Bioanalytical HILIC LC-MS Compatibility Using the GTxResolve™ Premier Amide Column and OligoWorks™ SPE Sample Preparation Solution

[ CONSUMABLES GUIDE BOOK ] Quantifying Oligonucleotides Sample Extraction and LC Tools for Reliable LC-MS Quantitation of Oligonucleotides A Changing Industry There has been a resurgence in synthetic oligonucleotide therapeutics in the past decade, as seen with burgeoning pipelines across…

Application Note Improved Bioanalytical Extraction of Therapeutic Antisense Oligonucleotides, Including a Lipid Conjugated ASO From Liver and Brain Tissue Using the OligoWorks™ SPE Microplate Kit Makda Araya, Mary Trudeau, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract To develop and…

Application Note Analytical Solutions and Method Development Considerations for Quantitative Bioanalytical Oligonucleotide Studies Marian Twohig, Catalin Doneanu, Margot Lee, Nikunj Tanna, Mary Trudeau Waters Corporation, United States Published on November 24, 2025 Abstract Oligonucleotide therapeutics are gaining momentum as innovative…

Application Note Studying Mobile Phases for HILIC UV/MS Analysis of Oligonucleotide Therapeutics including an siRNA Duplex, a Lipid Conjugated ASO, and a CRISPR sgRNA Szabolcs Fekete, Makda Araya, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract Hydrophilic interaction liquid chromatography…