Uncle stays hot for proteins with isothermal apps

Application Note See it all with Uncle's full-spectrum analysis Introduction Measuring thermal stability by pairing heat-induced denaturation with fluorescence detection is a well-established method to optimize stability and formulation for biologics. While in most cases it’s preferable to use label-free…

One-stop stability Cracking stability using a pile of one-trick, sample-hungry tools is a ton of work. Uncle combines 3 different measurement modes — fluorescence, SLS and DLS. So you can crank out all your data in just a few hours,…

Tech Note Meet Our Uncle: 12 Stability Applications on One Platform Uncle is an all-in-one stability platform that enables twelve different applications with one instrument. Fluorescence, static light scattering (SLS) and dynamic light scattering (DLS) detec­ tion methods are used…

Application Note DNA leaks before capsids pop: AAV thermal stability on Uncle Introduction Characterizing viral stability for gene therapies using adeno-associated virus (AAV) vectors is a complex task and requires understanding behaviors of whole viral particles, viral genomes, and capsid…