Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application

Application Note The INTACT Mass Application in waters_connect™ Platform Streamlines ADC DAR and Drug Distribution Analysis Samantha Ippoliti, Ying Qing Yu, Scott Berger Waters Corporation, United States Published on May 30, 2025 Contact Sales Application Brief This is an application…

Application Note Analysis of Cysteine-Conjugated Antibody Drug Conjugates (ADCs) Using a Native SEC LC-MS Workflow on the SYNAPT XS Henry Shion, Colette Quinn, Scott J. Berger, Ying Qing Yu Waters Corporation This is an Application Brief and does not contain…

[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…

Application note | 004331 Biopharma Automated workflow for intact antibody drug conjugates (ADCs) and DAR analysis in Chromeleon CDS Authors Application benefits Ulrik H. Mistarz1, Marcus Hoffmann2, • Automated, high-throughput capable analysis of intact antibody-drug conjugates (ADCs) and drug-to-antibody ratio…