Low Adduct Peptide LC-MS Obtained with IonHance DFA and Certified LDPE Containers

UNIVERSITY OF COPENHAGEN FA C U LT Y O F S C I E N C E Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion Pairing Jennifer M. Nguyen1,2, Xiaoxiao Liu2, and Matthew A. Lauber2 1University of Copenhagen, Frederiksberg,…

Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion Pairing Jennifer Nguyen, Xiaoxiao Liu, and Matthew A. Lauber Waters Corporation, Milford, MA, USA INTRODUCTION Peptide mapping is an important and critical technique in the characterization of biopharmaceuticals. These separations are…

[ APPLICATION NOTE ] Comparing Mobile Phase Additives for the Separation of mAb Tryptic Peptides: A Case Study on Formic, Difluoroacetic, and Trifluoroacetic Acid Jennifer M. Nguyen, Xiaoxiao Liu, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS…

[ APPLICATION NOTE ] Practical Considerations for Optimizing MS Quality during IEX-MS Andrew Schmudlach and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Improve mass spectral quality MS cleanliness is a surprisingly overlooked aspect of protein LC-MS…