PAMS 2019: Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion Pairing

UNIVERSITY OF COPENHAGEN FA C U LT Y O F S C I E N C E Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion Pairing Jennifer M. Nguyen1,2, Xiaoxiao Liu2, and Matthew A. Lauber2 1University of Copenhagen, Frederiksberg,…

[ APPLICATION NOTE ] Comparing Mobile Phase Additives for the Separation of mAb Tryptic Peptides: A Case Study on Formic, Difluoroacetic, and Trifluoroacetic Acid Jennifer M. Nguyen, Xiaoxiao Liu, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS…

[ TECHNOLOGY BRIEF ] Low Adduct Peptide LC-MS Obtained with IonHance DFA and Certified LDPE Containers Jennifer Nguyen, Xiaoxiao Liu, and Matthew Lauber Waters Corporation, Milford, MA, USA Minimizing metal ion contamination for low adduct LC-MS separations using high purity…

[ APPLICATION NOTE ] Selecting a Reversed-Phase Column for the Peptide Mapping Analysis of a Biotherapeutic Protein Stephan M. Koza and Erin E. Chambers Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Side-by-side performance of ten The peptide mapping…