Automating Rapid High-Throughput LC-MS mAb Subunit Screening of Microbioreactor Cell Culture Samples

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

Automating Rapid High-throughput mAb Attribute Screening of Microbioreactor Cell Culture Media Samples Alireza Aghayee1, Yamin Htet2, Lindsay Morrison2, Stephan M. Koza2, Ying Qing Yu2 1 Pall Corporation, Westborough, MA, USA; 2Waters Corporation, Milford, MA, USA INTRODUCTION RESULTS AND DISCUSSION …

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

AUTOMATING SUBUNIT MAB ATTRIBUTE SCREENING FOR IN-PROCESS MONITORING OF AN AUTOMATED HIGH-THROUGHPUT MULTI-PARALLEL BIOREACTOR Nick Pittman1; Patrick Boyce1; Caitlin Hanna2; Samantha Ippoliti2; Yun W Alelyunas2; Charles Prochaska3; Clint Kukla3; Guillaume Bechade1; Magnus Wetterhall1; Mark Wrona2; Stephan M Koza2; Ying Qing…