Why Biologics QC Is So Much Harder Than Small Molecule Pharma
Colette Quinn discusses how LC, high-resolution MS, light scattering, automation and data literacy are transforming QA/QC for increasingly complex biologics.
A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water
A two-stage liquid–liquid extraction method enables sensitive, reproducible analysis of ultrashort PFCAs such as TFA and longer-chain PFAS in water.
Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer Patients
Mass spectrometry-based lipidomics identifies distinct plasma lipid changes linked to long-term aromatase inhibitor therapy in postmenopausal breast cancer patients.
Residue-Level Determination of Small-Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry
This study introduces an HDX-MS titration workflow for quantifying protein–ligand affinities at global, peptide, and residue resolution.
Tracking Protein Misfolding and Oligomerization: A Temperature-Controlled Ion Mobility-Mass Spectrometry Approach
This study uses temperature-controlled IM-MS to monitor protein unfolding and oligomer formation in real time, revealing early aggregation pathways.
Comparative Evaluation of Total Ergot Alkaloids Determination by ELISA and UHPLC-MS/MS in Wheat: Implications of Cross-Reactivity and Matrix Effects
This study compares ELISA and UHPLC-MS/MS for ergot alkaloid analysis, highlighting the effects of cross-reactivity and sample matrix.
LCMS-Net: Deep Learning for Raw High Resolution Mass Spectrometry Data Applied to Forensic Cause-of-Death Screening
LCMS-Net is an end-to-end deep learning model for raw LC-HRMS data, improving accuracy, reducing preprocessing, and minimizing batch effects in metabolomics.
