Extensive LC-Top-Down MS Sequence Confirmation of the NISTmAb Reference Material 8671

Next-generation MALDI top-down sequencing of protein biotherapeutics – expanding the scope of timsTOF technology Next-generation MALDI top-down sequencing (MALDI-TDS) improves top-down sequence analysis of biopharmaceutical proteins, as demonstrated in this note for adalimumab subunits, recombinant SARS-CoV-2 S-glycoprotein RBD expression products,…

Recombinant SARS-CoV-2 Receptor Binding Domain: Comprehensive Top-Down Sequence Confirmation, Curation and O-Glycosylation Site Determination Know your SARS-CoV-2 antigen structure before it´s use in research and diagnostics Abstract The COVID pandemic dramatically influences our life and the demand remains very high…

AS M S 2 0 2 5 W P - 5 7 8 In-Depth Protein Sequence Verification by TIMS-enabled MALDI Top-Down Sequencing Detlev Suckau1, George Alevizos2, Georgia Orfanoudaki2, Guillaume NH3 Evers1, Arndt Asperger1 1Bruker Daltonics GmbH & Co. KG, Bremen,…

Rapid-Turnaround Top-Down Sequence Verification and Characterization of Modified Proteins and Oligonucleotides Using a Benchtop MALDI-TOF/TOF Instrument Sinduri Vuppala1, Savannah Snyder1, Arndt Asperger2 1 Bruker Scientific LLC, Billerica, MA, USA 2 Bruker Daltonics GmbH & Co. KG, Bremen, Germany Results i)…