Rapid Analyses of mAb Subunits and Intact mAb with 20 mm Polyphenyl Reversed- Phase Columns

Application Note Automating Rapid High-Throughput LC-MS mAb Subunit Screening of Microbioreactor Cell Culture Samples Alireza Aghayee, Yamin Htet, Stephan M. Koza, Lindsay Morrison, Henry Shion, Ying Qing Yu Waters Corporation Abstract Monoclonal antibodies (mAbs) remain one of the fast-growing classes…

[ APPLICATION NOTE ] A Novel Phenyl Bonded Phase for Improved Reversed-Phase Separations of Proteins Jennifer M. Nguyen, Lavelay Kizekai, Dan Walsh, Jim Cook, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Polyphenyl bonded phase…

High Efficiency Protein A Affinity Columns for the LC-MS and 2D LC-MS Analysis of mAb and msAb A quiver of LC-MS based approaches for the sub-unit and intact and analysis of intact monoclonal antibodies (mAb) and multispecific antibodies (msAb) directly…

Application Note Greener, Lower Cost Organic Mobile Phase Solvents for the LC-MS Analysis of Intact Biotherapeutic Proteins Henry Shion, Ying Qing Yu Waters Corporation Abstract This application note presents on the recent trend replacing acetonitrile (Class II Toxicity) with greener…