Discovery of Potential Soluble Epoxide Hydrolase Inhibitors Using a High-Throughput Screening Assay on a 235 Compound Library

© Title Image - Analytik Jena Kinase inhibition screening by label-free mass spectrometry employing the MALDI PharmaPulse HTS solution Bruker´s MALDI PharmaPulse solution, integrating the rapifleX high-speed MALDI-TOF instrument with the dedicated MALDI PharmaPulse software suite, represents an emerging technology…

Application Note Bravo & Seahorse XF Maximizing Efficiency and Performance of Seahorse XF Assays with the Bravo Automated Liquid Handling Platform Authors Abstract Lisa Winer, George W. Rogers, Sarah E. Burroughs, and Brian P. Dranka Agilent Technologies, Inc. It is…

Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS Application Note Authors Introduction Lauren E. Frick and William A. LaMarr Agilent Technologies, Inc. Wakefield, MA, USA Fragment-based screening offers advantages over…

Label-free drug uptake analysis of whole cells by MALDI-TOF mass spectrometry using the transport protein OATP2B1 as an example In this application note, we demonstrate a MALDI MS cellular drug uptake and inhibition assay [1]. It was conducted in HEK293…