<p><strong>Helium prices have roughly doubled since the Iran conflict began in early 2026, with global supply from Qatar — responsible for approximately one-third of world production — severely disrupted. For laboratories running gas chromatography and other helium-dependent instruments, the financial and operational impact is impossible to ignore.</strong></p><h3><strong>Part 1: The Helium Price Crisis — What Happened and Why It Matters to Your Lab</strong></h3><h4><strong>A Perfect Storm in the Helium Market</strong></h4><p>Helium has never been a cheap commodity, but what laboratories are facing in 2026 represents a genuine inflection point. The combination of escalating Middle East conflict, Strait of Hormuz shipping disruptions, and structural supply constraints has created the most severe helium pricing environment in recent memory — one that shows no sign of rapid reversal.</p><p>To understand why laboratory budgets are under pressure, it helps to understand where helium actually comes from. Unlike most industrial gases, helium cannot be manufactured. It is a byproduct of radioactive decay deep within the Earth's crust, and it must be captured from <a target="_blank" rel="noopener noreferrer" href="https://businessanalytiq.com/procurementanalytics/index/helium-price-index/"><strong>natural gas deposits </strong></a>before it escapes into the atmosphere. The practical result is that the entire world's commercial helium supply flows from a small number of producing regions — most critically, the United States and Qatar.</p><h4><strong>Qatar: The World's Helium Chokepoint</strong></h4><p>Qatar is responsible for approximately <a target="_blank" rel="noopener noreferrer" href="https://www.expertmarketresearch.com/price-forecast/helium-price-trends"><strong>one-third of global helium production</strong></a>, channeled through QatarEnergy LNG's massive purification facility at Ras Laffan Industrial City, which draws from the North Field — the world's largest non-associated natural gas reservoir. When this facility operates normally, it is the single largest stabilizing force in the global helium market. When it is disrupted, the entire world feels it.</p><p>In early 2026, it stopped operating normally. Iranian missile strikes damaged key industrial infrastructure in Qatar, and the resulting disruption to Ras Laffan created an immediate supply shock. Compounding the damage, the Strait of Hormuz — the critical shipping corridor through which Qatari LNG and helium exports must pass — became subject to elevated war-risk premiums and logistical disruptions that pushed shipping costs sharply higher.</p><h4><strong>Beyond Price: The Supply Reliability Problem</strong></h4><p>For laboratory managers, the helium crisis is not merely a budget problem — it is an operational continuity problem. A laboratory that cannot obtain helium cannot run its gas chromatography (GC) instruments, cannot perform MRI maintenance or calibration, and cannot complete analytical work that clients and researchers depend upon.</p><p>Supply allocation tightening, spot market shortages, and delays at ports serving Middle Eastern shipping lanes have created a new reality: even laboratories with long-term supply contracts have experienced <a target="_blank" rel="noopener noreferrer" href="https://www.procurementresource.com/resource-center/helium-price-trends"><strong>delivery disruptions</strong></a>. The gas that was once ordered and reliably delivered within a predictable lead time now arrives subject to geopolitical delays entirely outside the laboratory's control.</p><p>This represents a fundamental shift in risk exposure for laboratory operations. Helium's value to a laboratory was always its combination of technical performance and reliable availability. The second pillar of that value proposition has been significantly eroded.</p><h4><strong>Who Is Most Affected in the Laboratory Setting?</strong></h4><p>While the helium price surge affects any organization that uses the gas, laboratories face a particularly acute version of the problem for several reasons:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products?category=98&amp;manufacturerItems=540"><strong>GC carrier gas</strong></a><strong> consumption: </strong>Gas chromatography is one of the largest industrial uses of high-purity helium. Analytical laboratories running continuous GC workflows — environmental testing, pharmaceutical QC, food safety, petrochemical analysis — consume helium at a high, predictable rate. When the price of that gas doubles, it represents a direct and substantial increase in the variable cost of every single analytical run.</li><li><strong>No short-term substitution:</strong> Unlike some industrial uses where helium can be temporarily swapped for another gas, GC methods are validated for specific carrier gases. Switching requires revalidation — a time-consuming, resource-intensive process that cannot be completed in response to an acute supply disruption.</li><li><strong>Contractual and regulatory obligations: </strong>Laboratories operating under accreditation, client contracts, or regulatory frameworks face potential non-compliance consequences if supply disruptions prevent them from completing required analyses. The cost of a helium shortage extends far beyond the gas itself.</li></ul><h3><strong>Part 2: The Strategic Case for Switching to Hydrogen — and Installing a Generator</strong></h3><h4><strong>Hydrogen as a Carrier Gas: The Science Is Already Settled</strong></h4><p>The argument for<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/hydrogen-generators-for-chromatography"><strong>hydrogen as a GC carrier gas</strong></a><strong> </strong>is not new, and it is not driven solely by economics. For many applications, hydrogen is technically superior to helium. Its higher diffusivity in the column results in faster analyte movement, enabling shorter run times and higher throughput without loss of resolution. The van Deemter curve for hydrogen is flatter over a wider range of flow rates, giving analysts more operating flexibility.</p><p>The US EPA, the European pharmacopoeias, and numerous international standards bodies have long recognized hydrogen as an acceptable — and in some cases preferred — carrier gas for GC methods. Chromatography column and instrument manufacturers including Agilent, Shimadzu, PerkinElmer, and Thermo Fisher have published detailed application notes and validated methods for hydrogen carrier gas, often demonstrating equivalent or improved performance relative to helium.</p><p><strong>In short:</strong> <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/transitioning-from-helium-to-hydrogen-what-you-need-to-know"><strong>switching from helium to hydrogen</strong></a><strong> </strong>for GC is not an experimental or unproven step. It is a well-established, widely validated practice that thousands of laboratories around the world have already completed. The <a target="_blank" rel="noopener noreferrer" href="https://www.cruxinvestor.com/posts/helium-prices-surge-400-to-record-highs-as-global-supply-shortage-persist-in-the-rise-of-ai"><strong>current pricing environment</strong></a><strong> </strong>simply makes the decision more urgent — and the financial case more compelling — than it has ever been before.</p><h4><strong>Why Cylinders Are Not the Answer</strong></h4><p>It might be tempting to view the hydrogen transition simply as swapping one gas cylinder supplier for another. This approach misunderstands both the nature of the problem and the opportunity. Hydrogen delivered in cylinders carries its own logistical challenges: cylinder handling and storage requirements, regular delivery schedules, the same kind of supply chain dependencies that have proven so costly with helium, and — critically — safety considerations around the storage of high-pressure hydrogen in laboratory spaces.</p><p>The correct solution, adopted by the most forward-thinking laboratory managers, is to install an on-site hydrogen generator. This single decision transforms the laboratory's gas supply from a variable, externally-dependent cost into a stable, internally-controlled utility — analogous to the difference between buying bottled water and installing a purified water system.</p><h4><strong>The Hydrogen Generator Advantage: Six Reasons to Make the Switch</strong></h4><h5><strong>1. Complete Supply Independence</strong></h5><p>A hydrogen generator produces gas on demand from deionized water using electrolysis. There is no supply chain to be disrupted by conflict in the Middle East. There is no shipping container to be delayed at a port. There is no cylinder to run out mid-run. The laboratory's hydrogen supply is as reliable as its electricity supply — and in most facilities, that is extremely reliable.</p><p>For laboratory managers who have spent the past year managing helium allocation anxiety, explaining supply disruptions to clients, and rescheduling analytical work around delivery delays, this represents a profound operational upgrade.</p><h5><strong>2. Long-Term Cost Predictability and Savings</strong></h5><p>Hydrogen generators produce gas at a cost primarily determined by electricity consumption. Electricity prices, while subject to some variation, are dramatically more stable than helium spot markets and are not subject to geopolitical disruptions of the kind that have driven helium prices to double in a matter of months.</p><p>The total cost of ownership analysis for hydrogen generation versus helium cylinder purchase — factoring in current helium pricing, cylinder rental fees, delivery charges, and handling costs — now firmly favors hydrogen generation for any laboratory running one or more GC instruments full-time. With helium prices having doubled since the onset of the Iran conflict, the payback period for a generator investment has shortened significantly.</p><h5><strong>3. Superior Gas Purity and Consistency</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products?category=98&amp;manufacturerItems=540"><strong>Modern hydrogen generators </strong></a>produce gas at <strong>purities of 99.9999% or higher </strong>— exceeding the purity specifications required for the most demanding analytical GC applications. Critically, this purity is consistent from the first milliliter of gas produced to the last. There is no batch-to-batch variation, no risk of receiving a cylinder with a contamination issue, and no requirement to test incoming gas quality.</p><p>For laboratories operating under strict quality systems — ISO 17025, GMP, EPA method compliance — the shift to a generator can actually improve data quality and simplify the supplier qualification burden associated with managing a rotating roster of gas cylinder suppliers.</p><h5><strong>4. Improved Laboratory Safety Profile</strong></h5><p>Hydrogen requires appropriate safety management — adequate ventilation, hydrogen-compatible fittings, and basic leak detection protocols. These requirements are straightforward and well-understood, and are entirely manageable in a standard analytical laboratory environment. Modern hydrogen generators include integrated safety systems including automatic shutdown on leak detection, pressure limiting, and fail-safe electronics.</p><p>What is often overlooked is that a hydrogen generator improves overall laboratory safety relative to the cylinder-based alternative by eliminating the need to store and handle high-pressure compressed gas cylinders. The generator contains only a small volume of hydrogen at any given time — far less than a standard gas cylinder — and delivers it directly to the instrument through short, fixed lines.</p><h5><strong>5. Environmental and Sustainability Benefits</strong></h5><p>Helium extraction is an energy-intensive industrial process. The gas must be separated from natural gas streams, compressed, liquefied, and transported globally — often by sea freight from <a target="_blank" rel="noopener noreferrer" href="https://businessanalytiq.com/procurementanalytics/index/helium-price-index/"><strong>Qatar or the United States</strong></a>. Each step in that chain carries an environmental cost.</p><p>Hydrogen generation from water electrolysis has a fundamentally different environmental profile, particularly for laboratories that operate in facilities with access to renewable electricity. As laboratory sustainability programs become an increasing priority — driven by institutional ESG commitments, client expectations, and regulatory trends — the ability to point to an on-site, low-carbon gas supply is a meaningful differentiator.</p><h5><strong>6. Future-Proofing Against Ongoing Helium Market Instability</strong></h5><p>The current price spike is not an anomaly that will self-correct quickly. The structural conditions driving helium price increases — concentrated supply in geopolitically exposed regions, growing demand from semiconductor manufacturing and MRI imaging, the irreversibility of atmospheric helium loss once released — are not going away. New supply projects in South Africa, Canada, and elsewhere will add capacity over the medium term,but forecasters broadly expect helium pricing to remain elevated relative to historical norms.</p><p>A laboratory that installs a hydrogen generator today is not just solving the 2026 problem. It is making a strategic decision that positions the organization to be independent of whatever the next helium supply shock looks like.</p><p><strong>At a Glance: Helium Cylinder vs. On-Site Hydrogen Generation</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_The_Helium_Crisis_Is_Here_Why_Laboratories_Should_Switch_to_Hydrogen_Now_2_77969fd7aa.jpg" alt="Organomation: The Helium Crisis Is Here: Why Laboratories Should Switch to Hydrogen Now" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_The_Helium_Crisis_Is_Here_Why_Laboratories_Should_Switch_to_Hydrogen_Now_2_77969fd7aa.jpg 209w," sizes="100vw" width="1007" height="750"></p><h4><strong>How Organomation Supports Your Transition to Hydrogen</strong></h4><p>At Organomation, we have been supporting analytical laboratories with precision gas handling and concentration equipment for over six decades. We understand that the decision to transition carrier gases is not made lightly — it involves instrument requalification, method validation, staff training, and procurement changes that require planning and support.</p><p>Our team, in combination with <a target="_blank" rel="noopener noreferrer" href="https://claind.it/"><strong>Claind srl</strong></a>, can assist laboratories at every stage of the hydrogen transition: from initial feasibility assessment and instrument compatibility review, through gas flow optimization and generator sizing, to ongoing technical support after installation. We work with the leading hydrogen generator manufacturers and can help you specify the right system for your instrument fleet and throughput requirements.</p><p>The current helium pricing environment has created a narrow window in which laboratories that act decisively will establish a structural cost and reliability advantage over those that continue to absorb rising helium costs. We invite you to start that conversation with us today.</p><p>Contact the Organomation team to schedule a complimentary laboratory gas assessment and begin your transition to on-site hydrogen generation. Visit organomation.com or call us to speak with an applications specialist.</p><h4><strong>The Moment to Act Is Now</strong></h4><p>The helium crisis of 2026 is not a temporary inconvenience — it is a structural realignment of the global gas supply market, accelerated by a geopolitical conflict whose resolution timeline remains uncertain. Laboratories that approach this as a passing disruption to be absorbed through budget adjustments are likely to find themselves absorbing those costs indefinitely.</p><p>The case for switching to hydrogen carrier gas and installing an on-site hydrogen generator has never been more compelling. The technology is proven, the performance is validated, the safety is manageable, and the economics — already favorable before the current price surge — are now overwhelmingly advantageous.</p><p>The laboratories that will emerge from this crisis in the strongest position are those that use it as the catalyst to make a change they should have made years ago. The question is no longer whether to make the switch — it is how quickly you can do it.</p>

The Helium Crisis Is Here: Why Laboratories Should Switch to Hydrogen Now

<p><strong>A new study published in Nucleic Acids Research identifies short “start–stop” elements as highly effective regulators of protein synthesis in human cells. The study was co-led by Leoš Shivaya Valášek from IMIC CAS.</strong></p><section><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg" alt="MBU: Unassuming Start–Stop “Gates” Regulate Protein Production in Cells" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg 245w," sizes="100vw" width="720" height="390"></p><section><div><p>An international team of scientists has described a&nbsp;previously overlooked mechanism that regulates the levels of important proteins in human cells. A new study published in <strong>Nucleic Acids Research </strong>reveals that short regulatory “start–stop“ elements act as highly effective speed-limiting gates of protein synthesis. Compared with previously known regulatory sequences, these elements were found to suppress protein production even more efficiently. At the same time, they help maintain low but stable levels of important proteins in cells, even under stress conditions. The study brought together scientists from the <strong>United States, the Czech Republic, Canada, and Sweden</strong>. <strong>Leoš Shivaya Valášek</strong>, Head of the <strong>Laboratory of Regulation of Gene Expression </strong>at the <strong>Institute of Microbiology of the Czech Academy of Sciences (IMIC CAS)</strong> was a&nbsp;co-author and one of the corresponding authors of the study.</p></div></section><section><div><p>During protein production, ribosomes read and translate information encoded in messenger RNA (mRNA) into amino acids, which are then assembled into a&nbsp;new protein. The researchers focused on an unusual sequence in which a&nbsp;start signal is immediately followed by a&nbsp;stop signal. As a&nbsp;result, the ribosome receives instructions to begin and terminate translation almost simultaneously. Although such an arrangement may appear illogical, it proved to be an important regulatory tool.</p><p><strong>Start–stop motifs </strong>are found in more than <strong>1,400 human genes</strong> and are particularly common in genes that control cellular signaling pathways, the stress response, or the activity of transcription factors—that is, proteins that regulate the activity of other genes. These genes must be tightly controlled because even small changes in the amount of their protein products can have significant biological consequences.</p><h4><strong>Resilience Under Stress</strong></h4><p>The researchers tested the activity of this regulatory mechanism under stress conditions, including in the ATF4 gene, which plays a&nbsp;key role in the so-called integrated stress response. Cellular stress is typically associated with a&nbsp;global reduction in protein synthesis. The authors demonstrated that regulation mediated by start-stop elements is largely independent of the overall state of translation initiation and therefore remains effective even under cellular stress.</p><h4><strong>A Stronger Brake Than Known Regulatory Elements</strong></h4><p>The team compared start–stop sequences with similar regulatory regions known as uTranslons. Although both types of elements suppress protein synthesis, the start–stop sequences proved to be significantly more effective. Ribosomes remain associated with these motives for longer before proceeding to the main coding region of the gene.</p><p><i>“Start-stop sequences are specialized regulatory elements that ensure increased ribosome retention, thereby allowing for fine-tuning translation,” </i>says Leoš Valášek from IMIC CAS.</p><p>The study expands our understanding of how cells fine-tune protein synthesis and may ultimately contribute to research on &nbsp;certain cancer and neurodegenerative disorders, and other diseases linked to disrupted protein production.</p></div></section><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/13/gkag627/8725953?login=false"><strong>Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons</strong></a></h4><p>Justin Rendleman, Solomon A Haizel, Shaohuan Wu, Laurelle Lee Young, Junjie Liu, Xinyi Ge, Huijing Zou, Mahabub Pasha Mohammad, Matthew Pressler, Shuvadeep Maity, Vladislava Hronová, Zhaofeng Gao, Anna Hermannová, Anna Smirnova, Amy Lei, Kristina Allgoewer, Daniel Sultanov, Will Edward Hinckley, Ziyue Cheng, Lauren Shelby, Tanubrata Dey, Krzysztof J Szkop, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou, Leoš Shivaya Valášek, Christine Vogel</p><p><i><strong>Nucleic Acids Research</strong> </i>(2026), Volume 54, Issue 13&nbsp;</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1093/nar/gkag627">https://doi.org/10.1093/nar/gkag627</a></p><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Start–stop elements are translation regulatory elements in 5′ untranslated regions (UTR) of eukaryotic transcripts, consisting of a start codon immediately followed by a stop codon. In contrast to canonical upstream Translons (uTranslons), they exclude elongation which creates unique properties. We conducted a comprehensive, carefully controlled comparison of human start–stop elements and uTranslons both at a genome-wide level and with targeted reporter assays. We found that start–stops and uTranslons were similar with respect to their presence in the 5′ UTRs of hundreds of genes, in particular transcription factors and signaling molecules, the low transcript levels of the corresponding genes, short RNA half-lives, and the negative effect on downstream translation. However, start–stop containing genes were translationally even more repressed than genes with uTranslons. Analysing the start–stop architecture and diverse ribosome footprinting datasets, we found evidence for a start–stop-specific mechanism that involves repeat cycling between initiation, termination, ribosome splitting, and 60S rejoining—a process possibly modulated by ASCC3 and eIF1. This cycling explained increased ribosome retention at start–stops and was—in contrast to ribosome retention at uTranslons—independent of the global initiation state. Finally, we showed that the start–stop element in human <i>ATF4</i> augments the core regulatory model by controlling translation of the uTranslons.</p></div></section>

Unassuming Start–Stop “Gates” Regulate Protein Production in Cells

Why Biologics QC Is So Much Harder Than Small Molecule Pharma

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Watrex Streamline GPC system

GPC system is an isocratic HPLC system consisting of one P1 pump, CT1i column thermostat with manual injector and RI1 refractive index detector.

<p><strong>GPC system is an isocratic HPLC system consisting of one P1 pump, CT1i column thermostat with manual injector and RI1 refractive index detector.</strong></p><h3><strong>FEATURES</strong></h3><ul><li>Optimized pump mechanics of P1 pump with parallel piston design offers excellent flow rate accuracy and low RI signal pulsation.</li><li>The thermal isolated optic with a counter-current heat exchanger and programmable temperature control, results in an extremly stable baseline and an optimal Signal/Noise ratio od RI1.</li><li>The system can be upgraded with autosampler and fraction collector, or VD 400 Viscometer Detector.</li><li>Data acquisition, processing and instrument control is done by Clarity Chromatography Station with GPC option or Agilent TriSEC software.</li></ul><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=streamline+p1+pump&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>P1 HPLC pump: Flow Rates</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/detectors/other-hplc-detectors/streamline-ri1-detector/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>RI1 refractive index detector</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/column-thermostats/streamline-ct1-columm-thermostat/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>CT1 Column thermostat</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity™ Chromatography Station</strong></a></li></ul><h5><strong>COMPONENT SPECIFICATION - P1 HPLC pump: Flow Rates</strong></h5><ul><li><strong>Flow Rates:</strong> 0.001 to 10.000 mL/min</li><li><strong>Pressure:</strong> 0 to 6,000 psi (42 MPa)</li><li><strong>Flow precision:</strong> &gt; 0.2% RSD</li><li><strong>Flow accuracy:</strong> ± 1 % @ 1mL/min and 7 MPa,</li><li><strong>Pressure accuracy:</strong> ± 2% of full-scale, with 80:20 H2O/IPA @ 7 MPa</li><li><strong>Pulsation:</strong> ± 0.5 % @ 1mL/min and 7 MPa</li><li><strong>Remote inputs:</strong> USB</li></ul><h5><strong>COMPONENT SPECIFICATION - RI1 refractive index detector</strong></h5><ul><li><strong>Light Source:</strong> Long-life LED</li><li><strong>Refractive index Range:</strong> 1.00 - 1.75 RIU</li><li><strong>Baseline Noise:</strong> ± 2.5 nRIU</li><li><strong>Baseline Drift:</strong> 200 nRIU/h</li><li><strong>Linearity:</strong> &gt; 1000 μRIU</li><li><strong>Flow cell pressure resistance:</strong> 5 bar</li><li><strong>Flow cell volume:</strong> 15 μl</li><li><strong>Time constant:</strong> 0.00/0.01/0.02/0.05/0.1/0.2/0.5/1.0/2.0/5.0/10.0 s</li><li><strong>Analog Output:</strong> 1x 0-2.5V</li><li><strong>Outputs:</strong> Event 1, Start (OUT), Error (OUT), + 5 V, 24 V Valve</li></ul><h5><strong>COMPONENT SPECIFICATIONS - CT1 Column thermostat</strong></h5><ul><li><strong>Temperature range:</strong> 10 °C above ambient temperature to 100 °C</li><li><strong>Temperature accuracy:</strong> max. 0,5 % of actual temperature</li><li><strong>Temperature stability:</strong> RSD &lt; 0,4 %</li><li><strong>Settability:</strong> 0,1 °C</li><li><strong>Internal dimensions:</strong> 320 x 50 x 30 mm (L x W x H)</li><li><strong>Compartment material:</strong> PTFE coated metal</li><li><strong>Compartment connection:</strong> USB</li><li><strong>Control:</strong> build-in color touch panel, datasystem</li></ul><h5><strong>COMPONENT SPECIFICATIONS - </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity™ Chromatography Station:</strong></a></h5><p>Advanced chromatographic datastation for data acquisition and evaluation supported with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1004"><strong>GPC module for MWD, Mw, Mn, Mz calculation</strong></a>. Enables rutine separations with pre-set methods, containing all experimental and conditions and data evaluation settings. PC Win 10 Professional with LCD monitor included.</p><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SGPC01-001</strong> Streamline™ manual GPC system with Refractive index detector (Includes P1 pump, RI1 detector, CT1i column thermostat with manual injector, solvent rack, Clarity PC station)</li></ul><p><strong>Optional configurations:</strong></p><ul><li><strong>ST99-002</strong> Remove CT1i column thermostat with manual injector from system</li><li><strong>SAS90-001</strong> Add AS1 Autosampler to system</li><li><strong>SFC90-001</strong> Add FC1 Fraction collector to system</li></ul>

KNAUER AZURA GPC/SEC Systems

AZURA® SEC is KNAUER's line of GPC and SEC systems that offer solutions for different applications and labs. These systems can analyze, separate and fractionate sample components based on size and molecular weight. 

<p><strong>AZURA<sup>®</sup> SEC is KNAUER's line of GPC and SEC systems</strong> that offer solutions for different applications and labs. These systems can analyze, separate and fractionate sample components based on size and molecular weight, making them useful for industries such as polymer, food, biochemistry, and pharmaceuticals, as well as research.</p><p>The systems come in different variants, each tailored to specific lab needs, such as the <strong>AZURA SEC</strong> Compact for budget-friendly solutions or the &nbsp;Lab for highest analytical performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_SEC_Systems_Application_areas_caaeb1284f.jpg" alt="KNAUER: AZURA GPC/SEC Systems - Application areas" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_SEC_Systems_Application_areas_caaeb1284f.jpg 156w," sizes="100vw" width="1204" height="1204"></p><h3><strong>GPC/SEC&nbsp; – Principles and parameters</strong></h3><h4><strong>Principle of GPC/SEC</strong></h4><h5><strong>How does GPC/SEC work?</strong></h5><p>Gel Permeation Chromatography (<strong>GPC</strong>) and&nbsp;Size Exclusion Chromatography (<strong>SEC</strong>) separate&nbsp;analytes by size using special columns with a porous matrix. The basic separation principle relies on the fact that smaller molecules will be more likely to enter those pores, making their travel time through the matrix longer than that of larger molecules. Separations (typically of a mixture of polymers, polysaccharides or biomolecules) are facilitated by choosing optimal particle and pore sizes, as well as column length. GPC/SEC is often used in quality control and R&amp;D.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_SEC_System_principle_gpc_00e63025c7.jpg" alt="KNAUER: AZURA GPC/SEC Systems - principle of GPC" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_SEC_System_principle_gpc_00e63025c7.jpg 245w," sizes="100vw" width="648" height="232"></p><h4><strong>GPC, SEC or GFC</strong></h4><h5><strong>Terminology in GPC/SEC</strong></h5><p>Gel Permeation Chromatography (GPC), Size Exclusion Chromatography (SEC) and Gel Filtration Chromatography (GFC) &nbsp;all essentially describe the same methodology, but the term GPC tends to be used in polymer chemistry by those working with aggressive, organic solvents, while SEC and GFC are more commonly used by those separating biomolecules using aqueous solvents (buffers) or to reflect the use of aqueous buffers in polymer separations. Systems with organic solvents or aqueous-based solvents present some inherent challenges.</p><p>The solvents used in polymer analysis are chosen for their ability to dissolve polymeric substances – and therefore may damage certain components of a device. And the use of salt buffers in SEC is harmful to metal components of the system. Hence, all liquid-contacting system components, from the valves and seals to tubing, must be carefully considered when developing such systems.</p><h4><strong>What does GPC require?</strong></h4><h5><strong>What do I need for GPC?</strong></h5><p>GPC columns are typically long and runs are performed at&nbsp;low flow rates of up to 1 ml/min and at low (&lt;100 bar) pressures. For the precise molecular weight determination, which is the goal of most GPC/SEC users, a good isocratic pump is essential for a steady baseline. Also a degasser suitable for a wide range of partly highly aggressive solvents is very important to ensure reproducible results. Additionally, temperature is crucial for many GPC applications so a thermostat to control the column temperature is essential.</p><p>Due to the often very aggressive media used in polymer analysis, all wetted parts need to be compatible with the used solvent. Depending on the polymer it is important to keep this in mind when configuring a GPC system.</p><h4><strong>What is GPC Cleanup?</strong></h4><p>GPC Cleanup is a sample preparation method based on gel permeation chromatography (GPC). It is primarily employed for performing general cleanup tasks on a wide range of sample matrices such as foodstuffs, tissues, plants, and environmental samples. High-weight molecular substances, such as lipids, proteins, natural resins, cellular components, and steroids, interfering with subsequent analysis e.g. of pesticides are efficiently removed.</p><h3><strong>Components for GPC/SEC systems</strong></h3><h5><span lang="EN-GB"><strong>Columns</strong></span></h5><p><span lang="EN-GB">Columns GPC/SEC separation efficiency is driven by long columns with large diameters, and the matrix is often based on porous silica or polymer material – the pore size determines the molecular weight range of the separation, and columns with different pore sizes are determines the molecular&nbsp; weight range of the separation, and columns with different pore sizes are combined to broaden separation and increase resolution.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_SEC_System_Column_af59e0a074.jpg" alt="KNAUER: AZURA GPC/SEC Systems- Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_SEC_System_Column_af59e0a074.jpg 245w," sizes="100vw" width="1280" height="699"></p><h5><span lang="EN-GB"><strong>Software</strong></span></h5><p><span lang="EN-GB">The main goals are the determination of molar mass averages and the distribution of molar masses, which is performer through calibration using general standards with molar masses in a given range. Many chromatography data systems (CDS) are incapable of processing this data. With the GPC/SEC extension to our well-known ClarityChrom CDS software we offer our customers the possibility to continue working with a familiar software.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Clarity_Chrom_Workstation_7ed6c2cb72.jpg" alt="Knauer: ClarityChrom Workstation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Clarity_Chrom_Workstation_7ed6c2cb72.jpg 245w," sizes="100vw" width="839" height="495"></p><h5><span lang="EN-GB"><strong>Extensions</strong></span></h5><p><span lang="EN-GB">AZURA also affords customers the flexibility to extend their GPC/ SEC systems with autosamplers, valves, feed pumps, and column thermostats. In fact, many GPC runs are conducted at higher temperatures (&lt;60°C), so the AZURA column thermostat is of great interest.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_Educational_HPLC_System_Column_selection_and_thermostat_567c35ab61.jpg" alt="KNAUER: AZURA GPC/SEC Systems - column thermostats" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_Educational_HPLC_System_Column_selection_and_thermostat_567c35ab61.jpg 245w," sizes="100vw" width="1700" height="881"></p><h5><span lang="EN-GB"><strong>Pumps</strong></span></h5><p><span lang="EN-GB">GPC/SEC analyses necessitate lower flow rates and lower pressure than HPLC. GPC/SEC runs are conducted isocratically, so a good isocratic pump is essential for a steady baseline. The AZURA excellent isocratic pump has been optimized to meet the requirements of GPC applications.</span></p><p><span lang="EN-GB"><strong>Options:</strong></span></p><ul><li><span lang="EN-GB">Normal phase</span></li><li><span lang="EN-GB">Aqueous eluents</span></li><li><span lang="EN-GB">Reversed phase pump with integrated solvent selection valve and degasser</span></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_High_pressure_gradient_HPLC_pump_AZURA_P_6_1_L_High_Pressure_Pump_with_10_ml_pump_head_stainless_steel_b7d7d07d6c.jpg" alt="Knauer: AZURA GPC/SEC Systems - pumps" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_High_pressure_gradient_HPLC_pump_AZURA_P_6_1_L_High_Pressure_Pump_with_10_ml_pump_head_stainless_steel_b7d7d07d6c.jpg 245w," sizes="100vw" width="1280" height="627"></p><h5><span lang="EN-GB"><strong>Detectors</strong></span></h5><p><span lang="EN-GB">Our AZURA RI detector has been optimized for a better performance with organic solvents. Especially we have worked on significantly lower the drift with THF.</span></p><p><span lang="EN-GB">Yu can alternatively choose between our UV/VIS detectors, variable single wavelength, multi- wavelength, or diode array.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_SEC_System_AZURA_RID_2_1_2_13953c7ec5.jpg" alt="KNAUER: AZURA GPC/SEC Systems - RID 2.1 detector" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_SEC_System_AZURA_RID_2_1_2_13953c7ec5.jpg 245w," sizes="100vw" width="1066" height="438"></p>

KNAUER AZURA® Bio Compact SEC FPLC System

AZURA Compact SEC systems handle time-consuming SEC methods in your lab without occupying your valuable FPLC system.

<p class="cke-user_style-important"><strong>KNAUER protein purification: </strong>The flexible FPLC platform</p><p><strong>AZURA® Bio purification systems&nbsp;</strong></p><p>complete solutions for FPLC on a minimum footprint: AZURA FPLC systems combine flexibility and reliability. The biocompatible/metal-free FPLC is the perfect choice for your protein purification task.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_AC_FPLC_System_6_a874551078.jpg" alt="KNAUER: AZURA® Bio Compact AC FPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_AC_FPLC_System_6_a874551078.jpg 245w," sizes="100vw" width="1506" height="600"></p><p data-start="0" data-end="257">Design your AZURA Bio purification system to fit your needs. Multiple functionalities such as automatic sample injection via autosampler, column switching, buffer and sample selection, and fraction collection enable automation of the purification process.</p><p data-start="259" data-end="530" data-is-last-node="" data-is-only-node="">A wide range of detectors ensures the visibility of target molecules. Various flow rates and compatibility with columns from all vendors provide maximum flexibility. The intuitive <strong data-start="439" data-end="455">PurityChrom®</strong> software integrates all the advantages of a versatile purification system.</p><h3><strong>AZURA® Bio Compact </strong><font style="color:rgb(29, 29, 31);"><span style="animation-delay:0.25s;animation-name:o_anim_fade_in;animation-play-state:running;visibility:visible;"><strong>SEC FPLC System</strong></span></font></h3><h4><font style="color:rgb(29, 29, 31);"><span style="animation-delay:0.25s;animation-name:o_anim_fade_in;animation-play-state:running;visibility:visible;"><strong>For Size Exclusion Chromatography (SEC)</strong></span></font></h4><p data-start="0" data-end="249"><strong>AZURA Compact SEC</strong> systems take over time-consuming SEC methods in your lab without blocking your valuable FPLC system. Due to its compact design and intuitive FPLC <strong>software PurityChrom®</strong>, the system offers outstanding performance and ease of use.&nbsp;</p><p data-start="0" data-end="249"><strong>Pre-designed methods </strong>are included in the software for the designated SEC system and can be easily adapted by changing the column volume.<strong> AZURA Compact SEC</strong> supports <strong>all columns available on the market</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_SEC_FPLC_System_4_f5efb08061.jpg" alt="KNAUER: AZURA® Bio Compact SEC FPLC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_SEC_FPLC_System_4_f5efb08061.jpg 245w," sizes="100vw" width="1358" height="540"></p><h3><strong>Key features</strong></h3><ul><li data-start="93" data-end="157"><strong data-start="95" data-end="108">Flow rate</strong>: 0.001–10 ml/min (recommended: 0.1–8.0 ml/min)</li><li data-start="158" data-end="197"><strong data-start="160" data-end="187">Maximum system pressure</strong>: 50 bar</li><li data-start="198" data-end="276"><strong data-start="200" data-end="220">Injection system</strong>: Injection valve for sample injection via sample loop</li><li data-start="277" data-end="347"><strong data-start="279" data-end="292">Detection</strong>: Variable single wavelength UV detector (190–500 nm)</li><li data-start="348" data-end="423"><strong data-start="350" data-end="373">Fraction collection</strong>: Fraction collector for automated fractionation</li><li data-start="424" data-end="522"><strong data-start="426" data-end="450">Column compatibility</strong>: Supports columns from all vendors, including third-party SEC columns</li><li data-start="523" data-end="611"><strong data-start="525" data-end="537">Software</strong>: Intuitive and powerful PurityChrom® software, 21 CFR Part 11 compliant</li><li data-start="612" data-end="780"><strong data-start="614" data-end="631">System design</strong>:<ul data-start="637" data-end="780"><li data-start="637" data-end="666">Isocratic buffer delivery</li><li data-start="669" data-end="687">Loop injection</li><li data-start="690" data-end="734">Wide range of collection racks available</li><li data-start="737" data-end="780">Specially designed for SEC applications</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_SEC_FPLC_System_3_7a4bc1f60b.jpg" alt="KNAUER: AZURA® Bio Compact SEC FPLC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_SEC_FPLC_System_3_7a4bc1f60b.jpg 245w," sizes="100vw" width="1920" height="1152"></p><p><strong>Don't use your valuable gradient FPLC system for boring and time-consuming size exclusion separations. Choose your dedicated AZURA SEC system.</strong></p><figure class="image"><img style="aspect-ratio:690/490;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_SEC_FPLC_System_45d5079064.webp" alt="KNAUER: AZURA® Bio Compact SEC FPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_SEC_FPLC_System_45d5079064.webp 220w," sizes="100vw" width="690" height="490"></figure><p>With its compact design and intuitive software, the system offers excellent performance, ease of use and <strong>supports all SEC columns</strong> available on the market.​</p>

KNAUER AZURA® SEC Compact System

The AZURA SEC Compact systems provide excellent price-to-performance value, ideal for labs entering GPC/SEC, process control, or those with limited budgets and educational needs.

<h3><strong>Compact, versatile system for SEC and GPC applications&nbsp;</strong></h3><p data-start="0" data-end="257">The <strong>AZURA SEC Compact systems</strong> offer an outstanding price-to-performance ratio and are the perfect solution for every laboratory entering the analytical world of <strong>GPC/SEC</strong>, for process control applications, or for limited-budget and educational laboratories.</p><p data-start="259" data-end="530">The heart of the systems is the <strong data-start="290" data-end="312">Assistant ASM 2.2</strong><strong>L</strong> is a docking station for three compact devices. Valves, pumps and UV detectors can be combined in one housing. Routine maintenance work e.g. replacing the lamp of a detector is easily performed by the user.</p><p data-start="532" data-end="631">Thanks to its modular concept the systems can be extended with additional components at any time later.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Compact_System_3_313d153f48.jpg" alt="KNAUER: AZURA® SEC Compact System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Compact_System_3_313d153f48.jpg 237w," sizes="100vw" width="1009" height="664"></p><h3 data-start="857" data-end="879"><strong data-start="861" data-end="877">Key Features</strong></h3><ul data-start="880" data-end="1168"><li data-start="880" data-end="914"><strong data-start="882" data-end="895">Flow rate</strong>: 0.001–10 ml/min</li><li data-start="915" data-end="946"><strong data-start="917" data-end="929">Pressure</strong>: Up to 400 bar</li><li data-start="947" data-end="997"><strong data-start="949" data-end="995">Intuitive operation with maximum precision</strong></li><li><strong data-start="1000" data-end="1040">Injection via valve drive for minimal pressure spikes</strong></li><li data-start="1043" data-end="1095"><strong data-start="1045" data-end="1093">Supports a wide range of SEC and GPC columns</strong></li><li data-start="1096" data-end="1128"><strong data-start="1098" data-end="1126">Dedicated SEC/GPC ClarityChrom<sup>®</sup> add-on for in-depth data evaluation</strong></li><li data-start="1129" data-end="1168"><strong data-start="1131" data-end="1166">Expandable, space-saving design</strong></li><li data-start="1129" data-end="1168"><strong data-start="1131" data-end="1166">Suitable for organic and aqueous eluents</strong></li></ul><h3 data-start="1175" data-end="1219"><strong data-start="1179" data-end="1217">System Components &amp; Configurations</strong></h3><ul data-start="1220" data-end="1486"><li data-start="1220" data-end="1242">Isocratic pump</li><li data-start="1243" data-end="1270">UV and RI detectors</li><li data-start="1271" data-end="1296">Column thermostat</li><li data-start="1297" data-end="1335">Automatic injection (optional)</li><li data-start="1336" data-end="1393">ClarityChrom® add-on for in-depth data evaluation</li><li data-start="1394" data-end="1486">Choose a hardware version for aqueous SEC of biomolecules or organic GPC of polymers</li></ul><h3 data-start="1493" data-end="1520"><strong data-start="1497" data-end="1518">Detection Options</strong></h3><ul data-start="1521" data-end="1555"><li data-start="1521" data-end="1555">RI, UV, ELSD, PDA, FLD, MS</li></ul><h3 data-start="1562" data-end="1587"><strong data-start="1566" data-end="1585">Upgrade Options</strong></h3><ul data-start="1588" data-end="1745"><li data-start="1588" data-end="1649">Automatic solvent recycle valve (cost-saving feature)</li><li data-start="1650" data-end="1666">Degasser</li><li data-start="1667" data-end="1686">Autosampler</li><li data-start="1687" data-end="1745">Additional detectors (RI, UV, ELSD, PDA, FLD, ECD)</li></ul><p>&nbsp;</p><figure class="image"><img style="aspect-ratio:1886/1452;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Compact_System_3c56c6482f.webp" alt="KNAUER: AZURA® SEC Compact System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Compact_System_3c56c6482f.webp 203w," sizes="100vw" width="1886" height="1452"></figure>

KNAUER AZURA® SEC Lab System

The AZURA SEC Lab systems are ideal for labs requiring top analytical performance, offering unmatched flow precision and ultra-low pulsation for exceptional retention volume accuracy and reproducibility.

<h3><strong>Highest analytical performance and robustness for SEC and GPC applications</strong></h3><p>The <strong>AZURA SEC Lab</strong> systems are the perfect choice for laboratories that demands highest analytical performance. The system shows <strong>unsurpassed flow precision</strong> paired with <strong>ultra-low pulsation</strong> for outstanding retention volume precision and reproducibility.</p><p>The autosampler can inject from up to <strong>768 positions</strong> via microtiter plates or <strong>108 standard 1.5 ml sample vials</strong> and is therefore the perfect choice for larger sample amount as well as for high sample throughput laboratories. Thanks to the reliable and robust design it is the workhorse in any laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Lab_System_e161ecef84.webp" alt="KNAUER: AZURA® SEC Lab System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Lab_System_e161ecef84.webp 203w," sizes="100vw" width="1886" height="1452"></p><h3><strong>Key Features</strong></h3><ul><li><strong data-start="882" data-end="895">Injection volume</strong>: 1 –1000 µl&nbsp;</li><li><strong>Easy maintenance</strong></li><li>Great selection of <strong>SEC/GPC columns</strong></li><li><strong>Unsurpassed flow precision </strong>paired with <strong>ultra-low pulsation</strong> for</li><li>Highest analytical performance</li><li>Suitable for <strong>organic </strong>and <strong>aqueous eluents</strong></li><li><strong>Highest level of automation</strong></li><li>Choose the <strong>matching hardware</strong> version for aqueous <strong>SEC of biomolecules</strong> or organic <strong>GPC of polymers</strong></li></ul><h3><strong>Upgrade Options</strong></h3><ul><li>Save operating costs with an <strong>automatic solvent recycle valve</strong></li><li>Degasser</li><li>Detector (<strong>RI, UV, ELSD, PDA, FLD, ECD</strong>)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Lab_System_2_2cbe13a95d.webp" alt="KNAUER: AZURA® SEC Lab System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Lab_System_2_2cbe13a95d.webp 234w," sizes="100vw" width="953" height="635"><br><strong>All wetted parts are available in either bioinert materials or for standard phase solvents.</strong></p>

KNAUER AZURA® SEC Semi-Prep System

The AZURA SEC Semi-prep systems enable fractionation of specific molecular weight ranges or purification tasks, with a pump delivering up to 50 ml/min, making it ideal for all semi-preparative GPC/SEC columns.

<h3><strong>Automated system for semi-preparative SEC and GPC</strong></h3><p>The <strong>AZURA SEC Semi-prep </strong>systems offer the possibility of fractionating specific molecular weight ranges or purification tasks. The pump can deliver flow rates of up to <strong>50 ml/min </strong>and is therefore suitable for every semi-preparative <strong>GPC/SEC column</strong>.</p><p>Thanks to the modular concept of the AZURA platform and the dedicated <strong>PurityChrom® software</strong>, the systems can be highly adapted to any separation task.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Semi_Prep_System_12215b2eda.webp" alt="KNAUER: AZURA® SEC Semi-Prep System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Semi_Prep_System_12215b2eda.webp 203w," sizes="100vw" width="1886" height="1452"></p><h3><strong>Fraction Collection</strong></h3><p><strong>Collect large quantities or large numbers of fractions:</strong></p><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;"><strong>Manually </strong>– collection by direct control</li><li style="tab-stops:list 36.0pt;"><strong>Volume-based</strong> – collection at defined volumes</li><li style="tab-stops:list 36.0pt;"><strong>Peak-based</strong> – collection according to detector signal</li><li style="tab-stops:list 36.0pt;">From switching valve to fraction collector solutions</li></ul><h3><strong>Key Features</strong></h3><ul><li data-start="70" data-end="134"><strong data-start="72" data-end="91">Modular concept</strong> for any separation and purification task</li><li data-start="135" data-end="169"><strong data-start="137" data-end="151">Flow rates</strong>: 0.01–50 ml/min</li><li data-start="170" data-end="249"><strong data-start="172" data-end="193">Injection options</strong>: Manual or autosampler (up to 10 ml injection volume)</li><li data-start="250" data-end="320"><strong data-start="252" data-end="276">Eluent compatibility</strong>: Suitable for organic and aqueous eluents</li><li data-start="321" data-end="390"><strong data-start="323" data-end="343">Column selection</strong>: Wide range of SEC and GPC columns available</li><li data-start="563" data-end="649"><strong data-start="565" data-end="588">Efficiency features</strong>: Automatic solvent recycle valve to reduce operating costs</li><li data-start="650" data-end="757"><strong data-start="652" data-end="672">Hardware options</strong>: Choose a version for <strong data-start="695" data-end="725">aqueous SEC (biomolecules)</strong> or <strong data-start="729" data-end="755" data-is-only-node="">organic GPC (polymers)</strong></li><li data-start="758" data-end="813"><strong data-start="760" data-end="780">Software options</strong>: ClarityChrom® or PurityChrom®</li></ul><h3><strong>Available Detectors for Semi-prep</strong></h3><p>The<strong> AZURA SEC Semi-prep </strong>systems can be equipped with a dedicated<strong> high-flow RI detector</strong> that can be used up to <strong>10 ml/min</strong> as well as with the <strong>UV Detectors UVD 2.1S</strong> and <strong>UVD 2.1L</strong>.</p>

KNAUER AZURA® GPC Cleanup System

Do not waste time and labor with manual sample preparation. The AZURA GPC Cleanup system automates work-intensive and time-consuming cleanup tasks based on gel permeation chromatography (GPC).

<h3><strong>Save time with automatic sample preparation</strong></h3><p>Do not waste time and labor with manual sample preparation. The <strong>AZURA GPC Cleanup </strong>system automates work-intensive and time-consuming cleanup tasks based on gel permeation chromatography (GPC). Further, reproducibility and quality of the cleanup are improved.</p><p>After sample loading, the dedicated system fully automated processes up to <strong>15 samples</strong> while requiring minimal bench space. Based on the versatile AZURA device platform the system can be customized to fulfill individual requirements. The cost-effective software <strong>Mobile Control </strong>provides a touch-optimized user interface for intuitive device control directly at the system.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_Cleanup_System_224a241335.webp" alt="KNAUER: AZURA® GPC Cleanup System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_Cleanup_System_224a241335.webp 203w," sizes="100vw" width="1886" height="1452"></p><h3><strong>Key Features</strong></h3><ul><li data-start="69" data-end="102"><strong data-start="71" data-end="84">Flow rate</strong>: 0.01–10 ml/min</li><li data-start="103" data-end="169"><strong data-start="105" data-end="133">Enhanced reproducibility</strong> – consistent and reliable results</li><li data-start="170" data-end="214"><strong data-start="172" data-end="212">Handles viscous and complex matrices</strong></li><li data-start="215" data-end="269"><strong data-start="217" data-end="267">Fully automated processing of up to 15 samples</strong></li><li data-start="270" data-end="320"><strong data-start="272" data-end="318">Supports AOAC, EPA, and European Standards</strong></li><li data-start="321" data-end="365"><strong data-start="323" data-end="363">Adaptable to specific lab procedures</strong></li><li data-start="366" data-end="405"><strong data-start="368" data-end="403">Compact, space-efficient system</strong></li><li data-start="406" data-end="466"><strong data-start="408" data-end="464">Touch-optimized Mobile Control for device management</strong></li><li data-start="467" data-end="551"><strong data-start="469" data-end="549">Automated workflows for streamlined sample preparation and higher efficiency</strong></li><li data-start="552" data-end="606"><strong data-start="554" data-end="581">Optimized cleanup tasks</strong> for better performance</li><li data-start="607" data-end="658"><strong data-start="609" data-end="656">Easily adaptable for different applications</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_Cleanup_System_2_27867ae999.jpg" alt="KNAUER: AZURA® GPC Cleanup System: Chromatogram of US EPA method 3640A calibration standard containing 1) Corn oil matrix 2) Bis-(2-ethylhexyl)phalate 3) Methoxychlor 4) Perylene." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_Cleanup_System_2_27867ae999.jpg 245w," sizes="100vw" width="1247" height="626"></p><p><strong>In accordance with established methods to determine pesticide residues</strong></p><ul><li><strong>Method 984.21</strong> – AOAC international</li><li><strong>EPA SW-846 Method 3640A </strong>– US Environmental Protection Agency</li><li><strong>AEN 12393 and EN 1528</strong> – European Standard</li><li><strong>L 00.00-34 </strong>Method in accordance with §64 LFGB (formerly § 35 LMBG)</li></ul>

Waters ACQUITY Advanced Polymer Chromatography (APC) System

The ACQUITY APC System Increase sample throughput and laboratory operations by obtaining accurate and repeatable sample separation up to 20 time faster than before.

<div><div><h4><strong>The highest performance for polymers and oligomers</strong></h4></div></div><div><div><p><strong>Today’s polymer scientists operate within an increasingly dynamic market space, one with a growing demand for high-performing materials, bio-material innovations, and intense competition. But the long run times of traditional chromatography polymer characterization has made keeping up with this demand a challenge for many labs.</strong></p><p>Not anymore. With the <strong>next era in polymer separation</strong>, the <strong>ACQUITY Advanced Polymer Chromatography (APC) System</strong>, you can achieve the <strong>highest resolution size-based separations</strong> for <strong>chromatographic polymer and oligomer characterization</strong>, all <strong>faster than ever</strong>. With the <strong>ACQUITY APC System</strong>, you can <strong>improve data consistency and quality</strong> with <strong>fast, daily calibration</strong>, and <strong>automate your method development</strong> with <strong>advanced system technologies</strong> – so you can <strong>innovate faster</strong> while <strong>improving lab operations.</strong></p><div><div><div><div><h3><strong>Features and Benefits</strong></h3><ul><li><strong>Accelerate your insights</strong> - Reduce laboratory turnaround times for polymer samples by getting answers to your development labs, your manufacturing operations teams, and your customers 5 to 20 times faster than traditional SEC/GPC with the ultra-low system dispersion of the ACQUITY APC System paired with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1950"><strong>ACQUITY APC Columns</strong></a>.</li><li><strong>Get the accurate data you need for informed decisions</strong> - Gain more insight into your polymer samples through compatibility with a wide range of specific detection techniques (refractive index, UV/Vis, PDA, ELS) and third-party advanced detectors like multi-angle light scattering and viscometry. Get accurate molecular weight (MW) data every day with the precise flow delivery of the isocratic solvent manager.</li><li><strong>Optimize method development, even in harsh conditions</strong> - Optimize method development via rapid and automated solvent switching and aggressive solvent compatibility, which supports the harsh separation conditions associated with polymer analyses.</li><li><strong>Improve lab efficiency with one system</strong> - Increase analytical scope and laboratory efficiency by leveraging one system to perform multiple applications, including basic liquid chromatography (LC), gradient, isocratic, reverse-phase, and gel permeation chromatography (GPC).</li><li><strong>Simplify your column management</strong> - Simplify and optimize column bank calibration through standards that are matched to column bank MW ranges. Versatile column management allows you to automatically select up to two banks of <strong>ACQUITY APC</strong> columns and up to two banks of traditional GPC columns - all housed in a stable, temperature-controlled environment.</li></ul></div></div><div><div><h4><strong>Recommended Use</strong></h4><p>Highest-resolution, size-based separations for chromatographic polymer and oligomer characterization.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_APC_System_nakonfigurovany_pro_automaticke_prepinani_jak_APC_tak_GPC_kolon_e198c774f4/Waters-ACQUITY-APC-System-nakonfigurovany-pro-automaticke-prepinani-jak-APC-tak-GPC-kolon.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_APC_System_nakonfigurovany_pro_automaticke_prepinani_jak_APC_tak_GPC_kolon_e198c774f4/thumbnail_Waters-ACQUITY-APC-System-nakonfigurovany-pro-automaticke-prepinani-jak-APC-tak-GPC-kolon.jpg 213w," sizes="100vw" width="969" height="710"></p><div><div><h3><strong>Accelerate innovation with enhanced insight</strong></h3><p>Harnessing the benefits of advanced polymer chromatography with the ACQUITY APC System means obtaining accurate and repeatable polymer and oligomer molecular weight information anywhere between<strong> 5 to 20 times faster than was possible</strong> with traditional<strong> GPC/SEC technology</strong> - so you can innovate faster while improving laboratory operations.</p><p><strong>With the ACQUITY APC System, you can:</strong></p><ul><li><strong>Reduce laboratory turnaround times for polymer samples&nbsp;</strong>by getting answers to your development labs, your manufacturing operations teams, and your customers - faster.</li><li><strong>Drive innovation</strong>&nbsp;with faster results and more information so that your entire operation can respond more rapidly by decreasing development cycle times and accelerating time to market.</li><li><strong>Streamline process monitoring</strong>&nbsp;and achieve better batch control with the agility to make timely decisions “on-the-fly” about process and synthesis optimization<strong>.</strong></li><li><strong>Significantly reduce the analysis cost per sample</strong>&nbsp;by reducing solvent consumption and waste disposal volumes.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_ca5154865a.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Accelerate your innovation with enhanced insight into polymer chemical structure with the ACQUITY APC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_ca5154865a.jpg 245w," sizes="100vw" width="1024" height="600"></p><div><div><h3><strong>Optimize method development with solvent switching and compatibility</strong></h3><p>Using the ACQUITY APC System with <strong>Polymer Quaternary Solvent Manager</strong> (p-QSM) <strong>technology </strong>provides chemists and polymer scientists with the ultimate flexibility to analyze the most complex polymer blends and additives using standard polymer chromatography, gradient polymer elution chromatography (GPEC), and reverse-phase LC with a single system.</p><p>Additional system features allow automated solvent selection of up to six different solvents. Automated column bank switching capabilities can also be paired with the rigid and solvent-resilient particles of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1950"><strong>ACQUITY APC Columns</strong></a> to achieve the world’s first truly automated solution for method development of size-based polymer separations. This supports separation of polymers in hours, instead of days.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_2_b95f96f0a2.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Repeatable analysis of poly (methyl methacrylate co ethylacrylate) using the same two running ACQUITY APC 4.6 x 150 mm Columns (450 Å and 125 Å) in series after automated switching of the solvents from THF to toluene to DMF and back to THF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_2_b95f96f0a2.jpg 245w," sizes="100vw" width="1024" height="609"></p></div></div><div><div><h3><strong>Use advanced detection for even more insights</strong></h3><p>Get the valuable decision-making information you need from a single analysis by equipping the ACQUITY APC System with advanced detectors. Combining the ACQUITY APC System with advanced detection solutions significantly increases information attainable from <strong>size-exclusion chromatography</strong> (SEC) analysis through addition of <strong>refractive index</strong> (RI), <strong>ultraviolet </strong>(UV),<strong> photodiode array </strong>(PDA), <strong>light scattering</strong> (LS), and <strong>differential viscometry</strong> (IV). Advanced detection options from <strong>Wyatt Technology</strong> are seamlessly integrated with ACQUITY APC System, enabling you to fully characterize samples to better inform the structure-property relationship of novel complex polymers.</p></div></div><div><div><h3><strong>Keep pace with your research with dedicated consumables</strong></h3><p>The ACQUITY APC System is even more powerful with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/columns/acquity-apc-columns.html"><strong>ACQUITY APC Columns</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/standards-and-reagents/acquity-advanced-polymer-chromatography-calibration-standards-ki.html"><strong>ACQUITY APC Calibration Standards Kits</strong></a>. The Ethylene Bridged Hybrid (BEH) Technology in ACQUITY APC Columns creates particles that ensure extreme column performance and long column lifetime under harsh operating conditions – ideal for general purpose, reversed-phase chromatography, and for method development due to extreme pH stability and applicability to the broadest range of compound classes.</p><p>With run times of less than 10 minutes, a bank of ACQUITY APC Columns can be <strong>calibrated in less than 30 minutes</strong> using ACQUITY APC Calibration Standards Kits.&nbsp;These standard kits have been matched to the MW range of ACQUITY APC Columns, generating a 10-point calibration for any bank combination in a simple dilute-and-shoot format. With daily column bank calibration, you can greatly improve data consistency to increase confidence in batch-to-batch measurements. Select the best column and calibration standards for a given application with our convenient <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/promotionDetail.htm?id=134823417">selector tool</a>.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_4_056bb6d284.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Ethylene Bridged Hybrid (BEH) Technology helps you keep up with the pace of your research with state-of-the-art reversed-phase and HILIC HPLC columns." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_4_056bb6d284.jpg 245w," sizes="100vw" width="1024" height="620"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_5_7a814e249b.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Improve data and consistency with ACQUITY APC Calibration Standards." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_5_7a814e249b.jpg 245w," sizes="100vw" width="1024" height="591"></p></div></div></div></div></div></div></div></div></div></div>

Products from category GPC/SEC - page 1

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