IMPROVING SPATIAL DISTRIBUTION, SENSITIVITY AND SELECTIVITY IN MSI, USING A NOVEL DESI QQQ AND A HR-MULTI REFLECTING TOF SYSTEMS

VISUALIZATION AND QUANTIFICATION OF DRUG/METABOLITES BY SENSITIVE AND FAST TARGETED DESI IMAGING ON TQ SYSTEM Emmanuelle Claude1, Ross Chawner1, Nathalie Delallée2, Stephanie Molez2, Gregory Nicolas2, Joanne Ballantyne1 1 Waters Corporation, Wilmslow, UK; 2Bioprojet, Saint Gregoire, France INTRODUCTION Mass spectrometry (MS)…

EVALUATION OF DESI MOUNTED ON Q-TOF AND TQ MASS SPECTROMETERS TO IMAGE PFAS COMPOUNDS IN DIFFERENT MATRICES Emmanuelle Claude, Alexandra Lee, Mujeebatu Kadiri-Asamoah, Stuart Adams, Emrys Jones, Joanne Ballantyne Waters Corporation, Wilmslow, UK INTRODUCTION Per- and polyfluoroalkyl substances (PFAS) are…

NOVEL TARGETED DESI MRM TQ SYSTEM PROVIDING INCREASED SENSITIVITY AND ACQUISITION SPEED FOR MASS SPECTROMETRY IMAGING Emmanuelle Claude1, Steven Pringle1, Joanne Ballantyne1 1 Waters Corporation, Wilmslow, UK INTRODUCTION Gefitinib was detected with a S/N ~ 2,500 and was at least…

MULTI-STEP WORKFLOW FOR VISUALIZATION OF DRUG/METABOLITES AND METABOLISM WITH DESI TQ AND DESI Q-TOF MASS SPECTROMETERS Emmanuelle Claude1; Naysha Munjoma1; Alex Birsan3, Ian Wilson2, Joanne Ballantyne1 1 Waters Corporation, Wilmslow; 2Division of Systems Medicine, Department of Metabolism Department of Metabolism,…