High Sensitivity Analysis of Potential Mutagenic Boronic Acids Using Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer with an ACQUITY™ Premier System

Application Note High Sensitivity Quantification of Nitrosamines in Metformin Using Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer With an ACQUITY™ Premier System Margaret Maziarz, Paul D. Rainville, Amy Bartlett Waters Corporation Abstract The presence of nitrosamine impurities in the pharmaceutical…

Application Note Quantification of Warfarin and Furosemide in Human and Rat Plasma for Discovery Bioanalysis Using ACQUITY™ Premier UPLC™ System and Xevo™ TQ Absolute Mass Spectrometer Nikunj Tanna, Robert S. Plumb Waters Corporation Abstract Accurate and precise quantification of pharmaceutical…

Application Note Suggested Approaches for Minimizing Background Chemical Noise in Low Mass MRM Transitions for Trace Level Quantification of N-Nitrosamines Marian Twohig, Padmakar Wagh, Margaret Maziarz, Amy Bartlett Waters Corporation This is an Application Brief and does not contain a…

[ APPLICATION NOTE ] Analysis of Genotoxic Impurities of Imatinib Mesylate by LC-MS from Early Development to Routine Monitoring Margaret Maziarz and Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ INTRODUCTION Sensitive and selective UPLC® method…