Commercial and public spectral libraries provide broad coverage for LC-MS/MS identification, but they cannot contain every compound that matters to a specific laboratory. Proprietary products, metabolites, intermediates, impurities, degradation products, biomarkers, and internally characterized compounds may be highly relevant even if they are absent from standard reference collections. NIST26 allows laboratories to build their own MS/MS user libraries and integrate them directly into routine search workflows, creating a focused resource tailored to their analytical needs.<h4>Why Create a User MS/MS Library?</h4>User libraries are usually much smaller than commercial or public spectral databases, but their value is not determined by size alone.A laboratory-specific library may contain exactly the compounds most important for a particular application. These can include:<ul><li>proprietary products,</li><li>known metabolites,</li><li>synthesis intermediates,</li><li>impurities,</li><li>degradation products,</li><li>biomarkers,</li><li>compounds associated with specific industrial or environmental samples.</li></ul>Such libraries can therefore provide highly relevant identifications in pharmaceutical development, industrial R&amp;D, medical laboratories, environmental analysis, and other specialized fields. A relatively small collection of carefully characterized compounds may be more useful for a particular laboratory than a much larger general-purpose database.&nbsp;<h4>What Information Can Be Stored with Each Spectrum?</h4>Creating a useful library entry involves more than importing an MS/MS spectrum.A complete record can combine several types of information, including the experimental spectrum, chemical structure, instrumental parameters, ionization information, sample history, and additional user-defined metadata.Spectra can be transferred from vendor software into NIST Library Search, or they can be sent from the Chromatogram tab directly to the Library Search environment in NIST26. Chemical structures can be imported through the Windows clipboard from a molecular drawing program, while standard experimental parameters and sample-history information can be prepared separately and added to the entry.&nbsp;The ability to keep analytical metadata together with the spectrum is particularly important for internally generated libraries because it preserves the context in which the reference spectrum was acquired.<h4>Using Tags to Organize LC-MS/MS Metadata</h4>NIST26 supports a range of structured tags for LC-MS/MS spectra.These can describe parameters such as:<ul><li>spectrum type,</li><li>compound type,</li><li>ion name,</li><li>precursor type,</li><li>precursor m/z,</li><li>collision energy,</li><li>instrument type,</li><li>sample identifier,</li><li>ionization mode,</li><li>ion polarity,</li><li>collision gas,</li><li>pressure,</li><li>mass range,</li><li>maximum intensity,</li><li>cone voltage,</li><li>charge,</li><li>molecular weight,</li><li>known impurities,</li><li>related CAS numbers,</li><li>peptide sequence and peptide modifications.</li></ul>This provides a convenient way to attach searchable and standardized experimental information to spectra rather than leaving all metadata in an unstructured comment field.&nbsp;Tags can be entered individually through the Additional Info section in the Librarian interface, but when many spectra are being added, a grouped approach can be considerably faster.&nbsp;<h4>Adding Groups of Tags Efficiently</h4>For repetitive workflows, metadata can be prepared in advance and pasted into NIST26 as a group.The presentation recommends maintaining frequently used tag sets in a simple text document, then copying them into the synonym field and using Add to List to convert them into structured information.This is especially useful when the vendor software already transfers some parameters automatically. Users can then add only the missing information, such as ion adduct or polarity, rather than duplicating metadata already imported with the spectrum.&nbsp;Care is required because entering information that is already present may create duplicate metadata.This workflow can substantially accelerate library creation when many spectra share the same instrument configuration or acquisition parameters.<h4>Preserving Sample History</h4>A spectral match is more useful when the origin of the reference spectrum is known.NIST26 therefore allows detailed sample information to be stored in the comment field. For batches of related samples, the text can be prepared in Notepad or another editor and pasted into multiple records.Examples of useful information include sampling location, sampling date and time, analyst name, organization, internal sample identifier, project information, or other relevant context.&nbsp;For environmental, clinical, pharmaceutical, and industrial laboratories, this information can become an important part of data traceability.<h4>Adding Molecular Structures</h4>A user library becomes considerably more useful when spectra are linked to molecular structures.Structures can be created from scratch in a chemical drawing program. Alternatively, a similar structure can be located in NIST Search and sent to the default structure editor, where it can be modified as needed.Once completed, the structure can be copied to the Windows clipboard and inserted into the NIST Librarian spectrum-information window. NIST26 can then calculate the molecular formula and molecular weight from the imported structure.&nbsp;This linkage between spectrum and structure supports more informative library displays and structure-based searching.<h4>Creating Custom User-Defined Tags</h4>In addition to the standard LC-MS/MS tags, laboratories can define their own metadata fields.Examples shown include identifiers such as:<ul><li>chemist,</li><li>laboratory notebook number,</li><li>analyst.</li></ul>The information can be prepared in a text editor and added using the appropriate tag syntax. Once configured in the Comment Field Display settings, these values are displayed as separate structured lines rather than remaining embedded in the general comments.&nbsp;This flexibility makes the library more suitable for laboratories with established internal documentation systems or quality-management requirements.NIST can also automatically add information such as the InChIKey and an estimated retention index when appropriate structural information is available.&nbsp;<h4>High-Resolution and Low-Resolution Libraries Should Be Kept Separate</h4>User libraries do not have to contain only high-resolution spectra.Low-resolution MS/MS spectra may also be valuable, including spectra generated by:<ul><li>in-source collision on single-quadrupole instruments,</li><li>triple-quadrupole MS/MS,</li><li>other nominal-mass workflows.</li></ul>The recommendation is to maintain separate high-resolution and low-resolution user libraries, because the appropriate search strategies and handling can differ.&nbsp;Low-resolution spectra can still generate strong library-search results and may be particularly useful when laboratories want to preserve historical data or incorporate spectra from multiple instrument types.<h4>Important Software Considerations When Importing Spectra</h4>The presentation also highlights several practical software issues that users should be aware of.One concerns the Intensity Threshold setting in the Spectrum Import Options window. When an intensity threshold is applied during import from vendor software, high-resolution spectral values may be converted to nominal mass rather than preserving the expected decimal precision.For laboratories building high-resolution user libraries, this is an important detail because accurate-mass information is one of the main advantages of HRMS data.Another issue affects some library-search modes after high-resolution spectra are added to a user library.<h4>HiRes No Precursor and Hybrid Search Limitations</h4>After adding high-resolution spectra, certain HiRes NoPrecursor and Similarity Hybrid MS/MS searches may not function correctly.A workaround involves exporting the affected library using Lib2NIST into MSP ASCII files together with the associated molecular structure files, then importing the data back into NIST library format.&nbsp;The presentation specifically warns against attempting the problematic MS/MS Hybrid Search under these conditions because it may cause the software to crash.An EI Normal search can mimic some of the functionality of HiRes No Precursor and may work effectively when high- and low-resolution libraries are searched together. HiRes NoPrecursor can also operate with presearch disabled, although this can make searching considerably slower.&nbsp;<h4>Display Issues in the Chromatogram Window</h4>Another software behavior concerns how spectral values are displayed in the Chromatogram tab.Values from Spectrum Import Options are reflected in the head-to-head spectral display. If settings are adjusted for low-resolution spectra, the displayed masses may appear truncated.Importantly, this visual behavior does not affect the results in the accurate-mass deconvolution and library-searching table; it affects only the spectral display at the top of the Chromatogram window.&nbsp;Distinguishing display behavior from actual processing results is important to avoid misinterpreting valid search results as corrupted data.<h4>Updating the Library After Adding New Entries</h4>User-library maintenance does not end when a spectrum has been added.Whenever a new entry containing a molecular structure is introduced, the structure index should be updated so that the new compound can be included properly in structure searching.The InChIKey appears to update with the structure, but if duplicate records are not being handled correctly, the InChIKey index may also need to be rebuilt.&nbsp;If a new library folder is added to the NIST26 MSSEARCH directory while the software is already running, users should also update the library list so that the newly added collection becomes available without restarting the entire environment.&nbsp;<h4>Using Lib2NIST to Repair High-Resolution User Libraries</h4>The Lib2NIST utility plays an important role in resolving some high-resolution library-search issues.The workflow involves exporting the problematic high-resolution library to an MSP file together with its molecular structure files and then re-importing the data into NIST library format.The corrected library can then be placed back into the NIST26 MSSEARCH directory. It is advisable to preserve the original library under a different name until the repaired version has been tested successfully.&nbsp;The presentation also recommends closing NIST Search while performing Lib2NIST conversions.<h4>Small Libraries Can Deliver High Analytical Value</h4>The central message is straightforward: a user library does not need to contain hundreds of thousands of compounds to be useful.A carefully curated collection of spectra from compounds that repeatedly appear in a laboratory's own samples can dramatically improve identification relevance. This is especially valuable for compounds that are proprietary, newly synthesized, application-specific, or otherwise poorly represented in public and commercial databases.By combining MS/MS spectra with structures, acquisition metadata, sample history, tags, and internally defined information, NIST26 can become more than a search engine for commercial databases. It can serve as a laboratory-specific knowledge base built around compounds that genuinely matter to the user's work.For specialized LC-MS/MS workflows, that may be one of the most valuable ways to extend the capabilities of spectral library searching.

Creating MS/MS User Libraries in NIST26

Wiley announces the expansion of its spectral libraries across IR and Raman, adding empirical and computed reference data spanning forensics, pigments and dyes, mineralogy, materials, polymers, and pharmaceuticals. This release adds over a thousand new empirical reference spectra, plus more than 429,000 new SmartSpectra records, across dozens of updated and new databases. This brings the combined collections to over 1.4 million IR spectra and 230,000 Raman spectra.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Wiley_continues_to_expand_its_IR_Raman_and_Smart_Spectra_spectral_libraries_806b34cdc1.jpg" alt="Wiley: Wiley continues to expand its IR, Raman, and SmartSpectra spectral libraries" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Wiley_continues_to_expand_its_IR_Raman_and_Smart_Spectra_spectral_libraries_806b34cdc1.jpg 245w," sizes="100vw" width="1600" height="838">“Scientific discoveries and business decisions depend on trustworthy analytical results,” said Graeme Whitley, senior director, data science solutions at Wiley. “The value of a spectral library expansion is not simply that it adds more records. It gives analysts more relevant reference candidates when they encounter unfamiliar materials, whether they are verifying a polymer, investigating a pharmaceutical sample, examining a mineral, or screening a forensic specimen.”<h4>Highlights include:</h4><ul><li>Forensics: A new Raman forensics database adds reference spectra for colorant and dye identification on textiles, drawn from real fiber-evidence research, useful for investigators working on dye and textile analysis.</li><li>Pigments and dyes: New Raman and IR data significantly broadens pigment and dye coverage, including historic artists' pigments, supporting art conservation and cultural-heritage authentication work.</li><li>Minerals: New Raman and IR data extends coverage to minerals from different localities and Martian mineral analogs. This release includes new Raman additions from our ongoing collaboration with the American Museum of Natural History, now cross-referenced with DANA Classification Numbers and Mindat IDs, giving mineralogists and gemologists an easier way to identify entries against established references.</li><li>Materials and semiconductors: New Raman and IR data covers crystal growth relevant to battery materials, rare-earth-doped magnetic crystals, and flexible and 2D semiconductor materials, useful for researchers in battery, magnetic materials, and electronics work.</li><li>Polymers: New Raman and IR data spans 3D-printed, MOF-integrated microlattices, environmental plastic aging and recycled PET materials, and food packaging plastics. New Raman reference spectra also cover more than two dozen synthetic polymer types for identifying microplastics in environmental samples.</li><li>Clinical and pharma: New Raman and IR data covers antibiotic classes, including beta-lactams, and the WHO's essential antibiotic list, plus bone mineralization studies in clinical models. A new IR dataset also adds spectra for common over-the-counter medications, including aspirin, ibuprofen, and paracetamol, helping quality control teams confirm formulations faster.</li><li>SmartSpectra: Our SmartSpectra IR, Raman, and vapor-phase IR collections continue to grow, adding 243,000+ IR, 67,000+ Raman, and 119,000+ vapor-phase IR computed reference spectra to support broad, high-throughput identification.</li></ul><blockquote><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/spectral-databases/">Learn more about Wiley Spectral Databases</a><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/how-to-update-knowitall-databases/">Existing subscribers can find guidance on updating their databases here</a></blockquote><h4>Wiley Spectral Databases</h4>Wiley's spectral databases are consistently evolving to meet today's research demands, covering multiple spectral techniques across a wide range of applications including polymers, materials, environmental, forensics, toxicology, pharmaceutical, biotech, automotive, aerospace, food, cosmetics, and more. Built on rigorous quality protocols, Wiley delivers industry-leading spectral data and intelligent tools to accelerate analysis and deliver deeper insights — making it the authoritative, trusted source that analytical labs worldwide rely on.&nbsp;

Wiley continues to expand its IR, Raman, and SmartSpectra spectral libraries

Per- and polyfluoroalkyl substances (PFAS)&nbsp;analysis is no longer&nbsp;defined by&nbsp;a fixed list of known compounds.As regulatory frameworks evolve and scientific understanding deepens, laboratories are being asked to go beyond routine testing. In addition to quantifying known PFAS, they must also investigate unknown, unexpected, and emerging compounds that fall outside predefined target lists.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_509ce49fc2.webp" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_509ce49fc2.webp 245w," sizes="100vw" width="1024" height="526">This shift introduces a fundamental analytical challenge.Targeted quantitation provides robust and validated concentration data for known PFAS. However, by design, it only answers questions about compounds already included in the method. In contrast, non-targeted analysis,&nbsp;using high-resolution accurate-mass&nbsp;(HRAM)&nbsp;data,&nbsp;enables scientists to explore the broader chemical landscape, revealing&nbsp;additional&nbsp;PFAS&nbsp;that were not included in a targeted quantitation method.For PFAS, where thousands of structurally related compounds and transformation products may be present, neither approach&nbsp;alone provides a complete picture.The&nbsp;real challenge&nbsp;lies in connecting these workflows. Discovery findings must be translated into actionable results that can be reviewed, followed up, and reported within a controlled analytical framework.In a previous&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7167">blog post</a>, we introduced how <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759">Thermo Scientific Compound Discoverer software </a>and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/76">Thermo Scientific Chromeleon Chromatography Data System&nbsp;(CDS)&nbsp;</a>connect discovery and routine workflows.&nbsp;Here, we explore what that connection looks like in practice using PFAS analysis as an example.<h3>Why PFAS&nbsp;requires&nbsp;more than one analytical question</h3>PFAS&nbsp;represent a&nbsp;large&nbsp;and diverse class of compounds,&nbsp;with&nbsp;some&nbsp;estimates exceeding&nbsp;40,000 individual substances. Regulatory methods typically focus on a limited subset, yet environmental and biological samples often&nbsp;contain&nbsp;many more&nbsp;PFAS, including precursors and transformation products.This creates two&nbsp;essential and&nbsp;complementary analytical questions:How much of these known PFAS are present?andWhat other PFAS-related compounds might be present?A complete workflow needs to support both&nbsp;questions.<h3>Starting with targeted quantitation</h3>For known PFAS, targeted quantitation&nbsp;remains&nbsp;the&nbsp;backbone of routine analysis.Chromeleon CDS provides&nbsp;a&nbsp;controlled environment for&nbsp;data acquisition, processing, calibration, and reporting. In a PFAS workflow,&nbsp;this supports routine quantitation of predefined targets using laboratory-specific method and review criteria.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_2_7ff8eda8fe.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow: Figure 1. Targeted quantitation of known PFAS in Chromeleon CDS.&nbsp;This example is&nbsp;from the analysis of PFAS using a&nbsp;Thermo Scientific&nbsp;Orbitrap Exploris&nbsp;240. Here&nbsp;we are showing&nbsp;the&nbsp;calibration curve (right) and extracted&nbsp;ion chromatogram&nbsp;(left)&nbsp;of 7:3 FTCA&nbsp;at 6 ng/L.&nbsp;The bottom&nbsp;half&nbsp;shows the processing method that&nbsp;contains&nbsp;many target PFAS and&nbsp;isotopically-labelled&nbsp;internal standards." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_2_7ff8eda8fe.jpg 208w," sizes="100vw" width="794" height="596">This targeted workflow is essential, but it is only part of the story. A sample may contain PFAS-related compounds not included in the original method.<h3>Looking beyond known PFAS</h3>Once HRAM data have been acquired, the same dataset can be explored beyond the target list using Compound Discoverer software. This enables comprehensive analysis of complex datasets, including:<ul><li>Detection and alignment of unknown features</li><li>Statistical comparison across samples and blanks</li><li>Spectral library searching and database annotation</li><li>Evaluation of isotope patterns, fragmentation, and homologous series</li></ul>For PFAS, this is particularly valuable. The software can leverage characteristic properties such as negative mass defect, CF₂-based homologous series, and diagnostic fragment ions to prioritize PFAS-related candidates and assign confidence to putative identifications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_3_e523e1cdc9.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow: Figure 2. Discovery of additional PFAS-related components in Compound Discoverer software. Here we show an example of using PFAS fragment libraries, one of many PFAS-specific resources available within Compound Discoverer software, to annotate fragments within acquired MS2 spectra of two unknown compounds and then identify them as PFAS that were outside the targeted quantitation method." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_3_e523e1cdc9.jpg 233w," sizes="100vw" width="1520" height="1016">The goal of discovery is not simply to generate more data. It is to reduce complexity and identify the most relevant candidates for further investigation with a defined level of confidence.<h3>From discovery to follow-up</h3>One of the most important questions in non-targeted analysis is what happens after candidate identification.Discovery workflows can identify interesting candidates, but those candidates need to move into a practical follow-up process. Scientists may want to monitor them across additional samples, estimate relative or semi-quantitative abundance, trend their presence over time, or include them in a reviewable report.This is where the connection between Compound Discoverer software and Chromeleon CDS becomes especially valuable.After PFAS candidates have been prioritized in Compound Discoverer software, selected components can be transferred back into Chromeleon CDS and incorporated into the Chromeleon processing methods for follow-up analysis. This allows scientists to evaluate these compounds within the same controlled environment used for targeted quantitation.For PFAS analysis, this may support semi-quantitative follow-up for compounds where authentic standards are not yet available. While fully quantitative results require appropriate standards and validated methods, semi-quantitative workflows can provide useful estimates or relative comparisons to help prioritize further investigation.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_4_8ee8ebc2df.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow: Figure 3. Prioritized PFAS candidates brought back into Chromeleon CDS for follow-up. Prioritized PFAS candidates from Compound Discoverer software can be brought back into Chromeleon CDS for follow-up review, semi-quantitative evaluation, and controlled reporting." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_4_8ee8ebc2df.jpg 245w," sizes="100vw" width="1512" height="751">This is the key workflow advantage: discovery does not stop at identification. It can feed directly into a practical analytical process.<h3>Why this matters</h3>PFAS analysis increasingly requires laboratories to balance routine testing with exploratory investigation.A connected workflow between Chromeleon CDS and Compound Discoverer software supports this by:<ul><li>Combining targeted quantitation and non-targeted discovery to characterize samples more completely</li><li>Reducing manual data transfer and workflow fragmentation</li><li>Enabling discovery results to be reviewed and reported within a controlled CDS environment</li><li>Supporting investigation of emerging PFAS investigations without immediate method redevelopment</li><li>Bridging research-driven insights with routine analytical workflows</li></ul>This reflects a broader shift in analytical science, where the value lies not only in generating data, but in connecting workflows and turning data into actionable information.<h3>Moving PFAS analysis forward</h3>PFAS analysis is evolving from a fixed target list toward a more comprehensive understanding of complex chemical mixtures.Laboratories must quantify known compounds while remaining prepared to identify and evaluate what lies beyond them.By connecting Compound Discoverer software with Chromeleon CDS, laboratories can move seamlessly from targeted quantitation to discovery and into structured follow-up. The result is a more complete view of PFAS contamination and a more efficient path from data to insight.<h3>Learn more</h3>Explore how <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759">Compound Discoverer software</a> and<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/76"> Chromeleon CDS </a>can help connect targeted quantitation and non-targeted discovery workflows for <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/environmental/environmental-contaminant-analysis/emerging-contaminants/pfas-testing.html">PFAS analysis</a>.<blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PFAS #Chromeleon #CompoundDiscoverer #Environmental</blockquote>

PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow

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Thermo Scientific Dionex IonPac CS18 IC Columns

Separate polar amines with the Thermo Scientific™ Dionex™ IonPac™ CS18 Cation-Exchange Column. 

Separate polar amines with the Thermo Scientific™ Dionex™ IonPac™ CS18 Cation-Exchange Column. This low-capacity, carboxylate-functionalized column is specifically optimized for the separation of common cations, small polar amines, and moderately hydrophobic and polyvalent anions using simple aqueous eluents and elevated temperatures. However, the newer Thermo Scientific™ Dionex™ IonPac™ CS19 or Dionex IonPac CS19-4μm Cation Exchange Columns are the recommended columns for these applications.<h5>Cation and Amine Separations Using Suppressed and Non-suppressed Conductivity Detection</h5><ul><li>Low-capacity column optimized for the isocratic and gradient separations of polar amines, moderately hydrophobic amines, and polyvalent cations</li><li>Can be used with suppressed and nonsuppressed conductivity detection</li><li>Nonsuppressed conductivity detection is recommended to extend calibration linearity for ammonium or weak bases</li><li>Can also be used for many of the nonsuppressed applications supported by the Dionex IonPac SCS-1 column but with much greater column stability</li><li>Optimized for simple acidic gradient separations with minimal baseline shift</li><li>Low capacity facilitates modest acid concentrations to elute polyvalent cations</li><li>Compatible with moderate amounts of organic solvents, excluding alcohols, to enhance analyte solubility, modify column selectivity, and facilitate effective column clean-up</li></ul><h5>Formats Available for Application Flexibility</h5><ul><li>2x250mm analytical columns</li><li>2x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 290 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: Acidic Eluents (pH 0 to 7), 0 to 20% HPLC Solvents, Alcohols Should be Avoided</li><li>Stationary phase: IonPac CS18</li><li>Format: Microbore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS19 IC Columns

Separate common inorganic cations, small polar amines and polyvalent amines using Thermo Scientific Dionex IonPac CS19 IC Columns

Separate polar amines with the Thermo Scientific™ Dionex™ IonPac™ CS19 Cation-Exchange Column. This high-capacity, carboxylate-functionalized column is specifically optimized for the separation of common cations, small polar amines, and moderately hydrophobic and polyvalent cations using simple aqueous eluents and elevated temperatures. The column is ideal for analysis of power plant waters treated with ammonium, morpholine, or ethanolamine and can also be used to analyze chemical additives, chemical process solutions, scrubber solutions, personal care products, and food samples.<h5>Analyze Common Cations and Small Polar Amines in Diverse Matrices</h5><ul><li>Simple gradient separation of small polar amines (including alkanolamines and methylamines), and moderately hydrophobic and polyvalent amines (including biogenic amines and alkyl diamines)</li><li>Optimized for simple acidic gradient separations with minimal baseline shift</li><li>High capacity facilitates the analysis of widely disparate peak pairs and high ionic strength matrices with less overloading of the column</li><li>Compatible with moderate amounts of organic solvents, excluding alcohols, to enhance analyte solubility, modify column selectivity, and facilitate effective column clean-up</li></ul><h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x250mm, 2x250mm analytical columns</li><li>4x50mm, 2x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 2410 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 3000 psi (207 bar)</li><li>Solvent Compatibility: Acidic Eluents (pH 0 to 7), 0 to 10% HPLC Solvents, Alcohols Should be Avoided</li><li>Stationary phase: Super Macroporous Resin</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS19-4μm IC Columns

High-capacity ion-exchange column with 4 μm resin for highest resolution of cations and polar amines in complex samples. Enables fast, reliable separations and cost-effective operation with HPIC systems.

Attain the optimal combination of chromatographic speed and high resolution using the new Thermo Scientific™ Dionex™ IonPac™ CS19-4μm Capillary, Analytical, &amp; Guard Column. This high-capacity, high-resolution carboxylate-functionalized column provides excellent resolution of common cations, small polar amines, and polyvalent amines in complex sample matrices such as power plant waters treated with ammonium, morpholine, or ethanolamine, chemical additives, chemical process solutions, scrubber solutions, personal care products, and food samples. Compared to the Thermo Scientific™ Dionex™ IonPac™ CS19 column, this column uses smaller resin particles for more efficient separations resulting in more accurate peak integration and more reliable results.<h5>Highest Resolution Separation of Common Cations and Small Polar Amines in Diverse Matrices</h5><ul><li>Highest resolution, through the use of smaller resin particles, of common cations and small polar amines in complex sample matrices</li><li>Higher peak efficiency and increased peak resolution for more consistent integration and more reliable results</li><li>Easily transfer applications from the Dionex IonPac CS19 column to the 4 μm column due to the similar selectivity</li><li>Simple gradient separation of small polar amines (including alkanolamines and methylamines), and moderately hydrophobic and polyvalent amines (including biogenic amines and alkyl diamines)</li><li>High capacity facilitates injection of more concentrated samples without column overloading or peak broadening</li><li>Compatible with moderate amounts of organic solvents, excluding alcohols, to enhance analyte solubility, modify column selectivity, and facilitate effective column clean-up</li></ul><h5>Use With a High-Pressure IC System</h5>Higher resolution is achieved through the use of smaller resin particles, which produce a column backpressure over 3000 psi at the standard flow rates. A high-pressure IC system, such as the Thermo Scientific™ Dionex™ ICS-5000+ HPIC™ or the Dionex ICS-4000 Capillary HPIC system is required to operate this column under standard conditions and take advantage of elevated flow rates and faster run times.<h5>Reduce Operating Costs With Lower Eluent Requirements</h5>The Dionex IonPac CS19-4μm capillary column provides the same performance as the standard bore and microbore Dionex IonPac CS19-4μm columns because it is packed with the same material. Operating costs are reduced because the capillary system operates at only 1% of the eluent flow rate of the standard bore system, requiring less eluent and producing less waste.<h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x250mm, 2x250mm analytical columns</li><li>4x50mm, 2x50mm guard columns</li><li>0.4x250mm capillary column, 0.4x50mm capillary guard column</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 2410 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 5000 psi (345 bar)</li><li>Solvent Compatibility: Acidic Eluents (pH 0 to 7), 10% HPLC Solvents, Alcohols Should be Avoided</li><li>Stationary phase: IonPac CS19-4μm</li><li>Format: Standard Bore</li></ul>

Thermo Scientific Dionex IonPac CS20 IC Columns

Analyze inorganic cations and amines using the Thermo Scientific™ Dionex™ IonPac™ CS20 ion chromatography (IC) columns.

Analyze inorganic cations and amines using the Thermo Scientific™ Dionex™ IonPac™ CS20 ion chromatography (IC) columns. Designed to complement Dionex IonPac CS18 and Dionex IonPac CS19 columns, the Dionex IonPac CS20 columns provide a large separation window between monovalent and divalent cations. This allows most amines to elute after the alkali metals but before the alkaline earth metals, moving the amines away from matrix ions that would normally make quantitation difficult. Its selectivity makes the Dionex IonPac CS20 particularly useful for determining a variety of alkyl and alkanol amines.<h5>Superior performance in the separation of common inorganic cations and amines</h5><ul><li>Use the high capacity Dionex IonPac CS20 to determine inorganic cations and amines including methylamines, ethylamines, ethanolamines, and alkanolamines in diverse sample matrices</li><li>Unique stationary phase functionalized with a combination of sulfonic, phosphonic, and carboxylic acid groups can tolerate acidic samples containing up to 100mM hydronium ion (pH 1) with minimum loss of performance</li><li>Operable over a wide temperature range (15-70°C) to facilitate method development and improve critical pair separations</li><li>Compatible with 100% organic solvents (acetonitrile and acetone) to enhance analyte solubility, modify column selectivity, and facilitate effective column clean-up</li></ul><h5>Use with a high-pressure IC system</h5>A high-pressure IC system, such as the Thermo Scientific™ Dionex™ ICS-5000+ HPIC™, Dionex Integrion™ HPIC system, or the Dionex ICS-4000 Capillary HPIC system is required to operate this column under standard conditions.<h5>Reduce operating costs with lower eluent requirements</h5>The Dionex IonPac CS20 capillary columns provide the same performance as the standard bore and microbore Dionex IonPac CS20 columns because they are packed with the same material. Operating costs are reduced because the capillary system operates at only 1% of the eluent flow rate of the standard bore system, requiring less eluent and producing less waste.<h5>Multiple Formats Available</h5><ul><li>4x250mm and 2x250mm analytical columns</li><li>4x50mm and 2x50mm analytical guard columns</li><li>0.4x250mm capillary columns</li><li>0.4x50mm capillary guard columns</li><li>Smaller i.d. columns provide higher mass sensitivity, conserve eluent and reagents, and reduce operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 3000 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 5000 psi (345 bar)</li><li>Solvent Compatibility: pH 0 to 7, 0 to 100% Organic HPLC Solvents, Alcohols Should be Avoided</li><li>Stationary phase: Macroporous Resin</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS21-Fast-4μm IC Columns

Resolve quaternary amine cationic polar pesticides including chlormequat, mepiquat, paraquat, and diquat with the Thermo Scientific™ Dionex™ IonPac™ CS21-Fast-4μm column. 

Resolve quaternary amine cationic polar pesticides including chlormequat, mepiquat, paraquat, and diquat with the Thermo Scientific™ Dionex™ IonPac™ CS21-Fast-4μm column. The unique selectivity of the Dionex IonPac CS21-Fast-4μm column allows it to resolve trace amounts of cationic polar pesticides in high ionic strength matrices within approximately fifteen minutes using an electrolytically generated MSA gradient. Quaternary amines are eluted away from matrix cations, making the Dionex IonPac CS21-Fast-4μm column ideal for IC-MS/MS applications where matrix ions are diverted to waste.<h5>Superior Chromatographic Performance</h5><ul><li>High capacity allows injection of complex matrices without overloading the column while maintaining excellent peak shapes for lower concentration analytes.</li><li>Quickly separate trace levels of the four major quaternary amine cationic polar pesticides chlormequat, mepiquat, paraquat, and diquat in high ionic strength matrices using an MSA gradient.</li><li>Separate other cationic pesticides of interest including diethanolamine, triethanolamine, N-N-dimethylhydrazine, trimethylsulfonium, morpholine, melamine, streptomycin, and nereistoxin.</li></ul><h5>Specifically designed for IC-MS/MS applications</h5><ul><li>Completely resolves paraquat and diquat, species with similar masses.</li><li>Available in microbore format that is compatible with MS flow rates.</li><li>Selectivity allows matrix ions to be diverted to waste which keeps the MS source cleaner.</li><li>Solvent compatible (up to 100% acetonitrile and 20% isopropyl alcohol).</li><li>Fast analysis of cationic polar pesticides in food, beverages, and environmental waters.</li></ul><h5>Use with a High-Pressure IC system</h5>A high-pressure IC system, such as the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/410">Thermo Scientific™ Dionex™ ICS-6000 HPIC system</a> or <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/408">Thermo Scientific™ Dionex™ Integrion™ HPIC system</a> is required to operate this column under standard conditions.<h4>Specifications</h4><ul><li>Crosslinking: 80% DVB</li><li>Column Capacity: 110 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 5000 psi (345 bar)</li><li>Solvent Compatibility: pH 0-7, HPLC solvents (100% acetonitrile and up to 20% isopropyl alcohol), primary and secondary alcohols should be avoided)</li><li>Format: Microbore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific SurePac Bio 550 SEC MDi HPLC Columns

SurePac™ Bio 550 SEC MDi™ column delivers high-resolution, reproducible AAV size-based separations with 3 μm silica, 550 Å pores, and bioinert hardware for optimal recovery and QC reliability.

Experience the future of Size-Exclusion Chromatography (SEC) with SurePac™ Bio 550 SEC MDi™ analytical columns and guards exclusively designed to deliver robust and reproducible performance at high resolution and throughput to accelerate your therapeutics analysis process. The column's groundbreaking MDi™ technology integrates our advanced 3 μm monodisperse silica particle platform with bioinert hardware to ensure superior reliability for best sample recovery. SurePac™ Bio 550 SEC MDi™ column is ideal for AAV gene therapeutics analysis and offers excellent selectivity due to the dedicated smaller particle (3 μm) size combined with wide-pore (550Å) for separating monomeric AAVs from aggregates based on their size differences.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Sure_Pac_Bio_550_SEC_M_Di_HPLC_Columns_3_8391a584e0.jpg" alt="Thermo Scientific: SEM image of 3μm monodisperse silica particles (left) vs. 3 μm polydisperse particles (right)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Sure_Pac_Bio_550_SEC_M_Di_HPLC_Columns_3_8391a584e0.jpg 245w," sizes="100vw" width="1023" height="508">SurePac Bio 550 SEC MDi columns and guards are based on high-purity, spherical, porous (550 Å), 3 μm monodispersed silica particles that are covalently modified with a proprietary diol hydrophilic layer. This unique design yields shorter diffusion distances and enhanced reproducible mass transfer and narrower peaks. The consistent size of these particles facilitates precise control over media synthesis and column packing, significantly improving column-to-column and lot-to-lot reproducibility. The columns are housed in a hydrophilic bioinert-coated stainless-steel hardware to eliminate secondary interactions, ensuring optimal performance during the initial injection process.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Sure_Pac_Bio_550_SEC_M_Di_HPLC_Columns_043f131056.jpg" alt="Thermo Scientific: SurePac Bio 550 SEC MDi HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Sure_Pac_Bio_550_SEC_M_Di_HPLC_Columns_043f131056.jpg 156w," sizes="100vw" width="650" height="650"><ul><li>Ideal for AAV gene therapy characterization and quality control assessment due to selectivity of the dedicated smaller particle (3 μm) combined with wide-pore (550Å) size</li><li>Superior column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing</li><li>High-efficiency peaks with excellent recovery</li><li>Higher resolution and throughput for fast turnaround time without sacrificing performance</li><li>Bioinert hardware to eliminate analyte adsorption</li></ul><h4>Specifications</h4><ul><li>Max. Pressure: 3500 psi (241 bar)</li><li>Packing Material: Monodisperse Silica Resin</li><li>Flow Rate: 0.6 mL/min</li><li>Temperature: 20°C to 60°C</li><li>Phase: Size Exclusion</li><li>Particle Size: 3 μm</li><li>pH: 2 to 8</li></ul>

Phenomenex Lux Cellulose-3 Chiral HPLC Columns

Phenomenex Lux Cellulose-3 chiral HPLC column provides reliable enantiomer separation, performing as well or better than CHIRALCEL® OJ® with unique chiral selectivity.

This first to market halogenated cellulose phenyl carbamate derivative offers unique chiral recognition abilities that complement the rest of the Lux family of columns.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Lux_Cellulose_3_Chiral_HPLC_Columns_2_74f7d52275.jpg" alt="Phenomenex: Lux Cellulose-3 Chiral HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Lux_Cellulose_3_Chiral_HPLC_Columns_2_74f7d52275.jpg 216w," sizes="100vw" width="903" height="650"><ul><li>Separation Mode: Chiral</li><li>Stationary phase: Regenerated Cellulose (RC)<ul><li>Cellulose tris(4-methylbenzoate)</li></ul></li><li>Recommended Use: Separation of enantiomers and racemic mixtures by reversed phase, normal phase, polar organic and SFC with a fully porous particle, coated with a polysaccharide stationary phase.</li></ul><h4>Achieve Greater Chiral Separation Success</h4>Lux Cellulose-3 columns are guaranteed to perform as well or better than the equivalent CHIRALCEL® OJ® and OJ-H® Chiral Technologies column. Lux phases can also provide alternative selectivity to other chiral selectors for the most challenging chiral separations. Lux columns offer a wide and complementary range of enantioselectivity for even the most difficult chiral separation projects.The helical structure of the cellulose creates a complex steric environment that provides stronger interactions and better chiral recognition abilities. Additionally, the selector’s constituents produce hydrogen bonding, dipole, and π π interactions that all affect the CSPs ability to separate your enantiomers effectively.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Lux_Performance_Advantage_cellulose_3_a232dc359a.jpg" alt="Phenomenex: Lux Cellulose-3 Performance Advantage" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Lux_Performance_Advantage_cellulose_3_a232dc359a.jpg 179w," sizes="100vw" width="677" height="590">

Phenomenex Lux i-Cellulose-5 Chiral HPLC Columns

Phenomenex Lux i-Cellulose-5 chiral HPLC column delivers broad enantioselectivity, strong solvent compatibility, and scalable performance for LC and SFC separations.

<h4>Your New First Choice Chiral Column!</h4>The immobilization and bonding technology used within the Lux i-Cellulose-5 promotes column stability in strong organic solvents, which affords you the ability to expand your chiral separation success with more solvent systems and separation modes.<ul><li>Wide Solvent Flexibility</li><li>Broad Enantioselectivity</li><li>Strong Solvent Compatibility</li><li>Recommended Use: Separation of enantiomers and racemic mixtures by reversed phase, normal phase, polar organic and SFC with a fully porous particle, immobilized with a polysaccharide stationary phase. This Immobilization provides additional strong organic solvent ruggedness so that DCM, DMSO and other related strong solvents can be used on column.</li></ul><h4>Achieve Greater Chiral Separation Success</h4>Lux® i-Cellulose-5 contains achemical crosslinking between the polysaccharide and silica supports which inturn provides incredible strong solvent (THF, DCM, DMSO, MtBE, Ethyl Acetate, etc.) robustness compared to coated phases and prevents the phase from being dissolved in strong solvents.Lower pressure, all purpose particle size for analytical LC (HPLC) or SFC methods and especially for high performance preparative LC or SFC puriﬁcation work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Lux_i_Cellulose_5_Chiral_HPLC_Columns_28bc99dbb1.jpg" alt="Phenomenex: Lux i-Cellulose-5 Chiral HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Lux_i_Cellulose_5_Chiral_HPLC_Columns_28bc99dbb1.jpg 245w," sizes="100vw" width="1541" height="595"><h4>Dependability and Seamless Scalability</h4>Our highest standards of quality will ensure that you are fully satisfied with each and every Lux chiral column as consistent quantitation and results come with every Lux batch and column that we manufacture. With matching selectivity, the 3 μm and 5 μm i-Cellulose-5 particle sizes allow you to scale down to increase resolution or easily scale up for preparative purification work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Incredible_consistency_batch_to_batch_and_between_particle_sizes_4a8adc47b8.jpg" alt="Phenomenex: Incredible consistency batch-to-batch and between particle sizes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Incredible_consistency_batch_to_batch_and_between_particle_sizes_4a8adc47b8.jpg 103w," sizes="100vw" width="677" height="1025">

Phenomenex Lux Amylose-1 Chiral HPLC Columns

Phenomenex Lux Amylose-1 chiral HPLC column ensures reliable enantiomer separation, matching or exceeding CHIRALPAK® AD® with strong recognition and broad selectivity.

This universally trusted amylose phenylcarbamate derivative is absolutely essential to any chiral screen. Lux Amylose-1 is a guaranteed alternative to CHIRALPAK® AD®. Expect equivalent or better performance when using this Lux phase.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Lux_Amylose_1_Chiral_HPLC_Columns_a5e2773084.jpg" alt="Phenomenex: Lux Amylose-1 Chiral HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Lux_Amylose_1_Chiral_HPLC_Columns_a5e2773084.jpg 245w," sizes="100vw" width="1236" height="626"><ul><li>Stationary phase: Amylose tris(3,5-dimethylphenylcarbamate)</li><li>Recommended Use: Separation of enantiomers and racemic mixtures by reversed phase, normal phase, polar organic and SFC with a fully porous particle, coated with a polysaccharide stationary phase.</li></ul><h4>Achieve Greater Chiral Separation Success</h4>Lux columns are guaranteed to perform as well or better than the equivalent DAICEL® Chiral Technologies column. Lux phases can also provide alternative selectivity to other chiral selectors for the most challenging chiral separations. Lux columns offer a wide and complementary range of enantioselectivity for even the most difficult chiral separation projects.The helical structure of the amylose creates a complex steric environment that provides stronger interactions and better chiral recognition abilities. Additionally, the selector’s constituents produce hydrogen bonding, dipole, and π π interactions that all affect the CSPs ability to separate your enantiomers effectively.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Lux_Amylose_1_separation_c517f7e910.jpg" alt="Phenomenex: Separation comparison - Lux Amylose-1 vs. CHIRALPAK AD-H" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Lux_Amylose_1_separation_c517f7e910.jpg 179w," sizes="100vw" width="677" height="590">

Phenomenex Lux i-Amylose-3 Chiral HPLC Columns

Phenomenex Lux i-Amylose-3 chiral HPLC column offers broad enantioselectivity, strong solvent stability, and proven performance as an alternative to CHIRALPAK® IG®.

<h4>Your New First Choice Chiral Column!</h4>The immobilization and bonding technology used within the Lux i-Amylose-3 promotes column stability in strong organic solvents, which affords you the ability to expand your chiral separation success with more solvent systems and separation modes.<ul><li>Wide Solvent Flexibility</li><li>Broad Enantioselectivity</li><li>Strong Solvent Compatibility</li><li>Recommended Use: Separation of enantiomers and racemic mixtures with strong stability in strong organic solvents</li></ul><h4>Achieve Greater Chiral Separation Success</h4>The Lux i-Amylose-3, like the rest of the Lux product line, is an incredibly versatile phase that has been manufactured and developed to give you your desired results again and again. This is especially true under harsh conditions where coated phases are unable to perform.Lower pressure, all purpose particle size for analytical LC (HPLC) or SFC methods and especially for high performance preparative LC or SFC puriﬁcation work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Lux_i_Cellulose_5_Chiral_HPLC_Columns_28bc99dbb1.jpg" alt="Phenomenex: Lux i-Amylose-3 Chiral HPLC Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Lux_i_Cellulose_5_Chiral_HPLC_Columns_28bc99dbb1.jpg 245w," sizes="100vw" width="1541" height="595"><h4>Guaranteed Alternative to CHIRALPAK® IG®</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Guaranteed_Alternative_to_CHIRALPAK_IG_584996e87b.jpg" alt="Phenomenex: Guaranteed Alternative to CHIRALPAK® IG®" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Guaranteed_Alternative_to_CHIRALPAK_IG_584996e87b.jpg 176w," sizes="100vw" width="677" height="600">

Products from category HPLC columns - page 3

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