Size and Purity Assessment of Single-Guide RNAs by Anion-Exchange Chromatography (AEX)

Application Note Separation and Size Assessment of dsDNA Fragments by Anion-Exchange Chromatography (AEX) Hua Yang, Stephan M. Koza, Weibin Chen Waters Corporation Abstract Reliably separating dsDNA species and assessing their sizes are important analytical tasks in the fields of cell…

RNA Analysis for CRISPR by capillary electrophoresis with laser-induced fluorescence detection CE-LIF Jane Luo, Tingting Li, Marcia Santos, Fang Wang, Sahana Mollah and Handy Yowanto SCIEX Separations, Brea, California Introduction CRISPR (clustered regularly interspaced short palindromic repeats) is an immunological…

Application Note Cursory Analysis of Nucleic Acid Components in Adeno-Associated Virus (AAV) Samples Using Anion-Exchange Chromatography (AEX) Hua Yang, Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract It is important to analyze adeno-associated virus (AAV) therapeutics for contaminating nucleic…

Application Note High-Resolution Separations of Single and Double-Stranded Nucleic Acids Using Strong Anion-Exchange Chromatography Abraham S. Finny, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation, United States Published on November 18, 2025 Abstract High-Resolution Separations of Single and Double-Stranded Nucleic Acids…