Next-Generation Bio-Inert HPLC System for Enhanced Analysis of Biotherapeutics

ENHANCING ANALYTICAL PERFORMANCE WITH A BIO-INERT HPLC SYSTEM Pawel Bigos, Xiangsha Du, Duanduan Han, Robert Birdsall, Andrea Hoehnel, Karen Nyholm Waters Corporation INTRODUCTION RESULTS AND DISCUSSION In biopharmaceutical analysis, undesired secondary analyte/surface interactions have hindered performance in HPLC. Analytes that…

MODERNIZING BIOTHERAPEUTIC COMPENDIAL METHODS WITH A NEXT-GENERATION HPLC SYSTEM Pawel Bigos, Duanduan Han, Xiangsha Du, Robert Birdsall, Andrea Hoehnel, Karen Nyholm Waters Corporation INTRODUCTION RESULTS AND DISCUSSION As the field of analytics continues to evolve, methods guided by regulatory general…

METHOD MODERNIZATION OF COMPENDIAL METHODS USING USP <621> WITH A NEXT-GENERATION HPLC SYSTEM Pawel Bigos, Duanduan Han, Xiangsha Du, Robert Birdsall, Karen Nyholm Waters Corporation 0.0000 10.0 0.0030 0.0025 0.0025 System Column Inj. Vol. Flow Rate Run Time Mobile Phase…

Application Note: 52185 Maximizing Speed and Separations for Lowering Drinking Water Detection Limits with GC/MS Jessie Butler, Terry Jeffers, David Steiniger, Eric Phillips, Pat O’Brien, Thermo Fisher Scientific, Austin, TX, USA Overview Key Words • ISQ Single Quadrupole GC-MS •…