Biozen WCX was constructed with linear polycarboxylate chains grafted to monosized non-porous polymeric particles, to sinuously envelop and separate proteins from acidic and basic variants. With a highly tuned and controlled manufacturing process, Biozen WCX affords scientists a way to reproducibly characterize heterogeneity with an added advantage of excellent recovery using bioinert titanium column hardware.
Phenomenex: Biozen WCX HPLC Column
- Separation Mode: Ion Exchange
- Pore size: 0
- Particle size: 6
- Recommended Use: Separate proteins from acidic/basic variants
BioZen WCX Monosized Polymeric Non-Porous Particle
Monosized particles grafted with linear polycarboxylate chains to envelop and separate proteins from acidic/basic variants.
Phenomenex: bioZen WCX Monosized Polymeric Non-Porous Particle
Minimize your priming and promote better recovery with our BioTi™ biocompatible hardware
Phenomenex: BioTi™ biocompatible hardware
Monosized Particles for Optimal Consistency
Our specially crafted polymeric particle is produced with outstanding precision so that you can be confident in increased performance and minimized variation between lots.
Charge Variant Analysis
BioZen WCX was crafted to consistently decipher between native protein variants that arise from PTMs within a therapeutics creation and development. The linear polycarboxylate chains grafted to monosized non-porous polymeric particles, envelop and separate proteins from acidic and basic protein variants. With such a highly. tuned and controlled manufacturing process, bioZen WCX media affords scientists a way to reproducibly characterize heterogeneity while taking advantage of excellent recovery through high particle inertness and bioinert titanium BioTi™ column hardware.
Native Mode Mass Spectrometry with bioZen WCX
Ion-exchange chromatography (IEX) is a technique employed in the characterization of biotherapeutics under nondenaturing conditions. Standard mobile phase conditions for these techniques are high in salt concentration, rendering them incompatible with mass spectrometry (MS) detection. Native MS represents a cutting edge approach to employ MS compatible mobile phases for non-denaturing IEX analysis. Observe and measure the non-covalent interactions and charge variants of proteins at high resolution using bioZen WCX.
Phenomenex Biozen Biologics LC Columns
With a new titanium BioTi™ biocompatible hardware to minimize priming, four particle platforms for optimal versatility and nine particle chemistries to maximize selectivity and sensitivity, Biozen UHPLC/HPLC columns for protein analysis are seamlessly designed to bring peace of mind to your analysis of biologics through:
- Charge Variant Analysis
- Aggregate Analysis
- Peptide Mapping
- Intact Mass Analysis
- Intact and Subunit Analysis
- Glycan Analysis
- Peptide Quantitation
- Drug Antibody Ratio (DAR)
- Oligonucleotide Characterization
Biocompatible Flow Path with BioTi™ Hardware
Keep your mind at ease knowing that we’ve minimized the need for priming with a new titanium infused biocompatible hardware and frit that doesn’t interfere with protein or peptide integrity!
Phenomenex: BioTi Hardware
4 Advanced Particle Platforms
All four of the Biozen particle platforms were individually designed and built by Phenomenex to take advantage of integral levels of performance, ruggedness, and reproducibility for protein characterization applications. Individually, each platform differs in the proprietary processing techniques used to control particle size and morphology.
Phenomenex: Advanced Particle Platforms
