Improved Top-Down Sequence Coverage on an Orbitrap Fusion Lumos Tribrid Mass Spectrometer by Ion-Ion Proton Transfer (IIPT) Reactions Subsequent to ETD and UVPD

Improved Middle-Down Characterization of Antibodies Using Multiple Ion Activation Techniques and Ion-Ion Proton Transfer Reactions on a Modified Orbitrap Mass Spectrometer John E.P. Syka, Christopher Mullen, Stephane Houel, Romain Huguet, Joshua A. Silveira, Helene L. Cardasis, and Vlad Zabrouskov; Thermo…

Enhancing Ultraviolet Photodissociation Performance on a Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer for Small Molecule and Protein Analysis Dustin D. Holden, Jae C. Schwartz, Thermo Fisher Scientific, 355 River Oaks Parkway, San Jose, CA, USA, 95134 The laser…

NEW on Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ MS Stephane Houel, Ph.D. BioPharma Vertical Marketing The world leader in serving science NEW On Thermo Scientific Orbitrap Fusion Lumos MS in 2017 ADVANCED PEAK DETERMINATION ALGORITHM RESULTS IN SIGNIFICANT IMPROVEMENT IN…

APPLICATION NOTE 74160 Proton transfer charge reduction (PTCR) improves spectral matching and sequence coverage in middle-down analysis of monoclonal antibodies Luca Fornelli,1 Ryan N. Oates,1 Kristina Srzentić,2 Christopher Mullen,3 John E. P. Syka,3 and Romain Huguet3 University of Oklahoma, Norman,…