High Sensitivity Quantification of Nitrosamines in Metformin Using Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer With an ACQUITY™ Premier System

Waters Xevo TQ Absolute-A highly sensitive LCMSMS for quantification of low concentration of seven Nitrosamine impurities TM Pavan Kumar K, Dr. Taposh Kumar G, Dr. Padmakar Wagh India Applications Laboratory, Waters India, Bangalore. RESULTS AND DISCUSSION INTRODUCTION Since Mid-2018, Nitrosamine…

[ APPLICATION NOTE ] High Sensitivity Quantitation of Nitrosamine Genotoxic Impurities: LC-MS Analysis of Ranitidine Drug Product using the Waters ACQUITY UPLC I-Class/Xevo TQ-XS Tandem Quadrupole Mass Spectrometer Mary Trudeau Lame and Lindsay Hatch Waters Corporation, Milford, MA, USA APPLICATION…

Application Note Determination of Nitrosamine Impurities in Losartan Potassium Drug Substance and Drug Product using the Xevo TQ-S micro and Atlantis Premier BEH C18 AX Column Jun Xiang Lee, Zhen Han Mong, Wenlin Zhang Waters Corporation Abstract This application note…

Application Note Suggested Approaches for Minimizing Background Chemical Noise in Low Mass MRM Transitions for Trace Level Quantification of N-Nitrosamines Marian Twohig, Padmakar Wagh, Margaret Maziarz, Amy Bartlett Waters Corporation This is an Application Brief and does not contain a…