must be characterized. In the UK alone, the estimated final decommissioning cost for existing sites is predicted to range from £95 to 218 billion. Accurate measurement of radionuclides in decommissioning wastes improves measurement confidence and can contribute to safer, more cost-effective decommissioning.<sup>1,2</sup>&nbsp;</p><p>Nickel-59 is a radionuclide that is primarily formed through long-term neutron bombardment of stable <sup>58</sup>Ni in steel in nuclear reactors. It has a long half-life of 76,000 ± 5000 years.<sup>3</sup> Accurate characterization of <sup>59</sup>Ni is therefore important for appropriate waste sentencing and long-term monitoring.<sup>4</sup></p><p>Mass spectrometry, including triple quadrupole ICP-MS (ICP-QQQ), is increasingly used as a rapid technique for measuring long-lived radionuclides in decommissioning wastes. For this approach to be effective, isobaric, polyatomic, and tailing interferences must first be removed. In the case of <sup>59</sup>Ni, monoisotopic <sup>59</sup>Co, polyatomic <sup>58</sup>Ni<sup>1</sup>H, and peak tailing from the adjacent <sup>58</sup>Ni peak (68.08% abundance)<sup>5</sup> must all be fully separated before measurement. Previous mass spectrometric measurements of <sup>59</sup>Ni have been performed using accelerator mass spectrometry (AMS).<sup>6,7</sup> However, there is no routine analytical technique in place for <sup>59</sup>Ni determination. So far, significant interferences have prevented measurement of <sup>59</sup>Ni by ICP-MS. Offline separation of Ni and Co using anion exchange or extraction chromatography is effective.<sup>8,9</sup> However, because<sup> 59</sup>Co is monoisotopic, some level of interference at m/z 59 is still expected.&nbsp;</p><p>The in-instrument interference removal capability of ICP-QQQ has been shown to benefit multiple medium- and long-lived radionuclides, including <sup>90</sup>Sr, <sup>93</sup>Zr, <sup>99</sup>Tc, <sup>129</sup>I, and <sup>135</sup>/<sup>137</sup>Cs.<sup>10–12</sup> A recent study using methyl fluoride (CH<sub>3</sub>F) as a cell gas for the determination of a range of radionuclides by ICP-QQQ suggested that this method may be close to being considered an analytical technique for <sup>59</sup>Ni.<sup>13</sup> This study builds on those results through a detailed characterization of CH<sub>3</sub>F as a cell gas for Ni/Co separation using an Agilent 8900 ICP-QQQ.</p><h4><strong>Experimental</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><p>All measurements were performed using an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=8900"><strong>Agilent 8900 ICP-QQQ</strong></a> (#100 Advanced Applications model) located at the Agilent Center of Excellence in Cheadle, UK. The instrument was equipped with a MicroMist nebulizer, a Scott double-pass spray chamber, a 2.5&nbsp;mm internal-diameter quartz torch, Ni sample and skimmer cones, and x-lens. Before use, the instrument was tuned using a mixed stable standard solution to ensure that sensitivity, measurement uncertainty, oxide and doubly charged ion formation rates, and mass axis settings were within operational norms.&nbsp;</p><p>The instrument is equipped with four cell gas lines. The CH<sub>3</sub>F cylinder (Air Products) was pre-diluted to 10% CH<sub>3</sub>F, with the balance in helium (He). It was introduced through the hydrogen cell line, which allows flow rates up to 10&nbsp;mL/min.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The results demonstrate a significant step towards enabling radioactive 59Ni measurement by ICP-QQQ using optimized cell gas conditions. The stable isotope 60Ni was used as a stable analog of 59Ni as there is no available radioactive standard to evaluate 59Ni directly. Operating the Agilent 8900 ICP-QQQ with a fixed CH3F cell gas flow rate of 10.0 mL/min, and added helium, would provide the most effective separation of 59Co and 59Ni product ions. This approach has the potential to allow the concentration of the radioactive Ni isotope to be reliably assessed.&nbsp;</p><p>The method can next be tested on dissolved steel samples, which are the main sample matrix of interest within the nuclear industry. A broader issue is the lack of a suitable 59Ni tracer for method development and validation, which will need to be addressed as interest in this radionuclide increases.</p><h3><strong>2. LECO: Determination of Moisture in Pet Food</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/TGM_800_MOISTURE_PET_FOOD_203_821_735_dc5b444f40.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Determining moisture in pet food is fundamental for quality control, regulatory compliance, and nutritional evaluation. Pet food nutrient guarantees (protein, fat, fiber, etc.) are expressed on an as-fed basis and moisture content affects how these nutrients are calculated. High moisture content often reflects a lower nutrient concentration. To compare different pet food products fairly, nutrients are often converted to a dry matter basis, requiring accurate moisture data. High moisture content in non-canned pet food products can also lead to mold growth, toxin production, and yeast proliferation, which can be detrimental to an animal's health. This is especially important in semi-moist products, fresh/frozen diets, and treats.&nbsp;</p><p>Pet food regulations and industry standards worldwide establish requirements for product labeling, nutritional declarations, and quality control. Moisture content is a critical parameter, as declared values must accurately reflect product composition and meet applicable requirements. Moisture levels that exceed declared values can result in product recalls, customer complaints, reduced shelf life, and increased product waste. As a result, accurate and reliable moisture determination is essential for maintaining product quality, protecting brand reputation, and preserving consumer confidence.</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>Thermogravimetric analysis (TGA) is an analytical technique in which changes in sample mass due to changes in the physical and chemical properties of materials is measured as a function of temperature and time. TGA is commonly used to determine selected characteristics of materials that exhibit either mass loss or gain due to decomposition, oxidation, or loss of volatile materials such as moisture. Macro TGA systems typically use a nominal one-gram sample mass to allow more accurate mass change measurements in heterogeneous materials.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1878"><strong>LECO TGM800</strong></a> is a macro thermogravimetric analyzer designed to determine the moisture content of materials using a mass loss-on-drying technique. Mass loss of the sample is measured as a function of the oven temperature while controlling the atmosphere and ventilation rate. The TGM800 allows up to 16 samples to be analyzed simultaneously, with a maximum oven temperature of 175 °C.</p><h3><strong>3. Metrohm: Fish meal analysis by near-infrared spectroscopy</strong></h3><p><strong>NIR spectroscopy reduces analysis time from hours to seconds</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_nir_148_download_f4365741c6.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Regarding animal nutrition, fish meal is a premium source of omega-3 fatty acids, protein, and essential minerals. Due to its nutritional properties, it is not only widely used in aquaculture, but also as an additive to swine feed and poultry feed. To analyze the main quality components of fish meal, such as fiber, fat, protein, moisture, and ash content, multiple wet chemistry methods are usually needed. Instead of waiting hours for the results from these wet chemical techniques, near-infrared spectroscopy (NIRS) delivers results within seconds without the use of chemicals. This allows manufacturers to execute frequent checks against product specifications and perform fish meal quality control with ease.</p><h4><strong>EXPERIMENTAL EQUIPMENT&nbsp;</strong></h4><p>More than 1700 samples of fish meal from different suppliers were analyzed with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=220&amp;search=OMNIS+NIR"><strong>OMNIS NIR Analyzer Solid</strong></a> (Figure 1) and a large sample cup. Every fish meal powder sample was measured in reflection measurement mode at five different positions to create an average spectrum. This minimizes sample inhomogeneities and results in a more representative NIR spectrum. Model development and validation was performed with the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=220&amp;search=OMNIS+software"><strong>OMNIS Software</strong></a>.</p><h4><strong>CONCLUSION</strong></h4><p>This Application Note shows the feasibility of using near-infrared spectroscopy for fish meal feed analysis. The main composition parameters of protein, fat, ash, fiber, and water content are determined in seconds without the use of chemicals. NIRS helps to save costs and improve lab safety when compared to standard wet chemistry methods. By using NIRS for efficient multiparameter analysis, quality control laboratories can save hours of time per sample measurement (Table 1), resulting in much higher sample throughput.</p><h3><strong>4. Shimadzu: X-Ray Fluorescence Analysis of Crude Drugs</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01310_en_f21532d74d.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User benefits</strong></h5><ul><li>Energy-dispersive X-ray fluorescence (EDXRF) analysis enables rapid, non-destructive analysis of inorganic elements in crude drugs with only simple sample preparation.&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=ALTRACE+EDXRF"><strong>ALTRACE EDXRF spectrometers </strong></a>offer sufficient analytical sensitivity for screening samples with respect to the limits specified in the Japanese Pharmacopoeia for testing heavy metals and arsenic.&nbsp;</li><li>Qualitative-quantitative analysis can easily determine the elemental composition of crude drugs, including not only heavy metals but also mineral components.</li></ul><p>Crude drugs are derived from natural sources, such as plants and animals. Qualitative and quantitative analysis of their elemental composition is important for ensuring their quality and safety. In particular, the content of mineral components and heavy metals in crude drugs can vary depending on the cultivation environment and processing steps. Therefore, they must be evaluated by appropriate analytical methods.&nbsp;</p><p>Methods for analyzing elemental composition include colorimetric methods, such as specified in the Japanese Pharmacopoeia (JP) for testing heavy metals and arsenic. Instrumental techniques, such as atomic absorption spectrophotometry (AAS), inductively coupled plasma atomic emission spectrometry (ICP-AES), and inductively coupled plasma mass spectrometry (ICP-MS), are also used in some cases.&nbsp;</p><p>The heavy metals test protocol in the JP adds a sodium sulfide reagent under acidic conditions and then evaluates resulting coloration as a lead (Pb)-equivalent value. That offers the advantage of being able to assessthe total amount of heavy metals with a simple process. However, it has several drawbacks, including the need for skilled operation and reagent handling, as well as limited sensitivity and reproducibility.&nbsp;</p><p>In contrast, though AAS and ICP-AES, ICP-MS enable highly sensitive and highly accurate analysis, they require complete dissolution of samples in an acid, such as nitric acid or hydrochloric acid, as well as advanced expertise in chemical pretreatment. In addition, the instrument running costs and installation requirements can make their adoption difficult. Given such background circumstances, the adoption of analytical methods that enable rapid analysis with simplersample preparation are increasingly expected.&nbsp;</p><p>This article describes examples of analyzing hazardous heavy metals in crude drugs using the calibration curve method and examples of qualitative-quantitative analysis using the Fundamental Parameter (FP) method, both performed with an energy dispersive X-ray fluorescence (EDXRF)spectrometer.</p><h4><strong>Features of EDXRF&nbsp;</strong></h4><p>A major feature of <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=ALTRACE+EDXRF"><strong>ALTRACE EDXRF Spectrometer</strong></a> is that samples can be analyzed as-is or with only simple sample preparation, such as crushing. It can be used to analyze samples in various forms, including solids, powders, and liquids, and elements with a wide range of concentrations, from the ppm level to 100 %.&nbsp;</p><p>Two quantitative analysis methods are available, which can be selected according to the given application. The calibration curve method requires standard samples and the FP (fundamental parameter) method does not require standard samples and derives quantitative values based on theoretical intensity calculations.&nbsp;</p><p>In addition, because EDXRF spectrometry is a non-destructive analytical technique, the same sample can be subsequently reanalyzed by other analytical methods, which is also a major advantage.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>EDXRF spectrometry is an effective technique for simple, rapid, non-destructive analysis of mineral components and heavy metals in crude drugs. By using an ALTRACE EDXRF spectrometer, the burden on analysts associated with sample preparation can be reduced and large numbers of samples can be analyzed efficiently. As the quality control and monitoring of hazardous elements become increasingly important, X-ray fluorescence analysis holds considerable promise as a useful alternative technique in the field of crude drug analysis.</p>

News from LabRulezICPMS Library - Week 43, 2026

Article

Application

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Waters Sample & Collection Plate

Waters 96-well and 384-well plates are adherent to ANSI and SBS standards and are suitable for LC autosamplers and liquid handling robots.

<div><div><h4><strong>Broad selection of high-quality sample and collection plates</strong></h4></div></div><div><div><p><strong>Waters 96-well and 384-well plates are adherent to ANSI and SBS standards and are suitable for LC autosamplers and liquid handling robots. Waters plates are made from polypropylene (PP) for chemical resistance, and specialty 96-well plates with glass inserts are available for samples that are not suitable for polypropylene containers.</strong></p><h3><strong>Overview</strong></h3><div><div><div><div><div><div><ul><li>96- and 384-well collection plates and sample plates are SBS/ANSI compliant for robotic compatible systems&nbsp; &nbsp; &nbsp; &nbsp;</li><li>&nbsp;Constructed of polypropylene (PP) for chemical resistance</li><li>&nbsp;Glass inserts available for samples requiring glass surfaces</li><li>&nbsp;Heat seals and cap mats for plates and glass inserts</li></ul></div></div><div><div><h4><strong>Recommended Use</strong></h4><p>For general high-throughput LC and LC-MS work and for integration in (semi)-automated sample handling workflows.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/img_Waters_Sample_and_Collection_Plate_709693fdab.jpg" alt="imgWaters Sample &amp; Collection Plate." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_img_Waters_Sample_and_Collection_Plate_709693fdab.jpg 245w," sizes="100vw" width="1024" height="493"></p><h3><strong>Cap Mats</strong></h3><h4><strong>Silicone/PTFE &amp; Polypropylene Cap Mats</strong></h4><ul><li>Non-slit storage mats for long-term sample storage</li><li>Pre-slit silicone/PTFE and polypropylene cap mats for use in autosamplers for proper venting and sample draw accuracy with excellent resealing characteristics</li><li>Silicone/PTFE &amp; Polypropylene Cap Mats</li></ul><h3><strong>Heat Seals</strong></h3><h4><strong>Clear Polyester Heat Seals</strong></h4><ul><li>Can be used with most solvents &amp; buffers over a -80 °C to 80 °C temperature range</li><li>Requires a heat sealer to apply</li></ul><h4><strong>Aluminum Foil Heat Seals</strong></h4><ul><li>Made from a polyester/aluminum laminate</li><li>Ideal choice for long term storage to reduce evaporative loss</li><li>Aluminum layer reduces gas permeability of the seal</li><li>Can be used at temperatures from -200 °C to 90 °C</li><li>Requires a heat sealer to apply</li></ul><h4><strong>Adhesive Seals</strong></h4><ul><li>A polyolefin film with synthetic rubber adhesive</li><li>Ideal for use with protein and peptide samples and buffers</li><li>Resistant to small concentrations (0% to 30%) of polar organic solvents</li><li>Can be used at temperatures from -80 °C to 80 °C</li><li>Requires a heat sealer to apply</li></ul></div></div></div></div></div></div></div></div>

Waters CERTIFIED HPLC Vials

Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.

<div><div><h4><strong>Meet your analytical challenges with the right vial.</strong></h4></div></div><div><div><p><strong>The right vial.&nbsp;</strong><span><strong>A world of difference.</strong></span></p><p>Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.</p><p>All Waters sample vials are held to the tightest dimensional tolerances. Manufactured via a 2-, 3-, or 4-step certification process, we ensure that Waters Certified Vials meet and maintain specified vial dimensions, levels of cleanliness and adsorption properties from batch to batch.&nbsp;Find the right vial for your application and autosampler - use our <a target="_blank" rel="noopener noreferrer" href="https://find.waters.com/VialSelector/"><strong>Vial Selector</strong></a> to find your perfect match.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_118649175c.jpg" alt="Waters CERTIFIED Vials: Table 1. Vials for Routine and Advanced Analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_118649175c.jpg 245w," sizes="100vw" width="1226" height="754"></p><h3><strong>Waters LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><ul><li>Low MS interferences from known residues &amp; polymers</li><li>For routine QC and LC-MS analysis with lower analyte concentrations from 10-100s ng/ml.</li></ul><h3><strong>Waters TruView<sup>TM</sup> LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><p><span><strong>✅&nbsp;</strong></span>Low Adsorption Test</p><div><div><ul><li>Lowest MS interferences from known residues &amp; polymers</li><li>For high-end LC-MS analysis and quantification of analytes with a concentration of below 1 ng/ml with reduced adsorption of polar analytes.</li></ul><h3><strong>Waters CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><div><div><ul><li>No UV interferences caused caused by manufacturing and packaging residues</li><li>For routine QC LC-UV analysis&nbsp;of compounds in µg/mL&nbsp;concentrations.&nbsp;</li></ul><h3><strong>MAXPEAK QuanRecovery</strong></h3><ul><li>For high recovery peptide and protein quantification workflows. Reduces sample losses due to non-specific binding (NSB) and ionic interactions.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_2_4fba532335.jpg" alt="Waters CERTIFIED Vials: Vials Shapes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_2_4fba532335.jpg 245w," sizes="100vw" width="1261" height="617"></p><div><div><h3><strong>Control data quality risks and reduce unexpected or ghost peaks</strong></h3><p>Don’t let the presence of background noise impact your results, causing data quality risks and unexpected or ghost peaks. Background noise can come from many factors.&nbsp;One of the most important factors are vial and septa cleanliness, which introduces contamination peaks. Ghost peaks are introduced by analyte degradation that can be triggered by significant pH changes in the diluent. In this chromatogram, the top shows normal behavior, and the bottom chromatogram shows ghost peaks.</p><p>Waters Certified vials are cleanliness tested so you don’t have to worry about contaminant peaks. The TruView pH Control Vials are certified to minimize and control a pH shift away from the neutral.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_4_7749301ba1.jpg" alt="Waters CERTIFIED Vials: Prevent the appearance of unexpected peaks during LC/UV analysis with Waters LC/GC Certified Vials as a control strategy." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_4_7749301ba1.jpg 245w," sizes="100vw" width="1024" height="535"></p><h3><strong>More time on development. Less on troubleshooting</strong></h3><p>Stop losing valuable development time on troubleshooting due to analyte loss from non-specific adsorption. Waters TruView pH Control LCMS Certified Vials have the lowest adsorptive losses on the market, and you can rely on them to provide consistency from batch to batch and vial to vial. This chromatogram shows a comparison of adsorptive loss of chlorhexidine in a variety of vials.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg" alt="Waters CERTIFIED Vials: Comparison of adsorptive loss of chlorhexidine acetate in a variety of vials." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg 245w," sizes="100vw" width="1024" height="633"></p><div><div><h3><strong>Ideal for demanding MS work</strong></h3><p>LCMS Certified Vials are suited for analyte concentrations in the 100s ng/mL concentration. Waters LCMS Certified Vials are tested by MS scans from 250 to 1000 <i>m/z</i> with specifications set on the total ion count and presence of clusters in the high mass range. This chromatogram shows a comparison of typical MS scans of Waters LCMS Certified Vials to vials of other sources and clean solvents.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_3_4869fbf57a.jpg" alt="Waters CERTIFIED Vials: Comparing typical MS scans of Waters LCMS Certified Vials, with vials from other sources." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_3_4869fbf57a.jpg 245w," sizes="100vw" width="1024" height="406"></p><div><div><h3><strong>Stay in control of your samples' pH</strong></h3><p>The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.&nbsp;Ghost peaks are very difficult to troubleshoot.</p><p>Waters TruView pH Control LCMS Certified vials were used to analyze two compounds, drospirenone and lovastatin. The TruView pH Control LCMS Certified Vials show little to no degradant formed over the time tested. Standard glass vials showed considerable degradant formation over the same testing time with irreproducible formation of the degradant across different vials.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_6_4dc330d849.jpg" alt="Waters CERTIFIED Vials: UV peak areas of lovastatin degradant across replicate vials and different vial types. Error bars indicate standard deviation for the replicate injection peak area." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_6_4dc330d849.jpg 245w," sizes="100vw" width="1024" height="605"></p><div><div><h3><strong>Reducing adsorption starts here</strong></h3><p>Inconsistent analytical results from small molecule analyte adsorption onto the surface of glass vials can be a problem at today’s low analyte concentrations. Some scientists have even experienced total analyte loss with samples stored in vials for an extended time. The vial chemistry, specifically the&nbsp;glass surface, is the major contributor to this problem.</p><p>Polar analytes&nbsp;may adsorb to the glass vial surface by polar-polar interaction and/or ion exchange mechanisms, thereby reducing the overall amount of sample in solution. TruView Certified LCMS Vials&nbsp;reduce this problem dramatically due to a stringent manufacturing process. The process yields a glass surface that has a lower concentration of free ions on the surface.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_8_064003b933.jpg" alt="Waters CERTIFIED Vials: Nortriptyline at 1 ppb concentration in several vials. The tall peak is the initial injection; the smaller peak (overlaid) is the four-hour injection. The first two chromatograms are competitor’s vials. The third chromatogram is for the Waters TruView LCMS Certified vial. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_8_064003b933.jpg 245w," sizes="100vw" width="1912" height="1182"></p><div><div><h3><strong>No analyte left behind</strong></h3><p>Instrument development is yielding more sensitive mass spectrometers. With more sensitive instruments, analytes can be detected at pg/mL levels. At these concentrations, understanding adsorption issues is critical for good quantitative results. We tested adsorption loss for the major manufacturers and saw high sample loss across manufacturers and clear and amber glass types – with significantly less loss with Waters TruView Autosampler Vials.</p><h4><strong>Average Analyte Loss</strong></h4><p><strong>Manufacturer: Clear Glass / Amber Glass</strong></p><ul><li><strong>Vendor A</strong>: 55% / 69%</li><li><strong>Vendor B</strong>: 25% / 25%</li><li><strong>Vendor C</strong>: 54% / 74%</li><li><strong>Vendor D</strong>: 18% / 59%</li><li><strong>Vendor E</strong>: 75% / Not tested</li><li><strong>Waters TruView LCMS Certified Vial</strong>: 1% / 6%</li></ul></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters QuanRecovery HPS Vials & Plates

 QuanRecovery Vials and Plates minimize sample losses from NSB and ionic interactions, ensuring greater confidence in results and improved assay repeatability.

<div><div id="title-b8cf3c562d" data-locator="title-with-text"><h3><strong>Reduce sample losses due to non-specific binding (NSB)</strong></h3></div></div><div><div id="text-c1d5077d21" data-locator="text"><p><strong>Successfully quantitating proteins and peptides with LC–MS is often more challenging than doing so for small molecules. Their large and complex structure requires a different approach to LC–MS method development and may also cause other unique problems like nonspecific adsorption (or nonspecific binding). Proteins and peptides in solution tend to stick to the surfaces they encounter.</strong></p><p>Autosampler-ready QuanRecovery Vials and Plates with MaxPeak High Performance Surfaces (HPS)&nbsp;are designed to enable scientists like you to meet recovery, sensitivity and reproducibility challenges in LC-MS peptide and protein quantification. By reducing sample losses from non-specific binding (NSB) and ionic interactions, QuanRecovery Vials and Plates provide your lab greater confidence in analytical results and fewer long-term assay repeatability problems.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Quan_Recovery_HPS_Vials_and_Plates_Quan_Recovery_Vials_and_Plates_with_Max_Peak_HPS_ed65a9e3fe.jpg" alt="Waters QuanRecovery HPS Vials &amp; Plates: QuanRecovery Vials &amp; Plates with MaxPeak HPS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Quan_Recovery_HPS_Vials_and_Plates_Quan_Recovery_Vials_and_Plates_with_Max_Peak_HPS_ed65a9e3fe.jpg 234w," sizes="100vw" width="1024" height="682"></p><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-b5ef0a0cdd" data-locator="text"><div><div id="text-62116091dc" data-locator="text"><h3 data-locator="modal-title"><strong>Improved LC-MS analysis of peptides and proteins</strong></h3><p>It can be difficult to predict peptide losses due to non-specific binding and ionic interactions, as losses can be dependent on many characteristics, including pI and hydrophobicity. Demonstrated here are the recovery of four different peptides.&nbsp;The recovery of desmopressin is not affected by the sample container, while glucagon, insulin, and melittin suffer varying losses due to non-specific binding and ionic interactions in the glass and standard polypropylene containers.&nbsp;</p><p>Only QuanRecovery Vials and Plates with MaxPeak HPS protect these peptides from loss, enabling you to achieve higher recovery and improved repeatability.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Quan_Recovery_vialky_a_platicka_pro_lepsi_analyzy_proteinu_a_peptidu_caa551b7f1/Waters-QuanRecovery-vialky-a-platicka-pro-lepsi-analyzy-proteinu-a-peptidu_l.webp" alt="Waters QuanRecovery HPS Vials &amp; Plates: A comparison of the recovery of four peptides prepared in a typical LC-MS diluent and stored in various sample containers." width="1074" height="466"></p></div></div></div></div></div></div></div></div></div></div><div><div id="text-455dc5902f" data-locator="text"><h3 data-locator="modal-title"><strong>Enhanced recovery and sensitivity at high and low sample concentrations</strong></h3><p>Biomolecule sample losses are a problem at low concentrations. However, non-specific binding and ionic interactions can also cause losses at higher concentrations. Such losses not only negatively impact the assay sensitivity, they also compromise the reproducibility, precision, and accuracy of the analysis. QuanRecovery Vials and Plates with MaxPeak HPS protect your sample, ensuring improved analytical results.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Quan_Recovery_HPS_Vials_and_Plates_Improved_recovery_and_sensitivity_at_high_and_low_sample_concentrations_with_Quan_Recovery_Plates_2816689528.jpg" alt="Waters QuanRecovery HPS Vials &amp; Plates: Improved recovery and sensitivity at high and low sample concentrations with QuanRecovery Plates." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Quan_Recovery_HPS_Vials_and_Plates_Improved_recovery_and_sensitivity_at_high_and_low_sample_concentrations_with_Quan_Recovery_Plates_2816689528.jpg 221w," sizes="100vw" width="1024" height="724"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-9f8f97fb02" data-locator="text"><ul><li>For large molecule LC-MS bioanalysts who need the ultimate sensitivity, reproducibility and sample stability over multiple analyses.</li><li>Improve detection limits and analysis reproducibility for peptide and protein quantification with these low adsorption plates and vials.</li><li>Designed for LC-MS analysis in autosampler ready formats with low residual volumes in 700 µL 96-well plate and 300 µL sample vial formats.</li><li>Increase analyte recovery, sensitivity and reproducibility by minimizing analyte/surface interactions that can lead to sample losses with MaxPeak High Performance Surfaces (HPS).</li><li>Suitable for workflows with ACQUITY Premier Systems and Columns.</li></ul></div></div><div><div id="text-b5ef0a0cdd" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>To minimize sample losses due to non-specific binding (NSB) and ionic interactions.</p></div></div></div></div></div></div></div></div>

Waters Oasis SPE products

Waters Oasis SPE products come in a broad range of sorbents and an array of formats. With Oasis products, you can meet a wide variety of sample preparation needs.

<h4><strong>Faster, cleaner, and simpler SPE starts here</strong></h4><p>Analytical chemists worldwide use SPE to remove interfering matrix compounds and enrich the analyte of interest to ensure the generation of high-quality data.</p><p>Waters Oasis SPE products come in a broad range of sorbents and an array of formats. With Oasis products, you can meet a wide variety of sample preparation needs, from simple and fast sample matrix clean-up to more complex sample preparation challenges.</p><p>Oasis SPE products deliver unmatched purity, consistency, and quality for sample analysis. Along with seven different SPE chemistries, Oasis SPE products use universal to customized protocols to handle your unique sample.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Oasis_SPE_kolonky_2_967d461f2e/Waters-Oasis-SPE-kolonky-2.jpg" alt="Waters: Oasis SPE" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Oasis_SPE_kolonky_2_967d461f2e/thumbnail_Waters-Oasis-SPE-kolonky-2.jpg 245w," sizes="100vw" width="950" height="416"></p><h4><strong>Overview</strong></h4><ul><li>Fully water-wettable sorbents increase reproducibility and enable elimination of condition and equilibration steps</li><li>Co-polymer pH stable from 0–14 with no secondary silanol activity</li><li>Optimal sensitivity for small molecule and therapeutic peptide analysis</li><li>Reduced matrix effects for LC-MS/MS analyses</li><li>Unsurpassed selectivity</li><li>Consistent retention and capacity, yielding the highest SPE recovery</li><li>Reduces variability in analytical results and increases robustness of analysis</li><li><strong>Recommended Use: </strong>For the fastest, cleanest, and simplest approach to SPE-LC-MS/MS method development.</li></ul><h4><strong>Solid-Phase Extraction Chemistries</strong></h4><h5><strong>Oasis PRiME HLB</strong></h5><ul><li>Multi-purpose hydrophilic-lipophilic balanced reversed phase sorbent for acids, bases, and neutrals</li><li>Cleaner samples in fewer steps with simple three-and two-step protocols, no SPE expertise required</li><li>Removes 95% of common matrix interferences, such as proteins, salts, phospholipids, and pigments</li><li>No sorbent conditioning or equilibration steps required</li><li>Faster, more predictable analysis time</li><li>Ideal for reversed-phase SPE clean-up of samples in routine analysis.</li></ul><h5><strong>Oasis PRiME MCX</strong></h5><ul><li>Mixed-mode Cation eXchange sorbent to selectively retain, concentrate and elute basic compounds</li><li>Reversed-phase and ion-exchange functionality for orthogonal sample preparation</li><li>Cleaner samples in fewer steps with simple and fast 3 and 4-step protocols</li><li>Removes 99% of phospholipids from complex sample matrices</li><li>No sorbent conditioning or equilibration steps required</li><li>Faster, more predictable analysis time</li><li>Highly reproducible target analyte recoveries</li><li>Ideal for basic compound specificity while removing matrix interferences in a simple clean-up.</li></ul><h5><strong>Oasis HLB</strong></h5><ul><li>Multi-purpose hydrophilic-lipophilic balanced reversed phase sorbent</li><li>Provides high capacity for acids, bases, and neutrals</li><li>Ideal for ultra-high capacity of very polar compounds.</li></ul><h5><strong>Oasis MCX</strong></h5><ul><li>Mixed-mode Cation eXchange sorbent for bases</li><li>Increased analyte specificity and sensitivity</li><li>Reversed-phase and ion-exchange functionality for orthogonal sample preparation</li><li>Ideal for selective retention of basic analytes.</li></ul><h5><strong>Oasis MAX</strong></h5><ul><li>Mixed-mode Anion eXchange for acids</li><li>Increased analyte specificity and sensitivity</li><li>Reversed-phase and ion-exchange functionality for orthogonal sample preparation</li><li>Ideal for selective retention of acidic analytes.</li></ul><h5><strong>Oasis WAX</strong></h5><ul><li>Weak Anion eXchange mixed-mode sorbent for strong acidic compounds</li><li>Increased analyte specificity and sensitivity</li><li>Reversed-phase and ion-exchange functionality for orthogonal sample preparation</li><li>Ideal for improved retention of strong acidic compounds.</li></ul><h5><strong>Oasis WCX</strong></h5><ul><li>Weak Cation eXchange mixed-mode sorbent for strong basic compounds</li><li>Increased analyte specificity and sensitivity</li><li>Reversed-phase and ion-exchange functionality for orthogonal sample preparation</li><li>Ideal for improved retention of all basic analytes, especially strong bases.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Sorbenty_Oasis_SPE_na_bazi_kopolymeru_Oasis_HLB_c8ffee39b3/Waters-Sorbenty-Oasis-SPE-na-bazi-kopolymeru-Oasis-HLB.png" alt="Waters: Oasis Sorbents" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Sorbenty_Oasis_SPE_na_bazi_kopolymeru_Oasis_HLB_c8ffee39b3/thumbnail_Waters-Sorbenty-Oasis-SPE-na-bazi-kopolymeru-Oasis-HLB.png 211w," sizes="100vw" width="1511" height="1119"></p><h4><strong>Oasis Formats</strong></h4><h5><strong>Oasis μElution Plate</strong></h5><ul><li>Patented μElution plate design</li><li>No evaporation and reconstitution necessary due to elution volumes as low as 25 µL</li><li>Ideal for SPE clean-up and analyte enrichment of small sample volumes</li><li>Compatible with most liquid-handling robotic systems for automated, reliable high-throughput SPE (HT-SPE)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_m_Elution_Plate_aa7e36a4c1.jpg" alt="Waters: Oasis µElution Plate" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_m_Elution_Plate_aa7e36a4c1.jpg 245w," sizes="100vw" width="502" height="260"></p><h5><strong>Oasis 96-Well Sample Extraction Plates</strong></h5><ul><li>Innovative, award-winning two-stage well design</li><li>High throughput and high recovery</li><li>Compatible with most liquid-handling robotic systems for automated, reliable high-throughput SPE (HT-SPE)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_96_Well_Sample_Extraction_Plates_9528d532b9.jpg" alt="Waters: Oasis 96-Well Sample Extraction Plates" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_96_Well_Sample_Extraction_Plates_9528d532b9.jpg 245w," sizes="100vw" width="525" height="329"></p><h5><strong>Oasis Syringe-Barrel Cartridges</strong></h5><ul><li>Ultra-clean syringe barrel and frits</li><li>Available in cartridges ranging from 1 cc to 60 cc</li><li>Flangeless syringe-barrel cartridges available in 1 cc, 3 cc, and 6 cc sizes</li><li>Plus-style cartridges with Luer inlet hub and outlet tip, compatible with hand-held syringes</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_Syringe_Barrel_Cartridges_961aa06b8a.jpg" alt="Waters Corporation: Oasis Syringe-Barrel Cartridges" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_Syringe_Barrel_Cartridges_961aa06b8a.jpg 245w," sizes="100vw" width="503" height="311"></p><h5><strong>Oasis Glass Cartridges</strong></h5><ul><li>Ultra-clean glass syringe with Teflon® frit</li><li>For trace level detection and analysis at part-per-trillion (PPT) levels</li><li>Available in 5 cc (200 mg) configuration</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_Glass_Cartridges_5e96319c7f.jpg" alt="Waters: Oasis Glass Cartridges" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_Glass_Cartridges_5e96319c7f.jpg 188w," sizes="100vw" width="409" height="339"></p><h5><strong>Oasis On-Line Columns and Cartridges</strong></h5><ul><li>For rugged, reproducible, and ultra-fast on-line analysis</li><li>Wide choice of configurations, particle sizes, and sorbent chemistries</li><li>Available with all six patented Oasis sorbents—PRiME HLB, HLB, MCX, MAX, WCX, and WAX</li><li>High recovery and reproducible results for a wide range of compounds</li><li>Cartridge format for use with Spark Holland Prospekt-2™/Symbiosis™ systems also available</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_On_Line_Columns_and_Cartridges_ba02114c92.jpg" alt="Waters: Oasis On-Line Columns and Cartridges" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_On_Line_Columns_and_Cartridges_ba02114c92.jpg 168w," sizes="100vw" width="415" height="386"></p><h4><strong>Sample preparation, improved</strong></h4><p>Improving various aspects of chromatography and mass spectrometry analyses often starts with sample preparation. &nbsp;Solid-phase extraction (SPE) or "liquid-solid phase extraction" is a sample preparation technology that uses particles of chromatographic packing material, usually in a cartridge or 96-well plate format, to chemically separate different analytes and aid in removing matrix components in a sample. &nbsp;</p><p>SPE is a proven sample preparation tool for simple sample matrix removal, including common interferences like proteins, salts, fats and phospholipids. This matrix removal provides many benefits, including matrix effect reduction and an increase in sample concentration and analyte specificity. Matrix removal also significantly simplifies chromatographic complexity by reducing the number of interfering peaks in the LC and reducing signal suppression by providing clean samples for the MS.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_SPE_LC_MS_MS_chromatogram_of_1_pgm_L_of_alprazolam_from_rat_plasma_8b7275b25b.jpg" alt="Waters: Oasis SPE - LC-MS-MS chromatogram of 1 pgmL of alprazolam from rat plasma" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_SPE_LC_MS_MS_chromatogram_of_1_pgm_L_of_alprazolam_from_rat_plasma_8b7275b25b.jpg 169w," sizes="100vw" width="1024" height="946"></p><h4><strong>Get the cleanest extracts with the Oasis 2x4 method</strong></h4><p>Having a variety of tools for method development allows separation scientists to optimize protocols for maximum sensitivity and selectivity. The Oasis 2x4 method for SPE sorbent and protocol selection for acids, bases, and neutrals produces the cleanest extracts – all by eliminating matrix interferences and sample variability. Get the flexibility to extract acids, bases, and neutrals with high SPE recoveries while removing matrix components that may interfere with analysis with our two protocols and four sorbents. By following the simple steps outlined in the Oasis 2x4 method, you can achieve high recoveries and the cleanest extracts.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Oasis_2x4_protokol_pro_vyvoj_metody_c417be9006/Waters-Oasis-2x4-protokol-pro-vyvoj-metody.jpg" alt="Waters: Oasis SPE - Oasis 2 x 4 method development protocol." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Oasis_2x4_protokol_pro_vyvoj_metody_c417be9006/thumbnail_Waters-Oasis-2x4-protokol-pro-vyvoj-metody.jpg 242w," sizes="100vw" width="1519" height="979"></p><h4><strong>Isolate your compounds with the Oasis HLB method</strong></h4><p>Solid-phase extraction (SPE) method development starts with knowledge of the sample matrix—the nature and relative concentration of the analytes of interest and potentially interfering endogenous compounds. The right sorbent and solvents are selected for load, wash, and elute steps, resulting in the creation of rugged, reliable, and selective protocols. The Oasis HLB method is a generic protocol used to isolate a broad range of acidic, basic, and neutral compounds from a wide spectrum of matrices.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Oasis_SPE_Generic_Method_Protocol_with_Oasis_HLB_SPE_83d684704d.jpg" alt="Waters: Oasis SPE - Generic Method Protocol with Oasis HLB SPE" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Oasis_SPE_Generic_Method_Protocol_with_Oasis_HLB_SPE_83d684704d.jpg 139w," sizes="100vw" width="1024" height="1153"></p><h4><strong>Multiple contaminant analysis with the 2-step pass-through protocol</strong></h4><p>If you are doing multiple residue screening of veterinary drugs, pesticides and mycotoxins in various food matrices, you may be facing a high concentration of organic solvents. With our simple 2-step protocol (pass-through SPE), you can remove matrix interferences quickly if your samples contain a high concentration of organic solvent(s) and concentration and/or salt removal is not required. It can be used as the clean-up method following QuEChERS extraction, saving you significant time compared to the traditional dispersive SPE method - all while achieving superior clean-up.</p><p><strong>To do pass-through SPE, Waters offers 2 convenient and flexible formats:</strong></p><ul><li><strong>Traditional-style cartridges</strong> compatible with vacuum and positive pressure manifolds&nbsp;</li><li><strong>"Plus" style cartridges</strong> that can be used without manifolds when connected to a displacement syringe</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Oasis_SPE_kolonky_3_b4da6242de/Waters-Oasis-SPE-kolonky-3.jpg" alt="Waters: Oasis Plus Light and Plus Short Cartridges for 2-step pass through protocol." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Oasis_SPE_kolonky_3_b4da6242de/thumbnail_Waters-Oasis-SPE-kolonky-3.jpg 152w," sizes="100vw" width="1308" height="1342"></p>

Products from category Consumables - page 1

Related content

News from LabRulezICPMS Library - Week 43, 2026

News from LabRulezLCMS Library - Week 43, 2026

News from LabRulezGCMS Library - Week 43, 2026