Deep Identification and Quantitation of Unknown HCPs in NISTmAb Using an Optimized Sample Preparation Combined with NanoLC-MS

APPLICATION NOTE 74109 Comprehensive identification and label-free quantitation of host cell protein contaminants using BioPharma Finder 4.1 software Authors: Silvia Millán-Martín,1 Sara Carillo,1 Jonathan Bones1, Jennifer Sutton2 National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland 1 2 Thermo…

Application Note Enhanced Host Cell Protein Identification and Quantitation with Multi-Reflecting ToF LC-MS Jonathan Fox, Malcolm Anderson, Ying Qing Yu, Scott J Berger, Nick Pittman, Laetitia Denbigh Waters Corporation, United States Published on August 07, 2025 Abstract Host cell proteins…

APPLICATION NOTE 74162 LC-MS-based host cell protein (HCP) identification and monitoring during biopharmaceutical downstream process development Authors: Xiaoxi Zhang1, Zijuan Chen2, Bingnan Li2, Jennifer Sutton3, Min Du4 Thermo Fisher Scientific 1 Shanghai, China; 2 Bioprocess Design Center, Shanghai, China; 3…

APPLICATION NOTE 73412 Residual host cell protein analysis of NISTmAb: From simplified sample preparation to reliable results Authors: Amy Claydon, Phil Widdowson, and Andrew Williamson Thermo Fisher Scientific, Hemel Hempstead, UK Keywords: Host cell protein assay, HCP, monoclonal antibody, mAb,…