Whether a drug can effectively bind to its target protein, or how different parts of a virus or a cell interact, depends on processes taking place at the level of individual molecules. Their behaviour is determined not only by their shape, but also by the electrostatic forces acting between them. Understanding how these forces are distributed helps scientists explain why certain molecules attract each other, how they bind and how they interact.This is where the <a target="_blank" rel="noopener noreferrer" href="https://acc.biodata.ceitec.cz/">Atomic Charge Calculator (ACC)</a> comes in. Researchers at Masaryk University have been developing this computational tool for more than a decade. Its third and most advanced generation to date was developed at CEITEC Masaryk University and the Faculty of Science at Masaryk University, in collaboration with the Faculty of Informatics at Masaryk University and Palacký University Olomouc.ACC III calculates the electric charges of individual atoms and visualises their distribution directly within three-dimensional molecular structures. It brings together twenty different calculation methods in a single environment and can work with a wide range of molecules – from small organic compounds to proteins and other large biomolecular structures.A key advantage of Atomic Charge Calculator III is that it combines a broad range of computational methods with ease of access. Basic calculations can be performed directly in a web browser, with no need to install specialised software or register for an account. The resulting charges can be displayed directly on a 3D model of the molecule. For advanced users and large-scale analyses, the platform also supports automated data processing and allows its computational core to be run locally.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_d32d7bd2cd.jpg" alt="CEITEC/Biological Data Management and Analysis Core Facility: What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible: Oseltamivir bound to influenza virus neuraminidase (blue: positive partial charges, red: negative charges). A strong electrostatic interaction occurs between a negatively charged region of the drug and positively charged regions of the protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_d32d7bd2cd.jpg 140w," sizes="100vw" width="1600" height="1786"><h3>Why are scientists interested in the electric charges of atoms?</h3>Electrons are not distributed evenly within molecules. Individual atoms can therefore carry different partial electric charges. These charges play an important role in determining how molecules behave towards their surroundings and towards one another.Positively and negatively charged regions of molecules can attract each other, while regions with the same charge repel each other. The distribution of these charges therefore helps determine which molecules approach each other, how they orient themselves and how strongly they may bind. In biology, this is important, for example, in molecular recognition or when a drug binds to its target protein. Understanding partial charges therefore helps scientists gain insight into the interactions underlying the behaviour of many molecular systems.There is, however, no single universal way to determine partial charges. Different computational methods can produce different values, and the choice of method also depends on how the results will be used. Accurate quantum-chemical calculations can also become very computationally demanding when large numbers of structures are involved. ACC III therefore brings together empirical methods that allow these calculations to be performed more quickly and on a large scale.“From the outset, we designed ACC III to make calculating partial atomic charges as straightforward as possible. Users do not need to install anything or deal with complicated settings – they simply upload a molecule and start the calculation with a single click. The application then suggests suitable methods from the twenty available and can handle both small molecules and large biomolecular structures,” says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/tomas-racek-ph-d/u94476?page=publication">Tomáš Raček</a>, who has been developing and maintaining ACC since 2018.<h3>How an antiviral drug binds to an influenza virus protein</h3>The authors demonstrate what charge distribution can reveal using the well-known antiviral drug oseltamivir, marketed as Tamiflu. The drug binds to neuraminidase, a protein of the influenza A virus. ACC III can show directly within the three-dimensional structure where positive and negative partial charges are located and how they contribute to the interaction between the drug and the protein.“The example of oseltamivir clearly shows why it is useful not only to calculate the charges, but also to visualise them directly within the structure. This allows us to see which parts of the two molecules interact electrostatically. The same approach can be used to study many other molecular systems,” explains Tomáš Raček.ACC III is not limited to small molecules. It can also work with proteins and other large biomolecular structures. The authors demonstrate this using a second example: the SARS-CoV-2 pore complex. Coronaviruses form these pores during replication in infected cells and use them to transport viral RNA across membranes. Visualising partial charges helps distinguish the parts of the complex that pass through the non-polar environment of the membrane from its more highly charged regions.<h3>From calculation straight to a 3D model</h3>The new generation of the Atomic Charge Calculator also offers more advanced visualisation. It uses Mol*, which allows calculated charges to be mapped directly onto a three-dimensional structure and explored interactively. A visualisation created using ACC III was also selected for the cover of the special Nucleic Acids Research Web Server Issue. Created by Tomáš Raček, the cover image shows the distribution of partial charges in a membrane protein system.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_3_85cc310925.jpeg" alt="CEITEC/Oxford University Press: What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible: Cover page in Nucleic Acids Research journal." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_3_85cc310925.jpeg 124w," sizes="100vw" width="1600" height="2011">Results can be downloaded in several standard formats and, for the first time, stored directly in the mmCIF format commonly used for three-dimensional biomolecular structures. Information about the structure and its calculated charges can therefore remain together in a single file and be used by other tools.For researchers who need to process large numbers of structures, ACC III also provides an API and a computational core that can be run locally. The platform can therefore be used both for individual calculations through its web interface and as part of larger automated analyses.<h3>More than a decade of development</h3>Scientists introduced the first Atomic Charge Calculator in 2015, followed by its second generation in 2020. In the meantime, the team also developed specialised tools: PDBCharges for structures from the Protein Data Bank and AlphaCharges for structures from the AlphaFold Database.“The Atomic Charge Calculator was never a one-off project,” says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/prof-radka-svobodova-ph-d/u17518?page=publication">Radka Svobodová</a>, Head of the Biological Data Management and Analysis Core Facility at CEITEC Masaryk University. “For more than a decade, we have been continuously developing tools that respond both to new possibilities in structural bioinformatics and to the needs of their users. The third generation combines straightforward web-based use with capabilities that are important for the automated processing of large numbers of molecular structures.”<blockquote>Atomic Charge Calculator III is freely available through its web interface and does not require registration for basic use. Its development was supported by the ELIXIR CZ research infrastructure.</blockquote><h5>The authors presented the new generation of the tool in <a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/W1/W211/8662890">Nucleic Acids Research</a>.</h5>

What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible 

Not every concentration job can tolerate heat — and not every concentrator that handles heat well can handle cold. <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2441">Refrigerated centrifugal vacuum concentrators</a> exist for a specific reason: proteins, RNA, enzymes, and synthetic peptides degrade quickly under thermal stress, and standard concentrators that rely on heat alone can compromise sample integrity before evaporation finishes. We compared two of the leading refrigerated systems — the Labconco Refrigerated CentriVap and the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2611">Thermo Fisher Refrigerated SpeedVac SRF110</a> — to see how they stack up for labs where sample preservation is non-negotiable.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac">Download the full comparison with pricing here!</a></blockquote><h3>The Problem Refrigeration Actually Solves</h3>It's a detail that gets lost in most spec-sheet comparisons: running a<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?manufacturerItems=540&amp;search=centrivap"> vacuum concentrator </a>without temperature control can cause a sample to over-cool itself. As solvent evaporates under vacuum, the process pulls latent heat from the sample — the same evaporative cooling effect that makes sweat feel cold on skin. For a heat-stable solvent, that's irrelevant. For a temperature-sensitive biomolecule, it can drop the sample low enough to risk unwanted freezing or sublimation mid-run. Labconco's own engineering notes for the Refrigerated CentriVap describe this directly: the unit pairs a refrigeration system with a heater so operators can hold a precise set-point temperature and avoid sublimated samples caused by evaporative cooling. That's the whole reason this product category exists, and it's worth understanding before comparing specs line by line.<h3>Price: A Wider Gap at the High End</h3>The Labconco Refrigerated CentriVap is typically priced around $13,000 USD. The Thermo Fisher SRF110 runs higher, generally $15,000–$17,000 USD, and that's before factoring in the modular kit components — Thermo Fisher sells the SRF110 with a separate vacuum system, rotor, vapor trap, and heat transfer fluid bundled into the total kit price. The price gap between these two refrigerated units is proportionally larger than what we found comparing their non-refrigerated counterparts, which makes the value case for the CentriVap even more pronounced at this tier.<h3>Capacity: The Difference That Matters Most Right Now</h3>This is where the two systems really separate, and it lines up with where lab demand is heading. The Refrigerated CentriVap processes up to 312 samples per run; the SRF110 tops out at 132. Both handle volumes up to 50 mL, so this isn't a volume trade-off the way it was in our earlier comparison — it's a straight throughput advantage for the CentriVap.That gap matters because<a target="_blank" rel="noopener noreferrer" href="https://peptidestaff.com/industry-trends/peptide-therapy-market-forecast-2026/"> peptide-based therapeutics </a>have become one of the fastest-growing classes of drugs in the pharmaceutical industry, and manufacturing capacity — not demand — is widely cited as the primary bottleneck holding the sector back. <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7541">GLP-1 programs</a> in particular are pushing <a target="_blank" rel="noopener noreferrer" href="https://www.bachem.com/knowledge-center/glp-1-demand-for-peptide-manufacturers/">peptide manufacturers</a> toward industrialized, large-scale production platforms rather than one-off batch work. <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/">Sample prep equipment</a> sits squarely inside that bottleneck: every purification run, HPLC fraction, and concentration step has to scale alongside the chemistry. A concentrator that processes more than double the samples per run, like the Refrigerated CentriVap, is a meaningfully different proposition for a peptide synthesis or purification lab than it would have been five years ago.<h3>Temperature Range: How Cold You Can Go</h3>The CentriVap's refrigeration reaches as low as -10°C; the SRF110 bottoms out at -4°C. Both units heat up to +100°C. That six-degree gap on the cold end isn't dramatic on paper, but for the most heat-labile peptides and enzymes, the lower floor gives operators more margin before a sample is at risk — particularly during longer runs where evaporative cooling has more time to compound any thermal load on the sample.<h3>Vortex Speed and Mechanical Flexibility</h3>The CentriVap offers an adjustable vortex range from 500 to 1,800 rpm, while the SRF110 runs up to 1,725 rpm. The CentriVap's lower floor is the more useful distinction here — fragile, large, or shear-sensitive samples (think intact proteins or larger peptide constructs) sometimes need to run at reduced rotor speed to avoid mechanical stress, and the CentriVap gives operators that headroom on both ends rather than just a ceiling.<h3>Lid Material: Visibility vs. Durability</h3>The Refrigerated CentriVap uses a glass lid, letting operators see into the chamber during a run. The SRF110 uses an epoxy-coated aluminum lid, which trades visibility for added durability. For labs running visually distinct sample batches — colored buffers, multiple project codes, HPLC fractions pulled at different time points — the ability to glance at the chamber without interrupting a run has real workflow value, especially in a core facility setting where one instrument serves multiple research groups.<h3>What This Means for Core Facilities</h3>Shared instrumentation cores feel throughput and cold-temperature constraints differently than a single-PI lab does. A<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/an-appreciation-for-academic-core-labs"> core running samples from multiple research groups </a>— some doing routine RNA cleanup, others running heat-labile peptide fractions from an HPLC purification step — needs an instrument that won't bottleneck on either axis. The CentriVap's combination of higher per-run capacity and a lower refrigeration floor gives a shared facility more room to serve mixed workloads without forcing every group onto the same conservative settings a less flexible unit would require.<h3>Built for the Same Footprint</h3>Both units are sized for fume hood placement, with the CentriVap measuring 15.0 x 27.2 x 13.9 inches against the SRF110's 16.62 x 25 x 13.75 inches — close enough that floor planning isn't a deciding factor either way. Both carry standard one-year warranties.<h3>The Bottom Line</h3>For labs concentrating proteins, RNA, enzymes, or peptide fractions at scale — particularly anyone supporting peptide therapeutic development, where production capacity is already the limiting factor industry-wide — the Labconco Refrigerated CentriVap's combination of higher throughput, lower cold-temperature floor, and lower price makes it the stronger fit. The SRF110 remains a capable option for labs with smaller batch sizes already standardized on Thermo Fisher's modular vacuum ecosystem.Organomation distributes the full Labconco CentriVap line, including the Refrigerated and Refrigerated Pro models. Contact our team at sales@organomation.com to talk through rotor configuration, cold trap pairing, and throughput planning for your lab.&nbsp;<blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac">Download the full comparison with pricing here!</a></h5></blockquote>

Refrigerated SpeedVac SRF110 vs. CentriVap - Why Sample Capacity Matters More Than Ever for Peptide and Protein Labs

What if you could assess a tumor's metastatic potential — without extensive sample prep — directly from tissue? Rachel Wood is working on exactly that.Rachel Wood is a PhD candidate at Queen's University (Kingston, Ontario),&nbsp;working jointly in the labs of Dr. Richard Oleschuk (Chemistry) and Dr. Chris&nbsp;Nicoll (Pathology &amp; Molecular Medicine). Her research applies Ambient Ionization Mass Spectrometry — specifically the Liquid Microjunction Surface Sampling Probe &nbsp;(LMJ-SSP) and Desorption Electrospray Ionization (DESI) — to profile the metabolomics of non-metastatic and metastatic clear cell Renal Cell Carcinoma (ccRCC) cell lines. The long-term goal: a rapid, minimally invasive MS-based prognostic tool for kidney cancer.This is the first reported use of LMJ-SSP to assess metastatic status in ccRCC —&nbsp;and early PCA results are already showing distinct separation between cell line&nbsp; profiles.<h5>In this episode, David and Rachel cover:</h5><ul><li>Why ccRCC is such a resistant biomarker problem despite active genomic, proteomic, and metabolomic research</li><li>The clinical stakes of "diagnosed by accident" — and what a prognostic biomarker actually needs to do for a clinician</li><li>How AIMS complements (not replaces) LC-MS in a discovery-phase cancer workflow</li><li>LMJ-SSP vs. DESI: what each technique sees that the other misses, including spatial resolution differences (~1mm vs. ~50µm)</li><li>Why Rachel runs LMJ-SSP on both a triple quad and a Q-TOF — and what each instrument contributes to the same research question</li><li>How her lab repurposed a 3D printer as a custom automated XYZ sampling stage with 50µm movement precision</li><li>Managing high-dimensional metabolomics data across two polarities, two cell lines, and two mass analyzers — the pipeline explained</li><li>What unsupervised machine learning (PCA) showed in early results</li><li>The path from cell lines to excised tumor tissue to, ultimately, liquid biopsies</li><li>Advice for analytical chemists considering work at the chemistry–oncology interface</li></ul><h3>Video Transcription</h3>Kidney cancer remains a difficult biomarker problem, particularly when researchers try to distinguish tumors that are likely to behave aggressively from those that are not. In a recent episode of Concentrating on Chromatography, PhD researcher Rachel Wood discussed how she is combining rapid ambient ionization mass spectrometry, LMJ-SSP, DESI, multivariate data analysis, and conventional LC-MS workflows to investigate the molecular differences associated with clear cell renal cell carcinoma and its metastatic potential.<h4>Returning to the research question that started it all</h4>Wood first encountered kidney cancer research during her undergraduate studies. Although she later moved into a more instrumentation-focused master’s project involving breast cancer, the subject of kidney cancer remained unfinished business.When the opportunity arose to choose a PhD project, she returned to the field that had originally sparked her interest in research. She is now conducting her doctoral work at Queen’s University in Kingston, Ontario, in an interdisciplinary environment spanning chemistry, pathology, molecular medicine, computer science, and clinical research.<h4>Why clear cell renal cell carcinoma is such a difficult biomarker problem</h4>Wood’s research focuses on clear cell renal cell carcinoma (ccRCC), which represents the majority of kidney cancer cases discussed in the interview.The difficulty is not a lack of research effort. Genomics, proteomics, and metabolomics studies have all produced promising biomarker candidates. The challenge is that different studies often identify different sets of markers, with relatively little overlap between them.Patient-to-patient biological variability further complicates the picture. A candidate biomarker panel that performs well in one cohort may not reproduce equally well in another. Selecting which features deserve further investigation therefore becomes a major analytical and biological challenge.<h4>From incidental diagnosis to prognostic information</h4>Another difficulty is the way kidney cancer is often discovered.Rather than being detected through a dedicated screening program, tumors may be found incidentally during imaging performed for another reason. According to Wood, the ideal solution would be a diagnostic biomarker capable of detecting kidney cancer early. Such a marker is not currently available within the scope of the work she described.That places additional importance on prognostic biomarkers. Once a tumor has been detected, clinicians need as much information as possible about how aggressive it may be and how likely it is to progress.Wood’s current work is therefore not attempting to declare directly that a particular patient has metastatic disease. Instead, the goal is to understand what changes biologically as a tumor moves from a less aggressive to a more aggressive state.That means asking which molecular pathways change, which mechanisms become altered, and which analytes may eventually provide useful indicators of tumor behavior.<h4>AIMS and LC-MS answer different questions</h4>A central theme of the interview was the relationship between rapid ambient ionization mass spectrometry and conventional LC-MS.Wood is clear that AIMS is not intended to replace LC-MS. Instead, she sees the two approaches as complementary.AIMS provides a rapid way to obtain a broad molecular overview of a sample with minimal preparation. This makes it especially useful during the discovery phase, when the goal is to gather as much molecular information as possible and identify features that distinguish biological groups.LC-MS then becomes valuable when those features need to be separated, characterized more carefully, and quantified with greater confidence.In Wood’s workflow, rapid MS screening can therefore help identify which analytes deserve closer attention before more targeted LC-MS investigations are performed.<h4>What “minimal sample preparation” actually means</h4>The amount of sample preparation required depends strongly on the type of material being analyzed.Wood currently works mainly with cultured human cell lines, which means much of the preparation begins with growing the cells themselves. Depending on the experiment, the cells may then be chemically lysed or subjected to fixation, paraffin embedding, and sectioning before analysis by LMJ-SSP or DESI.She also notes that the possibilities would be different for freshly excised tumor material. In an appropriate perioperative or biosafety laboratory setting, LMJ-SSP could potentially be used to analyze tumor margins more directly.The practical meaning of “minimal preparation” is therefore highly dependent on the sample and the analytical question being asked.<h4>Why combine LMJ-SSP and DESI?</h4>Rather than choosing between LMJ-SSP and DESI, Wood uses the two approaches because they provide different types of information.LMJ-SSP offers rapid, localized analysis and can accommodate samples with uneven surface topography, which is particularly useful for excised tissue.DESI, by contrast, provides substantially higher spatial resolution. In the workflow described in the interview, DESI can achieve spatial resolution on the order of tens of micrometers, whereas LMJ-SSP operates at a much larger sampling scale depending on probe design.That higher spatial resolution is important when moving from simplified cell-line models toward actual tumor tissue, where the molecular organization of different regions may reveal biologically relevant differences.Combining both techniques therefore enables researchers to balance speed, surface compatibility, and spatial information.<h4>Two mass analyzers for two parts of the same problem</h4>Wood also uses two different mass spectrometers in her LMJ-SSP work.Most of the discovery work is carried out using a triple quadrupole mass spectrometer, particularly because her project focuses strongly on lower-mass analytes and small molecules.Once statistically important analytes have been identified, a Q-TOF instrument can be used for MS/MS experiments and tentative structural identification.The two instruments therefore address different stages of the workflow: one supports broad discovery and comparison, while the other provides additional structural information needed to connect selected features with possible metabolic pathways.<h4>Turning a 3D printer into an automated sampling platform</h4>One of the most unusual elements of the project is the automated sampling system used with LMJ-SSP.Historically, LMJ-SSP measurements could be performed manually or with custom-built XYZ positioning stages. Wood’s laboratory instead adapted a 3D printer into an automated positioning system.Custom software controls the printer and moves the sampling probe with precise control over its X, Y, and Z positions. According to Wood, the system enables movements down to approximately 50 µm and also controls parameters such as the contact time between the probe and sample and the delay between consecutive sampling events.This level of automation improves reproducibility because variables that would otherwise depend on manual operation can be controlled systematically.Even the Z-position can be programmed, allowing the probe to operate at constant or varying heights depending on the sample surface.<h4>Managing high-dimensional MS data</h4>The experimental design creates a large data-analysis challenge.Wood is working with multiple cell lines, both ionization polarities, and more than one mass analyzer. To maintain traceability, she analyzes the data in clearly defined subsets.A typical workflow might begin with one mass analyzer and one polarity. Within that condition, the lower-aggressiveness and higher-aggressiveness cell models can then be compared directly.The data processing pipeline includes steps such as:<ul><li>binning,</li><li>normalization,</li><li>transformation,</li><li>dimensionality reduction,</li><li>identification of discriminating molecular features.</li></ul>Once relevant features are identified, MS/MS analysis can be used to investigate them further. The same process is then repeated across other polarities and instruments.<h4>Unsupervised machine learning reveals distinct molecular profiles</h4>Machine learning is particularly valuable because the AIMS datasets are highly dimensional, containing very large numbers of molecular features across multiple samples.Wood’s initial analysis has included principal component analysis (PCA), an unsupervised dimensionality-reduction technique.The early results are encouraging: the non-metastatic and metastatic cell-line models separate clearly in PCA space.That does not itself identify a definitive biomarker panel, but it indicates that the two biological states have distinguishable molecular profiles even though both belong to the same kidney cancer subtype.This provides an important foundation for identifying which specific metabolites or molecular pathways may be responsible for the separation.<h4>Testing LMJ-SSP for metastatic status</h4>A particularly novel aspect of Wood’s project is the use of LMJ-SSP to investigate differences associated with metastatic status.She had previously worked on distinguishing healthy and cancerous tissues, where the biological differences are relatively large. Comparing two states within the same cancer type is more demanding because the molecular changes may be much subtler.The scientific motivation, however, is strong. Tumors discovered at later stages carry greater concern for metastatic progression, making it important to understand the molecular changes associated with increasingly aggressive behavior.For Wood, this made the methodological risk worthwhile: the analytical challenge directly addresses an area where better prognostic information could ultimately have clinical value.<h4>A long-term goal: rapid MS-based prognostic testing</h4>The long-term vision extends beyond cell-line research.Wood is interested in whether rapid, minimally invasive mass spectrometry could eventually contribute to clinical decision-making.One possibility would be identifying a diagnostic biomarker in a liquid biopsy, potentially using blood or urine. A urine-based marker capable of contributing to earlier detection would be particularly attractive for kidney cancer.For prognostic applications, the goal would be slightly different. Once a tumor is discovered, molecular information could help characterize its likely behavior and provide clinicians with additional evidence when deciding between immediate treatment, surgery, or other management strategies.Wood emphasizes that such a tool would not replace standard clinical workflows. Instead, it would provide additional molecular information to complement existing diagnostic and pathological approaches.<h4>Why interdisciplinary work matters</h4>Throughout the interview, Wood repeatedly returns to the importance of collaboration.Her research sits at the intersection of analytical chemistry, pathology, oncology, computation, and clinical medicine. No single researcher can remain equally current in all of these fields.Working closely with pathologists, computer scientists, surgeons, medical students, and other specialists therefore provides both scientific expertise and a way to stay connected with developments outside one’s immediate discipline.For Wood, the biological context has also changed how she thinks about analytical chemistry. Developing a new instrument or method is important, but understanding who may ultimately benefit from that analytical capability makes the research more meaningful.That patient-centered perspective is now an integral part of how she approaches the project.<h4>An intersection full of opportunities</h4>Wood describes the interface between analytical chemistry and oncology as an especially exciting area for young researchers.The work can range from troubleshooting instrumentation to interpreting pathology, developing statistical methods, and collaborating across disciplines. That diversity creates constant opportunities to learn and to apply analytical chemistry to clinically relevant questions.Her project illustrates that modern mass spectrometry research is increasingly about more than generating spectra. It involves connecting instrumentation, spatial sampling, multivariate statistics, machine learning, biological interpretation, and clinical needs into a single analytical strategy.And in kidney cancer, where reliable prognostic biomarkers remain difficult to establish, that integrated approach may be particularly valuable.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

AIMS vs. LC-MS for Cancer Diagnostics: ccRCC Metabolomics with Rachel Wood

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Characterization of polymers (Watrex)

Watrex Prague offers laboratory characterization of polymers using GPC.

<h4>WI08112 – Determination of Molecular Weight Distribution of Polymeric Materials</h4><ul><li>Determination by GPC method in water and THF, or optionally in other solvents upon request.</li><li>Each set of measurements requires calibration (WI08113).</li><li>Price: 3,300 CZK excl. VAT</li></ul><h4>WI08113 – Calibration for Molecular Weight Distribution of Polymeric Materials</h4><ul><li>Calibration using dextran, polymaltotriose, or polystyrene standards for GPC molecular weight distribution determination.</li><li>Price: 4,500 CZK excl. VAT</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_GPC_separace_polymeru_na_kolone_Watrex_Delta_Gel_47ce92deaa.jpg" alt="Watrex: GPC separation of polymers on Watrex DeltaGel column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_GPC_separace_polymeru_na_kolone_Watrex_Delta_Gel_47ce92deaa.jpg 213w," sizes="100vw" width="1385" height="1018"><blockquote><h3>Services – Laboratory</h3>The Watrex Analytical Laboratory will be happy to perform any of our standard analyses, custom analyses, or assist you with method development.We specialize primarily in liquid chromatography techniques and are ready to meet a wide range of requirements—from method development and optimization, through validation and verification of external methods, to training and troubleshooting.Our laboratory also manufactures and packs its own chromatographic columns and guard columns for basic HPLC modes (reversed phase, normal phase, ion chromatography, and ion exclusion chromatography).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637"></blockquote>

Determination of sugars and organic acids (Watrex)

Watrex Prague offers the determination of sugars and organic acids in food, beverages, and other samples using ion-exclusive chromatography.

<h4>WI08119 – Determination of Carbohydrates in Natural Materials and Food Products</h4><ul><li>Determination is performed using ion-exclusion chromatography.</li><li>Price: 1,500 CZK excl. VAT</li></ul><h4>WI08118 – Determination of Organic Acids in Natural Materials and Food Products</h4><ul><li>Organic carboxylic acids are determined by ion-exclusion chromatography in natural and food samples.</li><li>Price: 1,300 CZK excl. VAT</li></ul><blockquote>10% discount when submitting 10 or more samples at once.</blockquote><blockquote><h3>Services – Laboratory</h3>The Watrex Analytical Laboratory will be happy to perform any of our standard analyses, custom analyses, or assist you with method development.We specialize primarily in liquid chromatography techniques and are ready to meet a wide range of requirements—from method development and optimization, through validation and verification of external methods, to training and troubleshooting.Our laboratory also manufactures and packs its own chromatographic columns and guard columns for basic HPLC modes (reversed phase, normal phase, ion chromatography, and ion exclusion chromatography).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637"></blockquote>

Determination of ions, pH, and water hardness (Watrex)

Watrex Prague offers the determination of cations and anions in water and aqueous extracts, pH determination, and water hardness calculation.

<h4>WI08106 – Determination of Anions in Water</h4><ul><li>Determination of fluoride, chloride, nitrite, bromide, nitrate, phosphate, and sulfate ions in aqueous samples using ion chromatography.</li><li>Price: 1,825 CZK excl. VAT</li></ul><h4>WI081107 – Determination of Cations in Water</h4><ul><li>Determination of sodium, ammonium (NH₄⁺), potassium, calcium, and magnesium ions in aqueous samples using ion chromatography.</li><li>Price: 825 CZK excl. VAT</li></ul><h4>WI081108 – Determination of pH in Aqueous Samples</h4><ul><li>Measurement of pH in aqueous samples using a combined glass electrode. Approximately 20 mL of sample required.</li><li>Price: 115 CZK excl. VAT</li></ul><blockquote>10% discount when submitting 3 or more samples at once</blockquote><h3>Services – Laboratory</h3>The Watrex Analytical Laboratory will be happy to perform any of our standard analyses, custom analyses, or assist you with method development.We specialize primarily in liquid chromatography techniques and are ready to meet a wide range of requirements—from method development and optimization, through validation and verification of external methods, to training and troubleshooting.Our laboratory also manufactures and packs its own chromatographic columns and guard columns for basic HPLC modes (reversed phase, normal phase, ion chromatography, and ion exclusion chromatography).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637">

Analytical Services for Building Materials (Watrex Laboratory)

Comprehensive analysis of building materials by ion chromatography and gravimetry – salts, moisture, lime, gypsum, density, and absorption testing by Watrex Laboratory.

<h5>WI08101 – Determination of Water-Soluble Salts in Building Materials</h5><ul><li>Determination of chlorides, nitrates, and sulfates in aqueous extract using ion chromatography. Requires approx. 1 g of a homogeneous sample.</li><li>Price: 600 CZK excl. VAT</li></ul><h5>WI08102 – Determination of Moisture in Building Materials</h5><ul><li>Gravimetric method after drying the sample to constant weight. Moisture content is expressed in mass %. Requires at least 10 g of sample in sealed packaging.</li><li>Price: 300 CZK excl. VAT</li></ul><h5>WI08103 – Determination of Lime Content in Lime Mortars</h5><ul><li>After acid digestion, Ca and Mg content is determined to calculate CaCO₃ and MgCO₃. Sand content determined gravimetrically. Not suitable for cement mortars. Requires approx. 5 g of sample.</li><li>Price: 1,275 CZK excl. VAT</li></ul><h5>WI08104 – Semi-Quantitative Determination of Gypsum in Building Materials</h5><ul><li>Based on solubility differences of gypsum and alkaline sulfates. Requires approx. 11 g of sample.</li><li>Price: 1,100 CZK excl. VAT</li></ul><h5>WI08105 – Determination of Bulk Density of Building Materials</h5><ul><li>Performed using quartz sand displacement. Requires 30–50 cm³ of sample in pieces 2–4 cm.</li><li>Price: 440 CZK excl. VAT</li></ul><h5>WI08109 – Determination of Hygroscopic Moisture in Building Materials</h5><ul><li>Gravimetric method after equilibrium at 100% RH and drying at 105 °C for 2 hours. Requires approx. 10 g of sample.</li><li>Price: 440 CZK excl. VAT</li></ul><h5>WI08114 – Determination of Water Absorption of Building Materials</h5><ul><li>Gravimetric method from weight difference between dried and water-saturated sample. Bulk density determined simultaneously. Requires 30–50 cm³ of sample in pieces 2–4 cm.</li><li>Price: 4,495 CZK excl. VAT</li></ul><blockquote>10% discount when submitting 3 or more samples at once.</blockquote><blockquote><h3>Services – Laboratory</h3>The Watrex Analytical Laboratory will be happy to perform any of our standard analyses, custom analyses, or assist you with method development.We specialize primarily in liquid chromatography techniques and are ready to meet a wide range of requirements—from method development and optimization, through validation and verification of external methods, to training and troubleshooting.Our laboratory also manufactures and packs its own chromatographic columns and guard columns for basic HPLC modes (reversed phase, normal phase, ion chromatography, and ion exclusion chromatography).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637"></blockquote>

Watrex application and R&D laboratory

Watrex application and R&D laboratory is providing a range of analyses.

Watrex application and R&amp;D laboratory is providing a range of analyses with special focus in the following fields:<ul><li>Chemical analysis for construction industry</li><li>Environmental analysis</li><li>Sample preparation including online solid-phase extraction protocols</li><li>Development of methods for pharmaceutical analysis</li><li>Characterization of synthetic polymers by GPC</li><li>Column technology and methods for chiral separation</li><li>Parameters evaluation and testing in ion chromatography applications</li></ul><h5>Our ready-to-go tests include:</h5><ul><li>Analysis of carbohydrates</li><li>Characterization of polymers</li><li>Analysis of organic acids</li><li>Construction analysis</li><li>Analysis of ions, pH and water hardness</li></ul>

Determination of Explosives in Soil and Water Samples (ALS Global)

Monitoring, determination, and treatment of environmental contamination by explosives (TNT, RDX, HMX, nitrobenzene, etc.) using HPLC-DAD. ALS performs analyses of 20 target compounds in water and soil.

Detecting and analyzing explosives is a crucial aspect of forensic, environmental, and security work. ALS Laboratories has developed and accredited analytical techniques capable of identifying and quantifying nearly 20 explosive compounds in both soil and water samples.Analyzing explosive residues in soil is vital for environmental protection and sustainable land management. It helps prevent contamination of soil and groundwater, safeguards ecosystems and human health, and supports regulatory compliance, site remediation, and long-term monitoring. Additionally, explosives analysis provides essential information for forensic investigations, agricultural assessments, and risk evaluation in property transactions or redevelopment projects involving potentially contaminated land.Building on our accredited soil analysis procedures, ALS Laboratories now also offers comprehensive identification and quantification of explosives in water samples. Our analytical portfolio includes methods for determining nitroaromatics, nitramines, and related compounds in accordance with internationally recognized standards such as US EPA 8330B, EN ISO 22478, and ISO 11916-1.<h4>List of target analytes for their determination in water and soil</h4><ul><li>Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine — HMX / Oktogen; CAS: 2691-41-0</li><li>Hexahydro-1,3,5-trinitro-1,3,5-triazine — RDX / Hexogen; CAS: 121-82-4</li><li>1,3,5-Trinitrobenzene — 1,3,5-TNB; CAS: 99-35-4</li><li>1,3-Dinitrobenzene — 1,3-DNB; CAS: 99-65-0</li><li>Methyl-2,4,6-trinitrophenyl-nitramine — Tetryl / CE; CAS: 479-45-8</li><li>Nitrobenzene — NB; CAS: 98-95-3</li><li>2,4,6-Trinitrotoluene — 2,4,6-TNT; CAS: 118-96-7</li><li>4-Amino-2,6-dinitrotoluene — 4-Am-DNT; CAS: 19406-51-0</li><li>2-Amino-4,6-dinitrotoluene — 2-Am-DNT; CAS: 35572-78-2</li><li>2,4-Dinitrotoluene — 2,4-DNT; CAS: 121-14-2</li><li>2,6-Dinitrotoluene — 2,6-DNT; CAS: 606-20-2</li><li>2-Nitrotoluene — 2-NT; CAS: 88-72-2</li><li>3-Nitrotoluene — 3-NT; CAS: 99-08-1</li><li>4-Nitrotoluene — 4-NT; CAS: 99-99-0</li><li>Nitroglycerin (glycerol trinitrate) — NG; CAS: 55-63-0</li><li>Pentaerythritol tetranitrate — PETN; CAS: 78-11-5</li><li>3,5-Dinitroaniline — 3,5-DNA; CAS: 618-87-1</li><li>Diphenylamine — DPA / Dpha; CAS: 122-39-4</li><li>N-nitrosodiphenylamine — NDPhA; CAS: 86-30-6</li></ul>The detection of explosives in water is essential for the protection of ecosystems and public health. It enables early identification of contamination in both surface and groundwater, supports the development of effective remediation strategies, and provides a scientific basis for informed decision-making in water resource management. Certain substances, such as RDX and 2,4-DNT, are considered high-risk contaminants—our initial tests have revealed RDX concentrations of several tens of μg/L in water samples.<blockquote><h5>Contact our experienced Client Service!</h5><ul><li>+420 226 226 228</li><li><a href="mailto:customer.support@alsglobal.com">customer.support@alsglobal.com</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.alsglobal.eu/">alsglobal.eu</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Analysis_of_explosives_in_environment_1c79af0d0d.jpg" alt="ALS Global: Analysis of explosives in environment" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Analysis_of_explosives_in_environment_1c79af0d0d.jpg 156w," sizes="100vw" width="1000" height="1000"></blockquote><blockquote>Article: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/paper/32276">EnviroMail™28 / Europe: Modern Analytical Methods for Tracing Explosives in the Environment</a></blockquote>

Blind common anabolic steroid screening – ID only

Blind HPLC identification of common anabolic steroids and selected aromatase inhibitors in oils, oral products, and raw API powders. The analysis reports the detected compound without quantification.

The Blind Common Anabolic Steroid Screening – ID Only is a laboratory analysis designed to identify commonly encountered anabolic-androgenic steroids and selected aromatase inhibitors in an unknown sample. The test is suitable for oil-based samples, oral dosage forms such as tablets and capsules, and raw active pharmaceutical ingredient (API) powders.Because this is a blind analysis, there is no need to specify which substance is expected in the sample. The analysis screens for all target compounds listed below and reports the identity of the detected compound.<h4>About the Target Compounds</h4>Anabolic-androgenic steroids are synthetic derivatives of testosterone or structurally related steroid hormones. They interact with androgen receptors and produce both anabolic effects, associated with tissue and muscle growth, and androgenic effects.The analysis covers testosterone, trenbolone, nandrolone, drostanolone, methenolone, boldenone, and other commonly encountered anabolic steroids. It includes both non-esterified steroid bases and esterified forms, which differ in properties such as solubility and release rate after administration.The screening also includes letrozole, anastrozole, and exemestane. These compounds are aromatase inhibitors that reduce estrogen production by inhibiting the aromatase enzyme. Letrozole and anastrozole are non-steroidal inhibitors, whereas exemestane is a steroidal aromatase inhibitor.<h4>Key Features</h4><ul><li>Blind identification with no need to declare the expected compound</li><li>Identification of common anabolic steroids and selected aromatase inhibitors</li><li>Suitable for oil-based samples, tablets, capsules, and raw API powders</li><li>Broad selection of steroid bases and esterified compounds</li><li>Analysis by HPLC</li><li>Results reported as the name of the detected compound</li><li>Average turnaround time of 7 business days</li><li>Minimum sample requirements adapted to the submitted sample type</li></ul><h4>Analysis Parameters</h4><ul><li>Target compounds: testosterone propionate, testosterone phenylpropionate, testosterone isocaproate, testosterone enanthate, testosterone cypionate, testosterone decanoate, trenbolone base, trenbolone acetate, trenbolone hexahydrobenzylcarbonate, trestolone acetate, nandrolone phenylpropionate, nandrolone decanoate, drostanolone propionate, drostanolone enanthate, dihydroboldenone cypionate, boldenone undecylenate, letrozole, anastrozole, exemestane, fluoxymesterone, methandrostenolone, oxandrolone, stanozolol, 4-chlorodehydromethyltestosterone, mesterolone, methasterone, oxymetholone, methenolone acetate, methenolone enanthate, and testosterone base</li><li>Testing method: HPLC</li><li>Result format: Name of the AAS found in the sample</li><li>Minimum sample amount&nbsp;<ul><li>oils: 0.5–1 mL</li><li>oral products: One tablet or capsule</li><li>raw powders: 200 mg</li></ul></li><li>Average turnaround time: 7 business days</li></ul><blockquote>Important Notice: This analysis provides compound identification only. The amount, concentration, or percentage content of the detected substance is not measured.</blockquote><h4>Optional Additional Analyses</h4>The following optional laboratory services are available:<ul><li>Fentanyl Screening</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2524">GC–MS Contamination Screening</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2525">Heavy Metals Analysis (As, Cd, Pb, Hg)</a></li><li>Additional Laboratory Report</li></ul>

Blind common anabolic steroid screening – oils

Blind HPLC screening of common anabolic steroids in oil-based samples. The analysis identifies and quantifies all detected target compounds, including mixtures.

The Blind Common Anabolic Steroid Screening – Oils is a comprehensive laboratory analysis designed to identify and quantify commonly encountered anabolic-androgenic steroids in oil-based samples.Because this is a blind analysis, there is no need to specify which substance is expected in the sample. The analysis screens for all target compounds listed below and identifies and quantifies every detected substance, including samples containing mixtures of multiple compounds.<h4>About the Target Compounds</h4>Anabolic-androgenic steroids are synthetic derivatives of testosterone or structurally related steroid hormones. They interact with androgen receptors and produce both anabolic effects, associated with tissue and muscle growth, and androgenic effects.The analysis covers several esterified forms of testosterone, trenbolone, nandrolone, drostanolone, methenolone, and boldenone, as well as testosterone undecanoate, methyltestosterone, trestolone acetate, and dihydrotestosterone (DHT).Esterification influences properties such as solubility and the rate at which a steroid is released after administration. Different ester forms of the same steroid may therefore differ in their physicochemical and pharmacokinetic characteristics.<h4>Key Features</h4><ul><li>Blind screening with no need to declare the expected compound</li><li>Identification and quantification of common anabolic steroids in oil-based samples</li><li>Detection of mixtures containing multiple target compounds</li><li>Broad range of steroid bases and esterified compounds</li><li>Analysis by HPLC</li><li>Results reported in mg/mL</li><li>Average turnaround time of 7 business days</li><li>Minimum sample amount of 0.5–1 mL of oil</li></ul><h4>Analysis Parameters</h4><ul><li>Target compounds: testosterone propionate, testosterone phenylpropionate, testosterone isocaproate, testosterone enanthate, testosterone cypionate, testosterone decanoate, testosterone undecanoate, methyltestosterone, trenbolone acetate, trenbolone enanthate, trenbolone hexahydrobenzylcarbonate, trestolone acetate, dihydrotestosterone (DHT), nandrolone phenylpropionate, nandrolone cypionate, nandrolone decanoate, drostanolone propionate, drostanolone enanthate, dihydroboldenone cypionate, methenolone enanthate, boldenone acetate, boldenone cypionate, and boldenone undecylenate</li><li>Other common names and brand names: Sustanon, Test E, Test C, Deca, Tren, Parabolan, MENT, NPP, Masteron, Masteron Propionate, Mast P, Masteron Enanthate, Mast E, Primobolan, Primo E, BU, Equipoise, EQ, and Parenabol</li><li>Testing method: HPLC</li><li>Detection limit cutoff:&nbsp;<ul><li>15 mg/mL</li><li>drostanolone propionate and drostanolone enanthate: 25 mg/mL</li></ul></li><li>Result format: mg/mL</li><li>Minimum sample amount: 0.5–1 mL of oil</li><li>Average turnaround time: 7 business days</li></ul><blockquote>Important Notice: The standard detection cutoff is 15 mg/mL. For drostanolone propionate and drostanolone enanthate, the cutoff is 25 mg/mL. Target compounds present below these levels may not be reliably detected or quantified within the standard scope of the analysis.</blockquote><h4>Optional Additional Analyses</h4>The following optional laboratory services are available:<ul><li>Benzyl Alcohol and Benzyl Benzoate Testing</li><li>Complete Raw Analytical Data</li><li>Fentanyl Screening</li><li>pH Measurement</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2524">GC–MS Contamination Screening</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2527">Sterility Testing (TAMC and TYMC)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2525">Heavy Metals Analysis (As, Cd, Pb, Hg)</a></li><li>Additional Laboratory Report</li></ul>

DHT enanthate analysis

Targeted HPLC analysis of DHT enanthate in oil-based samples and raw API powders. The test confirms compound identity and determines its content in mg/mL or percentage.

The DHT Enanthate Analysis is a targeted laboratory test designed to confirm the identity and determine the amount of dihydrotestosterone enanthate in oil-based samples and raw active pharmaceutical ingredient (API) powders.The analysis specifically targets DHT enanthate. Samples expected to contain non-esterified DHT should instead be submitted for the appropriate blind common anabolic steroid screening for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2478">oils </a>or<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2476"> raw API powders</a>.<h4>About DHT Enanthate</h4>DHT enanthate, also known as dihydrotestosterone heptanoate, is an esterified form of DHT designed for slower release and potentially prolonged activity. The enanthate group increases the compound’s lipophilicity. After release, DHT activates androgen receptors and, unlike testosterone, cannot be converted into estradiol by aromatase.<h4>Key Features</h4><ul><li>Targeted identification and quantification of DHT enanthate</li><li>Suitable for oil-based samples and raw API powders</li><li>Analysis by HPLC</li><li>Results for oil samples reported in mg/mL</li><li>Results for raw API powders reported as percentage content</li><li>Optional mass-by-mass purity reporting for raw API powders</li><li>Minimum sample amount of 0.5–1 mL for oil samples</li><li>Minimum sample amount of 200 mg for raw API powders</li><li>Average turnaround time of 7 business days</li></ul><h4>Analysis Parameters</h4><ul><li>Target compound: DHT enanthate</li><li>Testing method: HPLC</li><li>Detection limit cutoff: 15 mg/mL</li><li>Result format for oil samples: mg/mL</li><li>Minimum sample amount for oil samples: 0.5–1 mL</li><li>Result format for raw API powders: % [98%+, 96%+ or % value such as 94.15%]</li><li>Minimum sample amount for raw API powders: 200 mg</li><li>Average turnaround time: 7 business days</li></ul><blockquote>Important Notice: This analysis is intended specifically for DHT enanthate. It is not designed for the analysis of non-esterified DHT.</blockquote><h4>Optional Additional Analyses</h4>The following optional laboratory services are available:<ul><li>Benzyl Alcohol and Benzyl Benzoate Testing</li><li>Complete Raw Analytical Data</li><li>Alternative Result Format: Mass-by-Mass Purity - only for raw API powders</li><li>pH Measurement</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2524">GC–MS Contamination Screening</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2527">Sterility Testing (TAMC and TYMC)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2525">Heavy Metals Analysis (As, Cd, Pb, Hg)</a></li><li>Additional Laboratory Report</li></ul>

Epistane analysis

Targeted HPLC analysis of epistane in tablets, capsules, and raw API powders. The test confirms compound identity and determines its content in mg per unit or as a percentage.

The Epistane Analysis is a targeted laboratory test designed to confirm the identity and determine the amount of epistane in oral dosage forms and raw active pharmaceutical ingredient (API) powders.&nbsp;The analysis is suitable for tablets and capsules, with results reported in milligrams per individual dosage unit. Raw API powders can be evaluated by percentage content, with optional purity reporting in % (m/m).<h4>About Epistane</h4>Epistane, also known as methylepitiostanol or 2,3-thioepoxy madol, is a synthetic, orally active anabolic-androgenic steroid structurally related to dihydrotestosterone (DHT). It is a 17α-methylated derivative of epitiostanol and interacts with androgen receptors, producing anabolic and androgenic effects.Epistane has been identified in products marketed as dietary or performance-enhancing supplements. Scientific studies have also associated its use with a risk of liver injury, including cholestasis.<h4>Key Features</h4><ul><li>Targeted identification and quantification of epistane</li><li>Suitable for tablets, capsules, and raw API powders</li><li>Analysis by HPLC</li><li>Results for oral products reported in mg per tablet or capsule</li><li>Results for raw API powders reported as percentage content</li><li>Optional purity reporting in % (m/m) for raw API powders</li><li>Minimum sample amount of three tablets or capsules</li><li>Minimum sample amount of 200 mg for raw API powders</li><li>Average turnaround time of 7 business days</li></ul><h4>Analysis Parameters</h4><ul><li>Target compound: Epistane</li><li>Other names: Hemapolin, 2,3-thioepoxy madol</li><li>CAS number: 4267-80-5</li><li>Testing method: HPLC</li><li>Minimum amount of target compound for evaluation in oral products: 4 mg per tablet / capsule</li><li>Minimum content of target compound for evaluation in raw API powders: 10%</li><li>Result format for oral products: mg per tablet or capsule</li><li>Result format for raw API powders: % [98%+, 96%+ or % value such as 94.15%]</li><li>Minimum sample amount for oral products: 3 tablets / capsules</li><li>Minimum sample amount for raw API powders: 200 mg</li><li>Average turnaround time: 7 business days</li></ul><h4>Optional Additional Analyses</h4>The following optional laboratory services are available:<ul><li>Complete Raw Analytical Data</li><li>Alternative Result Format: Purity in % (m/m) - only for raw API powders</li><li>Batch Variance Testing</li><li>Fentanyl Screening</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2524">GC–MS Contamination Screening</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2525">Heavy Metals Analysis (As, Cd, Pb, Hg)</a></li><li>Additional Laboratory Report</li></ul>

Products focused on Laboratory analysis - page 13

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