Label-Free Analysis by UHPLC with Charged Aerosol Detection of Glycans Separated by Charge, Size, and Isomeric Structure

In M M G N-linked glycans are released from proteins by PNGase-F. The released glycans are separated by ultra high performance liquid chromatography (UHPLC) on a new UHPLC platform that integrates the charged aerosol detector into the system for increased…

O-linked glycans are released from proteins by reductive β-elimination. The released glycans are separated by ultra high performance liquid chromatography (UHPLC) on a new UHPLC platform that integrates the charged aerosol detector into the system for increased performance and ease…

Application of Charged Aerosol HPLC Detection in Biopharmaceutical Analysis Application of Charged Aerosol HPLC Detection Poster Note 71 8 0 3 formulated in UV-transparent excipients that must be detected and measured. In contrast to UV/Vis instruments, the Charged Aerosol Detector…

Udayanath Aich1, Julian Saba2, Xiaodong Liu1 and Chris Pohl1 1 Thermo Fisher Scientific, Sunnyvale, CA, USA; 2Thermo Fisher Scientific, Mississuaga, ON, Canada Appli cat i on N ote 2 0 8 2 7 Structural Analysis of Native N-Glycans Released from…