LC-MS Analysis of Intact Lysine-Conjugated ADCs using the ACQUITY™ Premier UPLC™ and Xevo™ G3 QTof Mass Spectrometer

[ TECHNOLOGY BRIEF ] Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA Drug-to-Antibody Ratio (DAR) determination of Lys and Cys conjugated…

Application Note The INTACT Mass Application in waters_connect™ Platform Streamlines ADC DAR and Drug Distribution Analysis Samantha Ippoliti, Ying Qing Yu, Scott Berger Waters Corporation, United States Published on May 30, 2025 Contact Sales Application Brief This is an application…

[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…

[ APPLICATION NOTE ] Antibody-Drug Conjugate (ADC) Drug-to-Antibody Ratio (DAR) Analysis in Serum Using IA-LC-HRMS Armand Ngounou and Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Robust and reliable IA-UPLC-HRMS Antibody-drug conjugates (ADCs) are comprised of a…