The timsTOF Ultra 2 enables systematic understanding of ubiquitination and degradation kinetics of degrader drug targets using slice-PASEF acquisition schemes

Parallel accumulation – serial fragmentation combined with data-independent acquisition (diaPASEF) The timsTOF Pro with diaPASEF enables deeper proteome coverage in a single 4D shotgun proteomics experiment, with highly reproducible qualitative and quantitative results – making it a near-ideal mass analyzer…

ASMS2025, TP202 Optimizing Selectivity and Ion Utilization for Trapped Ion Mobility Spectrometry for Enhanced DIA Performance Markus Lubeck1, Andreas Schmidt1, Stephanie Kaspar-Schoenefeld1, Matt Albano2, Cory Lytle2, Dijana Vitko2, Matthew Willetts2, Daniel Hornburg3 1Bruker Daltonics GmbH & Co. KG, Bremen, Germany,…

Skyline Support for Proteome-wide Data Analysis of Bruker timsTOF dia-PASEF Acquisition Brian S. Pratt1, Matthew C. Chambers1, Stephanie Kaspar-Schoenefeld2, Sven Brehmer2, Markus Lubeck2, Ute Distler3, Stefan Tenzer3, Michael J. MacCoss1, Brendan X. MacLean1 of Washington, Department of Genome Sciences, 2Bruker…

ASMS2025, TP192 Benchmarking diagonal-PASEF data acquisition for high-throughput proteomics applications Christopher Below1, Oliver M. Bernhardt1, Stephanie Kaspar-Schoenefeld2, Roland Bruderer1, Shourjo Ghose3, Tejas Gandhi1, Jonathan Krieger4, Markus Lubeck2, Lukas Reiter1 More details: 1Biognosys AG, Zurich, Switzerland, 2Bruker Daltonics GmbH & Co…