ADVANCING ANALYTICAL PERFORMANCE FOR BIOTHERAPEUTICS WITH A BIO-INERT HPLC SYSTEM

Application Note Evaluating the Ruggedness of the Alliance™ iS Bio HPLC System for SEC Separations Pawel Bigos, Robert E. Birdsall, Karen Nyholm Waters Corporation Abstract Biopharmaceutical companies are often progressing several monoclonal antibody (mAb) drug candidates to mitigate the risks…

ENHANCING ANALYTICAL PERFORMANCE WITH A BIO-INERT HPLC SYSTEM Pawel Bigos, Xiangsha Du, Duanduan Han, Robert Birdsall, Andrea Hoehnel, Karen Nyholm Waters Corporation INTRODUCTION RESULTS AND DISCUSSION In biopharmaceutical analysis, undesired secondary analyte/surface interactions have hindered performance in HPLC. Analytes that…

W1330-02-10 Next-Generation Bio-Inert HPLC System for Enhanced Analysis of Biotherapeutics Pawel Bigos, Xiangsha Du, Duanduan Han, Robert Birdsall, Suraj Dhungana, Karen Nyholm Waters Corporationn, 34 Maple Street, Milford, MA 01757 USA CONTACT INFORMATION: [email protected] RESULT(S) Alliance iS Bio HPLC System…

METHOD MODERNIZATION OF COMPENDIAL METHODS USING USP <621> WITH A NEXT-GENERATION HPLC SYSTEM Pawel Bigos, Duanduan Han, Xiangsha Du, Robert Birdsall, Karen Nyholm Waters Corporation 0.0000 10.0 0.0030 0.0025 0.0025 System Column Inj. Vol. Flow Rate Run Time Mobile Phase…