Breeze through membrane protein stability with Uncle

Application Note See it all with Uncle's full-spectrum analysis Introduction Measuring thermal stability by pairing heat-induced denaturation with fluorescence detection is a well-established method to optimize stability and formulation for biologics. While in most cases it’s preferable to use label-free…

Application Note DNA leaks before capsids pop: AAV thermal stability on Uncle Introduction Characterizing viral stability for gene therapies using adeno-associated virus (AAV) vectors is a complex task and requires understanding behaviors of whole viral particles, viral genomes, and capsid…

APPLICATION NOTE Uncle stays hot for proteins with isothermal apps Introduction Testing the isothermal stability of proteins at high-throughput as early as candidate screening is the fastest way to see which ones would fail long-term storage trials. Unfolding and aggregation…

Tech Note Meet Our Uncle: 12 Stability Applications on One Platform Uncle is an all-in-one stability platform that enables twelve different applications with one instrument. Fluorescence, static light scattering (SLS) and dynamic light scattering (DLS) detec­ tion methods are used…