Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 1- OAR Analysis and Conjugation Process Monitoring

Comprehensive LC-MS Analytical Assays for Antibody-Oligonucleotide Conjugate (AOC) and siRNA Linker-Payload Characterization Samantha Ippoliti1; Brad Williams1; Ying Qing Yu1; Connor Brandenburg; Tara MacCulloch; Michelle Chen2; Sophia Kenrick2 1 Waters Corporation, Milford, MA; 2Waters Corporation, Goleta, California INTRODUCTION METHODS Antibody-oligo conjugates…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 3Partial and Complete AOC Conjugation Site Determination Samantha Ippoliti, Ying Qing Yu Waters Corporation, United States Note: This is the third application note in a three-part series on AOC characterization.…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 2Denaturing and Non-denaturing Analysis of siRNA Payload Samantha Ippoliti, Ying Qing Yu, Connor Brandenburg, Tara MacCulloch Waters Corporation, United States Note: This is the second application note in a three-part…

Application Note BioAccord™ LC-MS System Enhancements for Improved Native MS Analysis Samantha Ippoliti, Ying Qing Yu, Scott Berger Waters Corporation, Milford MA Published on May 27, 2025 Contact Sales Application Brief This is an application brief and does not contain…