A study of SIRT1- and SIRT2‑Mediated Deacetylation

High-Throughput Analysis of Epigenetic Targets with Agilent RapidFire/MS Systems: Sirtuin (SIRT) Enzymes Application Note Author Introduction Peter Rye, Lauren Frick, and William LaMarr Agilent Technologies, Inc. Wakefield, MA USA Histones and other proteins are subject to a variety of posttranslational…

Ultrafast Histone Deacetylase Selectivity Screening Using the Agilent RapidFire High-Throughput Mass Spectrometry System Application Note Authors Abstract Lauren E. Frick and William A. LaMarr Selectivity screening of a promising new compound requires testing against a Agilent Technologies, Inc. host of…

High-Throughput MS Detection of Histone H3 Demethylation by Lysine-Specific Demethylase 1 (LSD1) Application Note Author Introduction Peter Rye, Lauren Frick, and William LaMarr Agilent Technologies, Inc. Wakefield, MA USA The field of epigenetics focuses on the investigation of enzymes that…

Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS Application Note Authors Introduction Lauren E. Frick and William A. LaMarr Agilent Technologies, Inc. Wakefield, MA, USA Fragment-based screening offers advantages over…