Suggested Approaches for Minimizing Background Chemical Noise in Low Mass MRM Transitions for Trace Level Quantification of N-Nitrosamines

Application Note Pharmaceutical Enhanced Data Quality in LC/MS/MS Analysis of Nitrosamines Using the Agilent InfinityLab quick change solvent purifier significantly reduces background noise and enables reliable detection of trace-level nitrosamines in complex pharmaceutical matrices Authors Linda Lin and Rong-Jie Fu…

[ APPLICATION NOTE ] High Sensitivity Quantitation of Nitrosamine Genotoxic Impurities: LC-MS Analysis of Ranitidine Drug Product using the Waters ACQUITY UPLC I-Class/Xevo TQ-XS Tandem Quadrupole Mass Spectrometer Mary Trudeau Lame and Lindsay Hatch Waters Corporation, Milford, MA, USA APPLICATION…

Application Note Identification and Quantitation of NNitrosamines in Normal Saline Intravenous Infusion bags Using UHPLC-MS/MS Marian Twohig Waters Corporation, United States Published on May 08, 2026 Abstract N-nitrosamines (nitrosamines) have been a major pharmaceutical safety concern since 2018, beginning with…

[ TECHNOLOGY BRIEF ] Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Lindsay Hatch, Mary Lame, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA The Xevo TQ-XS Mass Spectrometer,…