Helium prices have roughly doubled since the Iran conflict began in early 2026, with global supply from Qatar — responsible for approximately one-third of world production — severely disrupted. For laboratories running gas chromatography and other helium-dependent instruments, the financial and operational impact is impossible to ignore.<h3>Part 1: The Helium Price Crisis — What Happened and Why It Matters to Your Lab</h3><h4>A Perfect Storm in the Helium Market</h4>Helium has never been a cheap commodity, but what laboratories are facing in 2026 represents a genuine inflection point. The combination of escalating Middle East conflict, Strait of Hormuz shipping disruptions, and structural supply constraints has created the most severe helium pricing environment in recent memory — one that shows no sign of rapid reversal.To understand why laboratory budgets are under pressure, it helps to understand where helium actually comes from. Unlike most industrial gases, helium cannot be manufactured. It is a byproduct of radioactive decay deep within the Earth's crust, and it must be captured from <a target="_blank" rel="noopener noreferrer" href="https://businessanalytiq.com/procurementanalytics/index/helium-price-index/">natural gas deposits </a>before it escapes into the atmosphere. The practical result is that the entire world's commercial helium supply flows from a small number of producing regions — most critically, the United States and Qatar.<h4>Qatar: The World's Helium Chokepoint</h4>Qatar is responsible for approximately <a target="_blank" rel="noopener noreferrer" href="https://www.expertmarketresearch.com/price-forecast/helium-price-trends">one-third of global helium production</a>, channeled through QatarEnergy LNG's massive purification facility at Ras Laffan Industrial City, which draws from the North Field — the world's largest non-associated natural gas reservoir. When this facility operates normally, it is the single largest stabilizing force in the global helium market. When it is disrupted, the entire world feels it.In early 2026, it stopped operating normally. Iranian missile strikes damaged key industrial infrastructure in Qatar, and the resulting disruption to Ras Laffan created an immediate supply shock. Compounding the damage, the Strait of Hormuz — the critical shipping corridor through which Qatari LNG and helium exports must pass — became subject to elevated war-risk premiums and logistical disruptions that pushed shipping costs sharply higher.<h4>Beyond Price: The Supply Reliability Problem</h4>For laboratory managers, the helium crisis is not merely a budget problem — it is an operational continuity problem. A laboratory that cannot obtain helium cannot run its gas chromatography (GC) instruments, cannot perform MRI maintenance or calibration, and cannot complete analytical work that clients and researchers depend upon.Supply allocation tightening, spot market shortages, and delays at ports serving Middle Eastern shipping lanes have created a new reality: even laboratories with long-term supply contracts have experienced <a target="_blank" rel="noopener noreferrer" href="https://www.procurementresource.com/resource-center/helium-price-trends">delivery disruptions</a>. The gas that was once ordered and reliably delivered within a predictable lead time now arrives subject to geopolitical delays entirely outside the laboratory's control.This represents a fundamental shift in risk exposure for laboratory operations. Helium's value to a laboratory was always its combination of technical performance and reliable availability. The second pillar of that value proposition has been significantly eroded.<h4>Who Is Most Affected in the Laboratory Setting?</h4>While the helium price surge affects any organization that uses the gas, laboratories face a particularly acute version of the problem for several reasons:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products?category=98&amp;manufacturerItems=540">GC carrier gas</a> consumption: Gas chromatography is one of the largest industrial uses of high-purity helium. Analytical laboratories running continuous GC workflows — environmental testing, pharmaceutical QC, food safety, petrochemical analysis — consume helium at a high, predictable rate. When the price of that gas doubles, it represents a direct and substantial increase in the variable cost of every single analytical run.</li><li>No short-term substitution: Unlike some industrial uses where helium can be temporarily swapped for another gas, GC methods are validated for specific carrier gases. Switching requires revalidation — a time-consuming, resource-intensive process that cannot be completed in response to an acute supply disruption.</li><li>Contractual and regulatory obligations: Laboratories operating under accreditation, client contracts, or regulatory frameworks face potential non-compliance consequences if supply disruptions prevent them from completing required analyses. The cost of a helium shortage extends far beyond the gas itself.</li></ul><h3>Part 2: The Strategic Case for Switching to Hydrogen — and Installing a Generator</h3><h4>Hydrogen as a Carrier Gas: The Science Is Already Settled</h4>The argument for <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/hydrogen-generators-for-chromatography">hydrogen as a GC carrier gas</a> is not new, and it is not driven solely by economics. For many applications, hydrogen is technically superior to helium. Its higher diffusivity in the column results in faster analyte movement, enabling shorter run times and higher throughput without loss of resolution. The van Deemter curve for hydrogen is flatter over a wider range of flow rates, giving analysts more operating flexibility.The US EPA, the European pharmacopoeias, and numerous international standards bodies have long recognized hydrogen as an acceptable — and in some cases preferred — carrier gas for GC methods. Chromatography column and instrument manufacturers including Agilent, Shimadzu, PerkinElmer, and Thermo Fisher have published detailed application notes and validated methods for hydrogen carrier gas, often demonstrating equivalent or improved performance relative to helium.In short: <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/transitioning-from-helium-to-hydrogen-what-you-need-to-know">switching from helium to hydrogen</a> for GC is not an experimental or unproven step. It is a well-established, widely validated practice that thousands of laboratories around the world have already completed. The <a target="_blank" rel="noopener noreferrer" href="https://www.cruxinvestor.com/posts/helium-prices-surge-400-to-record-highs-as-global-supply-shortage-persist-in-the-rise-of-ai">current pricing environment</a> simply makes the decision more urgent — and the financial case more compelling — than it has ever been before.<h4>Why Cylinders Are Not the Answer</h4>It might be tempting to view the hydrogen transition simply as swapping one gas cylinder supplier for another. This approach misunderstands both the nature of the problem and the opportunity. Hydrogen delivered in cylinders carries its own logistical challenges: cylinder handling and storage requirements, regular delivery schedules, the same kind of supply chain dependencies that have proven so costly with helium, and — critically — safety considerations around the storage of high-pressure hydrogen in laboratory spaces.The correct solution, adopted by the most forward-thinking laboratory managers, is to install an on-site hydrogen generator. This single decision transforms the laboratory's gas supply from a variable, externally-dependent cost into a stable, internally-controlled utility — analogous to the difference between buying bottled water and installing a purified water system.<h4>The Hydrogen Generator Advantage: Six Reasons to Make the Switch</h4><h5>1. Complete Supply Independence</h5>A hydrogen generator produces gas on demand from deionized water using electrolysis. There is no supply chain to be disrupted by conflict in the Middle East. There is no shipping container to be delayed at a port. There is no cylinder to run out mid-run. The laboratory's hydrogen supply is as reliable as its electricity supply — and in most facilities, that is extremely reliable.For laboratory managers who have spent the past year managing helium allocation anxiety, explaining supply disruptions to clients, and rescheduling analytical work around delivery delays, this represents a profound operational upgrade.<h5>2. Long-Term Cost Predictability and Savings</h5>Hydrogen generators produce gas at a cost primarily determined by electricity consumption. Electricity prices, while subject to some variation, are dramatically more stable than helium spot markets and are not subject to geopolitical disruptions of the kind that have driven helium prices to double in a matter of months.The total cost of ownership analysis for hydrogen generation versus helium cylinder purchase — factoring in current helium pricing, cylinder rental fees, delivery charges, and handling costs — now firmly favors hydrogen generation for any laboratory running one or more GC instruments full-time. With helium prices having doubled since the onset of the Iran conflict, the payback period for a generator investment has shortened significantly.<h5>3. Superior Gas Purity and Consistency</h5><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products?category=98&amp;manufacturerItems=540">Modern hydrogen generators </a>produce gas at purities of 99.9999% or higher — exceeding the purity specifications required for the most demanding analytical GC applications. Critically, this purity is consistent from the first milliliter of gas produced to the last. There is no batch-to-batch variation, no risk of receiving a cylinder with a contamination issue, and no requirement to test incoming gas quality.For laboratories operating under strict quality systems — ISO 17025, GMP, EPA method compliance — the shift to a generator can actually improve data quality and simplify the supplier qualification burden associated with managing a rotating roster of gas cylinder suppliers.<h5>4. Improved Laboratory Safety Profile</h5>Hydrogen requires appropriate safety management — adequate ventilation, hydrogen-compatible fittings, and basic leak detection protocols. These requirements are straightforward and well-understood, and are entirely manageable in a standard analytical laboratory environment. Modern hydrogen generators include integrated safety systems including automatic shutdown on leak detection, pressure limiting, and fail-safe electronics.What is often overlooked is that a hydrogen generator improves overall laboratory safety relative to the cylinder-based alternative by eliminating the need to store and handle high-pressure compressed gas cylinders. The generator contains only a small volume of hydrogen at any given time — far less than a standard gas cylinder — and delivers it directly to the instrument through short, fixed lines.<h5>5. Environmental and Sustainability Benefits</h5>Helium extraction is an energy-intensive industrial process. The gas must be separated from natural gas streams, compressed, liquefied, and transported globally — often by sea freight from <a target="_blank" rel="noopener noreferrer" href="https://businessanalytiq.com/procurementanalytics/index/helium-price-index/">Qatar or the United States</a>. Each step in that chain carries an environmental cost.Hydrogen generation from water electrolysis has a fundamentally different environmental profile, particularly for laboratories that operate in facilities with access to renewable electricity. As laboratory sustainability programs become an increasing priority — driven by institutional ESG commitments, client expectations, and regulatory trends — the ability to point to an on-site, low-carbon gas supply is a meaningful differentiator.<h5>6. Future-Proofing Against Ongoing Helium Market Instability</h5>The current price spike is not an anomaly that will self-correct quickly. The structural conditions driving helium price increases — concentrated supply in geopolitically exposed regions, growing demand from semiconductor manufacturing and MRI imaging, the irreversibility of atmospheric helium loss once released — are not going away. New supply projects in South Africa, Canada, and elsewhere will add capacity over the medium term,but forecasters broadly expect helium pricing to remain elevated relative to historical norms.A laboratory that installs a hydrogen generator today is not just solving the 2026 problem. It is making a strategic decision that positions the organization to be independent of whatever the next helium supply shock looks like.At a Glance: Helium Cylinder vs. On-Site Hydrogen Generation<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_The_Helium_Crisis_Is_Here_Why_Laboratories_Should_Switch_to_Hydrogen_Now_2_77969fd7aa.jpg" alt="Organomation: The Helium Crisis Is Here: Why Laboratories Should Switch to Hydrogen Now" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_The_Helium_Crisis_Is_Here_Why_Laboratories_Should_Switch_to_Hydrogen_Now_2_77969fd7aa.jpg 209w," sizes="100vw" width="1007" height="750"><h4>How Organomation Supports Your Transition to Hydrogen</h4>At Organomation, we have been supporting analytical laboratories with precision gas handling and concentration equipment for over six decades. We understand that the decision to transition carrier gases is not made lightly — it involves instrument requalification, method validation, staff training, and procurement changes that require planning and support.Our team, in combination with <a target="_blank" rel="noopener noreferrer" href="https://claind.it/">Claind srl</a>, can assist laboratories at every stage of the hydrogen transition: from initial feasibility assessment and instrument compatibility review, through gas flow optimization and generator sizing, to ongoing technical support after installation. We work with the leading hydrogen generator manufacturers and can help you specify the right system for your instrument fleet and throughput requirements.The current helium pricing environment has created a narrow window in which laboratories that act decisively will establish a structural cost and reliability advantage over those that continue to absorb rising helium costs. We invite you to start that conversation with us today.Contact the Organomation team to schedule a complimentary laboratory gas assessment and begin your transition to on-site hydrogen generation. Visit organomation.com or call us to speak with an applications specialist.<h4>The Moment to Act Is Now</h4>The helium crisis of 2026 is not a temporary inconvenience — it is a structural realignment of the global gas supply market, accelerated by a geopolitical conflict whose resolution timeline remains uncertain. Laboratories that approach this as a passing disruption to be absorbed through budget adjustments are likely to find themselves absorbing those costs indefinitely.The case for switching to hydrogen carrier gas and installing an on-site hydrogen generator has never been more compelling. The technology is proven, the performance is validated, the safety is manageable, and the economics — already favorable before the current price surge — are now overwhelmingly advantageous.The laboratories that will emerge from this crisis in the strongest position are those that use it as the catalyst to make a change they should have made years ago. The question is no longer whether to make the switch — it is how quickly you can do it.

The Helium Crisis Is Here: Why Laboratories Should Switch to Hydrogen Now

A new study published in Nucleic Acids Research identifies short “start–stop” elements as highly effective regulators of protein synthesis in human cells. The study was co-led by Leoš Shivaya Valášek from IMIC CAS.<section><div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg" alt="MBU: Unassuming Start–Stop “Gates” Regulate Protein Production in Cells" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg 245w," sizes="100vw" width="720" height="390"><section><div>An international team of scientists has described a&nbsp;previously overlooked mechanism that regulates the levels of important proteins in human cells. A new study published in Nucleic Acids Research reveals that short regulatory “start–stop“ elements act as highly effective speed-limiting gates of protein synthesis. Compared with previously known regulatory sequences, these elements were found to suppress protein production even more efficiently. At the same time, they help maintain low but stable levels of important proteins in cells, even under stress conditions. The study brought together scientists from the United States, the Czech Republic, Canada, and Sweden. Leoš Shivaya Valášek, Head of the Laboratory of Regulation of Gene Expression at the Institute of Microbiology of the Czech Academy of Sciences (IMIC CAS) was a&nbsp;co-author and one of the corresponding authors of the study.</div></section><section><div>During protein production, ribosomes read and translate information encoded in messenger RNA (mRNA) into amino acids, which are then assembled into a&nbsp;new protein. The researchers focused on an unusual sequence in which a&nbsp;start signal is immediately followed by a&nbsp;stop signal. As a&nbsp;result, the ribosome receives instructions to begin and terminate translation almost simultaneously. Although such an arrangement may appear illogical, it proved to be an important regulatory tool.Start–stop motifs are found in more than 1,400 human genes and are particularly common in genes that control cellular signaling pathways, the stress response, or the activity of transcription factors—that is, proteins that regulate the activity of other genes. These genes must be tightly controlled because even small changes in the amount of their protein products can have significant biological consequences.<h4>Resilience Under Stress</h4>The researchers tested the activity of this regulatory mechanism under stress conditions, including in the ATF4 gene, which plays a&nbsp;key role in the so-called integrated stress response. Cellular stress is typically associated with a&nbsp;global reduction in protein synthesis. The authors demonstrated that regulation mediated by start-stop elements is largely independent of the overall state of translation initiation and therefore remains effective even under cellular stress.<h4>A Stronger Brake Than Known Regulatory Elements</h4>The team compared start–stop sequences with similar regulatory regions known as uTranslons. Although both types of elements suppress protein synthesis, the start–stop sequences proved to be significantly more effective. Ribosomes remain associated with these motives for longer before proceeding to the main coding region of the gene.“Start-stop sequences are specialized regulatory elements that ensure increased ribosome retention, thereby allowing for fine-tuning translation,” says Leoš Valášek from IMIC CAS.The study expands our understanding of how cells fine-tune protein synthesis and may ultimately contribute to research on &nbsp;certain cancer and neurodegenerative disorders, and other diseases linked to disrupted protein production.</div></section><blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/13/gkag627/8725953?login=false">Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons</a></h4>Justin Rendleman, Solomon A Haizel, Shaohuan Wu, Laurelle Lee Young, Junjie Liu, Xinyi Ge, Huijing Zou, Mahabub Pasha Mohammad, Matthew Pressler, Shuvadeep Maity, Vladislava Hronová, Zhaofeng Gao, Anna Hermannová, Anna Smirnova, Amy Lei, Kristina Allgoewer, Daniel Sultanov, Will Edward Hinckley, Ziyue Cheng, Lauren Shelby, Tanubrata Dey, Krzysztof J Szkop, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou, Leoš Shivaya Valášek, Christine VogelNucleic Acids Research (2026), Volume 54, Issue 13&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1093/nar/gkag627">https://doi.org/10.1093/nar/gkag627</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Start–stop elements are translation regulatory elements in 5′ untranslated regions (UTR) of eukaryotic transcripts, consisting of a start codon immediately followed by a stop codon. In contrast to canonical upstream Translons (uTranslons), they exclude elongation which creates unique properties. We conducted a comprehensive, carefully controlled comparison of human start–stop elements and uTranslons both at a genome-wide level and with targeted reporter assays. We found that start–stops and uTranslons were similar with respect to their presence in the 5′ UTRs of hundreds of genes, in particular transcription factors and signaling molecules, the low transcript levels of the corresponding genes, short RNA half-lives, and the negative effect on downstream translation. However, start–stop containing genes were translationally even more repressed than genes with uTranslons. Analysing the start–stop architecture and diverse ribosome footprinting datasets, we found evidence for a start–stop-specific mechanism that involves repeat cycling between initiation, termination, ribosome splitting, and 60S rejoining—a process possibly modulated by ASCC3 and eIF1. This cycling explained increased ribosome retention at start–stops and was—in contrast to ribosome retention at uTranslons—independent of the global initiation state. Finally, we showed that the start–stop element in human ATF4 augments the core regulatory model by controlling translation of the uTranslons.</div></section>

Unassuming Start–Stop “Gates” Regulate Protein Production in Cells

Why Biologics QC Is So Much Harder Than Small Molecule Pharma

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Phenomenex Biozen WidePore C4 LC columns

Biozen WidePore C4 column contains skillfully manufactured large pore core shell particles that provide narrower, taller peaks in conjunction with higher resolution.

Impurity profiling and characterization of intact biologic fragments is a challenging undertaking because of the need to identify very small differences between variants. Both Biozen Intact columns contain skillfully manufactured large pore core shell particles that provide narrower, taller peaks in conjunction with higher resolution between the target HC/LC, Fc/Fab, or isoforms.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Biozen_Widepore_C4_HPLC_Column_56dfa53fcb.webp" alt="Phenomenex: Biozen Widepore C4 HPLC Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Biozen_Widepore_C4_HPLC_Column_56dfa53fcb.webp 245w," sizes="100vw" width="500" height="150"><ul><li>Separation Mode: Reversed Phase</li><li>Particle size: 2.6</li><li>Recommended Use: Optimal particle and pore size morphology for high reproducibility and resolution for intact and subunit analysis</li></ul><h3>Phenomenex Biozen Biologics LC Columns</h3>With a new titanium BioTi™ biocompatible hardware to minimize priming, four particle platforms for optimal versatility and nine particle chemistries to maximize selectivity and sensitivity, Biozen UHPLC/HPLC columns for protein analysis are seamlessly designed to bring peace of mind to your analysis of biologics through:<ul><li>Charge Variant Analysis</li><li>Aggregate Analysis</li><li>Peptide Mapping</li><li>Intact Mass Analysis</li><li>Intact and Subunit Analysis</li><li>Glycan Analysis</li><li>Peptide Quantitation</li><li>Drug Antibody Ratio (DAR)</li><li>Oligonucleotide Characterization</li></ul><h3>Biocompatible Flow Path with BioTi™ Hardware</h3>Keep your mind at ease knowing that we’ve minimized the need for priming with a new titanium infused biocompatible hardware and frit that doesn’t interfere with protein or peptide integrity!<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Bio_Ti_Hardware_991fb53395.jpg" alt="Phenomenex: BioTi Hardware" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Bio_Ti_Hardware_991fb53395.jpg 245w," sizes="100vw" width="1378" height="426"><h3>4 Advanced Particle Platforms</h3>All four of the Biozen particle platforms were individually designed and built by Phenomenex to take advantage of integral levels of performance, ruggedness, and reproducibility for protein characterization applications. Individually, each platform differs in the proprietary processing techniques used to control particle size and morphology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Advanced_Particle_Platforms_a0959aca03.jpg" alt="Phenomenex: Advanced Particle Platforms" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Advanced_Particle_Platforms_a0959aca03.jpg 245w," sizes="100vw" width="1439" height="868">

KNAUER Eurospher II 100 C4 (U)HPLC Columns (USP L26)

C4 stationary phases (USP L26) are often used in reversed phase mode for different application areas. 

C4 columns for Reversed Phase in HPLC and UHPLC (USP L26)C4 stationary phases (USP L26) are often used in reversed phase mode for different application areas.&nbsp;They are suitable for:<ul><li>Hydrophobic Interaction Chromatography (HIC mode)</li><li>Analysis of biomolecules like proteins and peptides</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_C4_3f3adfbdb4.webp" alt="KNAUER: C4" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_C4_3f3adfbdb4.webp 78w," sizes="100vw" width="200" height="400"><h3>KNAUER (U)HPLC Columns</h3>Widest range of HPLC and UHPLC columns for all separation modes and applications.<ul><li>Safe Investment: Robust and reliable columns for attractive price&nbsp;</li><li>Separation Mode: Reversed Phase, HILIC, Normale</li><li>Simplicity: Easy purchase via our online store with fast delivery</li><li>Application: All-rounder for research or highly specialised for high-throughput analysis? We have the best column for your requirements.</li><li>Flexibility: Wide selection of column and particle sizes, for (U)HPLC applications up to 1000 bar</li></ul>KNAUER offers the perfect column for any small molecule separation. No matter which separation mode, molecule and the mobile phase, we offer a suitable (U)HPLC stationary phase. Choose from a wide range of modifications, particle sizes and column dimensions to suit your application. To elongate the lifetime of your column, you can choose to use a suitable precolumn.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_KNAUER_U_HPLC_C8_and_C8_A_Columns_083c60f401.webp" alt="KNAUER: KNAUER (U)HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_KNAUER_U_HPLC_C8_and_C8_A_Columns_083c60f401.webp 182w," sizes="100vw" width="787" height="674">

KNAUER Eurosil Bioselect 300 C4 HPLC Columns (USP L26)

Eurosil Bioselect C4 has been specifically developed for the determination and purification of peptides, proteins, and oligonucleotides up to a molecular weight of approximately 100 kDa. 

Analytical wide pore phase for the determination of biomolecules bigger than 20 kDaEurosil Bioselect C4 has been specifically developed for the determination and purification of peptides, proteins, and oligonucleotides up to a molecular weight of approximately 100 kDa. The optimized manufacturing process guarantees excellent batch–to-batch reproducibility. The Eurosil Bioselect sorbent is the first choice for Biochromatography with silica material.<h5>Properties</h5><ul><li>Ultra pure, spherical wide pore HPLC phase based on wide pore silica gel</li><li>Unpolar, monomeric C4 modification, endcapped</li><li>2 % carbon content (conventional endcapping)</li><li>Separation mechanism: hydrophobic and hydrophilic interaction</li></ul><figure class="image"><img style="aspect-ratio:200/400;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_C4_3f3adfbdb4.webp" alt="KNAUER: C4" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_C4_3f3adfbdb4.webp 78w," sizes="100vw" width="200" height="400"></figure><h5>Recommended application areas</h5><ul><li>Hydrophilic biomolecules and especially peptides larger than 10 000- 20 000 Da</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Eurosil_Bioselect_Phases_98acc32d0e.jpg" alt="KNAUER: Eurosil Bioselect - Phases and recommended sizes of molecules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Eurosil_Bioselect_Phases_98acc32d0e.jpg 245w," sizes="100vw" width="1385" height="778"><h3>KNAUER Wide pore HPLC columns</h3>For enhanced resolution, capacity and recovery of proteins and other biomolecules<ul><li>Material: Silica or polymer particles</li><li>Separation Ranges: 2–100 kDa</li><li>Column Brands: Eurosil Bioselect or AppliChrom®</li><li>Particle sizes: 3–10 µm</li><li>Pore Sizes: 300 or 100–1000 Å</li><li>Specific surface: 90 ± 5 m2/g</li><li>Pore volume: 0.8 ml/g</li><li>Density: 450 g/l</li><li>Applications: Peptides exceeding approximately 50 amino acids and oligonucleotides greater than 25 residues</li><li>Customize: Bioanalysis requires a lot of flexibility in the pore size, the pH range, the temperatures and the solvents used. To achieve this, we cross phase limits.</li></ul><h4>Characteristics&nbsp;</h4><ul><li>Eurosil Bioselect columns are available in 4 modifications, useful for a wide range of separation tasks involving large molecules up to 100 000 Da.</li><li>Strict manufacturing procedures ensure a very narrow pore size distribution.</li><li>Interfering anions or heavy metal ions on the silica surface are not present in Eurosil Bioselect columns because only ultra pure silica gel and high quality chemical modifications are employed.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Eurosil_Bioselect_85cfc2d201.jpg" alt="KNAUER: Eurosil Bioselect" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Eurosil_Bioselect_85cfc2d201.jpg 222w," sizes="100vw" width="1114" height="782"><h4>Separation mechanism of Eurosil Bioselect</h4>To separate larger molecules, they need to freely access the interior of the pores of the packing material. Therefore, the analytes’ diameter must be smaller than the average pore diameter.&nbsp;For higher molecular weight solutes, the use of lower pore size materials (60-120 Å) as typically used for the analysis of small molecules may result restricted diffusion in the material´s pores and therewith reduced column efficiency.&nbsp;<h4>Modifications</h4>The recommended modification of Eurosil Bioselect depends on the molecular weight of the analytes.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Eurosil_Bioselect_chemical_modifications_1fd5d87f7b.jpg" alt="KNAUER: Eurosil Bioselect - chemical modifications" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Eurosil_Bioselect_chemical_modifications_1fd5d87f7b.jpg 245w," sizes="100vw" width="955" height="505"> &nbsp;

KNAUER Eurospher II 100 C4 Prep HPLC Columns (USP L26)

C4 columns for Reversed Phase in HPLC and UHPLC (USP L26)C4 stationary phases (USP L26) are often used in reversed phase mode for different application areas.&nbsp;They are suitable for:<ul><li>Hydrophobic Interaction Chromatography (HIC mode)</li><li>Analysis of biomolecules like proteins and peptides</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_C4_3f3adfbdb4.webp" alt="KNAUER: C4" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_C4_3f3adfbdb4.webp 78w," sizes="100vw" width="200" height="400"><h3>KNAUER Preparative HPLC Columns</h3>The right choice for all dimensions from semi-prep to batch chromatography to SMB.<ul><li>Modifications: Reversed Phase, HILIC, Normale Phase</li><li>Max. Pressure: 400–600 bar</li><li>Column Inner Diameter (ID): 16–50 mm in our shop, more on request</li><li>Column Brands: Eurospher, Eurospher II</li><li>Safe Investment: Robustness and durability based on superior technology</li><li>Application: Easy upscaling, as all materials are available from ultra high performance to preparative scale HPLC. You can also use our upscaling calculator.</li><li>Customizable: Standard flanged hardware &amp; dAX hardware with static or dynamic axial compression available</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Preparative_HPLC_Columns_31bc2477c3.webp" alt="KNAUER: KNAUER Preparative HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Preparative_HPLC_Columns_31bc2477c3.webp 221w," sizes="100vw" width="1024" height="724"><h5>Preparative HPLC columns can be offered with two different hardware types:</h5><ul><li>Versatile standard flanged hardware for nearly any application task in batch chromatography</li><li>dAX Hardware with static and dynamic axial compression for an extended lifetime and multi-column chromatography like SMB processes</li></ul>

Waters XBridge BEH Protein C4 HPLC Columns

Waters XBridge Protein BEH C4 column is QC tested and optimized to separate proteins based on size, hydrophobicity and isoelectric point. 

The XBridge Protein BEH C4 column is QC tested and optimized to separate proteins based on size, hydrophobicity and isoelectric point. If you compare to traditional C18 phases, the C4 ligand is less retentive and will minimize protein carryover, increase protein recovery, and improve peak capacity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_Protein_C4_HPLC_Columns_0aa4f56918.jpeg" alt="Waters: XBridge BEH Protein C4 HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_Protein_C4_HPLC_Columns_0aa4f56918.jpeg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: C4</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Hybrid</li><li>pH Range Min: 2 pH</li><li>pH Range Max: 10 pH</li><li>Maximum Pressure: 6000 psi (415 Bar)</li><li>Endcapped: No</li><li>Silanol Activity: Low</li><li>Molecular Weight Range Max: 150000</li><li>Particle Shape: Spherical</li><li>System: HPLC</li><li>Particle Technology: BEH</li><li>USP Classification: L26</li><li>Carbon Load: 8 %</li></ul><h3>XBridge Columns</h3><h4>Particle stability and performance for methods development</h4>Withstanding extreme operating conditions like high pH and high temperatures is essential for methods development. XBridge HPLC and UHPLC Columns utilize Ethylene Bridged Hybrid (BEH) Particle Technology and are built to withstand high pH, high temperatures, and other extreme operating conditions like volatile eluents, for a wide range of small molecule and biomolecule LC-MS analysis.XBridge HPLC and UHPLC Columns are available in a broad range of sorbent particles and sizes: XBridge eXtended Perfomance (XP) 2.5 µm Columns for rapid analytical UHPLC separations; 3.5 and 5 µm HPLC columns for reliable analytical method development; and 5 and 10 µm optimum bed density (OBD) preparative columns for purification chromatography.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Columns_b0b55de501/Waters-XBridge-Columns.jpg" alt="Waters: XBridge Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Columns_b0b55de501/thumbnail_Waters-XBridge-Columns.jpg 203w," sizes="100vw" width="900" height="691">

Waters Symmetry C4 HPLC Columns

With Waters Symmetry C4 Column, you get the sharpest peaks for biomolecules and more peak capacity for complex tryptic maps. 

Primarily supports legacy methods. Symmetry columns give you confidence in the long-term compliance of your HPLC methods. No need to compromise on peak shape, selectivity, column-to-column and batch-to-batch reproducibility, or other critical performance characteristics. Available in a variety of particle sizes, chemistries and dimensions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Atlantis_d_C18_HPLC_Columns_d7a741df9f.jpg" alt="Waters: Symmetry C4 HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Atlantis_d_C18_HPLC_Columns_d7a741df9f.jpg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: C4</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Silica</li><li>pH Range Min: 2 pH</li><li>pH Range Max: 8 pH</li><li>Maximum Pressure: 6000 psi (415 Bar)</li><li>Endcapped: Yes</li><li>Silanol Activity: Low</li><li>Particle Shape: Spherical</li><li>Pore Size: 300 Å</li><li>System: HPLC</li><li>USP Classification: L26</li><li>Carbon Load: 2.8 %</li><li>Application: Protein</li></ul><h3>Symmetry HPLC Columns</h3><h4>Silica-based columns that exceed HPLC column performance expectations</h4>Reproducible HPLC columns are essential when developing analytical methods for pharmaceutical and biopharmaceutical products. Achieving the same chromatographic results over the lifetime of a new drug product is critical, and no other silica-based LC column brand can match the column-to-column and batch-to-batch reproducibility of the Symmetry family.Available in column and guard formats, Symmetry Columns are manufactured using high purity silica and tightly controlled manufacturing processes to ensure that you receive a column that exceeds the standards for HPLC column performance.<h4>Overview</h4><ul><li>Deliver maximum reproducibility batch-to-batch and column-to-column</li><li>Provide superior peak shape</li><li>Achieve high recoveries of peptides and proteins</li><li>Manufactured using high purity silica and tightly controlled manufacturing processes</li><li>Recommended Use: For rugged and reproducible HPLC column performance.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Symmetry_Columns_a2367d8095/Waters-Symmetry-Columns.jpg" alt="Waters: Symmetry Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Symmetry_Columns_a2367d8095/thumbnail_Waters-Symmetry-Columns.jpg 223w," sizes="100vw" width="700" height="490">

Waters ACQUITY UPLC Protein BEH C4 Column

The Waters ACQUITY UPLC Protein BEH C4 column is QC tested and optimized to separate proteins based on size, hydrophobicity and isoelectric point. 

The ACQUITY UPLC Protein BEH C4 column is QC tested and optimized to separate proteins based on size, hydrophobicity and isoelectric point. If you compare to traditional C18 phases, the C4 ligand is less retentive and will minimize protein carryover, increase protein recovery, and improve peak capacity.<h5>Specifications</h5><ul><li>Chemistry: C4</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Hybrid</li><li>pH Range Min: 2 pH</li><li>pH Range Max: 10 pH</li><li>Endcapped: No</li><li>Silanol Activity: Low</li><li>Particle Shape: Spherical</li><li>Pore Size: 300 Å</li><li>System: UHPLC, UPLC</li><li>Particle Technology: BEH</li><li>USP Classification: L26</li><li>Carbon Load: 8 %</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_BEH_C8_Column_9c78ca994d.jpg" alt="Waters: Kolona ACQUITY UPLC BEH C8" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_BEH_C8_Column_9c78ca994d.jpg 234w," sizes="100vw" width="660" height="440"><h3>ACQUITY UPLC Columns</h3><h5>Increase speed, sensitivity, and resolution, without compromising data integrity</h5>Increasing sample throughput, achieving unmatched resolution, and improving analyte sensitivity are priorities for your separation goals. With Waters ACQUITY UPLC Columns, you can meet all your method requirements and substantially reduce your analysis time and cost-per-sample.Waters ACQUITY UPLC Columns’ sub-2-µm particle chemistries enable chromatographers to harness the separation efficiency improvements at increased flow rates of ultra-performance liquid chromatography (UPLC) technology, thereby improving analyte resolution and sensitivity as well as business productivity and profitability. &nbsp;<h4>Overview</h4><ul><li>Best-in-class column efficiency for superior separation speed, sensitivity, and resolution</li><li>8 UPLC particles of various substrate technologies, including Ethylene Bridged Hybrid (BEH), High Strength Silica (HSS), and Charged Surface Hybrid (CSH)</li><li>22 stationary phases, including C18, Phenyl-Hexyl, C8, Embedded-Polar, C4, HILIC, Amide, Diol, Cyano, and PFP</li><li>7 application-specific UPLC Column chemistries for SEC, proteins, peptides, oligonucleotides, glycan, and amino acid analysis</li><li>More than 50 different column dimensions and configurations, with internal column diameters ranging from 1.0–4.6 mm and column lengths ranging from 30–300 mm</li><li>Prolonged column lifetimes with optional VanGuard Cartridges specifically designed using ACQUITY stationary phases</li><li>Recommended Use: For improved speed, sensitivity, and resolution in methods development.</li></ul><h4>Particle technology</h4><h5>BEH - Ethylene Bridged Hybrid Particle Technology</h5>ACQUITY UPLC BEH 1.7 µm fully porous columns provide superior analyte peak shape, efficiency, and chemical stability to any separation. ACQUITY UPLC BEH Columns are available in both reversed-phase and HILIC separation modes, with chemistries that provide selectivities for a wide range of compounds. With the ruggedness to operate at extreme pH conditions, ACQUITY UPLC BEH Columns enable the separation scientist to use a wide pH range to influence retention, selectivity, and sensitivity for ionizable compounds.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_BEH_technology_c07876b8a3.jpg" alt="Waters: BEH particle technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_BEH_technology_c07876b8a3.jpg 170w," sizes="100vw" width="1050" height="964"><h5>CSH - Charged Surface Hybrid Particle Technology</h5>ACQUITY UPLC CSH™ 1.7 µm fully porous columns provide superior peak shape for basic analytes when using low ionic strength acidic mobile phases (e.g. 0.1% formic acid). With CSH Technology, the controlled low-level positive surface charge provides exceptional peak shape for basic analytes which can be achieved without the use of ion pairing reagents. Typically reversed-phase bonded phases have poor peak shape for basic compounds in formic acid even at analytical mass loads. Built on the rugged Ethylene Bridged Hybrid (BEH) particle, ACQUITY UPLC CSH phases can withstand the toughest operating conditions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CSH_technology_ff4ddc1708.jpg" alt="Waters: CSH particle technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CSH_technology_ff4ddc1708.jpg 169w," sizes="100vw" width="1049" height="968"><h5>HSS - High Strength Silica (HSS) Particle Technology</h5>ACQUITY UPLC HSS 1.8 µm fully porous columns provide expected silica particle-like performance to the UPLC family. The HSS particles’ high surface area, and lower pore volume provide increased retentivity over the hybrid particles. This robust particle technology is available in five uniquely different bonded phases, which truly maximize the selectivity space. The wide array of bonded phases associated with ACQUITY UPLC HSS Columns enable traditional hydrophobic reversed-phase interactions along with dipole-dipole interactions, aromatic interactions, and hydrogen bonding interactions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_HSS_technology_b12d3ddfab.jpg" alt="Waters: HSS particle technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_HSS_technology_b12d3ddfab.jpg 162w," sizes="100vw" width="975" height="936"><h4>Get superior peak shape for basic analytes</h4>Reversed-phase bonded phases typically have poor peak shape for basic compounds when using formic acid, even at analytical mass loads. However, ACQUITY UPLC CSH Columns are the exception. These rugged UPLC Columns provide superior peak shape for basic analytes with formic acid or other low ionic-strength, acidic mobile phases. The controlled, low-level, positive surface charge bonded to the ethylene-bridged hybrid (BEH) particles provides excellent peak shape for bases—without the need for the use of ion-pairing reagents.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Analysis_of_ziprasidone_peroxide_degradation_on_an_ACQUITY_UPLC_CSH_C18_Column_56909f1dc8.jpeg" alt="Waters: Analysis of ziprasidone peroxide degradation on an ACQUITY UPLC CSH C18 Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Analysis_of_ziprasidone_peroxide_degradation_on_an_ACQUITY_UPLC_CSH_C18_Column_56909f1dc8.jpeg 245w," sizes="100vw" width="1024" height="485"><h4>The ruggedness you want, the repeatability you need</h4>ACQUITY UPLC BEH 1.7 µm fully porous columns provide superior analyte peak shape, efficiency, and chemical stability to any separation. ACQUITY UPLC BEH Columns are available in both reversed-phase and HILIC separation modes, with chemistries that provide selectivities for a wide range of compounds. With the ruggedness to operate at extreme pH conditions, ACQUITY UPLC BEH Columns enable separation scientists to use a wide pH range to influence retention, selectivity, and sensitivity for ionizable compounds.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_BEH_Columns_can_be_used_at_the_extremes_of_mobile_phase_p_H_1_12_to_enhance_retention_and_specificity_for_complex_samples_that_include_mixtures_of_acidic_basic_and_neutral_analytes_5104d9a155.jpeg" alt="Waters: ACQUITY UPLC BEH Columns can be used at the extremes of mobile phase pH (1-12) to enhance retention and specificity for complex samples that include mixtures of acidic, basic, and neutral analytes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_BEH_Columns_can_be_used_at_the_extremes_of_mobile_phase_p_H_1_12_to_enhance_retention_and_specificity_for_complex_samples_that_include_mixtures_of_acidic_basic_and_neutral_analytes_5104d9a155.jpeg 195w," sizes="100vw" width="1024" height="823"><h4>Achieve flexibility in method development</h4>Chromatographic laboratories need to quickly and easily develop robust methods that are compatible with all modern chromatographic detection modes and transferrable to laboratories and sites that operate different LC system platforms. With ACQUITY UPLC CSH and XSelect Columns, method development scientists in all application areas can achieve a wide range of selectivities without compromising performance across attributes, including superior peak shape for basic compounds, low column bleeds, excellent batch-to-batch reproducibility, and high efficiency.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CSH_Columns_offer_a_wide_range_of_selectivity_differences_large_S_values_733305abf8.jpeg" alt="Waters: CSH Columns offer a wide range of selectivity differences (large S-values)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CSH_Columns_offer_a_wide_range_of_selectivity_differences_large_S_values_733305abf8.jpeg 136w," sizes="100vw" width="1024" height="1173">

Thermo Scientific Hypersil GOLD C4 HPLC Columns

For very hydrophobic analytes, achieve faster separations with excellent peak shapes using Thermo Scientific™ Hypersil GOLD™ C4 HPLC columns. 

For very hydrophobic analytes, achieve faster separations with excellent peak shapes using Thermo Scientific™ Hypersil GOLD™ C4 HPLC columns. Featuring a lower hydrophobicity than C18 or C8 columns, Hypersil GOLD C4 columns provide outstanding sensitivity and high efficiency.<h5>Similar selectivity, less retention than C18 or C8 columns</h5><ul><li>Successful retention and separation of very hydrophobic analytes with this short alkyl chain length, low hydrophobicity column</li><li>Ideal for analysis of hydrophobic polypeptides and proteins</li></ul><h5>Superior performance</h5><ul><li>Highly symmetrical peak shapes</li><li>1.9 μm particle size columns improve speed and efficiency</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>Max. Pressure: 18130 psi (1250 bar)</li><li>Packing Material: Spherical, Fully Porous, Ultrapure Silica</li><li>Stationary Phase: C4</li><li>Surface Area: 220 m²/g</li><li>Temperature: 60°C</li><li>USP Type: L26</li><li>Carbon Load: 5%</li><li>Phase: Reversed Phase</li><li>Pore Size: 175 Å</li><li>pH: 2 to 8</li></ul><h4>About the Hypersil GOLD Family of HPLC Columns</h4>Meet the challenges of modern chromatography with state-of-the-art columns that provide outstanding performance and consistent separations. Twelve different column chemistries are available so you can optimize separations and maximize productivity. Get outstanding peak shapes in reversed phase, ion exchange, HILIC, or normal phase chromatography.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Hypersil_GOLD_Columns_41d5984b62.jpg" alt="Thermo Fisher Scientific: Hypersil GOLD Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Hypersil_GOLD_Columns_41d5984b62.jpg 150w," sizes="100vw" width="747" height="775"><ul><li>Excellent peak symmetry<ul><li>Hypersil GOLD columns produce highly symmetrical peaks, which facilitate the detection of low-level impurities that elute immediately after the main component. When there is even minor tailing, small impurity peaks can elute on the shoulder of the main peak, complicating the integration process.</li></ul></li><li>Narrow peaks for outstanding efficiency</li><li>Enhanced sensitivity and improved resolution</li><li>Exceptional reproducibility for reliable chromatography, column after column</li><li>Solutions for high-throughput screening</li><li>1.9, 3, and 5 μm particle sizes for all your separation needs</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Hypersil_GOLD_Peak_symmetry_641b946673.jpg" alt="Thermo Fisher Scientific: Hypersil GOLD Columns: Peak symmetry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Hypersil_GOLD_Peak_symmetry_641b946673.jpg 149w," sizes="100vw" width="880" height="925">

Thermo Scientific Accucore 150-C4 HPLC Columns

Offer lower hydrophobic retention, ideal for optimal retention of proteins and larger peptides with Thermo Scientific™ Accucore™ 150-C4 LC Columns. 

Offer lower hydrophobic retention, ideal for optimal retention of proteins and larger peptides with Thermo Scientific™ Accucore™ 150-C4 LC Columns. Based on Core Enhanced Technology, Thermo Scientific Accucore columns provide fast, high-resolution biomolecule separations without the elevated backpressures required by sub-2μm particles.<ul><li>150Å pore size solid core particles for fast biomoleucule separations</li><li>Superb resolution at low backpressures</li><li>Exceptionally rugged columns</li><li>Significantly lower hydrophobic retention than C18</li><li>Ideal for optimal retention of proteins and larger peptides</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Stationary Phase: C4</li><li>Surface Area: 80 m²/g</li><li>Temperature: 60°C</li><li>USP Type: L26</li><li>Carbon load: 2%</li><li>Phase: Reversed phase</li><li>Pore Size: 150 Å</li><li>pH: 2 to 9</li></ul><h3>Accucore HPLC and UHPLC Columns</h3><h4>Resolve impurities without feeling the pressure</h4>Thermo Scientific Accucore HPLC and UHPLC columns provide ultimate core performance, allowing you to maximize your investment. Solid-core particles deliver UHPLC performance, with superb resolution delivering back-pressure compatible with HPLC instrumentation. A wide range of phases help meet all your separation needs, while our columns are exceptionally rugged and easy to use.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Accucore_columns_26e0ffa8d5.jpg" alt="Thermo Fisher Scientific: Accucore columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Accucore_columns_26e0ffa8d5.jpg 156w," sizes="100vw" width="708" height="711">

Products from category C4 HPLC columns - page 1

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