The INTACT Mass Application in waters_connect™ Platform Streamlines ADC DAR and Drug Distribution Analysis

Application Note Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application Jonathan Fox, Scott J Berger, Laetitia Denbigh, Sam Ippoliti Waters Corporation, United States Published on December 24, 2025 Abstract This technology…

Application Note LC-MS Analysis of Intact Lysine-Conjugated ADCs using the ACQUITY™ Premier UPLC™ and Xevo™ G3 QTof Mass Spectrometer Samantha Ippoliti, Ying Qing Yu Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract…

, Intact Analysis of Antibody Drug Conjugates Trastuzumab Emtansine Analysis using Benchtop X500B QTOF Mass Spectrometer Wen Jin1, Suya Liu1, Doug Simmons1, Ian Moore1, Sean McCarthy2 and Sibylle Heidelberger1 71 Four Valley Dr. Concord, ON L4K 4V8, Canada 500 Old…

Routine analysis of drug to antibody ratio and drug distribution with maXis II Antibody drug conjugates (ADC) are small molecule conjugated mAbs. These are rapidly emerging complex biological molecules in the biopharma space. Abstract Characterization of ADC’s includes intact mass…