PEGS: HIGH THROUGHPUT CYSTEINYLATION SCREENING AT MAB SUBUNIT LEVEL USING LC-MS MONITORING WORKFLOW

Application Note Efficient Non-Reduced mAb Subunit LC-MS Analysis to Screen for Modifications of Unpaired Cysteines in Innovator and Biosimilars Samantha Ippoliti, Bradley Prater, Ying Qing Yu, Magnus Wetterhall Similis Bio, Waters Corporation Abstract This application note highlights a collaboration between…

HIGH THROUGHPUT CYSTEINYLATION SCREENING AT MAB SUBUNIT LEVEL USING LC-MS SCREENING WORKFLOW Samantha Ippoliti1, Bradley Prater2, Ying Qing Yu1, Magnus Wetterhall3 1Waters Corporation, Milford, MA; 2Similis Bio, Sunnyvale, CA, USA; 3Waters Corporation, Solna, Sweden INTRODUCTION RESULTS & DISCUSSION Monoclonal antibodies…

Application Note Similis Bio - Streamlined mAb Subunit LCMS Workflow for Multiple Attribute Monitoring of Biosimilar mAb Candidates During Bioprocessing and Development Samantha Ippoliti, Jared Young, Katy McNally, Caitlin Hanna, Ying Qing Yu, Bradley Prater, Mark D. Wrona, Emma Harry…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 3Partial and Complete AOC Conjugation Site Determination Samantha Ippoliti, Ying Qing Yu Waters Corporation, United States Note: This is the third application note in a three-part series on AOC characterization.…