High-Resolution Aggregate Analysis for Peptide Therapeutics
Biozen dSEC-1 columns are engineered to meet the growing demand for aggregate analysis in peptide therapeutics and mid-sized biologics. Packed with 90 Å small pore silica and featuring inert diol-based surface chemistry, dSEC-1 delivers enhanced resolution for low and high molecular weight peptide aggregates. Its robust design ensures reproducibility and compatibility with advanced workflows like SEC-MS and SEC-MALS.
Robust Performance for Peptide Aggregate Analysis
- High resolution for low/high MW peptide aggregates (1–50 kDa)
- Reproducible, and fast analysis with extended column lifetime
- Improved peak asymmetry by up to 40%
- Recommended Use: Analysis of peptides, protein fragments, and small biologics with reduced analysis times and improved column lifetimes.
Aggregate and Monomer Separation in Liraglutide Formulations
- Baseline resolution of monomer and two aggregates achieved in under 10 minutes
- Exceptional reproducibility with retention time RSD ≤ 0.08% and peak area RSD ≤ 0.01%
- Clear detection at low levels with S/N ratios of 13, 75, and 10,917 for aggregates and monomer
Phenomenex: Aggregate and Monomer Separation in Liraglutide Formulations
Phenomenex: Aggregate and Monomer Separation in Liraglutide Formulations
Biozen SEC Proprietary Silica Particle Technology
The Biozen dSEC columns are packed with low pore volume silica coupled with a proprietary hydrophilic diol-type bonded surface chemistry that prevents the silica surface from interacting with protein samples.
Phenomenex: Biozen SEC Proprietary Silica Particle Technology
Improved Column Lifetime and Performance Stability
Phenomenex’s optimized SEC column loading technology has significantly improved the overall packing density and silica distribution of the columns leading to improved chromatographic lifetime and stability.
New Standard for Platform SEC Methods
Whether IgG2 or IgG4 isotypes, bispecifics, or Fc-Fusions, dSEC-2 provides excellent separation and sample recovery for many different classes of antibodies and related recombinant proteins.
Phenomenex Biozen Biologics LC Columns
With a new titanium BioTi™ biocompatible hardware to minimize priming, four particle platforms for optimal versatility and nine particle chemistries to maximize selectivity and sensitivity, Biozen UHPLC/HPLC columns for protein analysis are seamlessly designed to bring peace of mind to your analysis of biologics through:
- Charge Variant Analysis
- Aggregate Analysis
- Peptide Mapping
- Intact Mass Analysis
- Intact and Subunit Analysis
- Glycan Analysis
- Peptide Quantitation
- Drug Antibody Ratio (DAR)
- Oligonucleotide Characterization
Biocompatible Flow Path with BioTi™ Hardware
Keep your mind at ease knowing that we’ve minimized the need for priming with a new titanium infused biocompatible hardware and frit that doesn’t interfere with protein or peptide integrity!
Phenomenex: BioTi Hardware
4 Advanced Particle Platforms
All four of the Biozen particle platforms were individually designed and built by Phenomenex to take advantage of integral levels of performance, ruggedness, and reproducibility for protein characterization applications. Individually, each platform differs in the proprietary processing techniques used to control particle size and morphology.
Phenomenex: Advanced Particle Platforms
