Advancing Charge Variant Analysis with pHGradient Ion-Exchange Chromatography: Optimizing Monoclonal Antibody Characterization Using the High-pH Kit for the Alliance™ iS Bio HPLC System

[ APPLICATION NOTE ] Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis Qi Wang, Susan C. Rzewuski, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Platform method…

Application Note Extended Analysis of mAbs Using IonExchange Chromatography on the Alliance™ iS Bio HPLC System Corey Reed, Paula Hong Waters Corporation Abstract Large molecule biologics continue to be a major focus in the pharmaceutical market. These biopharmaceutical drugs require…

[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…

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