Post-translational modifications (PTMs) are where so much of biology’s complexity lives, but they are also some of the hardest molecular features to analyze with confidence. Phosphorylation, asymmetric dimethylarginine (ADMA), and O-GlcNAcylation (O-GlcNAc) often occur at low abundance, can be highly labile, and frequently require precise site localization to understand their biological meaning. This<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"> technical note </a>shows how the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958">Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer</a> helps address those challenges by combining fast, sensitive performance with complementary <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7217">HCD and EThcD fragmentation</a> workflows.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg" alt="Thermo Fisher Scientific: Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg 245w," sizes="100vw" width="1024" height="512">Using enriched PTM samples and automated data-dependent acquisition, the study demonstrates that the Orbitrap Excedion Pro MS can deliver both depth and confidence across multiple PTM classes. For phosphorylation analysis, the platform identified 5,892 unique phosphosites from IMAC-enriched samples and 2,941 unique phosphotyrosine sites after phosphotyrosine enrichment, highlighting strong performance for both broad and highly targeted signaling studies. Just as importantly, the data show that HCD and EThcD provide complementary value, with each fragmentation method contributing unique site identifications and helping resolve ambiguous assignments.The note also highlights the value of EThcD for more analytically demanding PTMs. In ADMA-enriched samples, EThcD delivered more ADMA peptide-spectrum matches and more unique modified peptides than HCD, supporting improved confidence in site characterization. For O-glycopeptides, the Orbitrap Excedion Pro MS uses an intelligent HCD-product-dependent-EThcD strategy that triggers EThcD only when oxonium ions are detected, improving productivity while preserving the fragmentation detail needed for confident glycosite localization.Overall, this technical note shows how Orbitrap Excedion Pro MS enables researchers to go deeper into PTM biology with greater sensitivity, better site confidence, and smarter acquisition. For scientists studying signaling, regulation, and disease mechanisms, it presents a powerful approach for expanding PTM coverage without compromising analytical rigor.<blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf">Download the technical note "Advancing phosphorylation, ADMA, and O-GlcNAc PTM analysis with HCD and EThcD on the Orbitrap Excedion Pro mass spectrometer"</a></h5></blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PTM #OrbitrapExcedionPro #glycosylation #phosphorylation

Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer

<h4>Latest edition of the Wiley Registry/NIST Mass Spectral Library for leading pharmaceutical, environmental, and forensic laboratories worldwide expands coverage to more than 1.2 million spectra</h4>Wiley, a global leader in authoritative content and research intelligence, today released the new edition of the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2591">Wiley Registry/NIST Mass Spectral Library</a>, a reference database that combines two essential mass spectrometry references in a single, integrated collection, giving scientists the full depth of both to identify unknown chemical compounds.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Wiley_Registry_NIST_EI_Mass_Spectral_Library_2026_4d3c8f440f.jpg" alt="Wiley: Wiley Registry/NIST EI Mass Spectral Library 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Wiley_Registry_NIST_EI_Mass_Spectral_Library_2026_4d3c8f440f.jpg 110w," sizes="100vw" width="1524" height="2161">For years, laboratories doing GC-MS analysis have relied on Wiley’s renowned <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/887">Wiley Registry of Mass Spectral Data</a> and the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2461">NIST/EPA/NIH EI Mass Spectral Library</a> from the U.S. government’s National Institute of Standards and Technology (NIST) to power their analytical workflows. These two respected references are united in this database, one of the most comprehensive resources of its kind.The new 2026 edition updates the collection, adding tens of thousands of newly validated compounds across both libraries and bringing the total to more than 1.2 million electron ionization (EI) mass spectra—unique chemical “signatures” used to identify substances.The Wiley Registry/NIST Mass Spectral Library is part of Wiley’s growing portfolio of scientific data and research intelligence solutions, which spans spectral databases, chemistry and materials literature, and analytical tools supporting researchers from discovery through applied outcomes.Wiley’s spectral database solutions are trusted by leading pharmaceutical, environmental, and forensic laboratories worldwide, reflecting Wiley’s mission to transform knowledge into actionable intelligence that helps researchers make confident, high-stakes decisions.<blockquote>“When a scientist runs a sample through a mass spectrometer, the results are only as good as the reference data behind them,” said Armughan Rafat, Wiley senior vice president and chief AI &amp; data analytics officer. “By uniting the Wiley Registry and the NIST Library in a single resource, we deliver the breadth, quality, and validation scientists need to identify unknown compounds faster and with confidence.”</blockquote>Available in the most common instrumentation manufacturer formats, the library supports high-confidence analysis across GC-MS workflows.<h4>Spectral Databases</h4>Spectral databases contain unique molecular “fingerprints” of substances captured through analytical techniques such as infrared (IR), mass spectrometry (MS), nuclear magnetic resonance (NMR), and Raman spectroscopy. By comparing experimental spectra against validated reference data, researchers can accurately identify unknown compounds across a wide range of applications. &nbsp;<h4>About Wiley</h4>Wiley is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what’s possible in science and learning.&nbsp;

Wiley Releases Database Combining Two of the World’s Most Trusted Chemical Identification Resources

The countdown is almost over. In just one week, the international chromatography community will meet in Prague for the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/events/644">35th International Symposium on Chromatography (ISC 2026)</a>, taking place from September 6–10, 2026. Whether your registration has been confirmed for months or you are still deciding whether to join, now is the time to finalize your plans. Here is what you need to know before ISC 2026 begins.<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/companies/314">ISC</a> is the oldest conference series dedicated to separation science, with symposia organized since 1956. This September, the Prague Congress Centre will welcome researchers, industry experts, instrument manufacturers, young scientists, and other specialists for five days of chromatography and separation science, covering everything from fundamental research to pharmaceutical, environmental, food, health, and omics applications.But before the scientific sessions begin, there are a few practical details worth checking.<h4>ISC officially starts on September 6 – but activities begin a day earlier</h4>The official dates for ISC 2026 are Sunday, September 6 through Thursday, September 10, but for some participants the conference starts already on Saturday, September 5.The first Short Courses are scheduled for Saturday (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/6770">SC 1 – Modern HPLC Separation in Theory and Practice</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7312">SC 2 – mzmine for LC-MS data analysis</a>), with additional courses continuing on Sunday morning and afternoon. If you have registered for a Short Course, make sure to check its exact date and starting time before arranging your journey to Prague.Sunday then marks the official opening of ISC 2026, with the Opening Ceremony, Award Ceremony, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7361">plenary lectures</a>, and Welcome Reception introducing delegates to the week ahead.<h4>Haven’t registered yet? You can still join ISC 2026</h4>Missed the late-registration deadline? It is still possible to attend.Onsite registration has been available since August 26, 2026, giving last-minute participants another opportunity to join the symposium. Current onsite registration fees are:<ul><li>Industry: €1,150</li><li>Academic: €890</li><li>Student: €390</li><li>Short Courses: €270</li></ul>The Short Course fee covers participation in up to three Short Courses.One practical point for last-minute registration: bank-transfer payments closed on August 19, so only card payments are now accepted.Full registration includes access to oral and poster sessions, the exhibition, the Sunday Welcome Reception, scheduled lunches and coffee breaks, the electronic Book of Abstracts, and a Prague public transportation pass.<h4>Where is ISC 2026 and how do you get there?</h4>ISC 2026 will take place at the:Prague Congress Centre<ul><li>5. května 65</li><li>140 21 Prague 4</li><li>Czech Republic</li></ul>The venue is particularly easy to reach by public transport. It is located directly on Prague’s Metro Line C at Vyšehrad station, just around five minutes by metro from Muzeum station in the city centre.The Prague Congress Centre brings the lecture halls, exhibition spaces, meeting rooms, and other conference facilities together in one venue, making it easy to move between scientific sessions, posters, industry activities, and the exhibition throughout the day.And since full conference registration includes public transportation in Prague, getting around the city during ISC should be straightforward.<h4>When can you pick up your conference materials?</h4>The registration desk will already be open during the Short Courses and will remain available throughout the symposium.Registration opening hours:<ul><li>Saturday, September 5: 8:30–17:00</li><li>Sunday, September 6: 7:30–19:00</li><li>Monday, September 7: 7:30–18:00</li><li>Tuesday, September 8: 7:30–19:00</li><li>Wednesday, September 9: 8:00–18:00</li><li>Thursday, September 10: 8:30–14:30</li></ul>If you are arriving in Prague on Sunday, allowing some extra time for registration before the Opening Ceremony will make the start of the conference considerably more relaxed.<h4>Now is the time to build your personal ISC program</h4>With several parallel sessions running throughout the week, trying to decide where to go only after arriving at the venue may mean missing something important.The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7477">main scientific program</a> is organized around three broad areas:<ul><li>Fundamentals</li><li>Bioanalysis and omics applications</li><li>Hyphenated techniques</li></ul>These are complemented by <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7280">Tutorials </a>+ Young Speakers, plenary and invited lectures, poster sessions, the international exhibition, vendor seminars, and industry-focused activities.Before leaving for Prague, take another look at the Interactive Program and mark the lectures, posters, and other activities that are most relevant to you. If you are presenting your own work, this is also the right time to double-check your assigned session, room, and presentation time.And don’t focus only on the oral program. Poster sessions and exhibition breaks are among the best opportunities to discuss new research directly with authors, meet instrument and technology specialists, and make new contacts.<h4>Don’t overlook the vendor seminars and industry program</h4>ISC 2026 is not limited to academic presentations. The conference also includes an extensive industry component, with activities covering current challenges in separation science and practical applications of new analytical technologies.During the lunchtime sessions, participants can attend <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7736">vendor seminars</a> presented by companies including Avantor, Shimadzu, Advanced Materials Technology, Restek, and Thermo Fisher Scientific. Topics range from stationary-phase selectivity and chromatographic modelling to HPLC and LC-MS column technologies and advanced characterization of biotherapeutics.The conference also includes dedicated <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7777">Industry Activities</a> from Monday through Wednesday, bringing together academic and industrial perspectives on topics relevant to analytical laboratories and the future of separation science. One of the discussions, for example, will examine how education in separation science can better reflect the skills required by modern industry, while another will focus on sustainability and the practical implementation of greener analytical workflows.On Wednesday, participants can also join the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7801">Publishing Workshop</a>, another activity worth adding to the schedule if scientific publishing is part of your work.<h4>Test your chromatography knowledge at the ISC Quiz</h4>Not every session needs to be completely serious.On Tuesday, September 8 from 18:30 to 19:30, ISC will host an interactive Chromatography Quiz, combining practical questions, chromatography fundamentals, unusual facts, and lighter challenges.There is no advance registration required. Any registered conference participant can join, but remember to bring a smartphone—the quiz uses live participation through a QR code.Results will be scored in real time, and prizes will be awarded to the top three participants.<h4>Start networking from the first evening</h4>The scientific program may be the main reason to attend ISC, but the conversations between sessions can be equally valuable.The first major networking opportunity comes immediately on Sunday.The Welcome Reception will take place on September 6 from 18:30 to 20:00 in the second-floor foyer of the Prague Congress Centre. It is open to registered participants and accompanying persons and includes a light buffet and drinks.As it takes place immediately after the opening program, it is an ideal opportunity to reconnect with colleagues, meet new contacts, and start conversations before the full parallel scientific program begins on Monday.Another social highlight will be the Gala Dinner on Wednesday, September 9 from 19:00 to midnight at the National House Vinohrady.The Gala Dinner requires a separate €100 ticket, is not included in the standard registration fee, and has a smart-casual dress code. Participants should also note that transportation to and from the venue is not organized by the conference.<h4>And perhaps leave a little time for Prague</h4>A conference schedule can fill up quickly, but ISC 2026 is taking place in one of Europe’s most walkable cities.If you find some free time between sessions, Vyšehrad is only about a 10-minute walk from the Prague Congress Centre and offers panoramic views across Prague and the Vltava River. It is an easy option for a short walk without travelling back into the historic city centre.See you at ISC 2026 in Prague!

ISC 2026 Starts in One Week: What You Need to Know

Article

Product

Events

Application

Software

Video

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

For over 200 years we have been helping people and organizations develop the skills and knowledge they need to succeed.
We develop digital education, learning, assessment, and certification solutions to help universities, businesses, and individuals move between education and employment and achieve their ambitions.

Wiley

BaySpec Swab-APCI Ionization Source

BaySpec Swab-APCI enables rapid, non-contact analysis of solid samples using TSA-approved swabs. Heated desorption converts trace residues into vapors for real-time MS detection.

<h4>Ambient Ionization Sources for Portable Mass Spectrometers</h4>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219">Portability™</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218">Continuity™</a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.<h4>Key Features</h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4>Swab-APCI</h4>Designed for TSA-approved swabs, converting solid samples like drugs and explosives on swabs into vapors via a heater unit, then drawing them into the ionization chamber.

BaySpec AM-APCI Ionization Source

BaySpec ambient ionization sources enable fast, gas-free field MS analysis of vapors, liquids, and solids. AM-APCI allows continuous air monitoring of VOCs with real-time results.

<h4>Ambient Ionization Sources for Portable Mass Spectrometers</h4>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219">Portability™</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218">Continuity™</a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.<h4>Key Features</h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4>Air Monitoring APCI (AM-APCI)</h4>A small sampling pump continuously draws air into the ionization chamber, where a corona discharge ionizes compounds of varying polarities, making it ideal for analyzing VOCs in buildings or urban environments.

BaySpec DBDI Ionization Source

BaySpec DBDI is a versatile plasma-based ambient ionization source for portable MS, enabling soft, gas-free analysis of vapors and gases with minimal fragmentation and real-time results.

<h4>Ambient Ionization Sources for Portable Mass Spectrometers</h4>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219">Portability™</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218">Continuity™</a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.<h4>Key Features</h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4>Dielectric Barrier Discharge Ionization (DBDI)</h4>Versatile plasma-based ion source designed for analyzing small molecules with low to high polarity. This soft ionization technique minimizes in-source fragmentation and requires no auxiliary gas supply, making it best suited for vapor and gas samples. An optional thermal desorber enhances the sample coverage.

BaySpec Multimodal Ionization Source

BaySpec Multimodal Ionization combines plasma and corona discharge ionization to expand analyte coverage, reduce noise, and deliver flexible ambient MS analysis of vapors and gases.

<h4>Ambient Ionization Sources for Portable Mass Spectrometers</h4>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219">Portability™</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218">Continuity™</a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.<h4>Key Features</h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4>Muiltimodal Ionization</h4>Combined plasma-based and corona discharge-based ionization, allowing for a greater coverage of analytes. This patented technology improves ion generation and reducing noise. Can be operated in combined, DBDI only, or APCI only mode, offering versatility for different analytical needs. It is best suited for the analysis of vapor and gas samples but an optional thermal desorber extends its capabilities to solid and liquid samples.

BaySpec PI Ionization Source

BaySpec PhotoIonization (PI) uses low-energy UV photons to selectively ionize analytes with minimal chemical noise, ideal for sensitive field analysis of pesticides and steroids.

<h4>Ambient Ionization Sources for Portable Mass Spectrometers</h4>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219">Portability™</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218">Continuity™</a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.<h4>Key Features</h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4>PhotoIonization (PI)</h4>Uses high-intensity, low-energy UV photons to ionize analytes, reducing chemical noise as common solvents and air components remain non-ionized. It is particularly effective for molecules such as pesticides and steroids with lower ionization energies. No auxiliary gas is needed, and a thermal desorber can be used to process solid or liquid samples.

BaySpec Custom Ionization Source

BaySpec Customized Ionization Solutions deliver tailor-made ambient ion sources to meet specific experimental and industrial needs, ensuring optimal performance for diverse sample types.

<h4>Ambient Ionization Sources for Portable Mass Spectrometers</h4>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219">Portability™</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218">Continuity™</a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.<h4>Key Features</h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4>Customized Solutions</h4>For applications requiring specialized solutions, we provide custom ionization sources designed to meet specific experimental and industrial demands. Our expert team develops bespoke modules that enhance your analytical capabilities, ensuring optimal performance and precise, targeted investigations for a variety of sample types, whether you’re expanding your current setup or integrating into new equipment.

Thermo Scientific VeriSpray PaperSpray Ion Source for Mass Spectrometry

Thermo Scientific VeriSpray PaperSpray Ion Source enables direct MS analysis without chromatography, delivering rapid results, simplified workflows, high throughput, and reduced cost per test.

The Thermo Scientific VeriSpray PaperSpray Ion Source is a mass spectrometry ionization source designed to enable direct sample analysis without chromatographic separation. Based on paper spray ionization technology, it significantly simplifies analytical workflows while delivering rapid and reliable MS results from complex sample matrices.Samples are applied to a paper substrate, wetted with solvent, and ionized by applying a high voltage. The resulting ions are introduced directly into the mass spectrometer via electrospray ionization, eliminating the need for time-consuming sample preparation or chromatography. This approach enables data acquisition within minutes and supports high-throughput analysis.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_ca9b0c1e64.jpg" alt="Thermo Scientific VeriSpray PaperSpray Ion Source for Mass Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_ca9b0c1e64.jpg 245w," sizes="100vw" width="2020" height="552">The VeriSpray ion source is engineered for unattended, high-capacity operation, allowing the analysis of hundreds of samples with minimal manual intervention. By removing chromatographic steps, solvent consumption is reduced, instrument maintenance demands are lowered, and overall cost per test is significantly decreased.Fully integrated with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=tsq">Thermo Scientific TSQ Series mass spectrometers</a>, the VeriSpray ion source is controlled through established software platforms, offering streamlined method setup, automated operation, and efficient data processing. This makes advanced mass spectrometric analysis accessible even in laboratories without extensive chromatography expertise.The VeriSpray PaperSpray Ion Source is particularly well suited for rapid quantitative analysis and screening applications in pharmaceutical, clinical, and research environments where speed, simplicity, and cost efficiency are essential.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_2_31a0e60dd5.jpg" alt="Thermo Scientific VeriSpray PaperSpray Ion Source for Mass Spectrometry: For Research Use Only. Not for use in diagnostic procedures." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_2_31a0e60dd5.jpg 171w," sizes="100vw" width="791" height="721"><h3>Key benefits and system integration</h3>The VeriSpray™ PaperSpray Ion Source improves turnaround time and reduces cost per test by eliminating chromatographic separation and minimizing sample preparation. Direct ionization enables one-step analysis of unprocessed samples, with MS results typically available in less than two minutes.Designed for high-throughput operation, the system supports unattended analysis of large sample batches and can be expanded with an optional automated plate loader for increased productivity. Proprietary VeriSpray PaperSpray sample plates are available for single-sample and high-throughput workflows, including barcoded formats to support automated sample tracking and integration with commercial robotic systems.The VeriSpray ion source is fully integrated into Thermo Scientific instrument control and application software, providing complete source control, predefined method templates, and streamlined data acquisition. Optional data analysis software further supports quantitative and screening applications in areas such as food safety, environmental analysis, clinical research, and forensic toxicology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_3_ec23b1733d.jpg" alt="Thermo Scientific VeriSpray PaperSpray Ion Source for Mass Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_3_ec23b1733d.jpg 216w," sizes="100vw" width="540" height="390"><h3>Instrument compatibility</h3>The VeriSpray™ PaperSpray Ion Source is compatible with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=tsq">Thermo Scientific TSQ triple quadrupole mass spectrometers</a>, including:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/404">TSQ Altis</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/414">TSQ Quantis</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/412">TSQ Fortis</a></li><li>TSQ Quantiva</li><li>TSQ Endura</li></ul><h3>Software support</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific Xcalibur</a> instrument control and data acquisition software (version 4.3 SP1 or higher)</li><li>Full VeriSpray ion source control via method editor</li><li>Predefined method templates for VeriSpray workflows</li><li>Optional <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77">Thermo Scientific TraceFinder </a>data analysis software (version 4.1 SP5 or higher)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_4_255b1d9010.jpg" alt="Thermo Scientific VeriSpray PaperSpray Ion Source for Mass Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Veri_Spray_Paper_Spray_Ion_Source_for_Mass_Spectrometry_4_255b1d9010.jpg 217w," sizes="100vw" width="650" height="467"><h3>Specifications</h3><ul><li>For Use With (Equipment): TSQ triple quadrupole MS</li><li>Height (Metric): 37.5 cm</li><li>Hertz: 50/60 Hz</li><li>Includes: Barcode reader for plate identification</li><li>Length (Metric): 15.25 cm</li><li>Weight (Metric): 10.7 kg</li><li>Width (Metric): 54 cm</li><li>Type: Ion Source</li><li>Unit Size: Each</li></ul>

Thermo Scientific Nanospray Flex Ion Source 

Thermo Scientific™ Nanospray Flex™ Ion Source is a flexible nano-electrospray ion source for LC-MS, delivering stable ionization, high sensitivity, and seamless integration with online and offline nano-ES workflows.

Thermo Scientific™ Nanospray Flex™ Ion Source is a nano-electrospray ion source designed to maximize LC-MS sensitivity while maintaining simple operation and exceptional flexibility. Developed for nanoflow LC-MS applications, it provides stable nano-electrospray ionization, low-flow operation, and flexible integration with a wide range of columns and emitters. The complete system is supplied with all required accessories for immediate installation.<h3>Key Features</h3><h4>High-Sensitivity Nano-ESI</h4><ul><li>Maximizes LC-MS sensitivity using stable nanoflow electrospray ionization</li><li>Supports nanoscale flow rates for efficient ionization and reduced sample consumption</li><li>Delivers highly stable spray performance for long analytical runs and stable spray performance during extended runs</li></ul><h4>Flexible Workflow</h4><ul><li>Single configuration for all online nanoflow LC-MS applications</li><li>Quickly switches between online LC-MS and offline nano-ES workflows</li><li>DirectJunction™ adaptor supports a wide range of column and emitter connections</li><li>Compatible with both stainless steel and glass emitters</li></ul><h4>Easy Operation</h4><ul><li>Precision X-Y-Z manipulator for accurate emitter positioning</li><li>Sliding rail design allows fast emitter access and replacement</li><li>Integrated camera, monitor, and illumination simplify emitter alignment</li><li>Supplied as a complete kit with accessories for immediate installation</li></ul><h3>Instrument Compatibility</h3><h4>Original Nanospray Flex Ion Source</h4><ul><li>Thermo Scientific™ LCQ Deca XP MAX™, LTQ™-series, and Velos™-series ion trap mass spectrometers</li><li>Thermo Scientific™ LTQ Orbitrap™-series and Orbitrap Velos™-series hybrid ion trap-Orbitrap mass spectrometers</li><li>Thermo Scientific™ Exactive™-series Orbitrap mass spectrometers</li><li>Thermo Scientific™ Q Exactive™-series hybrid quadrupole-Orbitrap mass spectrometers</li><li>Thermo Scientific™ TSQ Quantum™-series and TSQ Vantage™ triple-stage quadrupole mass spectrometers</li></ul><h4>Nanospray Flex NG</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/562">Thermo Scientific™ Orbitrap Fusion™ Tribrid™ mass spectrometer</a></li><li>Thermo Scientific™ TSQ Endura™ triple-stage quadrupole mass spectrometer</li></ul>

Thermo Scientific EASY-Spray Sources

Thermo Scientific™ EASY-Spray™ Sources are integrated nano-electrospray ion sources for nano-LC-MS featuring a temperature-controlled column-emitter assembly for stable ionization, excellent reproducibility, and simplified installation.

Thermo Scientific™ EASY-Spray™ Sources are integrated nano-electrospray ion sources designed for nanoflow LC-MS. Their temperature-controlled column-emitter assembly and single nanoViper™ connection simplify nanoLC-MS operation while delivering highly reproducible separations, stable spray performance, and high LC-MS sensitivity<h4>Integrated Design</h4><ul><li>Integrated temperature-controlled column and emitter assembly</li><li>Single nanoViper™ connection between the LC system and ion source</li><li>Integrated zero-dead-volume (ZDV) connections minimize dead volume</li><li>Simple plug-and-spray installation with quick column replacement</li></ul><h4>Chromatographic Performance</h4><ul><li>Stable nano-electrospray ionization for reliable LC-MS analysis</li><li>Supports long columns and small particle sizes for high peak-capacity separations</li><li>Column heating (30–60 °C) reduces solvent viscosity and backpressure</li><li>Ultra-sharp chromatographic peaks improve separation efficiency</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EASY_Spray_Sources_4_361e3bad42.jpg" alt="Thermo Scientific EASY-Spray Sources: The entire assembly is designed for heavy use so you can utilize the full pressure range of your UHPLC front-end (up to 1000 bar) and benefit from small particles and long columns. Longer columns and longer gradients both contribute to more identifications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EASY_Spray_Sources_4_361e3bad42.jpg 229w," sizes="100vw" width="921" height="628"><h4>Reproducibility</h4><ul><li>Stable performance during extended analytical operation</li><li>Excellent run-to-run reproducibility</li><li>Outstanding column-to-column reproducibility for large studies and multi-site laboratories</li></ul><h4>Ease of Use</h4><ul><li>Plug-and-spray operation requiring minimal setup</li><li>Integrated camera provides an illuminated, magnified view of the emitter tip</li><li>Eliminates the most error-prone nanoLC connections</li></ul><h4>Compatibility</h4>Compatible with Thermo Scientific EASY-Spray columns and selected Thermo Scientific nanoLC systems and mass spectrometers, including:<ul><li>Thermo Scientific™ LCQ Deca XP MAX™, LTQ™-series, and Velos™ series ion trap mass spectrometers</li><li>Thermo Scientific™ LTQ Orbitrap™-series and Orbitrap Velos™ series hybrid ion trap-Orbitrap mass spectrometers</li><li>Thermo Scientific™ Exactive™ series Orbitrap mass spectrometers</li><li>Thermo Scientific™ Q Exactive™ series hybrid quadrupole-Orbitrap mass spectrometers</li><li>Thermo Scientific™ TSQ Quantum™ series and TSQ Vantage™ triple-stage quadrupole mass spectrometers</li></ul>The EASY-Spray NG ion source works in conjunction with the latest next-generation Thermo Scientific mass spectrometers:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/562">Thermo Scientific™ Orbitrap™ Fusion™ Tribrid™ Mass Spectrometer</a></li><li>Thermo Scientific™ TSQ Endura™ Triple-stage Quadrupole Mass Spectrometer</li><li>Thermo Scientific™ TSQ Quantiva™ Triple-stage Quadrupole Mass Spectrometer</li></ul>

Thermo Scientific OptiSpray Ion Source

The Thermo Scientific™ OptiSpray™ Ion Source is an intelligent ESI interface for nano- and capillary LC-MS, combining automated spray optimization, high sensitivity, reproducibility, and easy operation with the OptiSpray™ Cartridge system.

The Thermo Scientific™ OptiSpray™ Ion Source is an intelligent electrospray ionization interface designed to simplify the acquisition of high-quality, reproducible nano- and capillary LC-MS data. Compatible with the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/398">Thermo Scientific™ Vanquish™ Neo UHPLC system </a>and the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3">Thermo Scientific mass spectrometers </a>portfolio, it combines automated spray optimization with cartridge-based nano and capillary columns to deliver high sensitivity, quantitative accuracy, precision, and robust performance for discovery and targeted assays.<h4>High Performance</h4>The OptiSpray™ ion source combines optimized fluidics with integrated temperature and sheath gas control to ensure stable, reproducible electrospray ionization. Automated spray positioning helps deliver reproducible, high-quality analytical results with or without the FAIMS interface.<h4>Simple and Automated Operation</h4>Designed for ease of use, the OptiSpray™ system features plug-and-play cartridge installation that virtually eliminates manual setup of nano and capillary columns. Automated spray optimization further simplifies operation, while onboard cartridge memory stores cartridge properties, usage data, and previous source settings, enabling rapid setup and consistent ESI performance over time.<h4>Reliable and Reproducible Results</h4>The source enhances robustness by automatically moving the spray to an inactive position between injections, helping maintain a cleaner MS system. Exchangeable emitters extend column lifetime, while automated spray positioning, cartridge memory, and integrated nebulization gas boost contribute to run-to-run and intercolumn reproducibility.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Opti_Spray_Ion_Source_2_fd937ef73f.jpg" alt="Thermo Scientific OptiSpray Ion Source" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Opti_Spray_Ion_Source_2_fd937ef73f.jpg 156w," sizes="100vw" width="650" height="650"><h3>Key Features</h3><ul><li>Intelligent electrospray ionization interface for nano- and capillary LC-MS</li><li>Automated spray optimization for consistent ESI performance</li><li>Plug-and-play cartridge installation with minimal manual setup</li><li>Optimized fluidics with integrated temperature and sheath gas control</li><li>Automated spray positioning</li><li>Compatible with or without the FAIMS interface</li><li>Onboard cartridge memory storing cartridge properties, usage data, and previous source settings</li><li>Automatic inactive spray position between injections for improved system robustness</li><li>Exchangeable emitters to extend column lifetime</li><li>Integrated nebulization gas boost for improved reproducibility</li><li>Designed for discovery and targeted assays</li></ul>

Products from category MS accessories - page 1

Related content

Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer

ISC 2026 Starts in One Week: What You Need to Know

Wiley Releases Database Combining Two of the World’s Most Trusted Chemical Identification Resources