Development of Label-Free, Enzymatic CYP17A1 Assays Using the Agilent 6150 Single Quadrupole LC/MS System

Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS Application Note Authors Introduction Lauren E. Frick and William A. LaMarr Agilent Technologies, Inc. Wakefield, MA, USA Fragment-based screening offers advantages over…

Application Note Drug Discovery A study of SIRT1- and SIRT2‑Mediated Deacetylation Using the Agilent RapidFire high-throughput mass spectrometry system Authors Abstract Peter Rye, Lauren Frick, and William Lamarr Agilent Technologies, Inc. The Agilent RapidFire high-throughput mass spectrometry (MS) system is…

Ultrafast Histone Deacetylase Selectivity Screening Using the Agilent RapidFire High-Throughput Mass Spectrometry System Application Note Authors Abstract Lauren E. Frick and William A. LaMarr Selectivity screening of a promising new compound requires testing against a Agilent Technologies, Inc. host of…

Application Note Discovery of Potential Soluble Epoxide Hydrolase Inhibitors Using a High-Throughput Screening Assay on a 235 Compound Library Authors David Hoffman, PhD Scientific Director, Contract Services Division Cayman Chemical Melissa Parsey, PhD Scientific Content Developer Cayman Chemical Agilent contact:…