Rapid and Cost-Effective Desalting of HPLC-Purified Oligonucleotides

Application Note Biologics and Biosimilars Direct Analysis of In-Process Oligonucleotides Without Manual Purification Ion-pair reversed-phase LC analysis with online desalting using Agilent InfinityLab 2D-LC Solutions Authors Abstract Sonja Krieger and Clarissa Dickhut Agilent Technologies, Inc. Waldbronn, Germany Oligonucleotides synthesized using…

An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations: From Analysis to Purification Melissa Goodlad, PhD Columns and Supplies Applications Engineer April 15, 2025 1 April 15, 2025 An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations DE-006001 Introduction to Ion-Paired Reverse-Phase (IP-RP) Separations…

An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations: From Analysis to Purification Melissa Goodlad, PhD Columns and Supplies Applications Engineer April 15, 2025 1 April 15, 2025 An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations DE-006001 Introduction to Ion-Paired Reverse-Phase (IP-RP) Separations…

Application Note Biopharma/Pharma Superficially Porous Columns for Semi-Preparative Purification of Synthetic Oligonucleotides Method development and scale-up using same analytical LC instrumentation Authors Abstract Andrea Angelo P. Tripodi and Andrew Coffey Agilent Technologies, Inc. Synthetic oligonucleotides inevitably contain many impurities due…