From R&D to GMP – How to Scale LNPs & PNPs Successfully

How do you preserve nanoparticle quality while increasing production by several orders of magnitude?

This webinar explores how Impingement Jets Mixing (IJM) and continuous manufacturing approaches enable robust scale-up of lipid and polymeric nanoparticles while maintaining particle size, PDI and encapsulation efficiency. We will also discuss downstream processing, purification and practical considerations for GMP manufacturing.

A live webinar presented by KNAUER in partnership with Curapath.

What you'll learn:

• How IJM and continuous manufacturing support scale-up from mL to GMP volumes while preserving critical quality attributes (size, PDI, encapsulation efficiency)
• Practical approaches to downstream processing and purification for lipid and polymeric nanoparticles
• Key considerations for transitioning nanoparticle production into GMP-compliant manufacturing

Who should attend:

• LNP/PNP application scientists in R&D
• Process development and manufacturing scientists working on nanoparticle scale-up
• Production and CMC customers preparing for GMP-scale manufacturing
• R&D and manufacturing leaders evaluating scale-up strategies

Speaker: Sergio Esteban (Formulation Development, Manager at Curapath)
Sergio is a Formulation Development Manager at Curapath, with extensive experience in the development, scale-up and characterization of advanced drug delivery systems. His expertise includes lipid nanoparticles (LNPs), liposomes and polymeric nanoparticles, as well as purification, analytical characterization and technology transfer. He leads multidisciplinary scientific teams and supports the translation of innovative formulations into robust, scalable and reproducible processes for pharmaceutical and biotech applications.

 Speaker: Svea Stephan (Senior Application Scientist, Customized Solutions at KNAUER) 

Svea is a Senior Application Scientist at KNAUER. She has a lot of experience in LNP formulation development and process scale-up, especially in the development and characterization of LNP systems using Impingement Jets Mixing technology. Her expertise covers process optimization, analytical characterization, technology transfer and the development of scalable and reproducible LNP manufacturing processes. She works closely with pharmaceutical and biotech partners to translate LNP technologies from early-stage development into practical solutions for research and production.