Online affinity and digestion: A flexible and robust tool for the characterization and quantification of proteins

PO-CON1457E A Rapid and Reproducible Immuno-MS Platform from Sample Collection to Quantitation of IgG ASMS 2014 ThP766 Rachel Lieberman1, David Colquhoun1, Jeremy Post1, Brian Feild1, Scott Kuzdzal1, Fred Regnier2, 1 Shimadzu Scientific Instruments, Columbia, MD, USA 2 Novilytic L.L.C, North…

A Single Injection LC-MS Analysis Scheme for Simultaneous Analysis of Biotherapeutics and Host-Cell Impurities via Online Digestion LC-MS/MS Novel Aspect Fully automated online protein digestion, affinity pulldown, intact mass analysis, peptide mapping of target therapeutics and host-cell proteins in a…

Rapid Automated Peptide Mapping Kate Erickson Application Scientist The world leader in serving science Why is there a growth in biotherapeutics? • 8/10 drugs in 2016 Biologics • Biopharma growing rapidly ~10% over the next 5 years • $160 Billion…

[ APPLICATION NOTE ] Automating Sample Preparation Workflows for Hybrid LC-MS/MS Bioanalysis of Protein Therapeutics: Quantification of Etanercept Using Affinity Purification and Digestion Paula Orens and Mary Lame Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Automating a hybrid LC-MS/MS…