Extended Gradients with Efficient Protein A Columns for the ProA-MS Analysis of mAb and msAb Variants

High Efficiency Protein A Affinity Columns for the LC-MS and 2D LC-MS Analysis of mAb and msAb A quiver of LC-MS based approaches for the sub-unit and intact and analysis of intact monoclonal antibodies (mAb) and multispecific antibodies (msAb) directly…

Application Note High-Throughput Native HRMS ProA-MS Analysis of mAb Variants in Cell-Culture Samples Stephan M. Koza, Matthew A. Lauber, Stephen J. Shiner Waters Corporation, United States Published on January 21, 2025 Abstract The use of rapid Protein-A (ProA) 1-minute elution…

Application Note A Trap & Elute Style 2D Protein A–SEC Heart-Cut Method for the Analysis of Monoclonal Antibody Titer and Size Variants in Cell Culture Stephan M. Koza, Steve Shiner, Matthew A. Lauber Waters Corporation, United States Published on June…

Application Note An Easy-to-Execute Direct-Connect 2D Protein A–SEC Method for the Analysis of Monoclonal Antibody Titer and Size Variants in Cell Culture Stephan M. Koza, Beatrice Muriithi, Steve Shiner, and Matthew A. Lauber Waters Corporation, United States Published on May…