Direct Analysis of In-Process Oligonucleotides Without Manual Purification

Application Note Biopharma/Pharma Rapid and Cost-Effective Desalting of HPLC-Purified Oligonucleotides Authors Andrea Angelo P. Tripodi and Andrew Coffey Agilent Technologies, Inc. Abstract Oligonucleotide purification by HPLC is a common technique used to dramatically increase purity by removing related impurities that…

Is 2D HPLC the Answer for You Rita Steed LC Columns Application Engineer Sue D’Antonio LC Instrument Application Engineer August 26, 2021 1 August 26, 2021 Is 2D HPLC the Answer for You DE44433.4275578704 2D-LC: What Is It and Why…

Application Note Biopharma/Pharma Optimizing Separation of Oligonucleotides with Anion‑Exchange Chromatography Authors Abstract Jordy Hsiao, Alex Apffel, and Matt Turner Agilent Technologies, Inc. Purification of synthetic oligonucleotides can represent a unique challenge. Impurities associated with the synthesis of the full-length product…

Oligonucleotide Analysis: Practical Techniques and Method Development Optimization for HPLC Mohit Patel LC Columns and Consumables Technical Support December 19, 2023 1 12/19/2023 DE # DE48216954 What Are Oligonucleotide Therapeutic Types? Oligonucleotides are being increasingly developed as therapeutics against a…