Comprehensive LC-MS Analytical Assays for Antibody-Oligonucleotide Conjugate (AOC) and siRNA Linker-Payload Characterization

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 1- OAR Analysis and Conjugation Process Monitoring Samantha Ippoliti, Ying Qing Yu, Connor Brandenburg, Tara MacCulloch, Michelle Chen Waters Corporation, United States Note: This is the first application note in…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 3Partial and Complete AOC Conjugation Site Determination Samantha Ippoliti, Ying Qing Yu Waters Corporation, United States Note: This is the third application note in a three-part series on AOC characterization.…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 2Denaturing and Non-denaturing Analysis of siRNA Payload Samantha Ippoliti, Ying Qing Yu, Connor Brandenburg, Tara MacCulloch Waters Corporation, United States Note: This is the second application note in a three-part…

Application Note Analysis of Antibody siRNA Conjugate Using BioAccord System Henry Shion, Catalin E. Doneanu, Ed Ha, Ying Qing Yu, Weibin Chen Waters Corporation, Angiex, Inc. Biopharmaceutical services at Waters Immerse Innovation and Research Center (www.waters.com/immerse <http://www.waters.com/immerse> ) aim to…