High-Resolution Separations of Single and Double-Stranded Nucleic Acids Using Strong Anion-Exchange Chromatography

Best Poster Award Participant (Poster #304) Strong Anion-Exchange HPLC for Size-Range and Topology-Resolved Analysis of Nucleic Acids Abraham S. Finny*, Fabrice G. Gritti, Balasubrahmanyam Addepalli, Matthew A. Lauber *[email protected] Waters Corporation, Milford, MA, USA Strong AEX resolves nucleic acids from…

Application Note Slalom-Aided Anion Exchange Chromatography for Enhanced Analysis of Plasmid DNA Topological Impurities Abraham S. Finny, Fabrice Gritti, Szabolcs Fekete, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation, United States Published on July 23, 2025 Abstract Slalom-Aided Anion Exchange Chromatography…

Application Note Separation and Size Assessment of dsDNA Fragments by Anion-Exchange Chromatography (AEX) Hua Yang, Stephan M. Koza, Weibin Chen Waters Corporation Abstract Reliably separating dsDNA species and assessing their sizes are important analytical tasks in the fields of cell…

Application Note Size and Purity Assessment of Single-Guide RNAs by Anion-Exchange Chromatography (AEX) Hua Yang, Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract Single-guide RNA (sgRNA) is a critical element in the CRISPR/Cas9 Technology for gene editing, the size…