Exploring the SEC Analysis of CRISPR Molecules and Their Complexes

Application Note Multiple Quality Attribute Characterization of a Ribonucleoprotein Complex by SEC-MALS Katayoun Morakabia, Sophia Kenricka, Matthew Gardnerb a Waters Corporation, United States b Scribe Therapeutics, United States Published on June 12, 2026 Abstract Size-exclusion chromatography coupled with multi-angle light…

Application Note Optimizing IP-RP CRISPR sgRNA Purification Passes With High Efficiency Oligonucleotide Certified BEH 300 Å C18 5 µm Preparative Sorbent Amy Howie, Mandana Fasth, Chris Boggess, Matthew A. Lauber Oligo Factory, Waters Corporation Abstract CRISPR technology, which utilizes single-guide…

Application Note CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column Maissa M. Gaye, Chris Knowles, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract The high speed, low cost, and reduced need…

RNA Analysis for CRISPR by capillary electrophoresis with laser-induced fluorescence detection CE-LIF Jane Luo, Tingting Li, Marcia Santos, Fang Wang, Sahana Mollah and Handy Yowanto SCIEX Separations, Brea, California Introduction CRISPR (clustered regularly interspaced short palindromic repeats) is an immunological…