<p><strong>Post-translational modifications (PTMs) are where so much of biology’s complexity lives, but they are also some of the hardest molecular features to analyze with confidence. Phosphorylation, asymmetric dimethylarginine (ADMA), and O-GlcNAcylation (O-GlcNAc) often occur at low abundance, can be highly labile, and frequently require precise site localization to understand their biological meaning. This</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"><strong> technical note </strong></a><strong>shows how the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer</strong></a><strong> helps address those challenges by combining fast, sensitive performance with complementary </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7217"><strong>HCD and EThcD fragmentation</strong></a><strong> workflows.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg" alt="Thermo Fisher Scientific: Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg 245w," sizes="100vw" width="1024" height="512"></p><p>Using enriched PTM samples and automated data-dependent acquisition, the study demonstrates that the <strong>Orbitrap Excedion Pro MS</strong> can deliver both depth and confidence across multiple PTM classes. For phosphorylation analysis, the platform identified 5,892 unique phosphosites from IMAC-enriched samples and <strong>2,941 </strong>unique phosphotyrosine sites after phosphotyrosine enrichment, highlighting strong performance for both broad and highly targeted signaling studies. Just as importantly, the data show that HCD and EThcD provide complementary value, with each fragmentation method contributing unique site identifications and helping resolve ambiguous assignments.</p><p>The note also highlights the value of EThcD for more analytically demanding PTMs. In ADMA-enriched samples, EThcD delivered more ADMA peptide-spectrum matches and more unique modified peptides than HCD, supporting improved confidence in site characterization. For O-glycopeptides, the Orbitrap Excedion Pro MS uses an intelligent HCD-product-dependent-EThcD strategy that triggers EThcD only when oxonium ions are detected, improving productivity while preserving the fragmentation detail needed for confident glycosite localization.</p><p>Overall, this technical note shows how <strong>Orbitrap Excedion Pro MS </strong>enables researchers to go deeper into PTM biology with greater sensitivity, better site confidence, and smarter acquisition. For scientists studying signaling, regulation, and disease mechanisms, it presents a powerful approach for expanding PTM coverage without compromising analytical rigor.</p><blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"><span><strong>Download the technical note</strong></span> "<strong>Advancing phosphorylation, ADMA, and O-GlcNAc PTM analysis with HCD and EThcD on the Orbitrap Excedion Pro mass spectrometer</strong>"</a></h5></blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#PTM #OrbitrapExcedionPro #glycosylation #phosphorylation</p>

Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer

<h3><strong>Refractive Index (RI) Detection in HPLC – Making Invisible Compounds Visible</strong></h3><p><strong>When HPLC detectors are discussed, UV-Vis absorbance detection is often the first technique that comes to mind. Its popularity is easy to understand: it is sensitive, selective, and suitable for a wide range of compounds. But what happens when the analyte does not absorb ultraviolet or visible light?</strong></p><p>This is where the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2429"><strong>Refractive Index Detector (RID)</strong></a> becomes particularly useful. Reliable, versatile, and often described as a “universal detector” for HPLC, RI detection can reveal compounds that remain invisible to many optical detectors. For substances such as sugars, polymers, lipids, or alcohols, it is often an important analytical option.</p><p>Let’s look at how RI detection works, where it performs best, what its main limitations are, and how to achieve stable, reproducible results.</p><h4><strong>How RI Detection Works</strong></h4><p>When light passes from one medium into another, its path changes direction, or refracts, depending on the phase velocity and angle of incidence. This phenomenon is described by <i>Snell’s law</i>, with the extent of refraction determined by the refractive index (RI) of the medium (Figure 1).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Refraction_of_light_at_the_interface_between_two_media_with_different_refractive_indices_baa4aad28c.webp" alt="KNAUER: Figure 1: Refraction of light at the interface between two media with different refractive indices, where n₁ &gt; n₂. Since the velocity is lower in the second medium (v₂ &lt; v₁), the angle of refraction α₂ is less than the angle of incidence α₁." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Refraction_of_light_at_the_interface_between_two_media_with_different_refractive_indices_baa4aad28c.webp 238w," sizes="100vw" width="1024" height="670"></p><p>In HPLC, an RI detector monitors <strong>small changes in the refractive index of the mobile phase as compounds elute from the column</strong>. Because each substance has its own refractive index, even relatively small changes in the composition of the column effluent can generate a measurable response.</p><p>Modern RI detectors generally use a <strong>differential optical design</strong> (Figure 2). Two optical paths are continuously compared: one passes through a <strong>reference cell</strong> containing pure mobile phase, while the other passes through a <strong>sample cell</strong> containing the column effluent, i.e. mobile phase plus analyte.</p><p>A light source, commonly an LED or tungsten lamp, illuminates both cells. Changes in refractive index alter the path of the light, and a photodiode detects the resulting deviation.</p><p>When only mobile phase is present, the two optical paths are effectively identical and no significant detector response is produced. As an analyte enters the sample cell, however, the refractive index changes. The light beam is slightly deflected, creating an <strong>optical imbalance</strong> and consequently a change in light intensity.</p><p>The detector converts this change into an electrical signal, which appears as a chromatographic peak. Because the response is related to analyte concentration, RI detection can also be used for quantitative analysis.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Schematic_of_a_differential_RI_detector_with_dual_flow_cell_6299f55b17.webp" alt="KNAUER: Figure 2: Schematic of a differential RI detector with dual flow cell. The sample cell carries column effluent; the reference cell contains pure mobile phase. A light beam passes through both and forms a slit image on a photodiode. Any analyte-induced change in refractive index alters the beam’s path, shifting the image on the photodiode and generating a signal peak." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Schematic_of_a_differential_RI_detector_with_dual_flow_cell_6299f55b17.webp 245w," sizes="100vw" width="1024" height="524"></p><p>For reliable measurements, the reference cell must always contain the same mobile phase as the sample cell, but without analyte. It therefore needs to be refreshed regularly with clean mobile phase, commonly using a switching valve and/or T-piece (Figure 3).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_Flow_path_in_the_AZURA_RID_2_1_L_during_analysis_left_and_flushing_right_e6bc30acef.webp" alt="KNAUER: Figure 3: Flow path in the AZURA® RID 2.1L during analysis (left) and flushing (right). During analysis, solvent flows from the IN port through the heat exchanger and sample cell, then continues through the T piece and flush valve to the OUT port. During flushing, the valve redirects the flow through the T piece so the solvent passes a second heat exchanger and reference cell before exiting via the OUT port." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_Flow_path_in_the_AZURA_RID_2_1_L_during_analysis_left_and_flushing_right_e6bc30acef.webp 245w," sizes="100vw" width="1024" height="410"></p><p>It is important to remember that refractive index depends on both <strong>light wavelength</strong> and <strong>medium density</strong>. The wavelength is fixed by the optical design of the detector, but density—and therefore refractive index—changes with <strong>temperature, pressure, and composition</strong>.</p><p>For this reason, RI detection is particularly sensitive to changes in operating conditions. Stable measurements depend heavily on maintaining a tightly controlled analytical environment.</p><h4><strong>Why Choose RI Detection?</strong></h4><p>RI detectors become especially valuable when other detector types cannot provide a useful response. They may be less sophisticated than some modern detection technologies, but several characteristics make them indispensable for particular applications.</p><h5><strong>Broad Applicability</strong></h5><p>An RID can detect virtually any compound that produces a change in the refractive index of the mobile phase. No UV-absorbing chromophore is required.</p><p>Because almost every dissolved substance changes refractive index to some degree, RI detection is commonly regarded as a <strong>universal detection technique</strong>. Typical analytes include sugars, alcohols, lipids, fatty acids, and polymers.</p><h5><strong>Non-Destructive Detection</strong></h5><p>RI measurement does not destroy the analyte. This makes it useful in workflows where the separated compound needs to be collected or analyzed further, including preparative chromatography.</p><p>KNAUER’s <a target="_blank" rel="noopener noreferrer" href="https://store.knauer.net/shop/add38-azura-r-rid-2-1l-highflow-preparative-refractive-index-detector-62927?category=75">AZURA® RID 2.1L for preparative applications</a>, for example, supports flow rates up to 100 mL/min.</p><h5><strong>Simple and Reliable Operation</strong></h5><p>RI detectors are suitable for aqueous and many organic mobile phases as long as the solvent composition remains constant.</p><p>Under stable isocratic conditions, they are relatively straightforward to use, robust, and require comparatively little maintenance.</p><h5><strong>Direct Detection Without Derivatization</strong></h5><p>Analytes do not need to be derivatized or labelled before RI detection. If a compound is soluble in the mobile phase and produces a sufficient difference in refractive index, it can be detected directly.</p><p>This simplifies sample preparation and reduces additional handling steps that could introduce variability or error.</p><p>These characteristics make RI detection particularly attractive for routine applications such as lactose determination in milk or polymer purity testing.</p><h5><strong>Limitations of RI Detection</strong></h5><p>Universal detection comes with several practical compromises. RI detectors require highly stable conditions and can be considerably more sensitive to environmental and system changes than other common HPLC detectors.</p><h5><strong>High Temperature Sensitivity</strong></h5><p>Refractive index is strongly influenced by temperature. For aqueous solvents, the change in refractive index with temperature is approximately dn/dT ≈ 10⁻⁴/°C.</p><p>Even small temperature fluctuations can therefore produce baseline drift that may be larger than the analytical signal itself.</p><p>Modern RI detectors use thermostated compartments and heat exchangers to stabilize the temperature of the flow cell. This improves accuracy and reproducibility, although the heat exchangers introduce additional system volume that can contribute to peak broadening compared with UV detection.</p><h5><strong>Limited Compatibility With Gradient Elution</strong></h5><p>RI detection is essentially restricted to <strong>isocratic chromatography</strong>.</p><p>Changing the composition of the mobile phase during a gradient produces a much larger change in refractive index than the analyte itself. The resulting baseline shift can easily overwhelm chromatographic peaks.</p><p>A stable RI baseline therefore requires the sample and reference cells to contain the same mobile-phase composition throughout the analysis.</p><h5><strong>Lower Sensitivity</strong></h5><p>Compared with UV detection, RI detection is generally about one to two orders of magnitude less sensitive.</p><p>Typical detection limits are in the µg–mg/mL range, making RID less suitable for trace-level analysis or impurity profiling.</p><h5><strong>Limited Pressure Tolerance</strong></h5><p>RI flow cells can tolerate only moderate backpressure. When several detectors are connected in series, the RI detector should therefore normally be positioned last.</p><h5><strong>Longer Equilibration</strong></h5><p>RID systems require time to reach thermal and optical stability. Warm-up and equilibration can take hours before a sufficiently stable baseline is obtained.</p><h5><strong>Sensitivity to Baseline Disturbances</strong></h5><p>Because the detector responds to any change in refractive index, many factors can affect the baseline.</p><p>Temperature fluctuations, unstable flow or pressure, pump pulsation, air bubbles, inadequate solvent mixing, and impurities in the mobile phase can all lead to noise, drift, or false signals.</p><p>Clean operation and stable system conditions are therefore essential.</p><h4><strong>How to Get the Best Performance From an RI Detector</strong></h4><p>Successful RI detection can largely be summarized in one word: <strong>stability</strong>.</p><p>Small variations in temperature, flow, solvent composition, or pressure can quickly become visible in the chromatographic baseline. Careful system preparation and handling can therefore make a major difference.</p><h5><strong>Maintain a Stable Temperature</strong></h5><p>Thermal equilibration should be one of the first priorities.</p><p>Allow the detector, column, and mobile phase to equilibrate fully before beginning analysis, ideally for at least 60 minutes. A column oven can help maintain stable conditions, and the column and detector should be operated at the same temperature whenever possible.</p><p>Environmental influences such as direct sunlight, air currents, or day-to-night laboratory temperature fluctuations should also be minimized.</p><h5><strong>Use Isocratic Methods</strong></h5><p>Keep the mobile-phase composition constant throughout the run.</p><p>If the separation requires gradient elution, an RI detector is generally not the appropriate choice.</p><h5><strong>Degas the Mobile Phase and Keep the System Clean</strong></h5><p>Use well-degassed, particle-free mobile phases and make sure the LC system is properly primed.</p><p>An in-line degasser can help prevent bubble formation. Tubing, solvent reservoirs, and the entire flow path should also be kept clean because even small bubbles or contaminants can generate spikes, noise, or other baseline disturbances.</p><h5><strong>Match the Sample Solvent Carefully</strong></h5><p>Whenever possible, prepare samples directly in the mobile phase or in a solvent with very similar composition.</p><p>Large differences between the injection solvent and mobile phase can produce strong refractive-index disturbances around the void volume.</p><p>Filtering samples also helps reduce the risk of blockages and protects the detector flow cell.</p><h5><strong>Keep Flow and Pressure Stable</strong></h5><p>Maintain a constant flow rate and avoid abrupt pressure changes, excessive pump pulsation, or leaks.</p><p>A restriction capillary or back-pressure regulator positioned after the flow cell may help stabilize pressure, although these measures cannot compensate for noise caused by a poorly performing pump.</p><h5><strong>Maintenance and Practical Considerations</strong></h5><p>Flush the reference cell regularly with fresh mobile phase. The mobile phase itself should also be replaced periodically to reduce microbial growth or compositional changes caused by evaporation.</p><p>When changing solvent systems, flush the instrument with mutually miscible solvents and allow sufficient time for the new system to equilibrate fully.</p><p>Where appropriate, mobile-phase recycling or a low-flow standby mode can help reduce solvent consumption and shorten restart times between analytical sequences.</p><blockquote><p>👉 <i>Pro Tip: Keep an eye on the baseline. A stable baseline is one of the best signs that the RID has equilibrated properly. Negative peaks are not necessarily an error—they simply indicate that the analyte has a lower refractive index than the mobile phase.</i></p></blockquote><h5><strong>The Bottom Line</strong></h5><p>With careful control of temperature, mobile-phase composition, pressure, and cleanliness, an RI detector can provide stable baselines and consistent quantitative data.</p><p>Keep the system clean, maintain constant operating conditions, and allow sufficient equilibration time, and even this demanding HPLC “diva” can deliver highly reliable results.</p><h4><strong>Typical Applications: Where RI Detection Performs Best</strong></h4><p>RI detection is particularly useful for substances that do not absorb UV light strongly and therefore cannot be detected effectively using conventional UV/VIS detectors.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AI_Figure_4_Common_uses_of_RI_detection_in_HPLC_d84d8458dc.webp" alt="KNAUER / AI: Figure 4: Common uses of RI detection in HPLC" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AI_Figure_4_Common_uses_of_RI_detection_in_HPLC_d84d8458dc.webp 245w," sizes="100vw" width="1024" height="433"></p><p>Typical analytes include sugars, alcohols, fatty acids, polymers, lipids, and other small organic molecules without strong chromophores.</p><h5><strong>Some common application areas include:</strong></h5><ul><li><strong>Carbohydrate and sugar analysis</strong>, including determination of glucose, fructose, sucrose, or lactose in food and beverages. HPLC-RI has been used for <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0195_sec_for_fingerprint_analysis_of_gummy_candies_ce5349cd95.pdf"><strong>product quality control of gummy candies</strong></a>, with further discussion available in this <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7186"><strong>related blog post</strong></a>.</li><li>KNAUER’s AZURA® RID 2.1L has also been used for the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0194_d497a35278.pdf"><strong>simultaneous determination of sugars and organic acids in wine</strong></a>, an application explored further in the article <a target="_blank" rel="noopener noreferrer" href="https://www.knauer.net/blog/blog-9/the-hidden-science-in-your-glass-147">“The hidden science in your glass”</a>.</li><li><strong>Polymer and macromolecule characterization</strong> in GPC/SEC applications, for example when determining molecular-weight distributions. Examples include <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/4czsecf32d70a6d2yugpojtljg8rvp4vd4ur_05660bfad3.pdf"><strong>optimization of molecular-weight determination with the KNAUER AZURA® GPC/SEC system</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/qpwsk0igeqca8b5bqunbjjqnwum09tucb83s_cc4dbbcec9.pdf"><strong>analysis of mucin proteins using an AZURA® SEC System</strong></a>.</li><li><strong>Bioprocessing</strong>, including monitoring fermentation products such as <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VBS_0079_Characterization_of_fructans_in_fermentation_products_with_sec_bc8f294f0e.pdf"><strong>fructans</strong></a>.</li><li><strong>Pharmaceutical applications</strong>, for example analysis of excipients such as sugars and polyols, as well as identity and purity testing of APIs. Dextranes, which are used as carrier materials in pharmaceuticals and as thickening or moisturizing agents in cosmetics, can be <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/h2oikq51kfvn6ebxij6hs88pxupstfgdqfyd_3e4f29d933.pdf"><strong>characterized by SEC</strong></a>, as their properties depend strongly on molecular-weight distribution.</li><li><strong>Lipid and surfactant analysis</strong> for formulation development and quality control.</li><li><strong>Environmental analysis</strong>, including determination of selected organic and inorganic impurities in water samples.</li></ul><p>Overall, RI detection works best for analytes that are soluble, stable in solution, and compatible with straightforward isocratic separation conditions.</p><p>It is not the preferred solution for trace analysis, gradient chromatography, or workflows requiring direct MS coupling. Nevertheless, it remains a practical and dependable option for compounds that are difficult or impossible to monitor using UV or fluorescence detection.</p><h4><strong>Final Thoughts: A Detector That Still Deserves Attention</strong></h4><p>As analytical laboratories adopt increasingly sophisticated detection technologies, refractive index detection can appear relatively simple. Yet for many applications, that simplicity is exactly its strength.</p><p>For analytes such as sugars, alcohols, polymers, and other compounds without strong UV absorption, RID offers a direct, reliable, and non-destructive method of detection.</p><p>Its greatest challenges are its sensitivity to temperature and its incompatibility with gradient elution. Under carefully controlled isocratic conditions, however, RI detection remains a dependable workhorse for routine HPLC and GPC/SEC applications.</p><blockquote><p><i><strong>Pro tip: If your analyte seems invisible to conventional optical detection, a change of perspective may be all that is needed. RI detection could make it visible.</strong></i></p></blockquote><p>In the next article in the <strong>“Seeing is Believing – Detection Made Easy”</strong> series, we will focus on <strong>Fluorescence Detection (FLD)</strong>, a highly selective and sensitive technique for compounds that fluoresce naturally or can be derivatized to do so.</p>

Seeing is Believing – Detection Made Easy Part 4: Refractive Index Detector

News from LabRulezLCMS Library - Week 36, 2026

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Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer

Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows.

<h4><strong>Superior performance in your routine quantitative analyses</strong></h4><p><strong>Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows. &nbsp;With solutions for today’s needs and technologies to overcome tomorrow’s challenges, explore what the adaptable, flexible, and proven Xevo TQ-XS Tandem Quadrupole Mass Spectrometer coupled with ACQUITY UPLC can afford your laboratory’s productivity and capabilities. &nbsp;</strong></p><div><div><div><div><ul><li><strong>Expanding your efficiencies</strong>: Maximize your laboratory’s potential in high sensitivity quantitative analysis by extending your capabilities, confidently and productively</li><li><strong>Performance that’s proven</strong>: Trust the proven Xevo TQ-XS to meet the analytical demands of your challenging applications , injection after injection</li><li><strong>Digesting your data</strong>: Reduce the burden in data handling with flexible and adaptable software solutions to meet your application and quality system needs</li><li><strong>Supporting your success</strong>: Have confidence that you will exceed your analytical requirements using Waters end to end solutions with flexible service and application focused training and support</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Quantitative analysis where <strong>high sensitivity instrument performance</strong> is required (e.g.,&nbsp;to reach <strong>low level concentrations (ppt)</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: The Xevo TQ-XS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg 245w," sizes="100vw" width="1024" height="545"></p><div><div><h3><strong>Expand your analytical capabilities with enhanced sensitivity</strong></h3><p>Delivering the next step in reliable sensitivity, the <strong>Xevo TQ-XS</strong> enables your laboratory to expand your analytical capacity and productivity. Whether seeking more sensitivity to detect your analytes routinely, looking to extend your scope of analytes with increased confidence or revise your workflow to reduce time and costs, explore what <strong>Xevo TQ-XS</strong>, coupled with <strong>ACQUITY UPLC</strong> and <strong>ACQUITY Premier Systems</strong> can offer your lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Vancomycin: Xevo TQ-XS versus Xevo TQ-S. On average, the analyte area counts on Xevo TQ-XS were >10x higher than area counts on Xevo TQ-S for Vancomycin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg 245w," sizes="100vw" width="1024" height="295"></p></div></div><div><div><h3><strong>Proven performance you can trust for your challenging analyses</strong></h3><p>Whether looking to streamline your methods or advance your laboratory’s performance, explore how <strong>Xevo TQ-XS</strong>, coupled with <strong>LC (UPLC), GC (APGC) or SFC (UPC2)</strong> can benefit your challenging applications. Trust the proven <strong>Xevo TQ-XS</strong> to meet your <strong>analytical demands</strong>, injection after injection.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Representative liraglutide LLOQ (0.5 ng/mL) chromatogram, extracted from plasma, demonstrating sensitivity and selectivity with Xevo TQ-XS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg 245w," sizes="100vw" width="1024" height="536"></p></div></div><div><div><h3><strong>Software solutions to overcome a common bottleneck</strong></h3><p>While quantitation of targeted analytes can be a routine experiment, the volume of data acquired and generated for processing, review and management can be significant. <strong>Waters</strong>’ informatics platforms offer extensive toolsets to support efficient and compliant <strong>data handling</strong> to support your <strong>21 CFR 11 and ISO 17025</strong> environments.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: With the Xevo TQ-XS System, you’ll get robust results you can trust with the most demanding sample matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg 234w," sizes="100vw" width="1024" height="683"></p></div></div><div><div><h3><strong>Accelerating your success with award winning service</strong></h3><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services.html"><strong>APS</strong></a>) and flexible and cost-effective solutions to advance your business with system service <strong>(</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services/flexchoice-instrument-service-coverage.html"><strong>FlexCHOICE</strong></a>), trade-ins and technological upgrades (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/FlexUP-Technology-Renewal-Program-%7C-Upgrade-Lab-Instruments/nav.htm?cid=135071972"><strong>FlexUP</strong></a>).</p></div></div></div></div></div></div>

Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.

<h3><strong>Defining Compact Performance</strong></h3><ul><li><strong>Robust Sensitivity Beyond Expectations</strong></li></ul><p><strong>From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.</strong></p><h4><strong>Reliable performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S micro study analyzing mycotoxins in wheat flour (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1000 injections and only 5-9% relative standard deviation (RSD) for peak areas.</p><h4><strong>Maximizing uptime</strong></h4><p>Get the most from your instrument and avoid time-consuming repair visits. Customers using the Xevo TQ-S micro will on average not need an unplanned service visit during the warranty period and for 3 years after.<strong>*</strong>&nbsp;</p><p><strong>*</strong>Source Waters internal service data on unplanned service visits for Xevo TQ-S micro issues that occur globally. Note that warranty period used is 1 year and planned visits for regular scheduled Performance Maintenance are recommended to ensure trouble-free operation</p><h4><strong>Achieve more with less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S micro is 2-3X narrower than other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S micro provides up to 34% lower electricity power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: With benchspace at a premium, choose an instrument designed to maximize performance per square inch." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg 245w," sizes="100vw" width="1024" height="300"></p><h4><strong>Flexibility to meet your analytical needs&nbsp;</strong></h4><p>With the most commonly used atmospheric pressure ionization source of ESI as standard, simply change chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S micro provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S micro won’t let you down.</p><p><strong>Experiment 1</strong> – 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 5-9% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg 245w," sizes="100vw" width="1221" height="647"></p><p><strong>Experiment 2</strong> – Acetaminophen in protein precipitated plasma also showed consistent performance over 6 ½ days of continuous use with 2,400 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 2 - Acetominophen in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg 245w," sizes="100vw" width="1220" height="649"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022.</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower Operational Costs and Improved Sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability while balancing the need to continually reduce operational costs. The Xevo TQ-S micro consumes less electricity than other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><p><strong>Table 1:</strong> Instrument / Power Consumption / Heat Output</p><ul><li><strong>Waters Xevo TQ-S micro</strong> / 1250 W / 4,263 Btu/h</li><li><strong>Competitor B</strong> / 1452 W / 4,950 Btu/h</li><li><strong>Competitor A</strong> / 1600 W / 5,456 Btu/h</li><li><strong>Competitor C</strong> / 1960 W / 6,500 Btu/h</li></ul><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S micro Site Preparation Guide</strong></a><br>Note that power stated for scroll pump configuration. Option for rotary pump configuration is available</p><p>Power and heat outputs for mid tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve More with Flexible Software Solutions</strong></h4><p>The Xevo TQ-S micro is available on both the waters_connect™ and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><ul data-spread="false"><li><strong>waters_connect™:</strong> Our modern, app-based software platform delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time.</li><li><strong>MassLynx™: </strong>A well-established software package delivering market-leading versatility and flexibility for all application areas.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems and APGC™. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S micro, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S micro into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S micro – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer

Quantitate with Absolute Power: up to 15× higher sensitivity, 6× longer uptime, and 50% less energy use. The Xevo TQ Absolute XR delivers eXtreme Robustness in a compact design.

<h4><strong>Quantitate with Absolute Power and eXtreme Robustness</strong></h4><p><strong>Gain absolute confidence to make powerful decisions and reach lower limits of quantitation, maintaining optimum sensitivity for longer, with the Xevo TQ Absolute XR instrument.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg" alt="Waters: Xevo TQ Absolute XR Triple Quadrupole MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg 245w," sizes="100vw" width="1603" height="900"></p><p>Engineered for maximum productivity in a compact, sustainable design, the Waters Xevo TQ Absolute XR instrument features the new <strong>StepWave XR ion guide</strong> for enhanced resilience against contamination, even with high-throughput, complex sample matrices. That means more uptime, fewer interventions, and lab performance you can trust, all while aligning with your environmental, social, and governance (ESG) goals.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg" alt="Waters: StepWave XR ion guide" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg 245w," sizes="100vw" width="936" height="388"></p><h4><strong>Overview</strong></h4><ul><li><strong>Absolute confidence: </strong>Experience up to six times more robustness<sup>1</sup> with the new StepWave XR ion guide, designed for superior resilience to contamination. The Xevo TQ Absolute XR Mass Spectrometer ensures consistent, reliable performance, even under the most challenging analytical conditions.</li><li><strong>Absolute performance: </strong>Push quantitation limits further and meet stringent regulatory requirements with up to 15x greater sensitivity<sup>2</sup> for difficult-to-ionize negative mode compounds, setting a new benchmark in high-performance quantitation.</li><li><strong>Absolute efficiency: </strong>Reduce your laboratory’s environmental impact and operational costs with a mass spectrometer that consumes up to 50% less electricity and gas while generating 50% less heat than other high-performance TQ instruments.</li><li><strong>Absolute productivity: </strong>Streamline data analysis with waters_connect software, featuring Exception Focused Review (XFR) functionality to accelerate workflows, cutting data review time by up to 50% for more efficient, accurate results.</li><li><strong>Absolute versatility:</strong> Choose from our differentiated range of source options to find the technology most suited to your applications including DESI XS, APGC, and UniSpray.</li></ul><p><i><strong><sup>1</sup></strong>In a well-controlled experiment, performance was maintained for up to six times the duration on the Xevo TQ Absolute XR compared to the Xevo TQ Absolute; more than 12,000 samples of pesticides in fish feed matrix were analyzed</i></p><p><i><strong><sup>2</sup></strong>Compared to previous generation high performance tandem mass spectrometer, the Xevo TQ-XS.</i></p><ul><li><strong>Recommended Use: </strong>Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.</li></ul><h5><strong>Ensure Absolute confidence with eXtreme Robustness</strong></h5><p>The Xevo TQ Absolute XR Mass Spectrometer analyzes up to six times more samples before service maintenance is required. Get the answer right first time and reduce unplanned downtime! This is one example of multiresidue pesticide analysis in a complex matrix (fish feed), for more examples please visit the brochure.</p><h5><strong>Accelerated Multiresidue Pesticides study</strong></h5><p>Fish feed, an example of a complex, challenging matrix, was tested using QuEChERS extraction without cleanup and without a divert-to-waste step. The Xevo TQ Absolute instrument demonstrated robust performance, operating effectively for approximately 1,500–2,000 injections (~3 months of continuous use1) before any signs of quadrupole charging appeared. The Xevo TQ Absolute XR mass spectrometer further extends this robustness, maintaining stable performance beyond 12,000 injections. Both instruments successfully handled over 400 MRMs in under 6 minutes, with no need for instrument venting for cleaning during the study.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg" alt="Waters: The Xevo TQ Absolute mass spectrometer began to show signs of quadrupole charging after approximately 1,500–2,000 injections of fish feed matrix (represented here by fluazinam; equivalent to ~3 months of use*). In contrast, the Xevo TQ Absolute XR system maintained system performance well beyond 12,000 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg 234w," sizes="100vw" width="1280" height="853"></p><h5><strong>Achieve Absolute performance with improved sensitivity</strong></h5><p>To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg" alt="Waters: The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg 245w," sizes="100vw" width="1280" height="676"></p><h5><strong>Realize Absolute efficiency and lower operational costs</strong></h5><p>Many businesses are trying to actively address environmental sustainability while also reducing operational costs – and the Xevo TQ Absolute XR instrument helps make that possible.</p><p>With lower electricity consumption, gas consumption, and BTU/hr output, it lessens the demand for air conditioning and drives down energy costs. The minimized LC-MS/MS footprint of the Xevo TQ Absolute XR Mass Spectrometer delivers more analytical power per square foot, enabling lab managers to maximize space and drive greater operational efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg" alt="Waters: The Xevo TQ Absolute XR instrument offers strong performance with less energy consumption in a compact form factor compared to today’s average high-end and high-end MS/MS systems, per data from published vendor site installation guides." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg 245w," sizes="100vw" width="1280" height="622"></p><h5><strong>Achieve Absolute productivity with flexible software options</strong></h5><p>Unlock the full potential of the instrument when paired with our next-generation solution software. From automated data processing to the time-saving Exception Focused Review (XFR) feature, you’ll streamline data review time by up to 50% and spend more time advancing your science.</p><p>Built on a secure, traceable platform, waters_connect for Quantitation is built to accelerate your LC-MS/MS workflows. giving you the absolute confidence to scale, adapt, and lead in any environment.</p><p>For labs that need proven versatility across applications, the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>Waters MassLynx Software</strong></a> continues to deliver time-tested flexibility and control.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg" alt="Waters: The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute XR provides absolute productivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg 234w," sizes="100vw" width="1024" height="682"></p><h5><strong>Accelerating your success with award-winning service</strong></h5><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with the Waters comprehensive analytical solutions with expert training (<strong>APS</strong>) and flexible and cost-effective solutions to advance your business with system service (<strong>FlexCHOICE</strong>), trade-ins and technological upgrades (<strong>FlexUP</strong>).</p><h5><strong>Cover more applications from our range of complementary technologies</strong></h5><p>Choose from our comprehensive range of ionization technologies providing differentiated application coverage to get the most from your analyses.</p><ul><li><strong>UniSpray</strong> - Absolute potential unlocked. Enable your lab to improve process efficiency through potential gains in sensitivity, precision and reduced matrix effects, relative to the equivalent electrospray ionization source option.3</li><li><strong>APGC </strong>- The next generation of GC is already here with Atmospheric Pressure Gas Chromatography offering labs absolute power - a powerful alternative to electron ionization technology, enabling low limits of detection, confident compound identification, and confirmation.</li><li><strong>DESI XS</strong> - With a combination of mass spectrometry imaging (MSI) and tandem quadrupole mass spectrometry, a remarkable technique emerges to perform sensitive, fast, and quantitative MSI directly on sample surfaces.&nbsp;</li></ul>

Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S cronos provides reliable performance at an attractive price point.

<h3><strong>Transform your Quantitative Capabilities</strong></h3><ul><li><strong>Affordable Reliable Performance</strong></li></ul><p><strong>From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S cronos provides reliable performance at an attractive price point.</strong></p><h4><strong>Reliable Performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S cronos study analyzing mycotoxins in cereal (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1,000 injections and only 3-8% relative standard deviation (RSD) for peak areas.</p><h4><strong>Affordable Performance</strong></h4><p>Cover your key applications with a robust and cost-efficient instrument that delivers reliable results. The Xevo TQ-S cronos can be applied to key demanding applications such as the quantification of nitrosamines in drug products and quantification of pesticides in fruits, vegetables, and cereals.</p><h4><strong>Cover a Wider Variety of Compounds in One Analysis</strong></h4><p>Choose the UniSpray source option to include ESI and non-ESI amenable compounds in one injection rather than changing chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h4><strong>Achieve More with Less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S cronos is 2-3X narrower than most other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S cronos provides up to 35% lower electrical power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_03f4497b5f.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry - With benchspace at a premium, choose an instrument designed to maximize performance per square inch..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_03f4497b5f.jpg 245w," sizes="100vw" width="1024" height="281"></p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S cronos provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S cronos won't let you down.</p><p><strong>Experiment 1:</strong> 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 3-8% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_47b4a3d71b.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_47b4a3d71b.jpg 245w," sizes="100vw" width="1201" height="637"></p><p><strong>Experiment 2:</strong> Sulfadimethoxine in protein-precipitated plasma also showed consistent performance over 3 days of continuous use with 1,780 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Sulfadimethoxine_in_protein_precipitated_plasma_25675e4fc5.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Experiment 2 - Sulfadimethoxine in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Sulfadimethoxine_in_protein_precipitated_plasma_25675e4fc5.jpg 245w," sizes="100vw" width="1200" height="636"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with its customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. The Xevo TQ-S cronos consumes less electricity than most other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><h5><strong>Table 1: Instrument / Power Consumption (W) / Heat Output (Btu/h)</strong></h5><ul><li><strong>Competitor B</strong> / 1,100 / 3,700</li><li><strong>Waters Xevo TQ-S cronos*</strong> / 1,230 / 4,194</li><li><strong>Competitor A</strong> / 1,600 / 5,456</li><li><strong>Competitor C</strong> / 1,960 / 6,500</li></ul><blockquote><p><strong>*</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S cronos Site Preparation Guide</strong></a></p><p>Power and heat outputs for entry tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ-S cronos is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><p><strong>waters_connect: </strong>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><p><strong>MassLynx:</strong> Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><p data-pm-slice="1 1 []"><strong>UniSpray™</strong> A novel ionization technique, exclusive to Waters, with wide compound coverage and potential sensitivity benefits. With applicability over a broad range of analytes and a simplified probe design, you can spend less time changing sources and performing maintenance, and more time analyzing your samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Uni_Spray_9cedf20611.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: UniSpray." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Uni_Spray_9cedf20611.jpg 235w," sizes="100vw" width="1465" height="974"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S cronos, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S cronos into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S cronos – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.

<h3><strong>Quantitate with Absolute Power</strong></h3><ul><li><strong>Harness Absolute Power for Confident, Fast Decisions</strong></li></ul><p><strong>The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.</strong></p><h4><strong>Absolute&nbsp;Performance</strong></h4><p>Achieve lower limits of quantitation to meet regulatory requirements with up to <strong>15x more sensitivity</strong> for challenging negative ionizing compounds than the previous product.</p><h4><strong>Absolute Efficiency &nbsp;</strong></h4><p>Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses <strong>up to 50% less electricity and gas and produces 50% less heat</strong> than most other high performance TQ mass spectrometry instruments on the market.</p><h4><strong>Absolute&nbsp;Productivity</strong></h4><p>Boost your productivity with flexible software solutions, including waters_connect,™ the modern, intuitive informatics solution that can<strong> save up to 50% of your data review time </strong>while facilitating data integrity.&nbsp;</p><h4><strong>Absolute Confidence</strong></h4><p>Ensure consistent robustness and reproducibility so you can <strong>maintain performance and productivity </strong>over a longer time period.</p><h3><strong>Absolute Performance</strong></h3><h4><strong>Increased sensitivity with lower limits of quantitation</strong></h4><p>One of the largest challenges facing many labs is the need to achieve lower limits of quantitation and meet regulatory requirements, particularly for challenging negative ionizing compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: *Xevo TQ Absolute shows up to 15x better ion response as compared to the Xevo TQ-XS and up to 6x better ion response than another leading high-performance LC-MS/MS instrument." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/thumbnail_Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp 245w," sizes="100vw" width="1024" height="540"></p><p>Ensure you have the confidence in your data to make decisions fast with an instrument that provides Absolute Performance. <strong>Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds</strong> than the previous product, so you can make decisions quickly and efficiently.</p><h3><strong>Absolute Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.&nbsp;</p><p>Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. During development of the Xevo TQ Absolute, Waters has addressed these challenges by providing an instrument with lower electricity consumption, gas consumption, and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p>The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, enabling laboratory managers to fully optimize their facilities and increase efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute Efficiency." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg 206w," sizes="100vw" width="1050" height="794"></p><p>*Source: <a target="_blank" rel="noopener noreferrer" href="https://sciex.com/content/dam/SCIEX/pdf/customer-docs/site-planning-guide/7500-site-planning-guide-en.pdf">https://sciex.com/</a></p><h3><strong>Absolute Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions&nbsp;</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ Absolute is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements</p><h5><strong>waters_connect</strong></h5><p>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><h5><strong>MassLynx</strong></h5><p>Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Absolute Confidence</strong></h3><h4><strong>Tackle your toughest challenges</strong></h4><p>Analytical laboratories face several challenges that are constantly changing, so it’s important to have Absolute Confidence that your analytical instrumentation can keep pace.&nbsp;</p><p>The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility, so you can maintain performance and productivity over a longer time period.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: New source shield technology featured in the Xevo TQ Absolute Mass Spectrometer minimizes contamination and increases uptime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/thumbnail_Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Better by design</strong></h4><p>Optimal probe positioning guidance ensures you can achieve the best possible performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument. A new source shield maximizes uptime by minimizing contamination of the source from sample matrix or mobile phase salts.</p><h3><strong>Absolute Support</strong></h3><h4><strong>Ensure your success with world-renowned services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute support." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/thumbnail_Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp 234w," sizes="100vw" width="1024" height="682"></p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ Absolute, you can:</strong></p><h4><strong>Get Up And Running Quicly</strong></h4><p>Get the onsite training and consultation you need to integrate the Xevo TQ Absolute into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet Your Lab’s Unique Requirements&nbsp;</strong></h4><p>Protect your high-performance instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitates Compliance</strong></h4><p>Simplify the process of qualification, validation, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce Total Cost Of Ownership</strong></h4><p>FlexCAPITAL<strong>** </strong>is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage Your Existing Technology</strong></h4><p>With the FlexUP technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ Absolute – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>** </strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

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